How is hedge fund similarity measured?

Similarity is computed from each fund's top conviction holdings in their latest 13F filing. Funds are scored by the overlap of distinctive shared positions (the mega-caps that nearly every fund owns are excluded), so the ranking reflects genuinely shared strategy rather than common index exposure.

Hedge Funds Similar to RTW INVESTMENTS,

13F Portfolio OverlapQ1 2026RTW INVESTMENTS, portfolio →

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Most similar hedge funds by 13F overlap

RTW INVESTMENTS, LP is an institutional investor managing $10.0B across 88 U.S. equity positions as of Q1 2026. Based on the overlap of conviction holdings in their latest 13F filings, the hedge funds with portfolios most similar to RTW INVESTMENTS, are Eagle Health Investments, Avoro Advisors, Rock Springs, with shared positions in $INSM, $ARGX, $PTGX, $NTRA, $GH, $CNTA. The full ranking of 25 similar funds is below.

#1Eagle Health Investments LPActive

Substantial overlap · 9 shared positions

$INSM $ARGX $PTGX $NTRA $GH $CNTA

$572M

28 positions

#2Avoro Capital Advisors LLCActive

Substantial overlap · 8 shared positions

$MDGL $ARGX $CELC $CYTK $APLS $CNTA

$10.2B

32 positions

#3Rock Springs Capital Management LPActive

Substantial overlap · 12 shared positions

$MDGL $ARGX $INSM $IRTC $COGT $NBIX

$1.7B

100 positions

#4BAKER BROS. ADVISORS LPSmart money

Substantial overlap · 8 shared positions

$INSM $MDGL $CELC $ACAD $IMVT $STOK

$17.4B

84 positions

#5Paradigm Biocapital Advisors LPActive

Substantial overlap · 11 shared positions

$INSM $ERAS $TARS $APGE $SYRE $CYTK

$4.9B

35 positions

#6Affinity Asset Advisors, LLCActive

Substantial overlap · 10 shared positions

$INSM $ERAS $APGE $SYRE $COGT $CYTK

$1.9B

105 positions

#7TANG CAPITAL MANAGEMENT LLCActive

Notable overlap · 8 shared positions

$PTCT $CELC $TARS $INSM $SYRE $IMCR

$2.0B

51 positions

#8BRAIDWELL LPPassive

Notable overlap · 12 shared positions

$CGON $ARGX $IRTC $SYRE $ACAD $RGEN

$3.0B

88 positions

#9Palo Alto Investors LPActive

Notable overlap · 9 shared positions

$INSM $PTCT $ACAD $RARE $TSHA $ORKA

$654M

51 positions

#10First Turn Management, LLCActive

Notable overlap · 7 shared positions

$INSM $CELC $APGE $COGT $NTRA $CYTK

$895M

33 positions

#11PERCEPTIVE ADVISORS LLCActive

Notable overlap · 11 shared positions

$CELC $PTGX $APGE $SYRE $IMTX $ORKA

$5.1B

94 positions

#12SILVERARC CAPITAL MANAGEMENT, LLCActive

Notable overlap · 12 shared positions

$CELC $ERAS $COGT $CGON $SYRE $GH

$980M

73 positions

#13Davern Capital Partners, LPActive

Notable overlap · 3 shared positions

$INSM $ARGX $NTRA

$365M

17 positions

#14Logos Global Management LPActive

Notable overlap · 9 shared positions

$TNGX $ERAS $MDGL $CGON $CYTK $IMCR

$2.0B

66 positions

#15Artia Global Partners LPActive

Notable overlap · 6 shared positions

$INSM $ARGX $BLTE $PTGX $CELC $CYTK

$499M

50 positions

#16Seven Fleet Capital Management LPActive

Notable overlap · 9 shared positions

$CGON $TNGX $COGT $ERAS $CYTK $MDGL

$315M

114 positions

#17Patient Square Capital LPSmart money

Notable overlap · 6 shared positions

$ARGX $INSM $COGT $CELC $BLTE $SYRE

$564M

29 positions

#18ARMISTICE CAPITAL, LLCActive

Notable overlap · 6 shared positions

$PTCT $MDGL $CYTK $NBIX $IMCR $IMVT

$5.6B

261 positions

#19Tri Locum Partners LPActive

Notable overlap · 4 shared positions

$MDGL $ARGX $TARS $ISRG

$713M

17 positions

#20TCG Crossover Management, LLCActive

Notable overlap · 7 shared positions

$CGON $TNGX $SYRE $COGT $XNCR $CNTA

$3.5B

49 positions

#21Arrowpoint Investment Partners (Singapore) Pte. Ltd.Passive

Notable overlap · 11 shared positions

$PTCT $INSM $PTGX $NBIX $BLTE $MDGL

$113M

82 positions

#22Defilade Capital Management, L.P.Active

Notable overlap · 5 shared positions

$PTCT $INSM $COGT $NBIX $ISRG

$712M

31 positions

#23Boxer Capital Management, LLCSmart money

Notable overlap · 8 shared positions

$CELC $TNGX $PTGX $PTCT $COGT $CYTK

$762M

54 positions

#24Integral Health Asset Management, LLCActive

Notable overlap · 7 shared positions

$INSM $CYTK $NBIX $ISRG $TARS $COGT

$2.1B

90 positions

#25HighVista Strategies LLCPassive

Notable overlap · 12 shared positions

$COGT $SYRE $INSM $CYTK $TARS $ORKA

$362M

156 positions

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Similarity is derived from each fund’s latest 13F-HR filing with the SEC. Funds are ranked by the overlap of distinctive conviction holdings; near-universal mega-cap positions are excluded so the ranking reflects shared strategy, not common index exposure. Data is informational only and not investment advice.