Spyre Therapeutics, Inc.(SYRE)— Stock Profile, AI Score & Financials

Healthcare · Nasdaq · AI-powered stock analysis, 32-signal quality score, SEC EDGAR financials, and institutional holdings. Updated .

Spyre Therapeutics, Inc. (SYRE) stock profile, AI quality score, and SEC EDGAR financial data, a Healthcare sector company. SYRE is not currently included in 13F Pro's AI-ranked quality universe — this company passes all size and coverage filters but hasn't been included in the latest quarterly ranking run. rankings refresh on jan 1, apr 1, jul 1, oct 1. Top institutional holders of SYRE by reported 13-F value include FMR, BlackRock, PERCEPTIVE ADVISORS, based on the most recent SEC filings. SYRE trades on the Nasdaq exchange and files with the SEC under CIK 1636282. 13F Pro's AI research platform runs 10 specialized AI analysts — value, growth, momentum, macro, and activist specialists — that debate SYRE daily and publish AI-generated analysis with cited SEC sources. The platform aggregates historical XBRL financial facts, 10-Q and 10-K filings, insider Form 4 transactions, and institutional 13-F holdings for Spyre Therapeutics, Inc. directly from SEC EDGAR.

Net Income

$-36.2M

SYRE key financials by period

Spyre Therapeutics, Inc. reported revenue, net income and margins by fiscal period, from SEC filings.
PeriodFormRevenueNet incomeOperating margin
FY 202310-K/A$886.0K$-338.8M
FY 202210-K/A$2.3M$-83.8M
FY 202110-K/A$18.7M$-65.8M
FY 201810-K$3.9M$-44.3M
FY 201710-K$5.2M$-27.2M
FY 201610-K$4.6M$-21.7M

Institutions holding SYRE

Institutional investors reporting a position in Spyre Therapeutics, Inc. on SEC Form 13F.
InstitutionSharesValueReported
FMR13,026,187$1.2B2026-06-30
BlackRock6,506,605$577.7M2026-06-30
PERCEPTIVE ADVISORS4,319,496$383.5M2026-06-30
RTW INVESTMENTS4,251,996$377.5M2026-06-30
Paradigm Biocapital Advisors3,840,778$341.0M2026-06-30
VANGUARD CAPITAL MANAGEMENT3,448,681$306.2M2026-06-30
STATE STREET3,057,416$271.4M2026-06-30
VR Adviser2,985,448$265.0M2026-06-30
PRICE T ROWE ASSOCIATES2,960,855$262.9M2026-06-30
DRIEHAUS CAPITAL MANAGEMENT2,799,166$248.5M2026-06-30
SYRE

Spyre Therapeutics, Inc.

SYRE
NasdaqMid CapHealthcare

13F Pro Quality Score

Not in ranked universe

Pending next ranking run

This company passes all size and coverage filters but hasn't been included in the latest quarterly ranking run. Rankings refresh on Jan 1, Apr 1, Jul 1, Oct 1.

Financial data, filings, and institutional holdings below are still tracked in full — only the proprietary quality composite is unavailable for this name.

Price Chart

Email me the moment this company reports earnings
AI Research Report
Two-page plain-English analysis: business, thesis, and three scenarios for the next two years. Refreshed every quarter.
Upgrade to Pro
Pro: 5 reports/month · Pro+: unlimitedOpinion, not investment advice. Do your own research.
Reading the latest SEC filing… (first load can take ~20s)

Key Metrics

Net Income

Q2 2026
EDGAR

$-36.20M

EPS (Diluted)

Q2 2026
EDGAR

$-0.35

ROIC

Q2 2026
EDGAR

-15.1%

Top Institutional Holders

as of Q2 2026
$8.58B total

Financial Trends

Revenue & Net Income

Earnings Per Share

Loading ratio trend…