HighVista Strategies LLC
Institutional InvestorSimilar funds →SEC EDGAR: CIK 1335325
Institutional-grade research for retail investors
13F Reported Value
ⓘ$362.2M
Holdings
156
Latest Filing
2026-03-31
Filing Quarter
Q1 2026
Portfolio Overview
HighVista Strategies LLC disclosed 156 positions worth $362.2M in its Form 13F-HR for Q1 2026, led by $DBC (Invesco DB Commodity Index Tracking Fund) at 8.4% of the equity portfolio, followed by $ABVX and $PRAX. During the quarter the fund opened 35 new positions and exited 24 — including a new stake in $ORKA. The portfolio is most concentrated in Healthcare (66.1% of disclosed assets). All figures are sourced directly from HighVista Strategies LLC’s Form 13F-HR filing with the SEC under CIK 1335325.
AI Fund Analysis
StableSector Allocation
HealthcareFinancialsTechnologyIndustrialsConsumer DiscretionaryUtilities
AUM History
Top Equity Holdings by Value
Quarterly Activity — Q1 2026
Click any card to unlockTop Holdings
AI Quality Scored
- $30.6M1,057,238 sh
- —
Quality
$12.6M113,254 sh - $8.5M26,323 sh
- —
Quality
$7.6M197,051 sh - —
Quality
$7.4M146,264 sh - —
Quality
$7.2M124,647 sh - —
Quality
$6.7M69,309 sh - —
Quality
$6.0M114,307 sh - —
Quality
$6.0M123,909 sh - —
Quality
$5.8M56,602 sh
| Company | Quality | Value | Shares |
|---|---|---|---|
 Invesco DB Commodity Index Tracking Fund$DBC | — | $30.6M | 1,057,238 |
 Abivax S.A.$ABVX | — | $12.6M | 113,254 |
 Praxis Precision Medicines, Inc.$PRAX | — | $8.5M | 26,323 |
 Cogent Biosciences, Inc.$COGT | — | $7.6M | 197,051 |
 Spyre Therapeutics, Inc.$SYRE | — | $7.4M | 146,264 |
 Vaxcyte, Inc.$PCVX | — | $7.2M | 124,647 |
 Revolution Medicines, Inc.$RVMD | — | $6.7M | 69,309 |
 Terns Pharmaceuticals, Inc.$TERN | — | $6.0M | 114,307 |
 Structure Therapeutics Inc.$GPCR | — | $6.0M | 123,909 |
 Nuvalent, Inc.$NUVL | — | $5.8M | 56,602 |
Unlock AI quality scores for every holding
32-signal composite ranking on each of HighVista Strategies LLC's 156 positions.
Showing top 10 of 156 holdings.
Sector Allocation
Healthcare
$239.5M
Financials
$39.8M
Technology
$36.8M
Industrials
$15.9M
Consumer Discretionary
$12.5M
Utilities
$7.7M
Energy
$3.1M
Materials
$3.1M
Full Holdings — HighVista Strategies LLC (Q1 2026)
All 156 disclosed positions from the latest Form 13F-HR, with quarter-over-quarter share changes and 13F Pro quality scores. Sourced from SEC EDGAR.
| # | Ticker | Company | Value | Weight | QoQ | Quality |
|---|---|---|---|---|---|---|
| 1 | $DBC | Invesco DB Commodity Index Tracking Fund | $30.6M | 8.4% | +0% | — |
| 2 | $ABVX | Abivax S.A. | $12.6M | 3.5% | +57% | — |
| 3 | $PRAX | Praxis Precision Medicines, Inc. | $8.5M | 2.3% | +2% | — |
| 4 | $COGT | Cogent Biosciences, Inc. | $7.6M | 2.1% | -41% | — |
| 5 | $SYRE | Spyre Therapeutics, Inc. | $7.4M | 2.0% | -22% | — |
| 6 | $PCVX | Vaxcyte, Inc. | $7.2M | 2.0% | +9% | — |
| 7 | $RVMD | Revolution Medicines, Inc. | $6.7M | 1.9% | -42% | — |
| 8 | $TERN | Terns Pharmaceuticals, Inc. | $6.0M | 1.7% | -35% | — |
| 9 | $GPCR | Structure Therapeutics Inc. | $6.0M | 1.6% | -36% | — |
| 10 | $NUVL | Nuvalent, Inc. | $5.8M | 1.6% | -23% | — |
| 11 |  $IMVT | Immunovant, Inc. | $5.6M | 1.5% | +1% | — |
| 12 |  $SLNO | SOLENO THERAPEUTICS INC | $5.5M | 1.5% | +22% | 46.3 |
| 13 |  $TYRA | Tyra Biosciences, Inc. | $5.0M | 1.4% | +274% | — |
| 14 |  $AMLX | Amylyx Pharmaceuticals, Inc. | $4.9M | 1.4% | +47% | — |
| 15 |  $AMZN | AMAZON COM INC | $4.7M | 1.3% | +29% | 74.6 |
| 16 |  $LBRX | LB PHARMACEUTICALS INC | $4.3M | 1.2% | +24% | — |
| 17 |  $RLAY | Relay Therapeutics, Inc. | $4.2M | 1.2% | -23% | 12.7 |
| 18 |  $INSM | INSMED Inc | $4.0M | 1.1% | -38% | 29.4 |
| 19 |  $NVDA | NVIDIA CORP | $3.9M | 1.1% | +58% | 90.2 |
| 20 |  $ORKA | Oruka Therapeutics, Inc. | $3.9M | 1.1% | NEW | — |
| 21 |  $CYTK | CYTOKINETICS INC | $3.9M | 1.1% | -49% | 28 |
| 22 |  $LQDA | Liquidia Corp | $3.8M | 1.0% | -36% | 37.4 |
| 23 |  $OCUL | OCULAR THERAPEUTIX, INC | $3.7M | 1.0% | +28% | 12.8 |
| 24 |  $TARS | Tarsus Pharmaceuticals, Inc. | $3.7M | 1.0% | -2% | 40.8 |
| 25 |  $BBIO | BridgeBio Pharma, Inc. | $3.7M | 1.0% | -38% | 31.7 |
| 26 |  $MLTX | MoonLake Immunotherapeutics | $3.6M | 1.0% | NEW | — |
| 27 |  $ARGX | ARGENX SE | $3.6M | 1.0% | +37% | — |
| 28 |  $PTGX | Protagonist Therapeutics, Inc | $3.6M | 1.0% | -54% | 24.8 |
| 29 |  $PALI | PALISADE BIO, INC. | $3.5M | 1.0% | +55% | — |
| 30 |  $DFTX | Definium Therapeutics, Inc. | $3.5M | 1.0% | NEW | — |
| 31 |  $NRIX | Nurix Therapeutics, Inc. | $3.5M | 1.0% | NEW | 13.2 |
| 32 |  $AXSM | Axsome Therapeutics, Inc. | $3.5M | 0.9% | +84% | 36.6 |
| 33 |  $IVA | Inventiva S.A. | $3.4M | 0.9% | NEW | — |
| 34 |  $DYN | Dyne Therapeutics, Inc. | $3.3M | 0.9% | +207% | — |
| 35 |  $APGE | Apogee Therapeutics, Inc. | $3.0M | 0.8% | -60% | — |
| 36 |  $GHRS | GH Research PLC | $3.0M | 0.8% | -11% | — |
| 37 |  $DNTH | Dianthus Therapeutics, Inc. /DE/ | $3.0M | 0.8% | -27% | 26.8 |
| 38 |  $MAZE | Maze Therapeutics, Inc. | $3.0M | 0.8% | -41% | 19.7 |
| 39 |  $ERAS | Erasca, Inc. | $2.9M | 0.8% | NEW | — |
| 40 |  $EWTX | Edgewise Therapeutics, Inc. | $2.9M | 0.8% | -46% | — |
| 41 |  $ELVN | Enliven Therapeutics, Inc. | $2.9M | 0.8% | -11% | — |
| 42 |  $XENE | Xenon Pharmaceuticals Inc. | $2.9M | 0.8% | NEW | 12.9 |
| 43 |  $CLDX | Celldex Therapeutics, Inc. | $2.8M | 0.8% | +73% | 13.2 |
| 44 |  $VERA | Vera Therapeutics, Inc. | $2.8M | 0.8% | NEW | — |
| 45 |  $PHVS | Pharvaris N.V. | $2.8M | 0.8% | -40% | — |
| 46 |  $VRDN | Viridian Therapeutics, Inc.\DE | $2.6M | 0.7% | -64% | 30.5 |
| 47 |  $ALKS | Alkermes plc. | $2.6M | 0.7% | +177% | — |
| 48 |  $ALMS | ALUMIS INC. | $2.5M | 0.7% | NEW | 9.2 |
| 49 |  $MSFT | MICROSOFT CORP | $2.4M | 0.7% | -1% | 83.7 |
| 50 |  $EYPT | EyePoint, Inc. | $2.4M | 0.7% | NEW | 10.3 |
| 51 |  $LITE | Lumentum Holdings Inc. | $2.2M | 0.6% | -28% | 63.4 |
| 52 |  $TNGX | Tango Therapeutics, Inc. | $2.2M | 0.6% | NEW | 26.9 |
| 53 |  $V | VISA INC. | $2.2M | 0.6% | +14% | 83.5 |
| 54 |  $GH | Guardant Health, Inc. | $2.2M | 0.6% | -36% | 36.1 |
| 55 |  $HPE | Hewlett Packard Enterprise Co | $2.1M | 0.6% | +18% | 52.5 |
| 56 |  $ASMB | ASSEMBLY BIOSCIENCES, INC. | $2.1M | 0.6% | NEW | 26.6 |
| 57 |  $CIEN | CIENA CORP | $2.1M | 0.6% | +2% | 70.7 |
| 58 |  $JAZZ | Jazz Pharmaceuticals plc | $2.0M | 0.6% | NEW | — |
| 59 |  $STOK | Stoke Therapeutics, Inc. | $2.0M | 0.6% | -46% | 53.4 |
| 60 |  $CMPS | COMPASS Pathways plc | $2.0M | 0.6% | -27% | — |
| 61 |  $FLS | FLOWSERVE CORP | $1.8M | 0.5% | +0% | 66.2 |
| 62 |  $IMCR | Immunocore Holdings plc | $1.8M | 0.5% | +78% | — |
| 63 |  $OLMA | Olema Pharmaceuticals, Inc. | $1.8M | 0.5% | -51% | — |
| 64 |  $NATL | NCR Atleos Corp | $1.7M | 0.5% | NEW | 46.3 |
| 65 |  $XPO | XPO, Inc. | $1.7M | 0.5% | -30% | 55.3 |
| 66 |  $ON | ON SEMICONDUCTOR CORP | $1.7M | 0.5% | NEW | 42.4 |
| 67 |  $AVGO | Broadcom Inc. | $1.7M | 0.5% | -1% | 86.4 |
| 68 |  $KOD | Kodiak Sciences Inc. | $1.7M | 0.5% | NEW | — |
| 69 |  $CEG | Constellation Energy Corp | $1.6M | 0.4% | +20% | 62.5 |
| 70 |  $CLH | CLEAN HARBORS INC | $1.6M | 0.4% | -11% | 56.3 |
| 71 |  $GOOGL | Alphabet Inc. | $1.6M | 0.4% | -13% | 80.2 |
| 72 |  $CRM | Salesforce, Inc. | $1.6M | 0.4% | -3% | 75.2 |
| 73 |  $CORZ | Core Scientific, Inc./tx | $1.5M | 0.4% | +63% | 14 |
| 74 |  $ETR | ENTERGY CORP /DE/ | $1.5M | 0.4% | +31% | 65.1 |
| 75 |  $CELC | Celcuity Inc. | $1.5M | 0.4% | -21% | — |
| 76 |  $XOMA | XOMA Royalty Corp | $1.5M | 0.4% | -59% | 74 |
| 77 |  $AVTR | Avantor, Inc. | $1.5M | 0.4% | NEW | 38.4 |
| 78 |  $MA | Mastercard Inc | $1.5M | 0.4% | +5% | 81.7 |
| 79 |  $RYTM | RHYTHM PHARMACEUTICALS, INC. | $1.5M | 0.4% | -61% | 30.3 |
| 80 |  $KBR | KBR, INC. | $1.5M | 0.4% | +31% | 64.7 |
| 81 |  $RBC | RBC Bearings INC | $1.4M | 0.4% | -1% | 67.1 |
| 82 |  $MIRM | Mirum Pharmaceuticals, Inc. | $1.4M | 0.4% | NEW | 32.7 |
| 83 |  $U | Unity Software Inc. | $1.4M | 0.4% | +119% | 35.1 |
| 84 |  $SVRA | Savara Inc | $1.4M | 0.4% | NEW | — |
| 85 |  $MDGL | MADRIGAL PHARMACEUTICALS, INC. | $1.4M | 0.4% | -8% | 25.4 |
| 86 |  $CTMX | CytomX Therapeutics, Inc. | $1.4M | 0.4% | +49% | 19.1 |
| 87 |  $CGON | CG Oncology, Inc. | $1.3M | 0.4% | -32% | 28 |
| 88 |  $TDG | TransDigm Group INC | $1.3M | 0.4% | -47% | 75.4 |
| 89 |  $ASND | Ascendis Pharma A/S | $1.3M | 0.4% | +58% | 41.5 |
| 90 |  $KNX | Knight-Swift Transportation Holdings Inc. | $1.3M | 0.4% | NEW | 49.3 |
| 91 |  $RKT | Rocket Companies, Inc. | $1.3M | 0.4% | -5% | — |
| 92 |  $INTU | INTUIT INC. | $1.3M | 0.4% | +66% | 82 |
| 93 |  $MU | MICRON TECHNOLOGY INC | $1.3M | 0.3% | NEW | 88.4 |
| 94 |  $BLTE | BELITE BIO, INC | $1.3M | 0.3% | NEW | — |
| 95 |  $MLYS | Mineralys Therapeutics, Inc. | $1.3M | 0.3% | -62% | — |
| 96 |  $JHX | James Hardie Industries plc | $1.2M | 0.3% | NEW | — |
| 97 |  $APH | AMPHENOL CORP /DE/ | $1.2M | 0.3% | +38% | 80.5 |
| 98 |  $BKNG | Booking Holdings Inc. | $1.2M | 0.3% | +16% | 55.3 |
| 99 |  $KRC | KILROY REALTY CORP | $1.2M | 0.3% | NEW | 67.8 |
| 100 |  $MTZ | MASTEC INC | $1.2M | 0.3% | -28% | 59.7 |
| 101 |  $EQT | EQT Corp | $1.2M | 0.3% | -32% | 83.3 |
| 102 |  $STX | Seagate Technology Holdings plc | $1.1M | 0.3% | NEW | — |
| 103 | — | PETROLEO BRASILEIRO S A | $1.1M | 0.3% | +8% | — |
| 104 |  $WDC | WESTERN DIGITAL CORP | $1.1M | 0.3% | NEW | 76.8 |
| 105 |  $FERG | Ferguson Enterprises Inc. /DE/ | $1.1M | 0.3% | -33% | 58.9 |
| 106 |  $APG | APi Group Corp | $1.1M | 0.3% | -14% | 61.3 |
| 107 |  $TVTX | Travere Therapeutics, Inc. | $1.1M | 0.3% | NEW | 39.2 |
| 108 |  $WDAY | Workday, Inc. | $1.1M | 0.3% | +28% | 74.2 |
| 109 |  $PTC | PTC INC. | $1.1M | 0.3% | +17% | 69.8 |
| 110 |  $GEV | GE Vernova Inc. | $1.1M | 0.3% | -31% | 70.1 |
| 111 |  $NKTR | NEKTAR THERAPEUTICS | $1.0M | 0.3% | +24% | 10.2 |
| 112 |  $AGX | ARGAN INC | $1.0M | 0.3% | +0% | 79.2 |
| 113 |  $NEE | NEXTERA ENERGY INC | $1.0M | 0.3% | -43% | 71.7 |
| 114 |  $DASH | DoorDash, Inc. | $1.0M | 0.3% | NEW | 70.6 |
| 115 |  $XEL | XCEL ENERGY INC | $997,608 | 0.3% | +56% | — |
| 116 |  $META | Meta Platforms, Inc. | $996,651 | 0.3% | -32% | 80.9 |
| 117 |  $TLN | Talen Energy Corp | $995,359 | 0.3% | -11% | 66.5 |
| 118 |  $AMRZ | Amrize Ltd | $956,149 | 0.3% | -49% | — |
| 119 |  $RDDT | Reddit, Inc. | $929,085 | 0.3% | +30% | 79.3 |
| 120 |  $UTHR | UNITED THERAPEUTICS Corp | $897,771 | 0.3% | -35% | 80.1 |
| 121 |  $MMM | 3M CO | $893,165 | 0.3% | +56% | 60.7 |
| 122 |  $UNP | UNION PACIFIC CORP | $887,504 | 0.3% | -55% | 74 |
| 123 |  $AVTX | Avalo Therapeutics, Inc. | $875,226 | 0.2% | -39% | 4.6 |
| 124 |  $CPNG | Coupang, Inc. | $869,160 | 0.2% | +86% | 56.4 |
| 125 |  $CLF | CLEVELAND-CLIFFS INC. | $865,905 | 0.2% | -14% | 35.7 |
| 126 |  $ZYME | Zymeworks Inc. | $853,488 | 0.2% | NEW | 27.2 |
| 127 | — | EVERPURE INC | $827,091 | 0.2% | -20% | — |
| 128 |  $SOBO | South Bow Corp | $760,164 | 0.2% | +9% | — |
| 129 |  $CAAP | CORPORACION AMERICA AIRPORTS S.A. | $752,251 | 0.2% | -20% | — |
| 130 |  $MELI | MERCADOLIBRE INC | $752,124 | 0.2% | -6% | 77.5 |
| 131 |  $PVLA | PALVELLA THERAPEUTICS, INC. | $735,809 | 0.2% | NEW | — |
| 132 |  $IBN | ICICI BANK LTD | $722,195 | 0.2% | +6% | — |
| 133 |  $NU | Nu Holdings Ltd. | $712,321 | 0.2% | -21% | — |
| 134 |  $PDD | PDD Holdings Inc. | $705,042 | 0.2% | NEW | — |
| 135 |  $BBOT | BridgeBio Oncology Therapeutics, Inc. | $699,774 | 0.2% | -66% | — |
| 136 |  $EDU | New Oriental Education & Technology Group Inc. | $697,512 | 0.2% | -4% | — |
| 137 |  $JANX | Janux Therapeutics, Inc. | $686,424 | 0.2% | +19% | 24.8 |
| 138 |  $RLX | RLX Technology Inc. | $685,740 | 0.2% | NEW | — |
| 139 |  $HDB | HDFC BANK LTD | $650,039 | 0.2% | +18% | — |
| 140 |  $NAMS | NewAmsterdam Pharma Co N.V. | $642,344 | 0.2% | -44% | — |
| 141 |  $YMM | Full Truck Alliance Co. Ltd. | $640,685 | 0.2% | -12% | — |
| 142 |  $XNCR | Xencor Inc | $639,723 | 0.2% | NEW | 13.1 |
| 143 |  $TRVI | Trevi Therapeutics, Inc. | $638,553 | 0.2% | -50% | — |
| 144 |  $PFSI | PennyMac Financial Services, Inc. | $638,544 | 0.2% | -6% | 54.2 |
| 145 |  $RXO | RXO, Inc. | $629,216 | 0.2% | -53% | 56 |
| 146 |  $SE | Sea Ltd | $616,935 | 0.2% | +0% | — |
| 147 |  $NOK | NOKIA CORP | $569,425 | 0.2% | +19% | — |
| 148 |  $QXO | QXO, Inc. | $511,134 | 0.1% | -55% | 53.5 |
| 149 |  $URGN | UroGen Pharma Ltd. | $476,650 | 0.1% | -5% | — |
| 150 |  $KRYS | Krystal Biotech, Inc. | $471,175 | 0.1% | NEW | 75.9 |
| 151 |  $JD | JD.com, Inc. | $398,101 | 0.1% | -23% | — |
| 152 |  $MBX | MBX Biosciences, Inc. | $342,439 | 0.1% | NEW | — |
| 153 |  $KYMR | Kymera Therapeutics, Inc. | $315,253 | 0.1% | -45% | 29.2 |
| 154 |  $BZ | Kanzhun Ltd | $285,180 | 0.1% | +3% | — |
| 155 |  $TCOM | Trip.com Group Ltd | $273,049 | 0.1% | -48% | — |
| 156 |  $CNTA | Centessa Pharmaceuticals plc | $236,890 | 0.1% | -87% | — |
New Positions (35)
$ORKA Oruka Therapeutics, Inc.$3.9M$MLTX MoonLake Immunotherapeutics$3.6M$DFTX Definium Therapeutics, Inc.$3.5M$NRIX Nurix Therapeutics, Inc.$3.5M$IVA Inventiva S.A.$3.4M$ERAS Erasca, Inc.$2.9M$XENE Xenon Pharmaceuticals Inc.$2.9M$VERA Vera Therapeutics, Inc.$2.8M$ALMS ALUMIS INC.$2.5M$EYPT EyePoint, Inc.$2.4M$TNGX Tango Therapeutics, Inc.$2.2M$ASMB ASSEMBLY BIOSCIENCES, INC.$2.1M$JAZZ Jazz Pharmaceuticals plc$2.0M$NATL NCR Atleos Corp$1.7M$ON ON SEMICONDUCTOR CORP$1.7MExited Positions (24)
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$UNF UNIFIRST CORP
$CMPX Compass Therapeutics, Inc.
$TMO THERMO FISHER SCIENTIFIC INC.
$OFIX Orthofix Medical Inc.
$ACHC Acadia Healthcare Company, Inc.
$SCHW SCHWAB CHARLES CORP
$SNDK Sandisk Corp
$AFRM Affirm Holdings, Inc.Browse Top Institutional Investors
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