Healthcare · Nasdaq · AI-powered stock analysis, 32-signal quality score, SEC EDGAR financials, and institutional holdings. Updated .
Spyre Therapeutics, Inc. (SYRE) stock profile, AI quality score, and SEC EDGAR financial data, a Healthcare sector company. SYRE is not currently included in 13F Pro's AI-ranked quality universe — this company passes all size and coverage filters but hasn't been included in the latest quarterly ranking run. rankings refresh on jan 1, apr 1, jul 1, oct 1. Top institutional holders of SYRE by reported 13-F value include FMR, BlackRock, PERCEPTIVE ADVISORS, based on the most recent SEC filings. SYRE trades on the Nasdaq exchange and files with the SEC under CIK 1636282. 13F Pro's AI research platform runs 10 specialized AI analysts — value, growth, momentum, macro, and activist specialists — that debate SYRE daily and publish AI-generated analysis with cited SEC sources. The platform aggregates historical XBRL financial facts, 10-Q and 10-K filings, insider Form 4 transactions, and institutional 13-F holdings for Spyre Therapeutics, Inc. directly from SEC EDGAR.
Net Income
$-36.2M
| Period | Form | Revenue | Net income | Operating margin |
|---|---|---|---|---|
| FY 2023 | 10-K/A | $886.0K | $-338.8M | — |
| FY 2022 | 10-K/A | $2.3M | $-83.8M | — |
| FY 2021 | 10-K/A | $18.7M | $-65.8M | — |
| FY 2018 | 10-K | $3.9M | $-44.3M | — |
| FY 2017 | 10-K | $5.2M | $-27.2M | — |
| FY 2016 | 10-K | $4.6M | $-21.7M | — |
| Institution | Shares | Value | Reported |
|---|---|---|---|
| FMR | 13,026,187 | $1.2B | 2026-06-30 |
| BlackRock | 6,506,605 | $577.7M | 2026-06-30 |
| PERCEPTIVE ADVISORS | 4,319,496 | $383.5M | 2026-06-30 |
| RTW INVESTMENTS | 4,251,996 | $377.5M | 2026-06-30 |
| Paradigm Biocapital Advisors | 3,840,778 | $341.0M | 2026-06-30 |
| VANGUARD CAPITAL MANAGEMENT | 3,448,681 | $306.2M | 2026-06-30 |
| STATE STREET | 3,057,416 | $271.4M | 2026-06-30 |
| VR Adviser | 2,985,448 | $265.0M | 2026-06-30 |
| PRICE T ROWE ASSOCIATES | 2,960,855 | $262.9M | 2026-06-30 |
| DRIEHAUS CAPITAL MANAGEMENT | 2,799,166 | $248.5M | 2026-06-30 |
13F Pro Quality Score
Pending next ranking run
This company passes all size and coverage filters but hasn't been included in the latest quarterly ranking run. Rankings refresh on Jan 1, Apr 1, Jul 1, Oct 1.
Financial data, filings, and institutional holdings below are still tracked in full — only the proprietary quality composite is unavailable for this name.