Spyre Therapeutics, Inc. (SYRE) — Institutional Holders, Q2 2026 (page 3)
269 institutional investment managers reported a SYRE position on SEC Form 13F-HR for the quarter ended June 30, 2026, with a combined reported value of $8.5B. Every filer is listed below, ranked by position value, 100 per page; this page shows ranks 201 to 269. Put and call option positions are excluded, and a firm filing several lots or share classes is shown once with its total.
SYRE 13F holders ranked 201–269 of 269
| # | Institution | Shares | Value | % of portfolio | QoQShares vs Q1 2026 |
|---|---|---|---|---|---|
| 201 | JANE STREET GROUP#201 · 2,909 sh | 2,909 | $258.3K | 0.00% | New |
| 202 | VARCOV#202 · 2,895 sh | 2,895 | $257.0K | 0.10% | New |
| 203 | Aster Capital Management (DIFC) Ltd#203 · 2,865 sh | 2,865 | $254.4K | 0.05% | New |
| 204 | Amundi#204 · 2,793 sh | 2,793 | $248.0K | <0.01% | New |
| 205 | Empowered Funds#205 · 2,731 sh | 2,731 | $242.5K | <0.01% | New |
| 206 | DnB Asset Management AS#206 · 2,661 sh | 2,661 | $236.2K | <0.01% | New |
| 207 | TUDOR INVESTMENT ET AL#207 · 2,645 sh | 2,645 | $234.8K | <0.01% | -68.4% |
| 208 | Orion Porfolio Solutions#208 · 2,577 sh | 2,577 | $228.8K | <0.01% | New |
| 209 | CIBC Asset Management#209 · 2,429 sh | 2,429 | $215.6K | <0.01% | New |
| 210 | NISA INVESTMENT ADVISORS#210 · 2,347 sh | 2,347 | $208.4K | — | +22.5% |
| 211 | ROYAL BANK OF CANADA#211 · 2,338 sh | 2,338 | $208.0K | 0.00% | -28.1% |
| 212 | LOS ANGELES CAPITAL MANAGEMENT#212 · 2,310 sh | 2,310 | $205.1K | <0.01% | -60.6% |
| 213 | Bayforest Capital Ltd#213 · 2,305 sh | 2,305 | $204.6K | 0.19% | New |
| 214 | ACADIAN ASSET MANAGEMENT#214 · 2,296 sh | 2,296 | $203.0K | <0.01% | New |
| 215 | CFC Planning#215 · 2,277 sh | 2,277 | $202.2K | 0.12% | New |
| 216 | Fulcrum Asset Management LLP#216 · 2,114 sh | 2,114 | $190.6K | 0.02% | New |
| 217 | ABS Investment Management#217 · 89 sh | 89 | $186.4K | 0.12% | — |
| 218 | ABS Direct Equity Fund#218 · 89 sh | 89 | $186.4K | 0.12% | -96.8% |
| 219 | Nykredit A/S#219 · 1,953 sh | 1,953 | $173.4K | <0.01% | — |
| 220 | Mitsubishi UFJ & Banking#220 · 1,844 sh | 1,844 | $163.7K | <0.01% | New |
| 221 | KBC Group NV#221 · 1,796 sh | 1,796 | $159.0K | — | +30.9% |
| 222 | GF FUND MANAGEMENT LTD.#222 · 1,664 sh | 1,664 | $147.7K | — | -4.5% |
| 223 | PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO#223 · 1,589 sh | 1,589 | $141.0K | <0.01% | 0.0% |
| 224 | US BANCORP \DE\#224 · 1,507 sh | 1,507 | $133.8K | <0.01% | +1453.6% |
| 225 | Farther Finance Advisors#225 · 1,129 sh | 1,129 | $100.2K | — | +1425.7% |
| 226 | PNC FINANCIAL SERVICES GROUP#226 · 914 sh | 914 | $81.1K | 0.00% | +643.1% |
| 227 | BNP Paribas Asset Management Holding S.A.#227 · 897 sh | 897 | $79.6K | <0.01% | +1.0% |
| 228 | Union Bancaire Privee, UBP SA#228 · 880 sh | 880 | $79.3K | <0.01% | -77.3% |
| 229 | Kemnay Advisory Services#229 · 741 sh | 741 | $65.8K | <0.01% | +29.1% |
| 230 | Parallel Advisors#230 · 720 sh | 720 | $63.9K | <0.01% | +2150.0% |
| 231 | GAMMA Investing#231 · 663 sh | 663 | $58.9K | — | +26.8% |
| 232 | Pacer Advisors#232 · 614 sh | 614 | $55.0K | <0.01% | New |
| 233 | Optiver Holding B.V.#233 · 400 sh | 400 | $35.5K | 0.00% | +38.9% |
| 234 | Integrated Wealth Concepts#234 · 353 sh | 353 | $31.3K | <0.01% | New |
| 235 | EverSource Wealth Advisors#235 · 345 sh | 345 | $30.6K | <0.01% | -85.2% |
| 236 | SIMPLEX TRADING#236 · 278 sh | 278 | $24.7K | 0.00% | New |
| 237 | TORONTO DOMINION BANK#237 · 270 sh | 270 | $24.0K | 0.00% | New |
| 238 | Sterling Capital Management#238 · 262 sh | 262 | $23.3K | — | -75.1% |
| 239 | Allworth Financial#239 · 226 sh | 226 | $20.1K | <0.01% | +93.2% |
| 240 | Axiom Investment Management#240 · 200 sh | 200 | $17.8K | 0.01% | New |
| 241 | SRS Capital Advisors#241 · 169 sh | 169 | $15.0K | <0.01% | +838.9% |
| 242 | J.Safra Asset Management#242 · 167 sh | 167 | $14.8K | <0.01% | New |
| 243 | IFG Advisory#243 · 161 sh | 161 | $14.3K | <0.01% | New |
| 244 | Smartleaf Asset Management#244 · 157 sh | 157 | $14.2K | <0.01% | 0.0% |
| 245 | NATIONAL BANK OF CANADA#245 · 124 sh | 124 | $11.0K | 0.00% | New |
| 246 | JONES FINANCIAL COMPANIES LLLP#246 · 103 sh | 103 | $9.1K | 0.00% | New |
| 247 | ROTHSCHILD INVESTMENT#247 · 99 sh | 99 | $8.8K | <0.01% | 0.0% |
| 248 | Parkside Financial Bank#248 · 90 sh | 90 | $8.0K | — | +157.1% |
| 249 | Larson Financial Group#249 · 63 sh | 63 | $5.6K | <0.01% | +75.0% |
| 250 | SIGNATUREFD#250 · 59 sh | 59 | $5.2K | — | -15.7% |
| 251 | MEEDER ASSET MANAGEMENT#251 · 30 sh | 30 | $2.7K | <0.01% | New |
| 252 | IFP Advisors#252 · 24 sh | 24 | $2.1K | — | 0.0% |
| 253 | Bare Financial Services#253 · 16 sh | 16 | $1.4K | <0.01% | 0.0% |
| 254 | Covestor Ltd#254 · 13 sh | 13 | $1.0K | <0.01% | +225.0% |
| 255 | Ares Financial Consulting#255 · 11 sh | 11 | $977.00 | — | New |
| 256 | HRT FINANCIAL#256 · 10,000 sh | 10,000 | $887.00 | 0.00% | New |
| 257 | Physician Wealth Advisors#257 · 5 sh | 5 | $444.00 | — | New |
| 258 | SBI Securities , Ltd.#258 · 5 sh | 5 | $444.00 | — | 0.0% |
| 259 | Stone House Investment Management#259 · 4 sh | 4 | $355.00 | — | New |
| 260 | Hughes Financial Services#260 · 4 sh | 4 | $355.00 | 0.00% | New |
| 261 | Keating Financial Advisory Services#261 · 4 sh | 4 | $355.00 | 0.00% | 0.0% |
| 262 | Silver Grove Financial Group#262 · 3 sh | 3 | $266.00 | <0.01% | New |
| 263 | Caitong International Asset Management , Ltd#263 · 2 sh | 2 | $178.00 | 0.00% | -99.3% |
| 264 | Quarry#264 · 2 sh | 2 | $178.00 | 0.00% | New |
| 265 | Essential Partners#265 · 2 sh | 2 | $178.00 | — | 0.0% |
| 266 | ZIONS BANCORPORATION, NATIONAL ASSOCIATION#266 · 1 sh | 1 | $89.00 | 0.00% | New |
| 267 | NOMURA ASSET MANAGEMENT LTD#267 · 0 sh | 0 | $0.00 | 0.00% | New |
| 268 | MassMutual Private Wealth & , FSB#268 · 0 sh | 0 | $0.00 | — | -100.0% |
| 269 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM#269 · 64,687 sh | 64,687 | — | — | +9.2% |
Source: Form 13F-HR filings on SEC EDGAR, Q2 2026. Values are as reported by each manager at quarter end. “% of portfolio” is the position’s share of the manager’s total reported 13F value for the same quarter. “New” means the manager filed a 13F for Q1 2026 without this position; a dash means no comparison is available. Where a manager’s own filing is internally inconsistent its value is withheld and it is listed last. 13F data shows reported holdings, not recommendations.