Definium Therapeutics, Inc. (DFTX) — Institutional Holders, Q2 2026
362 institutional investment managers reported a DFTX position on SEC Form 13F-HR for the quarter ended June 30, 2026, with a combined reported value of $5.3B. Every filer is listed below, ranked by position value, 100 per page; this page shows ranks 1 to 100. Put and call option positions are excluded, and a firm filing several lots or share classes is shown once with its total.
DFTX in Q2 2026: what funds did
Funds that filed a 13F for both Q1 2026 and Q2 2026, by what they did with the common stock. Share counts are adjusted for any split between the two quarters; dollar figures are the change in shares at this quarter’s price.
Biggest buyers
- Capital World InvestorsNew · +5,367,723 sh+$252.5M
- PRICE T ROWE ASSOCIATESAdded · +4,582,031 sh+$215.5M
- Capital International InvestorsNew · +2,963,410 sh+$139.4M
- FMRAdded · +2,943,311 sh+$138.5M
- BlackRockAdded · +2,752,604 sh+$129.5M
Biggest sellers
- Trails Edge Capital PartnersSold out · -1,738,110 sh-$81.8M
- ArrowMark ColoradoTrimmed · -1,030,648 sh-$48.5M
- Candriam S.C.A.Trimmed · -679,204 sh-$31.9M
- MILLENNIUM MANAGEMENTTrimmed · -580,820 sh-$27.3M
- Catalio Capital ManagementTrimmed · -475,312 sh-$22.4M
DFTX 13F holders ranked 1–100 of 362
| # | Institution | Shares | Value | % of portfolio | QoQShares vs Q1 2026 |
|---|---|---|---|---|---|
| 1 | BlackRock#1 · 11,232,834 sh | 11,232,834 | $528.4M | <0.01% | +32.5% |
| 2 | Avoro Capital Advisors#2 · 7,188,888 sh | 7,188,888 | $338.2M | 3.04% | +43.8% |
| 3 | DRIEHAUS CAPITAL MANAGEMENT#3 · 6,845,276 sh | 6,845,276 | $322.0M | 1.87% | +15.8% |
| 4 | Jupiter Topco#4 · 5,615,645 sh | 5,615,645 | $264.0M | 0.11% | — |
| 5 | Capital World Investors#5 · 5,367,723 sh | 5,367,723 | $252.5M | 0.03% | New |
| 6 | FMR#6 · 4,752,921 sh | 4,752,921 | $223.6M | <0.01% | +162.6% |
| 7 | PRICE T ROWE ASSOCIATES#7 · 4,652,032 sh | 4,652,032 | $218.8M | 0.02% | +6545.7% |
| 8 | GEODE CAPITAL MANAGEMENT#8 · 3,644,813 sh | 3,644,813 | $171.5M | <0.01% | +46.1% |
| 9 | STATE STREET#9 · 3,065,390 sh | 3,065,390 | $144.2M | <0.01% | +24.0% |
| 10 | Capital International Investors#10 · 2,963,410 sh | 2,963,410 | $139.4M | 0.03% | New |
| 11 | Octagon Capital Advisors#11 · 2,950,000 sh | 2,950,000 | $138.8M | 12.47% | +20.9% |
| 12 | WELLINGTON MANAGEMENT GROUP LLP#12 · 2,949,734 sh | 2,949,734 | $138.8M | 0.02% | +126.1% |
| 13 | Deep Track Capital#13 · 2,750,000 sh | 2,750,000 | $129.4M | 1.88% | -8.3% |
| 14 | Commodore Capital#14 · 2,000,000 sh | 2,000,000 | $94.1M | 5.60% | 0.0% |
| 15 | GOLDMAN SACHS GROUP#15 · 1,800,852 sh | 1,800,852 | $84.7M | <0.01% | +7.5% |
| 16 | CITADEL ADVISORS#16 · 1,688,587 sh | 1,688,587 | $79.4M | <0.01% | +26.6% |
| 17 | VANGUARD PORTFOLIO MANAGEMENT#17 · 1,648,426 sh | 1,648,426 | $77.5M | <0.01% | +88.9% |
| 18 | RA CAPITAL MANAGEMENT, L.P.#18 · 1,500,000 sh | 1,500,000 | $70.6M | 0.61% | New |
| 19 | VANGUARD CAPITAL MANAGEMENT#19 · 1,486,454 sh | 1,486,454 | $69.9M | <0.01% | +35.5% |
| 20 | Siren, L.L.C.#20 · 1,419,493 sh | 1,419,493 | $66.8M | 1.35% | +54.4% |
| 21 | MARSHALL WACE, LLP#21 · 1,298,946 sh | 1,298,946 | $61.1M | 0.05% | +8.2% |
| 22 | NORTHERN#22 · 1,169,238 sh | 1,169,238 | $55.0M | <0.01% | +46.3% |
| 23 | AMERIPRISE FINANCIAL#23 · 1,148,363 sh | 1,148,363 | $54.0M | 0.01% | +18.8% |
| 24 | Nuveen#24 · 1,105,314 sh | 1,105,314 | $52.0M | 0.01% | +58.3% |
| 25 | CHARLES SCHWAB INVESTMENT MANAGEMENT#25 · 1,083,576 sh | 1,083,576 | $51.0M | <0.01% | +34.0% |
| 26 | Woodline Partners#26 · 1,003,641 sh | 1,003,641 | $47.2M | 0.15% | +33.3% |
| 27 | ADAGE CAPITAL PARTNERS GP, L.L.C.#27 · 1,000,000 sh | 1,000,000 | $47.0M | 0.07% | -13.0% |
| 28 | Boxer Capital Management#28 · 998,500 sh | 998,500 | $47.0M | 3.54% | +66.8% |
| 29 | TWO SIGMA INVESTMENTS#29 · 921,818 sh | 921,818 | $43.4M | 0.03% | -23.3% |
| 30 | BALYASNY ASSET MANAGEMENT L.P.#30 · 897,658 sh | 897,658 | $42.2M | 0.05% | -29.6% |
| 31 | VANGUARD FIDUCIARY#31 · 827,693 sh | 827,693 | $38.9M | <0.01% | +43.7% |
| 32 | Holocene Advisors#32 · 796,574 sh | 796,574 | $37.5M | 0.08% | -27.1% |
| 33 | AWM Investment Company#33 · 784,800 sh | 784,800 | $36.9M | 3.20% | -27.1% |
| 34 | Bank of New York Mellon#34 · 777,271 sh | 777,271 | $36.6M | <0.01% | +3.2% |
| 35 | Polar Capital Plc#35 · 777,253 sh | 777,253 | $36.6M | 0.09% | New |
| 36 | ALLIANCEBERNSTEIN L.P.#36 · 1,803,287 sh | 1,803,287 | $34.1M | 0.01% | +1866.4% |
| 37 | EVENTIDE ASSET MANAGEMENT#37 · 710,000 sh | 710,000 | $33.4M | 0.45% | +3.5% |
| 38 | Neuberger Berman Group#38 · 687,539 sh | 687,539 | $32.3M | 0.02% | +415.5% |
| 39 | Qube Research & Technologies Ltd#39 · 682,901 sh | 682,901 | $32.1M | 0.03% | +60.3% |
| 40 | Candriam S.C.A.#40 · 614,425 sh | 614,425 | $28.9M | 0.13% | -52.5% |
| 41 | ArrowMark Colorado#41 · 564,069 sh | 564,069 | $26.5M | 1.10% | -64.6% |
| 42 | Catalio Capital Management#42 · 562,672 sh | 562,672 | $26.5M | 4.97% | -45.8% |
| 43 | Blackstone#43 · 561,612 sh | 561,612 | $26.4M | 0.07% | +10.4% |
| 44 | Integral Health Asset Management#44 · 550,000 sh | 550,000 | $25.9M | 1.02% | +37.5% |
| 45 | BAMCO#45 · 520,108 sh | 520,108 | $24.5M | 0.04% | New |
| 46 | UBS Group AG#46 · 499,467 sh | 499,467 | $23.5M | <0.01% | +1.1% |
| 47 | FRANKLIN RESOURCES#47 · 486,219 sh | 486,219 | $22.9M | <0.01% | New |
| 48 | Point72 Asset Management, L.P.#48 · 483,980 sh | 483,980 | $22.8M | 0.03% | +175.8% |
| 49 | Ensign Peak Advisors#49 · 466,106 sh | 466,106 | $21.9M | 0.04% | -14.8% |
| 50 | MORGAN STANLEY#50 · 454,912 sh | 454,912 | $21.4M | <0.01% | +3.7% |
| 51 | GREAT POINT PARTNERS#51 · 425,000 sh | 425,000 | $20.0M | 3.78% | New |
| 52 | RTW INVESTMENTS#52 · 400,000 sh | 400,000 | $18.8M | 0.16% | +33.3% |
| 53 | Cormorant Asset Management#53 · 400,000 sh | 400,000 | $18.8M | 0.96% | New |
| 54 | SILVERARC CAPITAL MANAGEMENT#54 · 400,000 sh | 400,000 | $18.8M | 1.96% | New |
| 55 | ASSETMARK#55 · 396,542 sh | 396,542 | $18.7M | — | New |
| 56 | ORBIMED ADVISORS#56 · 365,400 sh | 365,400 | $17.2M | 0.32% | -54.6% |
| 57 | Duquesne Family Office#57 · 356,600 sh | 356,600 | $16.8M | 0.32% | New |
| 58 | D. E. Shaw#58 · 315,410 sh | 315,410 | $14.8M | <0.01% | +16.1% |
| 59 | TFG Asset Management GP Ltd#59 · 286,990 sh | 286,990 | $13.5M | 2.13% | +43.5% |
| 60 | MILLENNIUM MANAGEMENT#60 · 266,076 sh | 266,076 | $12.5M | <0.01% | -68.6% |
| 61 | JPMORGAN CHASE#61 · 265,955 sh | 265,955 | $12.4M | <0.01% | +0.5% |
| 62 | Sofinnova Ventures#62 · 255,903 sh | 255,903 | $12.0M | 0.62% | -25.6% |
| 63 | PFM Health Sciences#63 · 249,020 sh | 249,020 | $11.7M | 1.01% | +21.3% |
| 64 | HighVista Strategies#64 · 242,884 sh | 242,884 | $11.4M | 2.60% | +30.7% |
| 65 | Trexquant Investment#65 · 233,199 sh | 233,199 | $11.0M | 0.06% | New |
| 66 | SEVEN GRAND MANAGERS#66 · 225,000 sh | 225,000 | $10.6M | 0.43% | 0.0% |
| 67 | Swiss National Bank#67 · 221,200 sh | 221,200 | $10.4M | <0.01% | +39.6% |
| 68 | Eversept Partners#68 · 217,185 sh | 217,185 | $10.2M | 0.53% | +35.1% |
| 69 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AME#69 · 211,183 sh | 211,183 | $9.9M | <0.01% | +8651.9% |
| 70 | TD ASSET MANAGEMENT#70 · 209,460 sh | 209,460 | $9.9M | <0.01% | New |
| 71 | ROYCE & ASSOCIATES#71 · 208,551 sh | 208,551 | $9.8M | 0.08% | -10.9% |
| 72 | SEB Asset Management AB#72 · 208,254 sh | 208,254 | $9.8M | 0.04% | New |
| 73 | SUPERSTRING CAPITAL MANAGEMENT#73 · 188,282 sh | 188,282 | $8.9M | 5.59% | -46.4% |
| 74 | EMERALD ADVISERS#74 · 178,751 sh | 178,751 | $8.4M | 0.20% | New |
| 75 | abrdn plc#75 · 175,000 sh | 175,000 | $8.2M | 0.01% | New |
| 76 | BANK OF AMERICA#76 · 164,575 sh | 164,575 | $7.7M | <0.01% | +3.9% |
| 77 | Tri Locum Partners#77 · 162,996 sh | 162,996 | $7.7M | 0.94% | -55.9% |
| 78 | RHUMBLINE ADVISERS#78 · 158,096 sh | 158,096 | $7.4M | <0.01% | +31.8% |
| 79 | Brevan Howard Capital Management#79 · 156,812 sh | 156,812 | $7.4M | 0.05% | -25.9% |
| 80 | Russell Investments Group, Ltd.#80 · 153,477 sh | 153,477 | $7.2M | <0.01% | +28.5% |
| 81 | LMR Partners LLP#81 · 150,200 sh | 150,200 | $7.1M | 0.03% | New |
| 82 | Seven Fleet Capital Management#82 · 148,647 sh | 148,647 | $7.0M | 1.15% | +48.8% |
| 83 | MANUFACTURERS LIFE INSURANCE COMPANY, THE#83 · 146,368 sh | 146,368 | $6.9M | <0.01% | +454.3% |
| 84 | Rock Springs Capital Management#84 · 143,187 sh | 143,187 | $6.7M | 0.33% | New |
| 85 | DEUTSCHE BANK AG\#85 · 142,947 sh | 142,947 | $6.7M | <0.01% | -65.3% |
| 86 | SummitTX Capital, L.P.#86 · 142,489 sh | 142,489 | $6.7M | 0.17% | New |
| 87 | StemPoint Capital#87 · 137,124 sh | 137,124 | $6.5M | 1.11% | -57.9% |
| 88 | AQR CAPITAL MANAGEMENT#88 · 134,152 sh | 134,152 | $6.3M | <0.01% | +135.0% |
| 89 | BIT Capital GmbH#89 · 128,131 sh | 128,131 | $6.0M | 0.18% | -53.8% |
| 90 | FRED ALGER MANAGEMENT#90 · 125,256 sh | 125,256 | $5.9M | 0.02% | +35.9% |
| 91 | WELLS FARGO & COMPANY#91 · 122,033 sh | 122,033 | $5.7M | <0.01% | +205.3% |
| 92 | Atika Capital Management#92 · 122,000 sh | 122,000 | $5.7M | 0.38% | New |
| 93 | AdvisorShares Investments#93 · 121,381 sh | 121,381 | $5.7M | 0.69% | +32.9% |
| 94 | EMERALD MUTUAL FUND ADVISERS#94 · 121,249 sh | 121,249 | $5.7M | 0.20% | New |
| 95 | Informed Momentum#95 · 120,928 sh | 120,928 | $5.7M | 0.51% | New |
| 96 | Schonfeld Strategic Advisors#96 · 119,610 sh | 119,610 | $5.6M | 0.02% | +1048.8% |
| 97 | HSBC PLC#97 · 117,482 sh | 117,482 | $5.5M | <0.01% | New |
| 98 | ALPS ADVISORS#98 · 110,388 sh | 110,388 | $5.2M | 0.02% | New |
| 99 | Data Collective IV GP#99 · 100,350 sh | 100,350 | $4.7M | 6.01% | 0.0% |
| 100 | ROYAL BANK OF CANADA#100 · 100,063 sh | 100,063 | $4.7M | <0.01% | +3.0% |
Funds that sold out of DFTX in Q2 2026 (30)
Held DFTX at the end of Q1 2026 and filed a Q2 2026 13F without it. Not in the list above, because they no longer hold it. Largest prior position first.
| Institution | Shares sold | Value in Q1 2026 |
|---|---|---|
| Trails Edge Capital Partners1,738,110 sh | 1,738,110 | $32.9M |
| Patient Square Capital331,000 sh | 331,000 | $6.3M |
| JANE STREET GROUP260,241 sh | 260,241 | $4.9M |
| Soviero Asset Management140,000 sh | 140,000 | $2.6M |
| Squarepoint Ops125,522 sh | 125,522 | $2.4M |
| Rosalind Advisors125,000 sh | 125,000 | $2.4M |
| HRT FINANCIAL89,141 sh | 89,141 | $1.7M |
| Ikarian Capital58,803 sh | 58,803 | $1.1M |
| TWINBEECH CAPITAL42,100 sh | 42,100 | $795.7K |
| CAXTON ASSOCIATES LLP37,255 sh | 37,255 | $704.1K |
| Campbell & Investment Adviser24,755 sh | 24,755 | $467.9K |
| Virtu Financial14,460 sh | 14,460 | $273.0K |
| BOOTHBAY FUND MANAGEMENT14,096 sh | 14,096 | $266.4K |
| FOX RUN MANAGEMENT, L.L.C.14,557 sh | 14,557 | $254.7K |
| Magnetar Financial13,178 sh | 13,178 | $249.1K |
| Summit Trail Advisors13,000 sh | 13,000 | $245.7K |
| RPS ADVISORY SOLUTIONS11,355 sh | 11,355 | $214.6K |
| Dynamic Technology Lab Private Ltd10,880 sh | 10,880 | $205.6K |
| Verition Fund Management10,384 sh | 10,384 | $196.3K |
| Sound Income Strategies3,690 sh | 3,690 | $76.0K |
| Advisory Services Network2,659 sh | 2,659 | $50.3K |
| Opal Wealth Advisors1,101 sh | 1,101 | $20.8K |
| Private Wealth Management Group450 sh | 450 | $8.5K |
| MEEDER ASSET MANAGEMENT353 sh | 353 | $6.7K |
| FEDERATED HERMES207 sh | 207 | $3.9K |
| Kohmann Bosshard Financial Services66 sh | 66 | $1.2K |
| LOUISBOURG INVESTMENTS52 sh | 52 | $983.00 |
| Western Wealth Management39 sh | 39 | $737.00 |
| RMG Wealth Management30 sh | 30 | $642.00 |
| CoreCap Advisors5 sh | 5 | $95.00 |
Source: Form 13F-HR filings on SEC EDGAR, Q2 2026. Values are as reported by each manager at quarter end. “% of portfolio” is the position’s share of the manager’s total reported 13F value for the same quarter. “New” means the manager filed a 13F for Q1 2026 without this position; a dash means no comparison is available. Where a manager’s own filing is internally inconsistent its value is withheld and it is listed last. 13F data shows reported holdings, not recommendations.