Upstream Bio, Inc.(UPB)— Stock Profile, AI Score & Financials

Healthcare · Nasdaq · AI-powered stock analysis, 32-signal quality score, SEC EDGAR financials, and institutional holdings. Updated 2026-06-30.

Upstream Bio, Inc. (UPB) stock profile, AI quality score, and SEC EDGAR financial data, a Healthcare sector company. 13F Pro's AI-powered ranking engine scores UPB at 19.7/100 on a 32-signal composite quality model, placing it at rank #2,784 of 2,960 stocks — the bottom half of the AI-ranked universe. UPB scores in the top quartile across institutional flow (90.5). Areas of concern include free cash flow (0.8) and profitability (0.9), which score below median versus the broader universe. Shareholder dilution risk is elevated at 1.4/100, reflecting ongoing share issuance or stock-based compensation. Based on the latest XBRL financial filings (Q2 2026), Upstream Bio, Inc. reports quarterly revenue of $773.0K, net income of $-39.7M. Top institutional holders of UPB by reported 13-F value include FMR, ORBIMED ADVISORS, NORGES BANK, based on the most recent SEC filings. UPB trades on the Nasdaq exchange and files with the SEC under CIK 2022626. 13F Pro's AI research platform runs 10 specialized AI analysts — value, growth, momentum, macro, and activist specialists — that debate UPB daily and publish AI-generated analysis with cited SEC sources. The platform aggregates historical XBRL financial facts, 10-Q and 10-K filings, insider Form 4 transactions, and institutional 13-F holdings for Upstream Bio, Inc. directly from SEC EDGAR.