| Mar 5, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · direct | 500 | $326.08 | $163K@ $326.08 | 18,693 | Form 4 |
| Mar 5, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · direct | 510 | $324.59 | $166K@ $324.59 | 19,193 | Form 4 |
| Mar 5, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · direct | 740 | $323.55 | $239K@ $323.55 | 19,703 | Form 4 |
| Mar 5, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · direct | 654 | $322.33 | $211K@ $322.33 | 20,443 | Form 4 |
| Mar 4, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · directAlso reported by Tanguler Tolga | 208 | $325.67 | $68K@ $325.67 | 21,097 | Form 4 |
| Mar 4, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · directAlso reported by Tanguler Tolga | 272 | $324.88 | $88K@ $324.88 | 21,305 | Form 4 |
| Mar 4, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · directAlso reported by Tanguler Tolga | 767 | $323.84 | $248K@ $323.84 | 21,577 | Form 4 |
| Mar 4, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · directAlso reported by Tanguler Tolga | 350 | $323.01 | $113K@ $323.01 | 22,344 | Form 4 |
| Mar 4, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · directAlso reported by Tanguler Tolga | 289 | $321.82 | $93K@ $321.82 | 22,694 | Form 4 |
| Mar 4, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · directAlso reported by Tanguler Tolga | 215 | $320.81 | $69K@ $320.81 | 22,983 | Form 4 |
| Mar 4, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · directAlso reported by Tanguler Tolga | 102 | $320.01 | $33K@ $320.01 | 23,198 | Form 4 |
| Mar 4, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · directAlso reported by Tanguler Tolga | 106 | $319.03 | $34K@ $319.03 | 23,300 | Form 4 |
| Mar 3, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · direct | 463 | $321.50 | $149K@ $321.50 | 23,406 | Form 4 |
| Mar 3, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · direct | 640 | $320.48 | $205K@ $320.48 | 23,869 | Form 4 |
| Mar 3, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · direct | 317 | $319.06 | $101K@ $319.06 | 24,509 | Form 4 |
| Mar 3, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · direct | 355 | $316.74 | $112K@ $316.74 | 24,826 | Form 4 |
| Mar 2, 2026 | ALNYEVP Chief R&D | Grant or awardCode A · direct | 10,480 | — | — | 10,480 | Form 4 |
| Mar 2, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · direct | 42 | $332.64 | $14K@ $332.64 | 25,181 | Form 4 |
| Mar 2, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · direct | 101 | $331.93 | $34K@ $331.93 | 25,223 | Form 4 |
| Mar 2, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · direct | 87 | $330.85 | $29K@ $330.85 | 25,324 | Form 4 |
| Mar 2, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · direct | 182 | $329.71 | $60K@ $329.71 | 25,411 | Form 4 |
| Mar 2, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · direct | 107 | $328.71 | $35K@ $328.71 | 25,593 | Form 4 |
| Mar 2, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · direct | 353 | $327.67 | $116K@ $327.67 | 25,700 | Form 4 |
| Mar 2, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · direct | 421 | $326.81 | $138K@ $326.81 | 26,053 | Form 4 |
| Mar 2, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · direct | 277 | $325.63 | $90K@ $325.63 | 26,474 | Form 4 |
| Mar 2, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · direct | 97 | $324.65 | $31K@ $324.65 | 26,751 | Form 4 |
| Mar 2, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · direct | 50 | $323.62 | $16K@ $323.62 | 26,848 | Form 4 |
| Mar 2, 2026 | ALNYEVP Chief R&D | Grant or awardCode A · direct | 4,769 | — | — | 26,898 | Form 4 |
| Feb 27, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · direct | 140 | $334.39 | $47K@ $334.39 | 22,129 | Form 4 |
| Feb 27, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · direct | 942 | $332.48 | $313K@ $332.48 | 22,269 | Form 4 |
| Feb 27, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · direct | 1,159 | $331.49 | $384K@ $331.49 | 23,211 | Form 4 |
| Feb 27, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · direct | 2,259 | $330.73 | $747K@ $330.73 | 24,370 | Form 4 |
| Feb 27, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · direct | 127 | $328.92 | $42K@ $328.92 | 26,629 | Form 4 |
| Feb 27, 2026 | ALNYEVP Chief R&D | Option exerciseCode M · direct | 1,908 | — | — | 26,756 | Form 4 |
| Feb 13, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · directAlso reported by Poulton Jeffrey V. | 2,242 | $310.08 | $695K@ $310.08 | 24,848 | Form 4 |
| Feb 12, 2026 | ALNYEVP Chief R&D | Grant or awardCode A · direct | 4,579 | — | — | 27,090 | Form 4 |
| Jan 12, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · directAlso reported by Tanguler Tolga, Fitzgerald Kevin Joseph | 15 | $377.82 | $6K@ $377.82 | 22,511 | Form 4 |
| Jan 12, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · direct | 19 | $375.65 | $7K@ $375.65 | 22,526 | Form 4 |
| Jan 12, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · directAlso reported by Tanguler Tolga, Fitzgerald Kevin Joseph | 14 | $374.44 | $5K@ $374.44 | 22,545 | Form 4 |
| Jan 12, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · direct | 3 | $372.46 | $1K@ $372.46 | 22,559 | Form 4 |
| Jan 12, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · direct | 18 | $370.87 | $7K@ $370.87 | 22,562 | Form 4 |
| Jan 12, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · directAlso reported by Tanguler Tolga, Fitzgerald Kevin Joseph | 40 | $369.48 | $15K@ $369.48 | 22,580 | Form 4 |
| Jan 12, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · directAlso reported by Tanguler Tolga, Fitzgerald Kevin Joseph | 92 | $368.62 | $34K@ $368.62 | 22,620 | Form 4 |
| Jan 12, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · directAlso reported by Tanguler Tolga, Fitzgerald Kevin Joseph | 50 | $366.41 | $18K@ $366.41 | 22,753 | Form 4 |
| Jan 12, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · directAlso reported by Tanguler Tolga, Fitzgerald Kevin Joseph | 220 | $365.56 | $80K@ $365.56 | 22,803 | Form 4 |
| Jan 12, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · directAlso reported by Tanguler Tolga, Fitzgerald Kevin Joseph | 199 | $364.83 | $73K@ $364.83 | 23,023 | Form 4 |
| Jan 12, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · directAlso reported by Tanguler Tolga, Fitzgerald Kevin Joseph | 47 | $363.55 | $17K@ $363.55 | 23,222 | Form 4 |
| Jan 12, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · directAlso reported by Tanguler Tolga, Fitzgerald Kevin Joseph | 73 | $362.38 | $26K@ $362.38 | 23,269 | Form 4 |
| Jan 12, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · directAlso reported by Tanguler Tolga, Fitzgerald Kevin Joseph | 98 | $361.45 | $35K@ $361.45 | 23,342 | Form 4 |
| Jan 12, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · directAlso reported by Tanguler Tolga, Fitzgerald Kevin Joseph | 155 | $360.22 | $56K@ $360.22 | 23,440 | Form 4 |
| Jan 12, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · directAlso reported by Tanguler Tolga, Fitzgerald Kevin Joseph | 85 | $359.14 | $31K@ $359.14 | 23,595 | Form 4 |
| Jan 12, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · directAlso reported by Tanguler Tolga, Fitzgerald Kevin Joseph | 123 | $358.18 | $44K@ $358.18 | 23,680 | Form 4 |
| Jan 12, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · directAlso reported by Tanguler Tolga, Fitzgerald Kevin Joseph | 96 | $357.17 | $34K@ $357.17 | 23,803 | Form 4 |
| Jan 12, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · directAlso reported by Tanguler Tolga, Fitzgerald Kevin Joseph | 41 | $356.09 | $15K@ $356.09 | 23,899 | Form 4 |
| Jan 12, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · directAlso reported by Tanguler Tolga, Fitzgerald Kevin Joseph | 42 | $355.16 | $15K@ $355.16 | 23,940 | Form 4 |
| Jan 12, 2026 | ALNYEVP Chief R&D | Open-market saleCode S · directAlso reported by Tanguler Tolga, Fitzgerald Kevin Joseph | 39 | $353.95 | $14K@ $353.95 | 23,982 | Form 4 |
| Jan 11, 2026 | ALNYEVP Chief R&D | Grant or awardCode A · direct | 3,800 | — | — | 24,021 | Form 4 |