What is the 13F Pro Quality Score for KRYS?

13F Pro ranks Krystal Biotech, Inc. (KRYS) on the 13F Pro Quality Score, a 0–100 composite of 32 fundamental signals including return on invested capital, free cash flow consistency, balance-sheet strength, earnings quality, growth durability, and valuation discipline. The score refreshes after each 10-K and 10-Q filing on SEC EDGAR. View KRYS's current score at https://13fpro.ai/research/KRYS (free sign-up required for the full ranking).

Which hedge funds own the most KRYS stock?

Based on the most recent Form 13F-HR filings on SEC EDGAR, the largest reported institutional holders of KRYS include FMR, BlackRock,, Avoro Capital Advisors. Holdings are reported quarterly within 45 days of quarter-end and updated on https://13fpro.ai/research/KRYS as soon as new 13F filings post.

Where does 13F Pro source KRYS data?

All Krystal Biotech, Inc. fundamentals and ownership data come directly from SEC EDGAR. Krystal Biotech, Inc. files with the SEC under CIK 1711279. 13F Pro ingests XBRL financial facts from 10-K and 10-Q filings, Form 13F-HR institutional holdings, and Form 4 insider transactions, with no third-party rewrites or estimates.

What sector is KRYS in?

Krystal Biotech, Inc. (KRYS) is classified in the Healthcare sector. 13F Pro publishes sector-level fund flow analysis and quality leaders at https://13fpro.ai/research/sector/healthcare.

How often is KRYS research updated on 13F Pro?

KRYS's fundamentals refresh within hours of each new 10-K or 10-Q filing on SEC EDGAR. Institutional ownership updates after each quarterly 13F filing window. Insider transactions update after each Form 4 filing. The 13F Pro Quality Score recalculates after every fundamentals refresh.

Krystal Biotech, Inc.(KRYS)Stock Analysis

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13F Pro Quality Score

75.9/100

Rank #116 of 2,879 stocksTOP 5%

View Healthcare peers →

Rankings refresh quarterly once 80% of peers have filed (~45 days after quarter-end). Next update: ~Aug 14, 2026.

Revenue Growth

91.7/100

Profitability

95.0/100

Balance Sheet

93.7/100

Earnings Quality

30.0/100

Free Cash Flow

91.9/100

Institutional Flow

70.9/100

Revenue Scale

33.4/100

Dilution Risk

13.0/100

KRYS Stock Analysis & AI Quality Score

AI stock analysis and institutional research for Krystal Biotech, Inc. (KRYS), a Healthcare sector company. 13F Pro's AI-powered ranking engine scores KRYS at 75.9/100 on a 32-signal composite quality model, placing it at rank #116 of 2,879 stocks — the top 5% of the AI-ranked universe. KRYS scores in the top quartile across profitability (95.0), balance sheet strength (93.7), free cash flow (91.9). Areas of concern include earnings quality (30.0) and revenue scale (33.4), which score below median versus the broader universe. Shareholder dilution risk is elevated at 13.0/100, reflecting ongoing share issuance or stock-based compensation. Based on the latest XBRL financial filings (Q1 2026), Krystal Biotech, Inc. reports quarterly revenue of $116.4M, net income of $55.9M, an operating margin of 46.1%. Top institutional holders of KRYS by reported 13-F value include FMR, BlackRock,, Avoro Capital Advisors, based on the most recent SEC filings. KRYS trades on the Nasdaq exchange and files with the SEC under CIK 1711279. 13F Pro's AI research platform runs 10 specialized AI analysts — value, growth, momentum, macro, and activist specialists — that debate KRYS daily and publish AI-generated analysis with cited SEC sources. The platform aggregates historical XBRL financial facts, 10-Q and 10-K filings, insider Form 4 transactions, and institutional 13-F holdings for Krystal Biotech, Inc. directly from SEC EDGAR. Krystal Biotech, Inc.'s 13F Pro composite quality score has ranged between 8 and 86 since 2024, currently 75.9 — an improving long-term trajectory across 44 quarterly and live scoring snapshots.

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Fun facts about Krystal Biotech, Inc.

Quirks, history, and lore behind KRYS — the kind of stuff that makes a stock memorable.

1
The Basics
U.S. biopharmaceutical company · small-cap · listed on Nasdaq · headquartered in Pennsylvania.
2
The Numbers
Annual revenue in the hundreds of millions of dollars — remarkable for a company that only recently transitioned from clinical-stage to commercial in a matter of a few years.
3
The History
Founded in 2016, it moved unusually fast from startup to approved product, built around a proprietary gene therapy delivery platform using modified herpes simplex virus vectors.
4
The Secret
Unlike most gene therapy players chasing one-and-done injections, this company's approach delivers treatment topically — straight to the skin — which is a genuinely weird flex in the gene therapy world.
5
The Lore
Its lead product targets dystrophic epidermolysis bullosa — a devastating rare skin disease nicknamed "butterfly skin" — giving patients something they'd never had before: an actual approved treatment.
6
The Giveaway
Its FDA-approved gel Vyjuvek is the first-ever redosable gene therapy, and the company's name sounds like it belongs in a fantasy novel but is spelled with a K and a Y.

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Revenue

Q1 2026

$116.4M

Net Income

Q1 2026

$55.9M

Free Cash Flow

Q1 2026

$73.2M

Operating Margin

Q1 2026

46.1%

Revenue & Net Income

Earnings Per Share

Key Financials Over Time

Export Financial Table · Pro+

Revenue

+33.9% YoY

$389.1MFY 2025

FY22 $0.00FY23 $50.7MFY24 $290.5MFY25 $389.1M

Net Income

+129.7% YoY

$204.8MFY 2025

FY22 $-140.0MFY23 $10.9MFY24 $89.2MFY25 $204.8M

Operating Income

+145.3% YoY

$161.3MFY 2025

FY22 $-145.2MFY23 $-109.6MFY24 $65.7MFY25 $161.3M

EPS (Diluted)

+128.0% YoY

$6.84FY 2025

FY22 $-5.49FY23 $0.39FY24 $3.00FY25 $6.84

Total Assets

+26.3% YoY

$1.33BFY 2025

FY22 $558.5MFY23 $818.4MFY24 $1.06BFY25 $1.33B

Op. Cash Flow

+62.7% YoY

$200.9MFY 2025

FY22 $-100.6MFY23 $-88.8MFY24 $123.4MFY25 $200.9M

Metric	FY 2025	FY 2024	FY 2023	FY 2022	FY 2018	FY 2017
Revenue	$389.1M +33.9%	$290.5M +473.0%	$50.7M	$0.00	—	—
Net Income	$204.8M +129.7%	$89.2M +715.6%	$10.9M +107.8%	$-140.0M -1185.5%	$-10.9M -37.5%	$-7.9M
Operating Income	$161.3M +145.3%	$65.7M +160.0%	$-109.6M +24.5%	$-145.2M -1118.5%	$-11.9M -149.7%	$-4.8M
EPS (Diluted)	$6.84 +128.0%	$3.00 +669.2%	$0.39 +107.1%	$-5.49	—	—
Total Assets	$1.33B +26.3%	$1.06B +29.0%	$818.4M +46.5%	$558.5M +380.9%	$116.1M +131.7%	$50.1M
Operating Cash Flow	$200.9M +62.7%	$123.4M +239.0%	$-88.8M +11.7%	$-100.6M -964.8%	$-9.4M	—

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Available Research

13F Pro tracks comprehensive data for Krystal Biotech, Inc. including:

SEC EDGAR filings (10-K, 10-Q, 8-K)

XBRL financial facts (revenue, EPS, margins)

Insider transactions (Form 4)

Institutional 13F holdings

Quality rankings (32 signals)

AI analyst debates & daily meetings

Historical financial trends

Peer comparison & sector analysis

Top Institutional Holders of KRYS

FMR LLC
$1.1B4,373,987 sh
BlackRock, Inc.
$1.0B3,940,456 sh
Avoro Capital Advisors LLC
$746.3M2,888,888 sh
VANGUARD PORTFOLIO MANAGEMENT LLC
$376.3M1,456,727 sh
STATE STREET CORP
$339.5M1,314,434 sh
VANGUARD CAPITAL MANAGEMENT LLC
$301.0M1,165,324 sh
Soleus Capital Management, L.P.
$297.9M1,153,087 sh
Capital World Investors
$213.0M824,720 sh
Redmile Group, LLC
$174.0M673,505 sh
GEODE CAPITAL MANAGEMENT, LLC
$166.4M643,975 sh

Fund	Value	Shares
FMR LLC	$1.1B	4,373,987
BlackRock, Inc.	$1.0B	3,940,456
Avoro Capital Advisors LLC	$746.3M	2,888,888
VANGUARD PORTFOLIO MANAGEMENT LLC	$376.3M	1,456,727
STATE STREET CORP	$339.5M	1,314,434
VANGUARD CAPITAL MANAGEMENT LLC	$301.0M	1,165,324
Soleus Capital Management, L.P.	$297.9M	1,153,087
Capital World Investors	$213.0M	824,720
Redmile Group, LLC	$174.0M	673,505
GEODE CAPITAL MANAGEMENT, LLC	$166.4M	643,975

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Is KRYS a good stock to buy?

13F Pro's AI-powered analysis of Krystal Biotech, Inc. (KRYS) draws on SEC EDGAR-sourced fundamentals, institutional 13F holdings, and insider Form 4 transactions in the Healthcare sector (listed on Nasdaq). The 32-signal AI Quality Score, current rank, and full bull/bear verdict for KRYS are available on the KRYS stock profile dashboard — with the same data, AI insights, ratios, and institutional activity refreshed after every 10-K, 10-Q, 13F, and Form 4 filing.

Which hedge funds own KRYS?

Institutional investors are required to disclose their holdings quarterly via SEC Form 13F. 13F Pro aggregates these filings to show which hedge funds, mutual funds, and asset managers are buying or selling KRYS. Combined with insider transaction data from Form 4 filings and AI-powered analysis from 10 specialized research agents, 13F Pro provides a comprehensive view of Krystal Biotech, Inc.'s investment landscape.