Septerna, Inc.(SEPN)Stock Analysis
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Rank #943 of 2,961 stocksTOP 50%
Rankings refresh quarterly once 80% of peers have filed (~45 days after quarter-end). Next update: ~Nov 14, 2026.
Revenue Growth
Profitability
Balance Sheet
Earnings Quality
Free Cash Flow
Institutional Flow
Revenue Scale
Dilution Risk
Unusual Activity in SEPN
Events flagged as statistical outliers against SEPN's own multi-year baseline — not fixed dollar thresholds.
- Score shock2026-08-10
SEPN quality score dropped 36 points (45→9) on a new filing
View source filing →
SEPN Stock Analysis & AI Quality Score
Data updated 2026-09-11AI stock analysis and institutional research for Septerna, Inc. (SEPN), a Healthcare sector company. 13F Pro's AI-powered ranking engine scores SEPN at 59.2/100 on a 32-signal composite quality model, placing it at rank #943 of 2,961 stocks — the top half of the AI-ranked universe. SEPN scores in the top quartile across free cash flow (99.4), revenue growth (99.3), earnings quality (93.9). Areas of concern include revenue scale (15.5) and profitability (16.1), which score below median versus the broader universe. Shareholder dilution risk is elevated at 9.7/100, reflecting ongoing share issuance or stock-based compensation. Based on the latest XBRL financial filings (Q2 2026), Septerna, Inc. reports quarterly revenue of $26.7M, net income of $-13.0M, free cash flow of $-22.2M. Top institutional holders of SEPN by reported 13-F value include RA CAPITAL MANAGEMENT, L.P., TRV GP V, DRIEHAUS CAPITAL MANAGEMENT, based on the most recent SEC filings. SEPN trades on the Nasdaq exchange and files with the SEC under CIK 1984086. 13F Pro's AI research platform runs 10 specialized AI analysts — value, growth, momentum, macro, and activist specialists — that debate SEPN daily and publish AI-generated analysis with cited SEC sources. The platform aggregates historical XBRL financial facts, 10-Q and 10-K filings, insider Form 4 transactions, and institutional 13-F holdings for Septerna, Inc. directly from SEC EDGAR. Septerna, Inc.'s 13F Pro composite quality score has ranged between 5 and 59 since 2025, currently 59.2 — an improving long-term trajectory across 52 quarterly and live scoring snapshots.
Revenue
Q2 2026
$26.7M
Net Income
Q2 2026
$-13.0M
Free Cash Flow
Q2 2026
$-22.2M
ROIC
Q2 2026
-17.4%
Revenue & Net Income
Earnings Per Share
Key Financials Over Time
Export Financial Table · ProRevenue
+4174.5% YoYNet Income
+31.9% YoYOperating Income
+15.5% YoYEPS (Diluted)
+84.8% YoYTotal Assets
+30.6% YoYOp. Cash Flow
+263.3% YoYFree Cash Flow
+257.6% YoY| Metric | FY 2025 | FY 2024 | FY 2023 | FY 2022 |
|---|---|---|---|---|
| Revenue | $46.0M +4174.5% | $1.1M +611.9% | $151.0K | — |
| Net Income | $-48.9M +31.9% | $-71.8M -1817.7% | $4.2M | — |
| Operating Income | $-68.3M +15.5% | $-80.8M -3995.1% | $2.1M | — |
| EPS (Diluted) | $-1.10 +84.8% | $-7.26 -35172.5% | $0.02 | — |
| Total Assets | $596.2M +30.6% | $456.6M +248.9% | $130.9M | — |
| Operating Cash Flow | $110.2M +263.3% | $-67.5M -74.2% | $-38.7M | — |
| Free Cash Flow | $109.7M +257.6% | $-69.6M -67.2% | $-41.6M | — |
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13F Pro tracks comprehensive data for Septerna, Inc. including:
Top Institutional Holders of SEPN
RA CAPITAL MANAGEMENT, L.P.
$234.3M6,995,858 shTRV GP V, LLC
$208.2M6,215,591 shDRIEHAUS CAPITAL MANAGEMENT LLC
$148.5M4,433,058 shTRV GP VI, LLC
$141.0M4,211,659 shSamsara BioCapital, LLC
$105.5M3,149,128 shGOLDMAN SACHS GROUP INC
$102.6M3,062,766 shBlackRock, Inc.
$64.7M1,932,088 shSiren, L.L.C.
$63.6M1,900,000 shAvoro Capital Advisors LLC
$44.8M1,337,500 shJupiter Topco LLC
$43.7M1,307,500 sh
| Fund | Value | Shares |
|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | $234.3M | 6,995,858 |
| TRV GP V, LLC | $208.2M | 6,215,591 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | $148.5M | 4,433,058 |
| TRV GP VI, LLC | $141.0M | 4,211,659 |
| Samsara BioCapital, LLC | $105.5M | 3,149,128 |
| GOLDMAN SACHS GROUP INC | $102.6M | 3,062,766 |
| BlackRock, Inc. | $64.7M | 1,932,088 |
| Siren, L.L.C. | $63.6M | 1,900,000 |
| Avoro Capital Advisors LLC | $44.8M | 1,337,500 |
| Jupiter Topco LLC | $43.7M | 1,307,500 |
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Similarity is computed from the 8 composite sub-scores and latest-quarter 13F conviction holdings (index-style filers excluded). Refreshed monthly.
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Popular Research
Is SEPN a good stock to buy?
13F Pro's AI-powered analysis of Septerna, Inc. (SEPN) draws on SEC EDGAR-sourced fundamentals, institutional 13F holdings, and insider Form 4 transactions in the Healthcare sector (listed on Nasdaq). The 32-signal AI Quality Score, current rank, and full bull/bear verdict for SEPN are available on the SEPN stock profile dashboard — with the same data, AI insights, ratios, and institutional activity refreshed after every 10-K, 10-Q, 13F, and Form 4 filing. SEPN is classified as a small company.
Which hedge funds own SEPN?
Institutional investors are required to disclose their holdings quarterly via SEC Form 13F. 13F Pro aggregates these filings to show which hedge funds, mutual funds, and asset managers are buying or selling SEPN. Combined with insider transaction data from Form 4 filings and AI-powered analysis from 10 specialized research agents, 13F Pro provides a comprehensive view of Septerna, Inc.'s investment landscape.