Spyre Therapeutics, Inc. (SYRE) — Institutional Holders, Q2 2026

269 institutional investment managers reported a SYRE position on SEC Form 13F-HR for the quarter ended June 30, 2026, with a combined reported value of $8.5B. Every filer is listed below, ranked by position value, 100 per page; this page shows ranks 1 to 100. Put and call option positions are excluded, and a firm filing several lots or share classes is shown once with its total.

← SYRE stock profile

SYRE in Q2 2026: what funds did

Funds that filed a 13F for both Q1 2026 and Q2 2026, by what they did with the common stock. Share counts are adjusted for any split between the two quarters; dollar figures are the change in shares at this quarter’s price.

New positions

Added to

102

Trimmed

Sold out

Biggest buyers

Paradigm Biocapital AdvisorsAdded · +1,883,512 sh+$167.2M
VANGUARD PORTFOLIO MANAGEMENTAdded · +1,744,968 sh+$154.9M
ADAGE CAPITAL PARTNERS GP, L.L.C.New · +1,722,300 sh+$152.9M
Capital World InvestorsAdded · +1,648,989 sh+$146.4M
PRICE T ROWE ASSOCIATESAdded · +1,362,125 sh+$120.9M

Biggest sellers

Fairmount Funds ManagementSold out · -4,018,101 sh-$356.7M
RA CAPITAL MANAGEMENT, L.P.Sold out · -1,621,620 sh-$144.0M
Commodore CapitalTrimmed · -1,065,594 sh-$94.6M
BAKER BROS. ADVISORSSold out · -1,000,000 sh-$88.8M
Caligan PartnersSold out · -878,127 sh-$78.0M

SYRE 13F holders ranked 1–100 of 269

Institutional investors reporting a position in Spyre Therapeutics, Inc. on SEC Form 13F-HR for Q2 2026, ranked by reported value.
#	Institution	Shares	Value	% of portfolio	QoQShares vs Q1 2026
1	FMR#1 · 13,026,187 sh	13,026,187	$1.2B	0.05%	+10.6%
2	BlackRock#2 · 6,506,605 sh	6,506,605	$577.7M	<0.01%	+17.8%
3	PERCEPTIVE ADVISORS#3 · 4,319,496 sh	4,319,496	$383.5M	5.76%	+14.2%
4	RTW INVESTMENTS#4 · 4,251,996 sh	4,251,996	$377.5M	3.22%	+1.9%
5	Paradigm Biocapital Advisors#5 · 3,840,778 sh	3,840,778	$341.0M	6.38%	+96.2%
6	VANGUARD CAPITAL MANAGEMENT#6 · 3,448,681 sh	3,448,681	$306.2M	<0.01%	+12.8%
7	STATE STREET#7 · 3,057,416 sh	3,057,416	$271.4M	<0.01%	+17.3%
8	VR Adviser#8 · 2,985,448 sh	2,985,448	$265.0M	8.04%	-19.0%
9	PRICE T ROWE ASSOCIATES#9 · 2,960,855 sh	2,960,855	$262.9M	0.03%	+85.2%
10	DRIEHAUS CAPITAL MANAGEMENT#10 · 2,799,166 sh	2,799,166	$248.5M	1.44%	+0.3%
11	GEODE CAPITAL MANAGEMENT#11 · 2,562,265 sh	2,562,265	$239.3M	0.01%	+48.9%
12	VANGUARD PORTFOLIO MANAGEMENT#12 · 2,330,098 sh	2,330,098	$206.9M	<0.01%	+298.2%
13	Capital World Investors#13 · 2,315,553 sh	2,315,553	$205.6M	0.02%	+247.4%
14	Jupiter Topco#14 · 2,206,936 sh	2,206,936	$195.9M	0.08%	—
15	TCG Crossover Management#15 · 1,900,582 sh	1,900,582	$168.7M	4.06%	0.0%
16	TANG CAPITAL MANAGEMENT#16 · 1,892,200 sh	1,892,200	$168.0M	7.63%	0.0%
17	BANK OF AMERICA#17 · 1,777,854 sh	1,777,854	$157.8M	0.01%	+44.8%
18	ADAGE CAPITAL PARTNERS GP, L.L.C.#18 · 1,722,300 sh	1,722,300	$152.9M	0.21%	New
19	WELLINGTON MANAGEMENT GROUP LLP#19 · 1,581,505 sh	1,581,505	$140.4M	0.02%	-13.3%
20	GOLDMAN SACHS GROUP#20 · 1,478,059 sh	1,478,059	$131.2M	0.01%	+447.6%
21	FRANKLIN RESOURCES#21 · 1,472,943 sh	1,472,943	$130.8M	0.03%	+66.8%
22	Remedium Capital Partners#22 · 1,464,169 sh	1,464,169	$130.0M	28.78%	-23.2%
23	Affinity Asset Advisors#23 · 1,279,134 sh	1,279,134	$113.6M	5.13%	0.0%
24	JPMORGAN CHASE#24 · 1,093,026 sh	1,093,026	$98.9M	<0.01%	+11.6%
25	Holocene Advisors#25 · 1,015,170 sh	1,015,170	$90.1M	0.20%	New
26	MARSHALL WACE, LLP#26 · 991,693 sh	991,693	$88.0M	0.07%	+612.1%
27	Polar Capital Plc#27 · 988,009 sh	988,009	$87.7M	0.21%	+24.6%
28	Siren, L.L.C.#28 · 968,598 sh	968,598	$86.0M	1.74%	+18.3%
29	Capital International Investors#29 · 955,196 sh	955,196	$84.8M	0.02%	-45.3%
30	BRAIDWELL#30 · 879,467 sh	879,467	$78.1M	2.89%	-5.7%
31	Commodore Capital#31 · 846,786 sh	846,786	$75.2M	4.48%	-55.7%
32	UBS Group AG#32 · 843,071 sh	843,071	$74.8M	<0.01%	+25.6%
33	NORTHERN#33 · 674,529 sh	674,529	$59.9M	<0.01%	+16.5%
34	CHARLES SCHWAB INVESTMENT MANAGEMENT#34 · 652,958 sh	652,958	$58.0M	<0.01%	+16.0%
35	Pictet Asset Management Holding SA#35 · 628,138 sh	628,138	$55.8M	0.05%	+27.8%
36	EMERALD ADVISERS#36 · 567,430 sh	567,430	$50.4M	1.19%	-7.5%
37	VICTORY CAPITAL MANAGEMENT#37 · 553,980 sh	553,980	$49.2M	0.03%	+89.6%
38	VANGUARD FIDUCIARY#38 · 551,389 sh	551,389	$49.0M	0.01%	+18.7%
39	Candriam S.C.A.#39 · 546,312 sh	546,312	$48.5M	0.22%	-10.5%
40	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AME#40 · 522,071 sh	522,071	$46.3M	<0.01%	+151.8%
41	MORGAN STANLEY#41 · 499,963 sh	499,963	$44.4M	<0.01%	+102.6%
42	VOYA INVESTMENT MANAGEMENT#42 · 431,694 sh	431,694	$38.3M	0.03%	+699.9%
43	EMERALD MUTUAL FUND ADVISERS#43 · 401,271 sh	401,271	$35.6M	1.25%	-1.7%
44	SAMLYN CAPITAL#44 · 400,075 sh	400,075	$35.5M	0.58%	+0.9%
45	AMERIPRISE FINANCIAL#45 · 356,082 sh	356,082	$31.6M	<0.01%	+123.6%
46	Integral Health Asset Management#46 · 325,000 sh	325,000	$28.9M	1.14%	New
47	Woodline Partners#47 · 306,049 sh	306,049	$27.2M	0.08%	+15.1%
48	JENNISON ASSOCIATES#48 · 303,180 sh	303,180	$26.9M	0.02%	New
49	ADAR1 Capital Management#49 · 283,982 sh	283,982	$25.2M	1.15%	-16.1%
50	BNP PARIBAS FINANCIAL MARKETS#50 · 259,923 sh	259,923	$23.1M	<0.01%	+1295.2%
51	Bank of New York Mellon#51 · 245,193 sh	245,193	$21.8M	<0.01%	+28.1%
52	Bellevue Group AG#52 · 229,931 sh	229,931	$20.4M	0.43%	New
53	Cormorant Asset Management#53 · 225,000 sh	225,000	$20.0M	1.02%	New
54	SEVEN GRAND MANAGERS#54 · 225,000 sh	225,000	$20.0M	0.80%	+125.0%
55	EVENTIDE ASSET MANAGEMENT#55 · 201,616 sh	201,616	$17.9M	0.24%	New
56	MILLENNIUM MANAGEMENT#56 · 196,712 sh	196,712	$17.5M	<0.01%	+34.1%
57	ORBIMED ADVISORS#57 · 186,145 sh	186,145	$16.5M	0.31%	New
58	FRONTIER CAPITAL MANAGEMENT#58 · 182,931 sh	182,931	$16.2M	0.15%	New
59	Nuveen#59 · 181,105 sh	181,105	$16.1M	<0.01%	+17.7%
60	Neuberger Berman Group#60 · 180,884 sh	180,884	$16.1M	0.01%	New
61	DEUTSCHE BANK AG\#61 · 174,459 sh	174,459	$15.5M	<0.01%	+35.0%
62	Universal- Beteiligungs- und Servicegesellschaft mbH#62 · 172,923 sh	172,923	$15.4M	0.02%	+1.5%
63	BALYASNY ASSET MANAGEMENT L.P.#63 · 147,042 sh	147,042	$13.1M	0.02%	+165.1%
64	Soleus Capital Management, L.P.#64 · 147,000 sh	147,000	$13.1M	0.45%	New
65	Squarepoint Ops#65 · 139,605 sh	139,605	$12.4M	0.01%	New
66	ARMISTICE CAPITAL#66 · 137,588 sh	137,588	$12.2M	0.15%	+13.8%
67	Russell Investments Group, Ltd.#67 · 134,757 sh	134,757	$12.0M	0.01%	+1256.9%
68	Ensign Peak Advisors#68 · 126,620 sh	126,620	$11.2M	0.02%	-14.8%
69	Invesco Ltd.#69 · 120,541 sh	120,541	$10.7M	<0.01%	-9.0%
70	Blackstone#70 · 120,177 sh	120,177	$10.7M	0.03%	-59.0%
71	Rhenman & Partners Asset Management AB#71 · 119,300 sh	119,300	$10.6M	1.00%	New
72	TD ASSET MANAGEMENT#72 · 115,990 sh	115,990	$10.3M	<0.01%	-15.6%
73	Swiss National Bank#73 · 112,500 sh	112,500	$10.0M	<0.01%	+16.6%
74	StemPoint Capital#74 · 106,926 sh	106,926	$9.5M	1.64%	-36.2%
75	MANUFACTURERS LIFE INSURANCE COMPANY, THE#75 · 104,516 sh	104,516	$9.3M	<0.01%	-7.4%
76	CITADEL ADVISORS#76 · 103,100 sh	103,100	$9.2M	<0.01%	-4.7%
77	Boxer Capital Management#77 · 100,000 sh	100,000	$8.9M	0.67%	New
78	RHUMBLINE ADVISERS#78 · 94,763 sh	94,763	$8.4M	<0.01%	+11.3%
79	BARCLAYS PLC#79 · 94,069 sh	94,069	$8.4M	<0.01%	+105.5%
80	F/m Investments#80 · 92,618 sh	92,618	$8.2M	0.42%	-6.9%
81	PRUDENTIAL FINANCIAL#81 · 87,370 sh	87,370	$7.8M	<0.01%	+46.7%
82	FEDERATED HERMES#82 · 85,950 sh	85,950	$7.6M	0.01%	New
83	Granahan Investment Management#83 · 82,991 sh	82,991	$7.4M	0.26%	New
84	CITIGROUP#84 · 82,593 sh	82,593	$7.3M	<0.01%	+587.9%
85	WELLS FARGO & COMPANY#85 · 82,506 sh	82,506	$7.3M	<0.01%	+148.5%
86	HighVista Strategies#86 · 77,807 sh	77,807	$6.9M	1.57%	-46.8%
87	MERCER GLOBAL ADVISORS#87 · 71,145 sh	71,145	$6.3M	<0.01%	+0.1%
88	B Group#88 · 70,000 sh	70,000	$6.2M	2.92%	-30.0%
89	Trexquant Investment#89 · 67,007 sh	67,007	$5.9M	0.04%	New
90	Informed Momentum#90 · 60,393 sh	60,393	$5.4M	0.48%	New
91	SILVERARC CAPITAL MANAGEMENT#91 · 59,959 sh	59,959	$5.3M	0.55%	-67.9%
92	PRINCIPAL FINANCIAL GROUP#92 · 59,747 sh	59,747	$5.3M	<0.01%	+1289.8%
93	Hudson Bay Capital Management#93 · 58,387 sh	58,387	$5.2M	0.01%	New
94	HealthInvest Partners AB#94 · 57,030 sh	57,030	$5.1M	1.36%	-9.1%
95	RAYMOND JAMES FINANCIAL#95 · 53,627 sh	53,627	$4.8M	<0.01%	+171.5%
96	Susquehanna Portfolio Strategies#96 · 53,101 sh	53,101	$4.7M	0.08%	0.0%
97	ALLIANCEBERNSTEIN L.P.#97 · 92,540 sh	92,540	$4.7M	<0.01%	+30.5%
98	ROYCE & ASSOCIATES#98 · 51,789 sh	51,789	$4.6M	0.04%	New
99	XTX Topco Ltd#99 · 50,483 sh	50,483	$4.5M	0.06%	+106.6%
100	Monashee Investment Management#100 · 50,000 sh	50,000	$4.4M	7.45%	New

Funds that sold out of SYRE in Q2 2026 (21)

Held SYRE at the end of Q1 2026 and filed a Q2 2026 13F without it. Not in the list above, because they no longer hold it. Largest prior position first.

Institutions that held SYRE in Q1 2026 and reported no position in Q2 2026.
Institution	Shares sold	Value in Q1 2026
Fairmount Funds Management4,018,101 sh	4,018,101	$202.7M
RA CAPITAL MANAGEMENT, L.P.1,621,620 sh	1,621,620	$81.8M
BAKER BROS. ADVISORS1,000,000 sh	1,000,000	$50.4M
Caligan Partners878,127 sh	878,127	$44.3M
ExodusPoint Capital Management87,065 sh	87,065	$4.4M
ALPS ADVISORS63,939 sh	63,939	$3.2M
Assenagon Asset Management S.A.18,647 sh	18,647	$940.6K
Carlyle Group9,620 sh	9,620	$485.2K
RWC Asset Management LLP8,166 sh	8,166	$411.9K
CAPSTONE INVESTMENT ADVISORS7,537 sh	7,537	$380.2K
Scientech Research7,088 sh	7,088	$357.5K
Arrowpoint Investment Partners (Singapore) Pte. Ltd.6,140 sh	6,140	$309.7K
DeepCurrents Investment Group4,740 sh	4,740	$239.1K
QUADRANT CAPITAL GROUP292 sh	292	$56.3K
Patient Square Capital1,000 sh	1,000	$50.4K
GROUP ONE TRADING, L.P.901 sh	901	$45.4K
SUMMIT SECURITIES GROUP562 sh	562	$28.3K
Delos Wealth Advisors250 sh	250	$12.6K
MAI Capital Management13 sh	13	$656.00
MassMutual Private Wealth & , FSB3 sh	3	$151.00
TWIN PEAKS WEALTH ADVISORS3 sh	3	$151.00

Source: Form 13F-HR filings on SEC EDGAR, Q2 2026. Values are as reported by each manager at quarter end. “% of portfolio” is the position’s share of the manager’s total reported 13F value for the same quarter. “New” means the manager filed a 13F for Q1 2026 without this position; a dash means no comparison is available. Where a manager’s own filing is internally inconsistent its value is withheld and it is listed last. 13F data shows reported holdings, not recommendations.