Healthcare · Nasdaq · AI-powered stock analysis, 32-signal quality score, SEC EDGAR financials, and institutional holdings. Updated .
Septerna, Inc. (SEPN) stock profile, AI quality score, and SEC EDGAR financial data, a Healthcare sector company. 13F Pro's AI-powered ranking engine scores SEPN at 59.2/100 on a 32-signal composite quality model, placing it at rank #943 of 2,961 stocks — the top half of the AI-ranked universe. SEPN scores in the top quartile across free cash flow (99.4), revenue growth (99.3), earnings quality (93.9). Areas of concern include revenue scale (15.5) and profitability (16.1), which score below median versus the broader universe. Shareholder dilution risk is elevated at 9.7/100, reflecting ongoing share issuance or stock-based compensation. Based on the latest XBRL financial filings (Q2 2026), Septerna, Inc. reports quarterly revenue of $26.7M, net income of $-13.0M, free cash flow of $-22.2M. Top institutional holders of SEPN by reported 13-F value include RA CAPITAL MANAGEMENT, L.P., TRV GP V, DRIEHAUS CAPITAL MANAGEMENT, based on the most recent SEC filings. SEPN trades on the Nasdaq exchange and files with the SEC under CIK 1984086. 13F Pro's AI research platform runs 10 specialized AI analysts — value, growth, momentum, macro, and activist specialists — that debate SEPN daily and publish AI-generated analysis with cited SEC sources. The platform aggregates historical XBRL financial facts, 10-Q and 10-K filings, insider Form 4 transactions, and institutional 13-F holdings for Septerna, Inc. directly from SEC EDGAR.
AI Quality Score
59.2/100
AI Rank
#943
Revenue
$26.7M
Net Income
$-13.0M
Free Cash Flow
$-22.2M
| Period | Form | Revenue | Net income | Operating margin |
|---|---|---|---|---|
| FY 2025 | 10-K | $46.0M | $-48.9M | -148.6% |
| FY 2024 | 10-K | $1.1M | $-71.8M | — |
| FY 2023 | 10-K | $151.0K | $4.2M | — |
| Institution | Shares | Value | Reported |
|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 6,995,858 | $234.3M | 2026-06-30 |
| TRV GP V | 6,215,591 | $208.2M | 2026-06-30 |
| DRIEHAUS CAPITAL MANAGEMENT | 4,433,058 | $148.5M | 2026-06-30 |
| TRV GP VI | 4,211,659 | $141.0M | 2026-06-30 |
| Samsara BioCapital | 3,149,128 | $105.5M | 2026-06-30 |
| GOLDMAN SACHS GROUP | 3,062,766 | $102.6M | 2026-06-30 |
| BlackRock | 1,932,088 | $64.7M | 2026-06-30 |
| Siren, L.L.C. | 1,900,000 | $63.6M | 2026-06-30 |
| Avoro Capital Advisors | 1,337,500 | $44.8M | 2026-06-30 |
| Jupiter Topco | 1,307,500 | $43.7M | 2026-06-30 |
13F Pro Quality Score
Rank #943 of 2,961 stocksTOP 50%
Rankings refresh quarterly once 80% of peers have filed (~45 days after quarter-end). Next update: ~Nov 14, 2026.
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