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RTW INVESTMENTS, LP

Institutional InvestorSimilar funds →SEC EDGAR: CIK 1493215
Institutional-grade research for retail investors

Sector Allocation

  • Healthcare99.7%$11.7B
  • Technology0.3%$41.5M

AUM History

13fpro.ai/research/fund/rtw-investments-lp-1493215

Conviction and streaks

Diversifying · top 10 = 47.7%

From the fund's last 12 quarters of 13F filings: positions held longest at size, and names it added to or trimmed several quarters running.

MDGL$MDGLConviction hold9.1% weight · held 10 quartersARGX$ARGXConviction hold5.6% weight · held 10 quartersPTCT$PTCTConviction hold5.4% weight · held 10 quartersPTGX$PTGXConviction hold5.3% weight · held 10 quartersCGON$CGONConviction hold5.2% weight · held 10 quartersRDNT$RDNTAccumulating+168% shares · 7 quarters runningCMPS$CMPSAccumulating+245% shares · 6 quarters runningIMTX$IMTXAccumulating+98% shares · 6 quarters runningTARS$TARSAccumulating+8% shares · 4 quarters runningREPL$REPLAccumulating+259% shares · 4 quarters runningNTRA$NTRATrimming-61% shares · 4 quarters runningTSHA$TSHATrimming-46% shares · 4 quarters runningBBNX$BBNXTrimming-55% shares · 3 quarters runningXGN$XGNTrimming-89% shares · 3 quarters runningCOGT$COGTTrimming-70% shares · 2 quarters running

Largest positions — Q2 2026

Top 20 stock positions. Options are left out: 13F reports them at the underlying's value.

13fpro.ai/research/fund/rtw-investments-lp-1493215

RTW INVESTMENTS, LP 13F holdings — Q2 2026

$11.7B portfolio (+16.6% QoQ) · 84 holdings · Q2 2026 13F · top 10 are 48% of the stock portfolio

All holdings — RTW INVESTMENTS, LP (Q2 2026)

84 disclosed positions from the Form 13F-HR on SEC EDGAR, with quarter-over-quarter share changes. Largest by value first; the ten above are not repeated.

Company
RDNT$RDNTRadNet, Inc.$298.9M+13%
ORKA$ORKAOruka Therapeutics, Inc.$298.7M+53%
NTRA$NTRANatera, Inc.$271.4M-20%
RARE$RAREUltragenyx Pharmaceutical Inc.$260.3M+114%
IRTC$IRTCiRhythm Holdings, Inc.$259.6M+31%
CYTK$CYTKCYTOKINETICS INC$243.8M+5%
KLRA$KLRAKailera Therapeutics, Inc.$237.4MNew
ESTA$ESTAESTABLISHMENT LABS HOLDINGS INC.$227.9M—
GH$GHGuardant Health, Inc.$222.2M—
NBIX$NBIXNEUROCRINE BIOSCIENCES INC$213.7M+19%
TARS$TARSTarsus Pharmaceuticals, Inc.$211.3M+0.3%
STOK$STOKStoke Therapeutics, Inc.$184.0M—
QURE$QUREuniQure N.V.$181.5M+52%
ACAD$ACADACADIA PHARMACEUTICALS INC$180.8M—
RGEN$RGENREPLIGEN CORP$169.3M+3%

What changed in Q2 2026

Against the previous quarter's 13F: 9 new, 26 added to, 8 trimmed, 13 sold out. Share-count changes; largest moves by dollar size first.

New positions (9)

  • KLRA$KLRAKailera Therapeutics, Inc.$237.4M

    first bought this quarter

  • GPCR$GPCRStructure Therapeutics Inc.$86.3M

    first bought this quarter

  • AXGN$AXGNAxogen, Inc.$46.7M

    first bought this quarter

  • DHR$DHRDANAHER CORP /DE/$43.8M

    first bought this quarter

  • SLDB$SLDBSolid Biosciences Inc.$38.9M

    first bought this quarter

  • IDYA$IDYAIDEAYA Biosciences, Inc.$13.8M

    first bought this quarter

+3 more in the Excel export

Added to (26)

  • RARE$RAREUltragenyx Pharmaceutical Inc.+114%

    now $260.3M · held 10+ qtrs, 2 adds in a row

  • CGON$CGONCG Oncology, Inc.+22%

    now $605.0M · held 10+ qtrs, 3 adds in a row

  • ORKA$ORKAOruka Therapeutics, Inc.+53%

    now $298.7M · held 8 qtrs

  • QURE$QUREuniQure N.V.+52%

    now $181.5M · held 8 qtrs

  • IRTC$IRTCiRhythm Holdings, Inc.+31%

    now $259.6M · held 3 qtrs, 3 adds in a row

  • NBIX$NBIXNEUROCRINE BIOSCIENCES INC+19%

    now $213.7M · held 5 qtrs

+20 more in the Excel export

Trimmed (8)

  • COGT$COGTCogent Biosciences, Inc.-58%

    now $89.4M · held 4 qtrs, 2 trims in a row

  • HNGE$HNGEHinge Health, Inc.-74%

    now $41.5M · held 3 qtrs

  • NTRA$NTRANatera, Inc.-20%

    now $271.4M · held 10+ qtrs, 4 trims in a row

  • AVTX$AVTXAvalo Therapeutics, Inc.-80%

    now $3.2M · held 2 qtrs

  • BBNX$BBNXBeta Bionics, Inc.-25%

    now $23.5M · held 6 qtrs, 3 trims in a row

  • HTFL$HTFLHeartflow, Inc.-40%

    now $8.7M · held 4 qtrs

+2 more in the Excel export

Sold out (13)

  • APGE$APGEApogee Therapeutics, Inc.was $234.2M

    held 9+ qtrs

  • APLS$APLSApellis Pharmaceuticals, Inc.was $148.2M

    held 2 qtrs

  • ISRG$ISRGINTUITIVE SURGICAL INCwas $101.4M

    held 5 qtrs

  • CNTA$CNTACentessa Pharmaceuticals plcwas $81.6M

    held 7 qtrs

  • CRNX$CRNXCrinetics Pharmaceuticals, Inc.was $52.7M

    held 4 qtrs

  • WAY$WAYWaystar Holding Corp.was $39.3M

+7 more in the Excel export

Firm AUM (Form ADV): $14.1B as of 2025-12-31 · SEC IAPD

Share

Holdings by quarter

Every 13F RTW INVESTMENTS, LP has filed, 37 earlier quarters. Pick one to see what it held then.

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Is it too late to follow RTW INVESTMENTS?

Q2 2026 13F filed with the SEC on Aug 14, 2026. Prices are closing prices as of Oct 26, 2026.

Average quality of RTW INVESTMENTS's top 20 holdings: 36/100 (our AI quality score, weighted by position size; 14 of the 20 are scored)

Top 10 since filing

-13.9%

Value-weighted move of the 10 largest stock positions

Turnover

10%

Last quarter; 47% over the last 4

Top 10 weight

48%

Share of the stock portfolio in its 10 largest positions

Held 4+ quarters

77%

Share of portfolio value in positions held a year or more

Highest-quality names it owns(among its 100 largest positions)

The 8 highest-scoring companies in this portfolio are a Pro feature.

How these are measured
  • Moves since the quarter-end and since the filing date use our own daily closing prices, from the close on (or just before) each date to the latest close.
  • Turnover is the lesser of shares bought or sold in a quarter, valued at the quarter-end prices in the 13F, divided by the average of the two quarters' stock portfolio values.
  • Quarters held and add/trim streaks count back only through quarters whose filed holdings add up to the filing's own cover-page total (back to Q1 2024 for this fund). A change counts as an add or a trim when the split-adjusted share count moves by more than 1%.
  • Estimate, not the fund's reported cost. For each quarter in the current holding period in which the fund's share count rose (split-adjusted), we take that quarter's average daily close and weight it by the shares added; sales do not change an average cost. Quarters where the stock's price history and the 13F's own implied price disagree by more than 2x are left out.
  • Put and call option rows report the value of the underlying shares, not a position the fund paid for, so they are left out of all of the above.

Portfolio Overview

RTW INVESTMENTS, LP disclosed 84 positions worth $11.7B in its Form 13F-HR for Q2 2026, led by $MDGL (MADRIGAL PHARMACEUTICALS, INC.) at 9.1% of the equity portfolio, followed by $ARGX and $PTCT. During the quarter the fund opened 9 new positions and exited 13 — including a new stake in $KLRA and a full exit from $APGE. The portfolio is most concentrated in Healthcare (99.7% of disclosed assets). All figures are sourced directly from RTW INVESTMENTS, LP’s Form 13F-HR filing with the SEC under CIK 1493215.

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AI-Powered Hedge Fund Analysis: RTW INVESTMENTS, LP

13F Pro is an AI hedge fund tracker and stock research platform. For RTW INVESTMENTS, LP (SEC CIK: 1493215), the platform ingests every quarterly Form 13F filing and applies AI-powered analysis on top — 10 specialized AI analysts (value, growth, momentum, macro, activist, and more) debate the fund's top positions and publish AI-generated analysis with cited SEC sources.

Every holding in RTW INVESTMENTS, LP's portfolio is scored on an AI quality ranking built from its SEC filings (ROIC, FCF margin, revenue growth, institutional flow, earnings quality, shareholder dilution, and more). Track accumulation and distribution quarter over quarter, identify conviction positions, and see AI stock analysis for each position — alongside 8,700+ other institutional filers and 2,800+ AI-ranked companies.