Spyre Therapeutics, Inc. (SYRE) — Institutional Holders, Q2 2026 (page 2)
269 institutional investment managers reported a SYRE position on SEC Form 13F-HR for the quarter ended June 30, 2026, with a combined reported value of $8.5B. Every filer is listed below, ranked by position value, 100 per page; this page shows ranks 101 to 200. Put and call option positions are excluded, and a firm filing several lots or share classes is shown once with its total.
SYRE 13F holders ranked 101–200 of 269
| # | Institution | Shares | Value | % of portfolio | QoQShares vs Q1 2026 |
|---|---|---|---|---|---|
| 101 | Legal & General Group Plc#101 · 49,141 sh | 49,141 | $4.4M | <0.01% | +9.7% |
| 102 | Cinctive Capital Management#102 · 48,978 sh | 48,978 | $4.3M | 0.16% | +78.6% |
| 103 | DIMENSIONAL FUND ADVISORS#103 · 47,698 sh | 47,698 | $4.2M | <0.01% | 0.0% |
| 104 | Rockefeller Capital Management L.P.#104 · 47,466 sh | 47,466 | $4.2M | <0.01% | -25.8% |
| 105 | PFM Health Sciences#105 · 46,217 sh | 46,217 | $4.1M | 0.35% | New |
| 106 | SCHRODER INVESTMENT MANAGEMENT GROUP#106 · 44,586 sh | 44,586 | $4.0M | <0.01% | -30.0% |
| 107 | STATE OF WISCONSIN INVESTMENT BOARD#107 · 45,030 sh | 45,030 | $4.0M | <0.01% | +69.8% |
| 108 | MetLife Investment Management#108 · 43,316 sh | 43,316 | $3.8M | 0.02% | +12.8% |
| 109 | NOMURA ASSET MANAGEMENT INTERNATIONAL#109 · 43,071 sh | 43,071 | $3.8M | <0.01% | New |
| 110 | MOODY ALDRICH PARTNERS#110 · 42,458 sh | 42,458 | $3.8M | 0.68% | New |
| 111 | Rock Springs Capital Management#111 · 42,254 sh | 42,254 | $3.8M | 0.18% | New |
| 112 | Maven Securities LTD#112 · 40,000 sh | 40,000 | $3.6M | 0.07% | New |
| 113 | SUSQUEHANNA INTERNATIONAL GROUP, LLP#113 · 39,311 sh | 39,311 | $3.5M | <0.01% | +35.7% |
| 114 | VANGUARD ASSET MANAGEMENT, Ltd#114 · 39,220 sh | 39,220 | $3.5M | <0.01% | +18.0% |
| 115 | MIRAE ASSET GLOBAL ETFS Ltd.#115 · 38,439 sh | 38,439 | $3.4M | <0.01% | +5.8% |
| 116 | Engineers Gate Manager#116 · 38,474 sh | 38,474 | $3.4M | 0.04% | New |
| 117 | Rafferty Asset Management#117 · 36,767 sh | 36,767 | $3.3M | <0.01% | -35.4% |
| 118 | Caption Management#118 · 36,000 sh | 36,000 | $3.2M | 0.01% | New |
| 119 | Vanguard Global Advisers#119 · 34,500 sh | 34,500 | $3.1M | <0.01% | +10.8% |
| 120 | Ghisallo Capital Management#120 · 30,000 sh | 30,000 | $2.7M | 0.05% | New |
| 121 | FRED ALGER MANAGEMENT#121 · 28,834 sh | 28,834 | $2.6M | <0.01% | -51.5% |
| 122 | D. E. Shaw#122 · 26,452 sh | 26,452 | $2.3M | <0.01% | New |
| 123 | CASTLEARK MANAGEMENT#123 · 26,420 sh | 26,420 | $2.3M | 0.06% | New |
| 124 | NEW YORK STATE COMMON RETIREMENT FUND#124 · 26,165 sh | 26,165 | $2.3M | <0.01% | +17.5% |
| 125 | Zurcher Kantonalbank (Zurich Cantonalbank)#125 · 26,143 sh | 26,143 | $2.3M | <0.01% | +87.3% |
| 126 | Handelsbanken Fonder AB#126 · 26,000 sh | 26,000 | $2.3M | <0.01% | New |
| 127 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY#127 · 25,799 sh | 25,799 | $2.3M | 0.02% | 0.0% |
| 128 | Creative Planning#128 · 25,713 sh | 25,713 | $2.3M | <0.01% | +66.0% |
| 129 | Waverly Advisors#129 · 25,512 sh | 25,512 | $2.3M | 0.01% | -1.7% |
| 130 | Aquatic Capital Management#130 · 25,222 sh | 25,222 | $2.2M | 0.08% | New |
| 131 | AQR CAPITAL MANAGEMENT#131 · 22,937 sh | 22,937 | $2.0M | <0.01% | +9.9% |
| 132 | Freestone Grove Partners#132 · 22,777 sh | 22,777 | $2.0M | 0.01% | New |
| 133 | VIRGINIA RETIREMENT SYSTEMS ET Al#133 · 22,500 sh | 22,500 | $2.0M | <0.01% | -18.3% |
| 134 | Police & Firemen's Retirement System of New Jersey#134 · 21,968 sh | 21,968 | $2.0M | 0.01% | +19.7% |
| 135 | PROFUND ADVISORS#135 · 19,419 sh | 19,419 | $1.7M | 0.05% | -25.4% |
| 136 | Schonfeld Strategic Advisors#136 · 19,089 sh | 19,089 | $1.7M | <0.01% | New |
| 137 | Ellsworth Advisors#137 · 16,553 sh | 16,553 | $1.7M | — | -24.6% |
| 138 | OSAIC#138 · 18,146 sh | 18,146 | $1.6M | <0.01% | +3543.8% |
| 139 | State of New Jersey Common Pension Fund D#139 · 18,129 sh | 18,129 | $1.6M | <0.01% | +8.4% |
| 140 | STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM#140 · 18,076 sh | 18,076 | $1.6M | <0.01% | +30.0% |
| 141 | INTECH INVESTMENT MANAGEMENT#141 · 17,628 sh | 17,628 | $1.6M | 0.01% | +7.2% |
| 142 | KENNEDY CAPITAL MANAGEMENT#142 · 17,310 sh | 17,310 | $1.5M | 0.03% | +2.6% |
| 143 | ALGERT GLOBAL#143 · 16,460 sh | 16,460 | $1.5M | 0.02% | New |
| 144 | FIFTH THIRD BANCORP#144 · 15,638 sh | 15,638 | $1.4M | <0.01% | New |
| 145 | Arizona State Retirement System#145 · 15,471 sh | 15,471 | $1.4M | <0.01% | +15.1% |
| 146 | DIADEMA PARTNERS#146 · 15,000 sh | 15,000 | $1.3M | 0.17% | New |
| 147 | Vanguard Investments Australia, Ltd.#147 · 14,752 sh | 14,752 | $1.3M | <0.01% | +15.1% |
| 148 | Neo Ivy Capital Management#148 · 14,551 sh | 14,551 | $1.3M | 0.30% | +2333.3% |
| 149 | SEI INVESTMENTS#149 · 13,941 sh | 13,941 | $1.2M | <0.01% | +55.3% |
| 150 | China Universal Asset Management , Ltd.#150 · 13,821 sh | 13,821 | $1.2M | 0.07% | -0.8% |
| 151 | BROWN ADVISORY#151 · 13,550 sh | 13,550 | $1.2M | <0.01% | +9.3% |
| 152 | Seven Fleet Capital Management#152 · 13,300 sh | 13,300 | $1.2M | 0.19% | -32.5% |
| 153 | KLP KAPITALFORVALTNING AS#153 · 12,800 sh | 12,800 | $1.1M | <0.01% | +17.4% |
| 154 | TWO SIGMA INVESTMENTS#154 · 12,771 sh | 12,771 | $1.1M | <0.01% | New |
| 155 | SG Americas Securities#155 · 12,727 sh | 12,727 | $1.1M | <0.01% | -5.0% |
| 156 | ProShare Advisors#156 · 12,599 sh | 12,599 | $1.1M | <0.01% | -6.7% |
| 157 | Atom Investors#157 · 12,457 sh | 12,457 | $1.1M | 0.10% | New |
| 158 | Global Endowment Management#158 · 12,123 sh | 12,123 | $1.1M | 0.11% | -33.3% |
| 159 | STRS OHIO#159 · 11,500 sh | 11,500 | $1.0M | <0.01% | +155.6% |
| 160 | Calamos Advisors#160 · 11,323 sh | 11,323 | $1.0M | <0.01% | New |
| 161 | Diametric Capital#161 · 10,000 sh | 10,000 | $887.8K | 0.09% | New |
| 162 | GLENMEDE NA#162 · 9,966 sh | 9,966 | $884.8K | <0.01% | New |
| 163 | FIRST ADVISORS#163 · 9,779 sh | 9,779 | $868.2K | <0.01% | -94.5% |
| 164 | Quantbot Technologies#164 · 8,884 sh | 8,884 | $788.7K | 0.03% | +9995.5% |
| 165 | Persistent Asset Partners Ltd#165 · 8,760 sh | 8,760 | $777.7K | 0.23% | +82.4% |
| 166 | Brevan Howard Capital Management#166 · 8,288 sh | 8,288 | $735.8K | <0.01% | New |
| 167 | Man Group plc#167 · 7,714 sh | 7,714 | $684.8K | <0.01% | -19.2% |
| 168 | ENVESTNET ASSET MANAGEMENT#168 · 7,666 sh | 7,666 | $680.6K | <0.01% | New |
| 169 | XPONANCE#169 · 7,291 sh | 7,291 | $647.3K | <0.01% | +13.1% |
| 170 | Ameritas Investment Partners#170 · 6,760 sh | 6,760 | $600.2K | 0.02% | +20.9% |
| 171 | State of Wyoming#171 · 6,690 sh | 6,690 | $593.9K | 0.06% | New |
| 172 | AlphaCentric Advisors#172 · 6,670 sh | 6,670 | $592.2K | 0.50% | +0.5% |
| 173 | TEACHER RETIREMENT SYSTEM OF TEXAS#173 · 6,554 sh | 6,554 | $581.9K | <0.01% | +4.4% |
| 174 | BOOTHBAY FUND MANAGEMENT#174 · 6,453 sh | 6,453 | $572.9K | <0.01% | -96.7% |
| 175 | Harvest Investment Services#175 · 6,432 sh | 6,432 | $571.0K | 0.09% | New |
| 176 | Fieldview Capital Management#176 · 6,392 sh | 6,392 | $567.5K | 0.16% | New |
| 177 | Allspring Global Investments#177 · 6,090 sh | 6,090 | $541.3K | <0.01% | New |
| 178 | Quantinno Capital Management#178 · 6,015 sh | 6,015 | $534.0K | <0.01% | +31.9% |
| 179 | High Net Worth Advisory Group#179 · 6,000 sh | 6,000 | $532.7K | — | 0.0% |
| 180 | OMERS ADMINISTRATION#180 · 5,200 sh | 5,200 | $461.7K | <0.01% | New |
| 181 | DARK FOREST CAPITAL MANAGEMENT#181 · 5,192 sh | 5,192 | $460.9K | 0.03% | New |
| 182 | E Fund Management , Ltd.#182 · 5,184 sh | 5,184 | $460.2K | 0.01% | -27.6% |
| 183 | Vanguard Personalized Indexing Management#183 · 5,118 sh | 5,118 | $454.4K | <0.01% | +16.4% |
| 184 | CAPTRUST FINANCIAL ADVISORS#184 · 5,023 sh | 5,023 | $445.9K | <0.01% | New |
| 185 | Connor, Clark & Lunn Investment Management Ltd.#185 · 4,801 sh | 4,801 | $426.2K | <0.01% | New |
| 186 | MARTINGALE ASSET MANAGEMENT L P#186 · 4,425 sh | 4,425 | $392.9K | <0.01% | -51.3% |
| 187 | Virtu Financial#187 · 4,351 sh | 4,351 | $386.0K | 0.01% | -46.2% |
| 188 | CIBC Bancorp USA#188 · 4,122 sh | 4,122 | $366.0K | <0.01% | New |
| 189 | Virtus Investment Advisers#189 · 4,050 sh | 4,050 | $359.6K | 0.08% | -50.1% |
| 190 | WEXFORD CAPITAL#190 · 4,000 sh | 4,000 | $355.1K | 0.05% | New |
| 191 | Artia Global Partners#191 · 4,000 sh | 4,000 | $355.1K | 0.07% | New |
| 192 | PSP Research#192 · 4,000 sh | 4,000 | $355.1K | — | -22.5% |
| 193 | Mirae Asset Global Investments , Ltd.#193 · 3,884 sh | 3,884 | $344.8K | <0.01% | -5.2% |
| 194 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C.#194 · 3,875 sh | 3,875 | $344.0K | 0.02% | -25.5% |
| 195 | Jump Financial#195 · 3,813 sh | 3,813 | $338.5K | <0.01% | New |
| 196 | Swiss Life Asset Management Ltd#196 · 3,601 sh | 3,601 | $319.7K | <0.01% | New |
| 197 | Bridgefront Capital#197 · 3,577 sh | 3,577 | $317.6K | 0.08% | -58.7% |
| 198 | STIFEL FINANCIAL#198 · 3,011 sh | 3,011 | $267.3K | <0.01% | New |
| 199 | TWO SIGMA SECURITIES#199 · 3,003 sh | 3,003 | $266.6K | 0.02% | -56.2% |
| 200 | Tower Research Capital (TRC)#200 · 3,001 sh | 3,001 | $266.4K | <0.01% | -65.9% |
Source: Form 13F-HR filings on SEC EDGAR, Q2 2026. Values are as reported by each manager at quarter end. “% of portfolio” is the position’s share of the manager’s total reported 13F value for the same quarter. “New” means the manager filed a 13F for Q1 2026 without this position; a dash means no comparison is available. Where a manager’s own filing is internally inconsistent its value is withheld and it is listed last. 13F data shows reported holdings, not recommendations.