What is the 13F Pro Quality Score for XENE?

13F Pro ranks Xenon Pharmaceuticals Inc. (XENE) on the 13F Pro Quality Score, a 0–100 composite of 32 fundamental signals including return on invested capital, free cash flow consistency, balance-sheet strength, earnings quality, growth durability, and valuation discipline. The score refreshes after each 10-K and 10-Q filing on SEC EDGAR. View XENE's current score at https://13fpro.ai/company/XENE (free sign-up required for the full ranking).

Which hedge funds own the most XENE stock?

Based on the most recent Form 13F-HR filings on SEC EDGAR, the largest reported institutional holders of XENE include FMR, BlackRock,, Avoro Capital Advisors. Holdings are reported quarterly within 45 days of quarter-end and updated on https://13fpro.ai/company/XENE as soon as new 13F filings post.

Where does 13F Pro source XENE data?

All Xenon Pharmaceuticals Inc. fundamentals and ownership data come directly from SEC EDGAR. Xenon Pharmaceuticals Inc. files with the SEC under CIK 1582313. 13F Pro ingests XBRL financial facts from 10-K and 10-Q filings, Form 13F-HR institutional holdings, and Form 4 insider transactions, with no third-party rewrites or estimates.

What sector is XENE in?

Xenon Pharmaceuticals Inc. (XENE) is classified in the Healthcare sector. 13F Pro publishes sector-level fund flow analysis and quality leaders at https://13fpro.ai/research/sector/healthcare.

How often is XENE research updated on 13F Pro?

XENE's fundamentals refresh within hours of each new 10-K or 10-Q filing on SEC EDGAR. Institutional ownership updates after each quarterly 13F filing window. Insider transactions update after each Form 4 filing. The 13F Pro Quality Score recalculates after every fundamentals refresh.

Xenon Pharmaceuticals Inc.(XENE)Stock Analysis

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SEC EDGAR: CIK 1582313 XENE stock profile & AI dashboard →

13F Pro Quality Score

24.0/100

Rank #2,804 of 3,064 stocks

View Healthcare peers →

Rankings refresh quarterly once 80% of peers have filed (~45 days after quarter-end). Next update: ~Nov 14, 2026.

Revenue Growth

30.0/100

Profitability

30.0/100

Balance Sheet

2.3/100

Earnings Quality

19.3/100

Free Cash Flow

30.0/100

Institutional Flow

16.0/100

Revenue Scale

30.0/100

Dilution Risk

0.8/100

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Why XENE Scores 24/100

exact factor attribution · 2026-08-23

XENE's composite is held back by capital efficiency and revenue growth. Bars show each factor's exact push vs. a median company, using the same weights the ranking engine applies.

Earnings growth

-1.0 pts

30th pct

Institutional flow

-1.7 pts

16th pct

Shareholder dilution

-2.5 pts

1th pct

Profitability

-3.0 pts

30th pct

Free cash flow

-3.0 pts

30th pct

Scale

-3.0 pts

30th pct

Earnings quality

-3.1 pts

19th pct

Revenue growth

-4.0 pts

30th pct

Capital efficiency

-4.8 pts

2th pct

Factor percentiles are cross-sectional ranks across the ~2,800-stock scored universe, computed from SEC EDGAR filings. Not investment advice.

Unusual Activity in XENE

Events flagged as statistical outliers against XENE's own multi-year baseline — not fixed dollar thresholds.

Score shock2026-08-07
XENE quality score jumped 15 points (13→28) on a new filing
View source filing →

XENE Stock Analysis & AI Quality Score

Data updated 2026-08-23

AI stock analysis and institutional research for Xenon Pharmaceuticals Inc. (XENE), a Healthcare sector company. 13F Pro's AI-powered ranking engine scores XENE at 24.0/100 on a 32-signal composite quality model, placing it at rank #2,804 of 3,064 stocks — the bottom half of the AI-ranked universe. Areas of concern include balance sheet strength (2.3) and institutional flow (16.0), which score below median versus the broader universe. Shareholder dilution risk is elevated at 0.8/100, reflecting ongoing share issuance or stock-based compensation. Based on the latest XBRL financial filings (Q2 2026), Xenon Pharmaceuticals Inc. reports net income of $-110.7M, free cash flow of $-95.7M. Top institutional holders of XENE by reported 13-F value include FMR, BlackRock, Avoro Capital Advisors, based on the most recent SEC filings. XENE trades on the Nasdaq exchange and files with the SEC under CIK 1582313. 13F Pro's AI research platform runs 10 specialized AI analysts — value, growth, momentum, macro, and activist specialists — that debate XENE daily and publish AI-generated analysis with cited SEC sources. The platform aggregates historical XBRL financial facts, 10-Q and 10-K filings, insider Form 4 transactions, and institutional 13-F holdings for Xenon Pharmaceuticals Inc. directly from SEC EDGAR. Xenon Pharmaceuticals Inc.'s 13F Pro composite quality score has ranged between 11 and 29 since 2021, currently 24.0 — a stable long-term trajectory across 46 quarterly and live scoring snapshots.

✦

Fun facts about Xenon Pharmaceuticals Inc.

Quirks, history, and lore behind XENE — the kind of stuff that makes a stock memorable.

1
The Basics
Canadian clinical-stage biopharmaceutical company · listed on Nasdaq · focused on developing drugs that target ion channels in the nervous system.
2
The Numbers
A small-cap biotech with minimal product revenue — the company is largely funded by partnership deals and milestone payments from larger pharma collaborators.
3
The History
Founded in the early 2000s in British Columbia, it built its pipeline around the idea that selectively blocking specific sodium channels could treat pain without the addiction risk of opioids.
4
The Secret
Its crown-jewel programs target Nav1.7 and Nav1.8 sodium channel subtypes — the kind of hyper-specific science that makes neurologists excited and everyone else's eyes glaze over.
5
The Lore
The company struck a major collaboration with Neurocrine Biosciences to co-develop its lead epilepsy and pain candidates, bringing in hundreds of millions in potential milestone payments.
6
The Giveaway
Its name is literally a noble gas — atomic number 54 — attached to the word Pharmaceuticals, traded under a ticker that is basically the element's chemical symbol plus an E.

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Revenue

Q2 2026

$0.00

Net Income

Q2 2026

$-110.7M

Free Cash Flow

Q2 2026

$-95.7M

ROIC

Q2 2026

-39.6%

Period

Revenue & Net Income

Earnings Per Share

Key Financials Over Time

Export Financial Table · Pro

Revenue

$7.5MFY 2025

FY22 $9.4MFY23 $0.00FY24 $0.00FY25 $7.5M

Net Income

-47.6% YoY

$-345.9MFY 2025

FY22 $-125.4MFY23 $-182.4MFY24 $-234.3MFY25 $-345.9M

Operating Income

-33.6% YoY

$-373.1MFY 2025

FY22 $-129.1MFY23 $-214.1MFY24 $-279.3MFY25 $-373.1M

EPS (Diluted)

-44.9% YoY

$-4.36FY 2025

FY22 $-2.06FY23 $-2.73FY24 $-3.01FY25 $-4.36

Total Assets

-20.7% YoY

$633.2MFY 2025

FY22 $754.1MFY23 $964.8MFY24 $798.1MFY25 $633.2M

Op. Cash Flow

-53.9% YoY

$-279.1MFY 2025

FY22 $-101.0MFY23 $-151.1MFY24 $-181.4MFY25 $-279.1M

Free Cash Flow

-51.7% YoY

$-279.9MFY 2025

FY22 $-103.9MFY23 $-156.7MFY24 $-184.5MFY25 $-279.9M

Metric	FY 2025	FY 2024	FY 2023	FY 2022	FY 2021	FY 2020
Revenue	$7.5M	$0.00	$0.00 -100.0%	$9.4M -48.8%	$18.4M -42.7%	$32.2M
Net Income	$-345.9M -47.6%	$-234.3M -28.5%	$-182.4M -45.5%	$-125.4M -58.9%	$-78.9M -173.5%	$-28.8M
Operating Income	$-373.1M -33.6%	$-279.3M -30.5%	$-214.1M -65.7%	$-129.1M -63.5%	$-79.0M -152.4%	$-31.3M
EPS (Diluted)	$-4.36 -44.9%	$-3.01 -10.3%	$-2.73 -32.5%	$-2.06 -16.4%	$-1.77 -118.5%	$-0.81
Total Assets	$633.2M -20.7%	$798.1M -17.3%	$964.8M +27.9%	$754.1M +31.8%	$572.0M +202.4%	$189.2M
Operating Cash Flow	$-279.1M -53.9%	$-181.4M -20.0%	$-151.1M -49.6%	$-101.0M -45.4%	$-69.5M -44.4%	$-48.1M
Free Cash Flow	$-279.9M -51.7%	$-184.5M -17.7%	$-156.7M -50.8%	$-103.9M -45.2%	$-71.6M -41.0%	$-50.8M

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Available Research

13F Pro tracks comprehensive data for Xenon Pharmaceuticals Inc. including:

SEC EDGAR filings (10-K, 10-Q, 8-K)

XBRL financial facts (revenue, EPS, margins)

Insider transactions (Form 4)

Institutional 13F holdings

Quality rankings (32 signals)

AI analyst debates & daily meetings

Historical financial trends

Peer comparison & sector analysis

Top Institutional Holders of XENE

FMR LLC
$582.4M9,647,998 sh
BlackRock, Inc.
$454.1M7,522,482 sh
Avoro Capital Advisors LLC
$348.7M5,777,777 sh
Polar Capital Holdings Plc
$275.9M4,570,556 sh
DRIEHAUS CAPITAL MANAGEMENT LLC
$266.7M4,418,557 sh
Jupiter Topco LLC
$252.7M4,186,519 sh
PRICE T ROWE ASSOCIATES INC /MD/
$196.1M3,248,219 sh
JPMORGAN CHASE & CO
$157.4M2,617,360 sh
Capital International Investors
$142.5M2,361,639 sh
T. Rowe Price Investment Management, Inc.
$130.9M2,168,581 sh

Fund	Value	Shares
FMR LLC	$582.4M	9,647,998
BlackRock, Inc.	$454.1M	7,522,482
Avoro Capital Advisors LLC	$348.7M	5,777,777
Polar Capital Holdings Plc	$275.9M	4,570,556
DRIEHAUS CAPITAL MANAGEMENT LLC	$266.7M	4,418,557
Jupiter Topco LLC	$252.7M	4,186,519
PRICE T ROWE ASSOCIATES INC /MD/	$196.1M	3,248,219
JPMORGAN CHASE & CO	$157.4M	2,617,360
Capital International Investors	$142.5M	2,361,639
T. Rowe Price Investment Management, Inc.	$130.9M	2,168,581

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Is XENE a good stock to buy?

13F Pro's AI-powered analysis of Xenon Pharmaceuticals Inc. (XENE) draws on SEC EDGAR-sourced fundamentals, institutional 13F holdings, and insider Form 4 transactions in the Healthcare sector (listed on Nasdaq). The 32-signal AI Quality Score, current rank, and full bull/bear verdict for XENE are available on the XENE stock profile dashboard — with the same data, AI insights, ratios, and institutional activity refreshed after every 10-K, 10-Q, 13F, and Form 4 filing. XENE is classified as a mid company.

Which hedge funds own XENE?

Institutional investors are required to disclose their holdings quarterly via SEC Form 13F. 13F Pro aggregates these filings to show which hedge funds, mutual funds, and asset managers are buying or selling XENE. Combined with insider transaction data from Form 4 filings and AI-powered analysis from 10 specialized research agents, 13F Pro provides a comprehensive view of Xenon Pharmaceuticals Inc.'s investment landscape.