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HighVista Strategies LLC

Institutional InvestorSimilar funds →SEC EDGAR: CIK 1335325
Institutional-grade research for retail investors

Sector Allocation

  • Healthcare71.0%$311.2M
  • Financials9.6%$42.1M
  • Technology8.3%$36.2M
  • Industrials3.6%$15.6M
  • Consumer Discretionary2.9%$12.8M
  • Utilities2.1%$9.3M
  • Energy1.3%$5.8M
  • Materials0.9%$3.9M
  • Communication Services0.4%$1.6M

AUM History

13fpro.ai/research/fund/highvista-strategies-llc-1335325

Conviction and streaks

Stable · top 10 = 28.2%

From the fund's last 12 quarters of 13F filings: positions held longest at size, and names it added to or trimmed several quarters running.

DBC$DBCConviction hold6.4% weight · held 10 quartersABVX$ABVXConviction hold3.4% weight · held 10 quartersRVMD$RVMDConviction hold2.9% weight · held 10 quartersIMVT$IMVTConviction hold2.4% weight · held 6 quartersPRAX$PRAXConviction hold2.3% weight · held 8 quartersPCVX$PCVXAccumulating+352% shares · 5 quarters runningIMVT$IMVTAccumulating+25% shares · 2 quarters runningPRAX$PRAXAccumulating+17% shares · 2 quarters runningALKS$ALKSAccumulating+579% shares · 2 quarters runningAMLX$AMLXAccumulating+62% shares · 2 quarters runningAVGO$AVGOTrimming-74% shares · 5 quarters runningGOOG$GOOGTrimming-62% shares · 4 quarters runningSTX$STXTrimming-92% shares · 4 quarters runningFERG$FERGTrimming-58% shares · 4 quarters runningURGN$URGNTrimming-35% shares · 4 quarters running

Largest positions — Q2 2026

Top 20 stock positions. Options are left out: 13F reports them at the underlying's value.

13fpro.ai/research/fund/highvista-strategies-llc-1335325

HighVista Strategies LLC 13F holdings — Q2 2026

$438.6M portfolio (+21.1% QoQ) · 147 holdings · Q2 2026 13F · top 10 are 28% of the stock portfolio

All holdings — HighVista Strategies LLC (Q2 2026)

147 disclosed positions from the Form 13F-HR on SEC EDGAR, with quarter-over-quarter share changes. Largest by value first; the ten above are not repeated.

Company
LQDA$LQDALiquidia Corp$7.8M-2%
COGT$COGTCogent Biosciences, Inc.$7.3M-4%
GPCR$GPCRStructure Therapeutics Inc.adr$7.0M+6%
ELVN$ELVNEnliven Therapeutics, Inc.$7.0M+89%
AMLX$AMLXAmylyx Pharmaceuticals, Inc.$6.9M+10%
SYRE$SYRESpyre Therapeutics, Inc.$6.9M-47%
LBRX$LBRXLB PHARMACEUTICALS INC$6.9M+22%
CYTK$CYTKCYTOKINETICS INC$6.6M+33%
CCCC$CCCCC4 Therapeutics, Inc.$6.3MNew
TYRA$TYRATyra Biosciences, Inc.$5.9M+41%
ALMS$ALMSALUMIS INC.$5.6M+77%
PHVS$PHVSPharvaris N.V.$5.5M+64%
TARS$TARSTarsus Pharmaceuticals, Inc.$5.5M+66%
CMPS$CMPSCOMPASS Pathways plcadr$5.3M+2%
DNTH$DNTHDianthus Therapeutics, Inc. /DE/$5.0M+44%

What changed in Q2 2026

Against the previous quarter's 13F: 29 new, 50 added to, 66 trimmed, 38 sold out. Share-count changes; largest moves by dollar size first.

New positions (29)

  • CCCC$CCCCC4 Therapeutics, Inc.$6.3M

    first bought this quarter

  • RLMD$RLMDRELMADA THERAPEUTICS, INC.$3.1M

    first bought this quarter

  • TXN$TXNTEXAS INSTRUMENTS INC$1.9M

    first bought this quarter

  • DNOW$DNOWDNOW Inc.$1.7M

    first bought this quarter

  • NUE$NUENUCOR CORP$1.7M

    first bought this quarter

  • TDAY$TDAYUSA TODAY Co., Inc.$1.6M

    first bought this quarter

+23 more in the Excel export

Added to (50)

  • ALKS$ALKSAlkermes plc.+145%

    now $9.4M · held 7 qtrs, 2 adds in a row

  • TNGX$TNGXTango Therapeutics, Inc.+150%

    now $8.1M · held 2 qtrs, 2 adds in a row

  • ELVN$ELVNEnliven Therapeutics, Inc.+89%

    now $7.0M · held 10+ qtrs

  • TVTX$TVTXTravere Therapeutics, Inc.+137%

    now $4.9M · held 2 qtrs, 2 adds in a row

  • DFTX$DFTXDefinium Therapeutics, Inc.+31%

    now $11.4M · held 2 qtrs, 2 adds in a row

  • ALMS$ALMSALUMIS INC.+77%

    now $5.6M · held 2 qtrs, 2 adds in a row

+44 more in the Excel export

Trimmed (66)

  • SYRE$SYRESpyre Therapeutics, Inc.-47%

    now $6.9M · held 10+ qtrs, 3 trims in a row

  • ORKA$ORKAOruka Therapeutics, Inc.-47%

    now $4.0M · held 2 qtrs

  • MU$MUMICRON TECHNOLOGY INC-67%

    now $1.5M · held 2 qtrs

  • BBIO$BBIOBridgeBio Pharma, Inc.-73%

    now $980K · held 10+ qtrs, 3 trims in a row

  • AMZN$AMZNAMAZON COM INC-40%

    now $3.2M · held 10+ qtrs

  • MSFT$MSFTMICROSOFT CORP-63%

    now $900K · held 10+ qtrs, 4 trims in a row

+60 more in the Excel export

Sold out (38)

  • TERN$TERNTerns Pharmaceuticals, Inc.was $6.0M

    held 2 qtrs

  • NUVL$NUVLNuvalent, Inc.was $5.8M

    held 9+ qtrs

  • SLNO$SLNOSOLENO THERAPEUTICS INCwas $5.5M

    held 7 qtrs

  • APGE$APGEApogee Therapeutics, Inc.was $3.0M

    held 9+ qtrs

  • JAZZ$JAZZJazz Pharmaceuticals plcwas $2.0M

    held 1 qtr

  • NATL$NATLNCR Atleos Corpwas $1.7M

+32 more in the Excel export

Firm AUM (Form ADV): $9.1B as of 2025-12-31 · SEC IAPD

Share

Holdings by quarter

Every 13F HighVista Strategies LLC has filed, 41 earlier quarters. Pick one to see what it held then.

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Is it too late to follow HighVista Strategies?

Q2 2026 13F filed with the SEC on Aug 14, 2026. Prices are closing prices as of Oct 26, 2026.

Average quality of HighVista Strategies's top 20 holdings: 34/100 (our AI quality score, weighted by position size; 6 of the 20 are scored)

Top 10 since filing

-10.0%

Value-weighted move of the 10 largest stock positions

Turnover

24%

Last quarter; 92% over the last 4

Top 10 weight

28%

Share of the stock portfolio in its 10 largest positions

Held 4+ quarters

60%

Share of portfolio value in positions held a year or more

Highest-quality names it owns(among its 100 largest positions)

The 8 highest-scoring companies in this portfolio are a Pro feature.

How these are measured
  • Moves since the quarter-end and since the filing date use our own daily closing prices, from the close on (or just before) each date to the latest close.
  • Turnover is the lesser of shares bought or sold in a quarter, valued at the quarter-end prices in the 13F, divided by the average of the two quarters' stock portfolio values.
  • Quarters held and add/trim streaks count back only through quarters whose filed holdings add up to the filing's own cover-page total (back to Q1 2024 for this fund). A change counts as an add or a trim when the split-adjusted share count moves by more than 1%.
  • Estimate, not the fund's reported cost. For each quarter in the current holding period in which the fund's share count rose (split-adjusted), we take that quarter's average daily close and weight it by the shares added; sales do not change an average cost. Quarters where the stock's price history and the 13F's own implied price disagree by more than 2x are left out.
  • Put and call option rows report the value of the underlying shares, not a position the fund paid for, so they are left out of all of the above.

Portfolio Overview

HighVista Strategies LLC disclosed 147 positions worth $438.6M in its Form 13F-HR for Q2 2026, led by $DBC (Invesco DB Commodity Index Tracking Fund) at 6.4% of the equity portfolio, followed by $ABVX and $RVMD. During the quarter the fund opened 29 new positions and exited 38 — including a new stake in $CCCC and a full exit from $TERN. The portfolio is most concentrated in Healthcare (71.0% of disclosed assets). All figures are sourced directly from HighVista Strategies LLC’s Form 13F-HR filing with the SEC under CIK 1335325.

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AI-Powered Hedge Fund Analysis: HighVista Strategies LLC

13F Pro is an AI hedge fund tracker and stock research platform. For HighVista Strategies LLC (SEC CIK: 1335325), the platform ingests every quarterly Form 13F filing and applies AI-powered analysis on top — 10 specialized AI analysts (value, growth, momentum, macro, activist, and more) debate the fund's top positions and publish AI-generated analysis with cited SEC sources.

Every holding in HighVista Strategies LLC's portfolio is scored on an AI quality ranking built from its SEC filings (ROIC, FCF margin, revenue growth, institutional flow, earnings quality, shareholder dilution, and more). Track accumulation and distribution quarter over quarter, identify conviction positions, and see AI stock analysis for each position — alongside 8,700+ other institutional filers and 2,800+ AI-ranked companies.