Septerna, Inc.(SEPN)— Stock Profile, AI Score & Financials

Healthcare · Nasdaq · AI-powered stock analysis, 32-signal quality score, SEC EDGAR financials, and institutional holdings. Updated .

Septerna, Inc. (SEPN) stock profile, AI quality score, and SEC EDGAR financial data, a Healthcare sector company. 13F Pro's AI-powered ranking engine scores SEPN at 59.2/100 on a 32-signal composite quality model, placing it at rank #943 of 2,961 stocks — the top half of the AI-ranked universe. SEPN scores in the top quartile across free cash flow (99.4), revenue growth (99.3), earnings quality (93.9). Areas of concern include revenue scale (15.5) and profitability (16.1), which score below median versus the broader universe. Shareholder dilution risk is elevated at 9.7/100, reflecting ongoing share issuance or stock-based compensation. Based on the latest XBRL financial filings (Q2 2026), Septerna, Inc. reports quarterly revenue of $26.7M, net income of $-13.0M, free cash flow of $-22.2M. Top institutional holders of SEPN by reported 13-F value include RA CAPITAL MANAGEMENT, L.P., TRV GP V, DRIEHAUS CAPITAL MANAGEMENT, based on the most recent SEC filings. SEPN trades on the Nasdaq exchange and files with the SEC under CIK 1984086. 13F Pro's AI research platform runs 10 specialized AI analysts — value, growth, momentum, macro, and activist specialists — that debate SEPN daily and publish AI-generated analysis with cited SEC sources. The platform aggregates historical XBRL financial facts, 10-Q and 10-K filings, insider Form 4 transactions, and institutional 13-F holdings for Septerna, Inc. directly from SEC EDGAR.

AI Quality Score

59.2/100

AI Rank

#943

Revenue

$26.7M

Net Income

$-13.0M

Free Cash Flow

$-22.2M

SEPN key financials by period

Septerna, Inc. reported revenue, net income and margins by fiscal period, from SEC filings.
PeriodFormRevenueNet incomeOperating margin
FY 202510-K$46.0M$-48.9M-148.6%
FY 202410-K$1.1M$-71.8M
FY 202310-K$151.0K$4.2M

Institutions holding SEPN

Institutional investors reporting a position in Septerna, Inc. on SEC Form 13F.
InstitutionSharesValueReported
RA CAPITAL MANAGEMENT, L.P.6,995,858$234.3M2026-06-30
TRV GP V6,215,591$208.2M2026-06-30
DRIEHAUS CAPITAL MANAGEMENT4,433,058$148.5M2026-06-30
TRV GP VI4,211,659$141.0M2026-06-30
Samsara BioCapital3,149,128$105.5M2026-06-30
GOLDMAN SACHS GROUP3,062,766$102.6M2026-06-30
BlackRock1,932,088$64.7M2026-06-30
Siren, L.L.C.1,900,000$63.6M2026-06-30
Avoro Capital Advisors1,337,500$44.8M2026-06-30
Jupiter Topco1,307,500$43.7M2026-06-30
SEPN

Septerna, Inc.

SEPN
NasdaqSmall CapHealthcare

13F Pro Quality Score

59.2/100

Rank #943 of 2,961 stocksTOP 50%

View Healthcare peers →

Rankings refresh quarterly once 80% of peers have filed (~45 days after quarter-end). Next update: ~Nov 14, 2026.

Revenue Growth

99.3/100

Profitability

16.1/100

Balance Sheet

23.0/100

Earnings Quality

93.9/100

Free Cash Flow

99.4/100

Institutional Flow

61.1/100

Revenue Scale

15.5/100

Dilution Risk

9.7/100

Price Chart

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Key Metrics

Revenue

Q2 2026
EDGAR

$26.75M

Net Income

Q2 2026
EDGAR

$-13.03M

EPS (Diluted)

Q2 2026
EDGAR

$-0.29

ROIC

Q2 2026
EDGAR

-17.4%

Free Cash Flow

Q2 2026
EDGAR

$-22.18M

Top Institutional Holders

as of Q2 2026
$1.63B total

Financial Trends

Revenue & Net Income

Earnings Per Share

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