What is the 13F Pro Quality Score for XLO?

13F Pro ranks Xilio Therapeutics, Inc. (XLO) on the 13F Pro Quality Score, a 0–100 composite of 32 fundamental signals including return on invested capital, free cash flow consistency, balance-sheet strength, earnings quality, growth durability, and valuation discipline. The score refreshes after each 10-K and 10-Q filing on SEC EDGAR. View XLO's current score at https://13fpro.ai/company/XLO (free sign-up required for the full ranking).

Where does 13F Pro source XLO data?

All Xilio Therapeutics, Inc. fundamentals and ownership data come directly from SEC EDGAR. Xilio Therapeutics, Inc. files with the SEC under CIK 1840233. 13F Pro ingests XBRL financial facts from 10-K and 10-Q filings, Form 13F-HR institutional holdings, and Form 4 insider transactions, with no third-party rewrites or estimates.

What sector is XLO in?

Xilio Therapeutics, Inc. (XLO) is classified in the Healthcare sector. 13F Pro publishes sector-level fund flow analysis and quality leaders at https://13fpro.ai/research/sector/healthcare.

How often is XLO research updated on 13F Pro?

XLO's fundamentals refresh within hours of each new 10-K or 10-Q filing on SEC EDGAR. Institutional ownership updates after each quarterly 13F filing window. Insider transactions update after each Form 4 filing. The 13F Pro Quality Score recalculates after every fundamentals refresh.

Xilio Therapeutics, Inc.(XLO)Stock Analysis

AI analysis on 2,800+ stocks →Deep AI analysis on 2,800+ stocks →

Healthcare →Nasdaqsmall

Institutional-grade research for retail investors

SEC EDGAR: CIK 1840233 XLO stock profile & AI dashboard →

13F Pro Quality Score

35.6/100

Rank #2,302 of 2,962 stocks

View Healthcare peers →

Rankings refresh quarterly once 80% of peers have filed (~45 days after quarter-end). Next update: ~Nov 14, 2026.

Revenue Growth

97.3/100

Profitability

13.8/100

Balance Sheet

13.3/100

Earnings Quality

1.3/100

Free Cash Flow

6.6/100

Institutional Flow

98.9/100

Revenue Scale

11.1/100

Dilution Risk

11.2/100

Email me the moment this company reports earnings

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Two-page plain-English analysis: business, thesis, and three scenarios for the next two years. Refreshed every quarter.

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Why XLO Scores 36/100

exact factor attribution · 2026-09-11

XLO's composite is driven by revenue growth and institutional flow, held back by free cash flow and scale. Bars show each factor's exact push vs. a median company, using the same weights the ranking engine applies.

Revenue growth

+9.5 pts

97th pct

Institutional flow

+2.5 pts

99th pct

Earnings growth

+1.9 pts

88th pct

Shareholder dilution

-1.9 pts

11th pct

Capital efficiency

-3.7 pts

13th pct

Earnings quality

-4.9 pts

1th pct

Profitability

-5.4 pts

14th pct

Scale

-5.8 pts

11th pct

Free cash flow

-6.5 pts

7th pct

Latest change (2026-08-16): 14 → 34 · ↑ Revenue growth 3→100; ↑ Capital efficiency 6→15; despite ↓ earnings_quality 16→2

Factor percentiles are cross-sectional ranks across the ~2,800-stock scored universe, computed from SEC EDGAR filings. Not investment advice.

Unusual Activity in XLO

Events flagged as statistical outliers against XLO's own multi-year baseline — not fixed dollar thresholds.

Score shock2026-08-16
XLO quality score jumped 20 points (14→34) on a new filing
View source filing →

XLO Stock Analysis & AI Quality Score

Data updated 2026-09-11

AI stock analysis and institutional research for Xilio Therapeutics, Inc. (XLO), a Healthcare sector company. 13F Pro's AI-powered ranking engine scores XLO at 35.6/100 on a 32-signal composite quality model, placing it at rank #2,302 of 2,962 stocks — the bottom half of the AI-ranked universe. XLO scores in the top quartile across institutional flow (98.9), revenue growth (97.3). Areas of concern include earnings quality (1.3) and free cash flow (6.6), which score below median versus the broader universe. Shareholder dilution risk is elevated at 11.2/100, reflecting ongoing share issuance or stock-based compensation. Based on the latest XBRL financial filings (Q2 2026), Xilio Therapeutics, Inc. reports quarterly revenue of $18.7M, net income of $-6.4M, free cash flow of $-18.8M. Top institutional holders of XLO by reported 13-F value include Bain Capital Life Sciences Investors, GILEAD SCIENCES, ORBIMED ADVISORS, based on the most recent SEC filings. XLO trades on the Nasdaq exchange and files with the SEC under CIK 1840233. 13F Pro's AI research platform runs 10 specialized AI analysts — value, growth, momentum, macro, and activist specialists — that debate XLO daily and publish AI-generated analysis with cited SEC sources. The platform aggregates historical XBRL financial facts, 10-Q and 10-K filings, insider Form 4 transactions, and institutional 13-F holdings for Xilio Therapeutics, Inc. directly from SEC EDGAR. Xilio Therapeutics, Inc.'s 13F Pro composite quality score has ranged between 18 and 36 since 2026, currently 35.6 — a stable long-term trajectory across 25 quarterly and live scoring snapshots.

✦

Fun facts about Xilio Therapeutics, Inc.

Quirks, history, and lore behind XLO — the kind of stuff that makes a stock memorable.

1
The Basics
U.S. clinical-stage biopharmaceutical company · listed on Nasdaq · headquartered in Massachusetts · focused on oncology.
2
The Numbers
A micro-cap with no approved products and no commercial revenue — the balance sheet is essentially cash runway funding its pipeline.
3
The History
Founded in the 2010s and went public in 2021, riding a wave of investor enthusiasm for next-generation immuno-oncology startups.
4
The Secret
Its whole thesis is that systemic immunotherapies are too blunt — it engineers drugs designed to activate only inside the tumor microenvironment, sparing healthy tissue.
5
The Lore
The company's name is a mashup evoking tumor-localized biology — its lead programs are conditionally activated cytokine and checkpoint therapies that stay silent until they reach the right zip code.
6
The Giveaway
Its ticker spells out almost exactly what it is: a biotech whose name starts with an X, ends in "-lio," and whose whole mission is keeping cancer-killing immune signals locked until they hit the tumor itself.

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Revenue

Q2 2026

$18.7M

Net Income

Q2 2026

$-6.4M

Free Cash Flow

Q2 2026

$-18.8M

ROIC

Q2 2026

-19.3%

Period

Revenue & Net Income

Earnings Per Share

Key Financials Over Time

Export Financial Table · Pro

Revenue

+589.9% YoY

$43.8MFY 2025

FY22 —FY23 —FY24 $6.3MFY25 $43.8M

Net Income

+39.8% YoY

$-35.0MFY 2025

FY22 $-88.2MFY23 $-76.4MFY24 $-58.2MFY25 $-35.0M

Operating Income

+30.7% YoY

$-42.0MFY 2025

FY22 $-89.1MFY23 $-79.1MFY24 $-60.6MFY25 $-42.0M

EPS (Diluted)

+72.5% YoY

$-4.19FY 2025

FY22 $-3.22FY23 $-2.78FY24 $-15.24FY25 $-4.19

Total Assets

+117.6% YoY

$154.7MFY 2025

FY22 $139.2MFY23 $60.9MFY24 $71.1MFY25 $154.7M

Op. Cash Flow

+72.8% YoY

$-5.0MFY 2025

FY22 $-75.7MFY23 $-68.6MFY24 $-18.4MFY25 $-5.0M

Free Cash Flow

+70.1% YoY

$-5.5MFY 2025

FY22 $-77.6MFY23 $-69.1MFY24 $-18.4MFY25 $-5.5M

Metric	FY 2025	FY 2024	FY 2023	FY 2022	FY 2021	FY 2020
Revenue	$43.8M +589.9%	$6.3M	—	—	—	—
Net Income	$-35.0M +39.8%	$-58.2M +23.8%	$-76.4M +13.4%	$-88.2M -16.4%	$-75.8M -37.3%	$-55.2M
Operating Income	$-42.0M +30.7%	$-60.6M +23.4%	$-79.1M +11.2%	$-89.1M -18.8%	$-75.0M -37.5%	$-54.6M
EPS (Diluted)	$-4.19 +72.5%	$-15.24 -448.2%	$-2.78 +13.7%	$-3.22 +76.2%	$-13.52 +67.9%	$-42.17
Total Assets	$154.7M +117.6%	$71.1M +16.7%	$60.9M -56.2%	$139.2M -36.2%	$218.1M +500.4%	$36.3M
Operating Cash Flow	$-5.0M +72.8%	$-18.4M +73.2%	$-68.6M +9.4%	$-75.7M +6.2%	$-80.8M -123.7%	$-36.1M
Free Cash Flow	$-5.5M +70.1%	$-18.4M +73.4%	$-69.1M +10.9%	$-77.6M +5.2%	$-81.9M -113.8%	$-38.3M

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Available Research

13F Pro tracks comprehensive data for Xilio Therapeutics, Inc. including:

SEC EDGAR filings (10-K, 10-Q, 8-K)

XBRL financial facts (revenue, EPS, margins)

Insider transactions (Form 4)

Institutional 13F holdings

Quality rankings (32 signals)

AI analyst debates & daily meetings

Historical financial trends

Peer comparison & sector analysis

Top Institutional Holders of XLO

Bain Capital Life Sciences Investors, LLC
$6.4M664,021 sh
GILEAD SCIENCES, INC.
$6.2M650,389 sh
ORBIMED ADVISORS LLC
$5.7M592,300 sh
Frazier Life Sciences Management, L.P.
$4.0M422,505 sh
Stonepine Capital Management, LLC
$2.2M225,994 sh
VANGUARD CAPITAL MANAGEMENT LLC
$1.7M178,517 sh
Sio Capital Management, LLC
$1.5M152,464 sh
ADAGE CAPITAL PARTNERS GP, L.L.C.
$1.1M111,541 sh
Merck & Co., Inc.
$1.0M105,982 sh
RENAISSANCE TECHNOLOGIES LLC
$614.6K64,153 sh

Fund	Value	Shares
Bain Capital Life Sciences Investors, LLC	$6.4M	664,021
GILEAD SCIENCES, INC.	$6.2M	650,389
ORBIMED ADVISORS LLC	$5.7M	592,300
Frazier Life Sciences Management, L.P.	$4.0M	422,505
Stonepine Capital Management, LLC	$2.2M	225,994
VANGUARD CAPITAL MANAGEMENT LLC	$1.7M	178,517
Sio Capital Management, LLC	$1.5M	152,464
ADAGE CAPITAL PARTNERS GP, L.L.C.	$1.1M	111,541
Merck & Co., Inc.	$1.0M	105,982
RENAISSANCE TECHNOLOGIES LLC	$614.6K	64,153

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Is XLO a good stock to buy?

13F Pro's AI-powered analysis of Xilio Therapeutics, Inc. (XLO) draws on SEC EDGAR-sourced fundamentals, institutional 13F holdings, and insider Form 4 transactions in the Healthcare sector (listed on Nasdaq). The 32-signal AI Quality Score, current rank, and full bull/bear verdict for XLO are available on the XLO stock profile dashboard — with the same data, AI insights, ratios, and institutional activity refreshed after every 10-K, 10-Q, 13F, and Form 4 filing. XLO is classified as a small company.

Which hedge funds own XLO?

Institutional investors are required to disclose their holdings quarterly via SEC Form 13F. 13F Pro aggregates these filings to show which hedge funds, mutual funds, and asset managers are buying or selling XLO. Combined with insider transaction data from Form 4 filings and AI-powered analysis from 10 specialized research agents, 13F Pro provides a comprehensive view of Xilio Therapeutics, Inc.'s investment landscape.