VERTEX PHARMACEUTICALS INC / MA (VRTX) — Institutional Holders, Q2 2026

1,768 institutional investment managers reported a VRTX position on SEC Form 13F-HR for the quarter ended June 30, 2026, with a combined reported value of $119.6B. Every filer is listed below, ranked by position value, 100 per page; this page shows ranks 1 to 100. Put and call option positions are excluded, and a firm filing several lots or share classes is shown once with its total.

← VRTX stock profile

VRTX in Q2 2026: what funds did

Funds that filed a 13F for both Q1 2026 and Q2 2026, by what they did with the common stock. Share counts are adjusted for any split between the two quarters; dollar figures are the change in shares at this quarter’s price.

New positions

176

Added to

708

Trimmed

622

Sold out

111

Biggest buyers

Invesco Ltd.Added · +5,481,995 sh+$2.7B
FRANKLIN RESOURCESAdded · +2,796,121 sh+$1.4B
Capital World InvestorsAdded · +746,890 sh+$371.0M
SG Americas SecuritiesAdded · +466,738 sh+$231.8M
AQR CAPITAL MANAGEMENTAdded · +445,139 sh+$221.1M

Biggest sellers

Capital Research Global InvestorsTrimmed · -1,635,327 sh-$812.3M
ALLIANCEBERNSTEIN L.P.Trimmed · -891,471 sh-$442.8M
FMRTrimmed · -563,107 sh-$279.7M
JPMORGAN CHASETrimmed · -515,556 sh-$256.1M
Capital International InvestorsTrimmed · -430,933 sh-$214.1M

VRTX 13F holders ranked 1–100 of 1,768

Institutional investors reporting a position in VERTEX PHARMACEUTICALS INC / MA on SEC Form 13F-HR for Q2 2026, ranked by reported value.
#	Institution	Shares	Value	% of portfolio	QoQShares vs Q1 2026
1	Capital World Investors#1 · 26,115,014 sh	26,115,014	$13.0B	1.53%	+2.9%
2	BlackRock#2 · 24,109,373 sh	24,109,373	$12.0B	0.18%	+0.6%
3	Capital Research Global Investors#3 · 19,490,637 sh	19,490,637	$9.7B	1.35%	-7.7%
4	VANGUARD CAPITAL MANAGEMENT#4 · 16,580,713 sh	16,580,713	$8.2B	0.18%	+0.4%
5	STATE STREET#5 · 11,871,459 sh	11,871,459	$5.9B	0.17%	+1.2%
6	Invesco Ltd.#6 · 8,043,052 sh	8,043,052	$4.0B	0.32%	+214.1%
7	JPMORGAN CHASE#7 · 6,517,600 sh	6,517,600	$3.3B	0.18%	-7.3%
8	GEODE CAPITAL MANAGEMENT#8 · 6,017,848 sh	6,017,848	$3.0B	0.16%	-2.0%
9	VANGUARD PORTFOLIO MANAGEMENT#9 · 4,878,987 sh	4,878,987	$2.4B	0.11%	-5.2%
10	Capital International Investors#10 · 4,695,144 sh	4,695,144	$2.3B	0.48%	-8.4%
11	LOOMIS SAYLES & L P#11 · 3,920,953 sh	3,920,953	$1.9B	2.44%	-2.1%
12	FRANKLIN RESOURCES#12 · 3,347,253 sh	3,347,253	$1.7B	0.36%	+507.3%
13	WELLINGTON MANAGEMENT GROUP LLP#13 · 3,247,658 sh	3,247,658	$1.6B	0.28%	+1.1%
14	MORGAN STANLEY#14 · 3,242,139 sh	3,242,139	$1.6B	0.09%	+1.7%
15	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AME#15 · 3,086,683 sh	3,086,683	$1.5B	0.28%	+1.0%
16	BANK OF AMERICA#16 · 3,039,178 sh	3,039,178	$1.5B	0.10%	+5.6%
17	JENNISON ASSOCIATES#17 · 2,998,530 sh	2,998,530	$1.5B	0.89%	+9.4%
18	NORGES BANK#18 · 2,971,681 sh	2,971,681	$1.5B	0.15%	—
19	ALLIANCEBERNSTEIN L.P.#19 · 3,019,315 sh	3,019,315	$1.3B	0.45%	-22.8%
20	AMERIPRISE FINANCIAL#20 · 2,604,822 sh	2,604,822	$1.3B	0.26%	-1.1%
21	NORTHERN#21 · 2,486,478 sh	2,486,478	$1.2B	0.14%	-3.0%
22	GOLDMAN SACHS GROUP#22 · 2,481,761 sh	2,481,761	$1.2B	0.11%	+2.6%
23	Clearbridge Investments#23 · 2,342,915 sh	2,342,915	$1.2B	0.96%	-13.3%
24	VICTORY CAPITAL MANAGEMENT#24 · 2,173,152 sh	2,173,152	$1.1B	0.61%	+15.1%
25	CHARLES SCHWAB INVESTMENT MANAGEMENT#25 · 2,041,282 sh	2,041,282	$1.0B	0.14%	+6.3%
26	Legal & General Group Plc#26 · 1,870,015 sh	1,870,015	$928.9M	0.19%	-4.4%
27	PRICE T ROWE ASSOCIATES#27 · 1,728,421 sh	1,728,421	$858.6M	0.09%	-1.8%
28	Bank of New York Mellon#28 · 1,672,623 sh	1,672,623	$830.8M	0.14%	+5.4%
29	DEUTSCHE BANK AG\#29 · 1,579,110 sh	1,579,110	$784.4M	0.23%	+2.7%
30	Amundi#30 · 1,546,509 sh	1,546,509	$768.2M	0.19%	+5.0%
31	FMR#31 · 1,457,158 sh	1,457,158	$723.8M	0.03%	-27.9%
32	VANGUARD FIDUCIARY#32 · 1,425,390 sh	1,425,390	$708.0M	0.16%	-2.8%
33	Jupiter Topco#33 · 1,259,997 sh	1,259,997	$625.8M	0.26%	—
34	DIMENSIONAL FUND ADVISORS#34 · 1,168,956 sh	1,168,956	$580.7M	0.11%	+18.2%
35	WCM INVESTMENT MANAGEMENT#35 · 1,152,094 sh	1,152,094	$575.6M	1.04%	+2.7%
36	Nuveen#36 · 1,081,685 sh	1,081,685	$537.3M	0.13%	-0.3%
37	ROYAL BANK OF CANADA#37 · 980,259 sh	980,259	$486.9M	0.07%	-11.8%
38	BNP Paribas Asset Management Holding S.A.#38 · 897,893 sh	897,893	$446.0M	0.45%	+5.9%
39	Assenagon Asset Management S.A.#39 · 759,564 sh	759,564	$377.3M	—	+41.4%
40	WELLS FARGO & COMPANY#40 · 749,528 sh	749,528	$372.3M	0.06%	+0.6%
41	ARROWSTREET CAPITAL, LIMITED PARTNERSHIP#41 · 738,378 sh	738,378	$366.8M	0.16%	+15.6%
42	BARCLAYS PLC#42 · 733,274 sh	733,274	$364.2M	0.07%	+10.6%
43	Swiss National Bank#43 · 717,440 sh	717,440	$356.4M	0.19%	-3.6%
44	UBS Group AG#44 · 712,259 sh	712,259	$353.8M	0.04%	+12.9%
45	CITIGROUP#45 · 706,968 sh	706,968	$351.2M	0.12%	+3.5%
46	HSBC PLC#46 · 676,247 sh	676,247	$335.8M	0.14%	+3.2%
47	Mitsubishi UFJ Asset Management , Ltd.#47 · 647,193 sh	647,193	$321.5M	0.18%	+8.3%
48	AQR CAPITAL MANAGEMENT#48 · 616,170 sh	616,170	$305.0M	0.11%	+260.3%
49	Sumitomo Mitsui#49 · 611,907 sh	611,907	$304.0M	0.17%	-0.4%
50	AMERICAN CENTURY COMPANIES#50 · 580,901 sh	580,901	$288.6M	0.13%	-28.6%
51	Bellevue Group AG#51 · 578,634 sh	578,634	$287.4M	6.05%	-15.1%
52	Neuberger Berman Group#52 · 559,445 sh	559,445	$277.9M	0.18%	+1.4%
53	RAYMOND JAMES FINANCIAL#53 · 556,876 sh	556,876	$276.6M	0.07%	+25.3%
54	MANUFACTURERS LIFE INSURANCE COMPANY, THE#54 · 554,085 sh	554,085	$275.2M	0.21%	+0.2%
55	Vanguard Global Advisers#55 · 547,463 sh	547,463	$271.9M	0.13%	-1.5%
56	MARSHALL WACE, LLP#56 · 543,897 sh	543,897	$270.2M	0.21%	+71.5%
57	Pictet Asset Management Holding SA#57 · 539,255 sh	539,255	$268.3M	0.26%	+59.7%
58	National Pension Service#58 · 539,530 sh	539,530	$268.0M	0.17%	+1.4%
59	EDGEWOOD MANAGEMENT#59 · 531,003 sh	531,003	$263.8M	2.72%	-41.3%
60	SG Americas Securities#60 · 523,720 sh	523,720	$260.1M	0.15%	+819.1%
61	Life Cycle Investment Partners Ltd#61 · 514,179 sh	514,179	$255.4M	1.19%	+16.8%
62	CITADEL ADVISORS#62 · 510,430 sh	510,430	$253.5M	0.03%	+50.4%
63	VOYA INVESTMENT MANAGEMENT#63 · 505,219 sh	505,219	$250.4M	0.22%	-4.1%
64	VANGUARD ASSET MANAGEMENT, Ltd#64 · 494,186 sh	494,186	$245.5M	0.17%	+11.8%
65	ENVESTNET ASSET MANAGEMENT#65 · 487,627 sh	487,627	$242.2M	0.06%	-3.2%
66	MILLENNIUM MANAGEMENT#66 · 468,410 sh	468,410	$232.7M	0.08%	+1419.7%
67	DekaBank Deutsche Girozentrale#67 · 506,457 sh	506,457	$225.3M	0.38%	0.0%
68	NATIXIS ADVISORS#68 · 448,631 sh	448,631	$222.8M	0.25%	-19.0%
69	CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM#69 · 447,499 sh	447,499	$222.3M	0.13%	-11.1%
70	MASSACHUSETTS FINANCIAL SERVICES#70 · 423,049 sh	423,049	$214.6M	0.07%	+29.2%
71	BANK OF MONTREAL#71 · 427,448 sh	427,448	$212.3M	0.07%	+9.5%
72	Chevy Chase#72 · 406,303 sh	406,303	$201.8M	0.52%	-0.3%
73	Robeco Institutional Asset Management B.V.#73 · 404,396 sh	404,396	$200.9M	—	+0.7%
74	RHUMBLINE ADVISERS#74 · 396,380 sh	396,380	$196.9M	0.15%	-6.3%
75	ADAGE CAPITAL PARTNERS GP, L.L.C.#75 · 393,964 sh	393,964	$195.7M	0.27%	+56.3%
76	Hudson Bay Capital Management#76 · 390,440 sh	390,440	$193.9M	0.53%	+767.6%
77	PRINCIPAL FINANCIAL GROUP#77 · 389,511 sh	389,511	$193.5M	0.10%	-8.7%
78	Zurcher Kantonalbank (Zurich Cantonalbank)#78 · 380,762 sh	380,762	$189.1M	0.36%	+1.0%
79	DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt#79 · 359,332 sh	359,332	$178.5M	0.14%	-1.4%
80	CANADA PENSION PLAN INVESTMENT BOARD#80 · 355,082 sh	355,082	$176.4M	0.10%	+86.8%
81	Russell Investments Group, Ltd.#81 · 336,990 sh	336,990	$167.5M	0.15%	-8.3%
82	Universal- Beteiligungs- und Servicegesellschaft mbH#82 · 323,752 sh	323,752	$160.7M	0.25%	-4.3%
83	RENAISSANCE TECHNOLOGIES#83 · 320,008 sh	320,008	$159.0M	0.22%	-24.1%
84	Bank Julius Baer & Ltd, Zurich#84 · 319,371 sh	319,371	$158.9M	0.41%	+0.6%
85	AMF Tjanstepension AB#85 · 314,765 sh	314,765	$156.4M	—	+0.6%
86	FIRST ADVISORS#86 · 289,179 sh	289,179	$143.6M	0.08%	-5.6%
87	LPL Financial#87 · 289,111 sh	289,111	$143.6M	0.03%	+7.9%
88	ProShare Advisors#88 · 287,847 sh	287,847	$143.0M	0.21%	-22.9%
89	TWO SIGMA INVESTMENTS#89 · 285,000 sh	285,000	$141.6M	0.10%	-24.6%
90	Swedbank AB#90 · 282,444 sh	282,444	$140.3M	0.12%	+4.0%
91	NEW YORK STATE COMMON RETIREMENT FUND#91 · 277,614 sh	277,614	$137.9M	0.17%	-5.1%
92	BAILLIE GIFFORD#92 · 272,561 sh	272,561	$135.4M	0.12%	+36.7%
93	BNP PARIBAS FINANCIAL MARKETS#93 · 262,258 sh	262,258	$130.3M	0.05%	-36.9%
94	Cerity Partners#94 · 255,874 sh	255,874	$127.1M	0.15%	-13.7%
95	PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO#95 · 250,189 sh	250,189	$124.3M	0.43%	-19.7%
96	Nykredit A/S#96 · 248,068 sh	248,068	$123.2M	0.39%	—
97	ROYAL LONDON ASSET MANAGEMENT LTD#97 · 241,280 sh	241,280	$119.9M	0.22%	-4.3%
98	B. Metzler seel. Sohn & AG#98 · 231,381 sh	231,381	$114.9M	0.99%	-54.7%
99	AVIVA PLC#99 · 223,593 sh	223,593	$111.1M	0.16%	+0.5%
100	ING GROEP NV#100 · 223,124 sh	223,124	$110.8M	0.54%	+241.0%

Funds that sold out of VRTX in Q2 2026 (111)

Held VRTX at the end of Q1 2026 and filed a Q2 2026 13F without it. Not in the list above, because they no longer hold it. Largest prior position first.

Institutions that held VRTX in Q1 2026 and reported no position in Q2 2026.
Institution	Shares sold	Value in Q1 2026
Smith Group Asset Management55,746 sh	55,746	$24.9M
Gradient Investments41,736 sh	41,736	$18.6M
CAXTON ASSOCIATES LLP36,026 sh	36,026	$16.1M
ExodusPoint Capital Management22,403 sh	22,403	$10.0M
XTX Topco Ltd15,632 sh	15,632	$7.0M
Trexquant Investment15,171 sh	15,171	$6.8M
ADAR1 Capital Management15,075 sh	15,075	$6.7M
SUPERSTRING CAPITAL MANAGEMENT11,010 sh	11,010	$4.9M
GROUP ONE TRADING, L.P.9,357 sh	9,357	$4.2M
Emerald Investment Advisers8,012 sh	8,012	$3.6M
Twin Tree Management7,769 sh	7,769	$3.5M
Virtu Financial7,634 sh	7,634	$3.4M
Freemont Management S.A.6,500 sh	6,500	$2.9M
Havemeyer Place5,655 sh	5,655	$2.5M
Campbell & Investment Adviser5,580 sh	5,580	$2.5M
Fiduciary Alliance5,583 sh	5,583	$2.5M
IMC-Chicago4,533 sh	4,533	$2.0M
Qube Research & Technologies Ltd3,998 sh	3,998	$1.8M
Mattson Financial Services3,861 sh	3,861	$1.7M
DIADEMA PARTNERS3,840 sh	3,840	$1.7M
GLR Partners3,538 sh	3,538	$1.6M
Arrowpoint Investment Partners (Singapore) Pte. Ltd.3,412 sh	3,412	$1.5M
SWS Partners2,573 sh	2,573	$1.1M
OXFORD ASSET MANAGEMENT LLP2,499 sh	2,499	$1.1M
Centiva Capital2,147 sh	2,147	$958.7K
Brown Financial Advisors2,141 sh	2,141	$956.0K
OAK RIDGE INVESTMENTS2,009 sh	2,009	$897.1K
Farringdon Capital, Ltd.1,831 sh	1,831	$817.6K
Polymer Capital Management (US)1,669 sh	1,669	$745.3K
Magnetar Financial1,672 sh	1,672	$741.0K
STEVENS CAPITAL MANAGEMENT1,588 sh	1,588	$709.0K
GSA CAPITAL PARTNERS LLP1,570 sh	1,570	$701.0K
LECAP ASSET MANAGEMENT LTD1,507 sh	1,507	$672.9K
EVOKE WEALTH1,485 sh	1,485	$663.1K
SIMPLEX TRADING1,401 sh	1,401	$625.6K
BankChampaign, National Association1,374 sh	1,374	$613.5K
Resurgent Financial Advisors1,260 sh	1,260	$562.6K
Merrion Investment Management1,250 sh	1,250	$558.2K
St. Louis1,218 sh	1,218	$543.9K
ABC ARBITRAGE SA1,215 sh	1,215	$542.5K
PARK NATIONAL1,180 sh	1,180	$526.9K
Paladin Wealth1,074 sh	1,074	$479.6K
INVESTMENT MANAGEMENT /VA1,064 sh	1,064	$475.0K
Diametric Capital1,020 sh	1,020	$455.5K
Larry Mathis Financial Planning962 sh	962	$429.6K
VARCOV941 sh	941	$420.2K
Persistent Asset Partners Ltd939 sh	939	$419.3K
National Wealth Management Group902 sh	902	$402.8K
OXFORD FINANCIAL GROUP, LTD.900 sh	900	$401.9K
Oasis Advisors885 sh	885	$395.2K
Legato Capital Management808 sh	808	$360.8K
Cercano Management780 sh	780	$348.3K
AlphaGrep UK Ltd774 sh	774	$345.6K
Sustainable Insight Capital Management731 sh	731	$326.4K
Asset One Wealth Management689 sh	689	$300.8K
Hilltop671 sh	671	$299.6K
Haverford663 sh	663	$296.1K
Gilman Hill Asset Management650 sh	650	$290.3K
Koss-Olinger Consulting646 sh	646	$288.5K
Pacific Excel Wealth Advisors625 sh	625	$279.1K
Fullerton Fund Management Ltd.568 sh	568	$253.6K
Asset Allocation & Management Company567 sh	567	$253.0K
Centurion Wealth Management561 sh	561	$250.5K
Quantbot Technologies555 sh	555	$247.8K
PATTON FUND MANAGEMENT526 sh	526	$234.9K
EntryPoint Capital523 sh	523	$233.5K
VICTORY FINANCIAL GROUP517 sh	517	$230.9K
Baer Investment Advisory517 sh	517	$230.9K
New World Advisors515 sh	515	$230.0K
Parsonex Advisory Services499 sh	499	$222.8K
HMS Capital Management497 sh	497	$221.9K
Sageworth481 sh	481	$214.8K
Aviso Financial476 sh	476	$212.6K
Pinion Investment Advisors475 sh	475	$212.1K
Timothy G. Youngquist 2020 Irrevocable376 sh	376	$167.9K
Goodman Advisory Group311 sh	311	$138.9K
TWIN PEAKS WEALTH ADVISORS280 sh	280	$125.0K
Munich Reinsurance Stock in Munich260 sh	260	$116.1K
Cache Advisors231 sh	231	$103.2K
Destiny Wealth Partners200 sh	200	$89.3K
EDMOND DE ROTHSCHILD HOLDING S.A.191 sh	191	$85.3K
Golden State Equity Partners161 sh	161	$71.9K
Migdal Insurance & Financial Ltd.145 sh	145	$64.7K
GoalVest Advisory110 sh	110	$49.1K
Innovative Asset Advisors Group96 sh	96	$42.9K
Legacy Wealth Managment78 sh	78	$34.8K
Clayton Financial Group77 sh	77	$34.4K
Founders Capital Management75 sh	75	$33.5K
Riverview55 sh	55	$24.6K
Sachetta49 sh	49	$21.9K
Scarborough Advisors47 sh	47	$21.0K
Measured Wealth Private Client Group39 sh	39	$17.4K
Team Financial Group27 sh	27	$12.1K
Portus Wealth Advisors22 sh	22	$9.8K
Vermillion Wealth Management18 sh	18	$8.0K
Intentional Wealth Strategies18 sh	18	$8.0K
Kohmann Bosshard Financial Services16 sh	16	$7.1K
Magnolia Wealth Management15 sh	15	$6.7K
POM Investment Strategies10 sh	10	$4.5K
MASECO LLP7 sh	7	$3.1K

And 11 smaller positions.

Source: Form 13F-HR filings on SEC EDGAR, Q2 2026. Values are as reported by each manager at quarter end. “% of portfolio” is the position’s share of the manager’s total reported 13F value for the same quarter. “New” means the manager filed a 13F for Q1 2026 without this position; a dash means no comparison is available. Where a manager’s own filing is internally inconsistent its value is withheld and it is listed last. 13F data shows reported holdings, not recommendations.