| Jun 25, 2026 | LXEO | Grant or awardCode A · direct | 35,000 | — | — | 35,000 | Form 4 |
| Mar 4, 2026 | ALNYEVP, Chief Commercial Officer | Open-market saleCode S · directAlso reported by Garg Pushkal | 208 | $325.67 | $68K@ $325.67 | 34,297 | Form 4 |
| Mar 4, 2026 | ALNYEVP, Chief Commercial Officer | Open-market saleCode S · directAlso reported by Garg Pushkal | 272 | $324.88 | $88K@ $324.88 | 34,505 | Form 4 |
| Mar 4, 2026 | ALNYEVP, Chief Commercial Officer | Open-market saleCode S · directAlso reported by Garg Pushkal | 767 | $323.84 | $248K@ $323.84 | 34,777 | Form 4 |
| Mar 4, 2026 | ALNYEVP, Chief Commercial Officer | Open-market saleCode S · directAlso reported by Garg Pushkal | 350 | $323.01 | $113K@ $323.01 | 35,544 | Form 4 |
| Mar 4, 2026 | ALNYEVP, Chief Commercial Officer | Open-market saleCode S · directAlso reported by Garg Pushkal | 289 | $321.82 | $93K@ $321.82 | 35,894 | Form 4 |
| Mar 4, 2026 | ALNYEVP, Chief Commercial Officer | Open-market saleCode S · directAlso reported by Garg Pushkal | 215 | $320.81 | $69K@ $320.81 | 36,183 | Form 4 |
| Mar 4, 2026 | ALNYEVP, Chief Commercial Officer | Open-market saleCode S · directAlso reported by Garg Pushkal | 102 | $320.01 | $33K@ $320.01 | 36,398 | Form 4 |
| Mar 4, 2026 | ALNYEVP, Chief Commercial Officer | Open-market saleCode S · directAlso reported by Garg Pushkal | 106 | $319.03 | $34K@ $319.03 | 36,500 | Form 4 |
| Mar 2, 2026 | ALNYEVP, Chief Commercial Officer | Grant or awardCode A · direct | 10,480 | — | — | 10,480 | Form 4 |
| Mar 2, 2026 | ALNYEVP, Chief Commercial Officer | Open-market saleCode S · directAlso reported by Fitzgerald Kevin Joseph | 37 | $332.64 | $12K@ $332.64 | 36,606 | Form 4 |
| Mar 2, 2026 | ALNYEVP, Chief Commercial Officer | Open-market saleCode S · directAlso reported by Fitzgerald Kevin Joseph | 94 | $331.93 | $31K@ $331.93 | 36,643 | Form 4 |
| Mar 2, 2026 | ALNYEVP, Chief Commercial Officer | Open-market saleCode S · directAlso reported by Fitzgerald Kevin Joseph | 81 | $330.85 | $27K@ $330.85 | 36,737 | Form 4 |
| Mar 2, 2026 | ALNYEVP, Chief Commercial Officer | Open-market saleCode S · directAlso reported by Fitzgerald Kevin Joseph | 170 | $329.71 | $56K@ $329.71 | 36,818 | Form 4 |
| Mar 2, 2026 | ALNYEVP, Chief Commercial Officer | Open-market saleCode S · directAlso reported by Fitzgerald Kevin Joseph | 100 | $328.71 | $33K@ $328.71 | 36,988 | Form 4 |
| Mar 2, 2026 | ALNYEVP, Chief Commercial Officer | Open-market saleCode S · directAlso reported by Fitzgerald Kevin Joseph | 329 | $327.67 | $108K@ $327.67 | 37,088 | Form 4 |
| Mar 2, 2026 | ALNYEVP, Chief Commercial Officer | Open-market saleCode S · directAlso reported by Fitzgerald Kevin Joseph | 392 | $326.81 | $128K@ $326.81 | 37,417 | Form 4 |
| Mar 2, 2026 | ALNYEVP, Chief Commercial Officer | Open-market saleCode S · directAlso reported by Fitzgerald Kevin Joseph | 258 | $325.63 | $84K@ $325.63 | 37,809 | Form 4 |
| Mar 2, 2026 | ALNYEVP, Chief Commercial Officer | Open-market saleCode S · directAlso reported by Fitzgerald Kevin Joseph | 90 | $324.65 | $29K@ $324.65 | 38,067 | Form 4 |
| Mar 2, 2026 | ALNYEVP, Chief Commercial Officer | Open-market saleCode S · directAlso reported by Fitzgerald Kevin Joseph | 47 | $323.62 | $15K@ $323.62 | 38,157 | Form 4 |
| Mar 2, 2026 | ALNYEVP, Chief Commercial Officer | Grant or awardCode A · direct | 4,769 | — | — | 38,204 | Form 4 |
| Feb 27, 2026 | ALNYEVP, Chief Commercial Officer | Option exerciseCode M · direct | 1,666 | — | — | 33,435 | Form 4 |
| Feb 13, 2026 | ALNYEVP, Chief Commercial Officer | Open-market saleCode S · directAlso reported by Fitzgerald Kevin Joseph | 1,959 | $310.08 | $607K@ $310.08 | 31,769 | Form 4 |
| Feb 12, 2026 | ALNYEVP, Chief Commercial Officer | Grant or awardCode A · direct | 4,000 | — | — | 33,728 | Form 4 |
| Jan 12, 2026 | ALNYEVP, Chief Commercial Officer | Open-market saleCode S · directAlso reported by Garg Pushkal, Fitzgerald Kevin Joseph | 15 | $377.82 | $6K@ $377.82 | 29,728 | Form 4 |
| Jan 12, 2026 | ALNYEVP, Chief Commercial Officer | Open-market saleCode S · directAlso reported by Garg Pushkal, Fitzgerald Kevin Joseph | 14 | $374.44 | $5K@ $374.44 | 29,762 | Form 4 |
| Jan 12, 2026 | ALNYEVP, Chief Commercial Officer | Open-market saleCode S · directAlso reported by Fitzgerald Kevin Joseph | 2 | $372.46 | $745@ $372.46 | 29,776 | Form 4 |
| Jan 12, 2026 | ALNYEVP, Chief Commercial Officer | Open-market saleCode S · directAlso reported by Fitzgerald Kevin Joseph | 19 | $370.87 | $7K@ $370.87 | 29,778 | Form 4 |
| Jan 12, 2026 | ALNYEVP, Chief Commercial Officer | Open-market saleCode S · directAlso reported by Garg Pushkal, Fitzgerald Kevin Joseph | 40 | $369.48 | $15K@ $369.48 | 29,797 | Form 4 |
| Jan 12, 2026 | ALNYEVP, Chief Commercial Officer | Open-market saleCode S · directAlso reported by Garg Pushkal, Fitzgerald Kevin Joseph | 92 | $368.62 | $34K@ $368.62 | 29,837 | Form 4 |
| Jan 12, 2026 | ALNYEVP, Chief Commercial Officer | Open-market saleCode S · directAlso reported by Garg Pushkal, Fitzgerald Kevin Joseph | 50 | $366.41 | $18K@ $366.41 | 29,970 | Form 4 |
| Jan 12, 2026 | ALNYEVP, Chief Commercial Officer | Open-market saleCode S · directAlso reported by Garg Pushkal, Fitzgerald Kevin Joseph | 220 | $365.56 | $80K@ $365.56 | 30,020 | Form 4 |
| Jan 12, 2026 | ALNYEVP, Chief Commercial Officer | Open-market saleCode S · directAlso reported by Garg Pushkal, Fitzgerald Kevin Joseph | 199 | $364.83 | $73K@ $364.83 | 30,240 | Form 4 |
| Jan 12, 2026 | ALNYEVP, Chief Commercial Officer | Open-market saleCode S · directAlso reported by Garg Pushkal, Fitzgerald Kevin Joseph | 47 | $363.55 | $17K@ $363.55 | 30,439 | Form 4 |
| Jan 12, 2026 | ALNYEVP, Chief Commercial Officer | Open-market saleCode S · directAlso reported by Garg Pushkal, Fitzgerald Kevin Joseph | 73 | $362.38 | $26K@ $362.38 | 30,486 | Form 4 |
| Jan 12, 2026 | ALNYEVP, Chief Commercial Officer | Open-market saleCode S · directAlso reported by Garg Pushkal, Fitzgerald Kevin Joseph | 98 | $361.45 | $35K@ $361.45 | 30,559 | Form 4 |
| Jan 12, 2026 | ALNYEVP, Chief Commercial Officer | Open-market saleCode S · directAlso reported by Garg Pushkal, Fitzgerald Kevin Joseph | 155 | $360.22 | $56K@ $360.22 | 30,657 | Form 4 |
| Jan 12, 2026 | ALNYEVP, Chief Commercial Officer | Open-market saleCode S · directAlso reported by Garg Pushkal, Fitzgerald Kevin Joseph | 85 | $359.14 | $31K@ $359.14 | 30,812 | Form 4 |
| Jan 12, 2026 | ALNYEVP, Chief Commercial Officer | Open-market saleCode S · directAlso reported by Garg Pushkal, Fitzgerald Kevin Joseph | 123 | $358.18 | $44K@ $358.18 | 30,897 | Form 4 |
| Jan 12, 2026 | ALNYEVP, Chief Commercial Officer | Open-market saleCode S · directAlso reported by Garg Pushkal, Fitzgerald Kevin Joseph | 96 | $357.17 | $34K@ $357.17 | 31,020 | Form 4 |
| Jan 12, 2026 | ALNYEVP, Chief Commercial Officer | Open-market saleCode S · directAlso reported by Garg Pushkal, Fitzgerald Kevin Joseph | 41 | $356.09 | $15K@ $356.09 | 31,116 | Form 4 |
| Jan 12, 2026 | ALNYEVP, Chief Commercial Officer | Open-market saleCode S · directAlso reported by Garg Pushkal, Fitzgerald Kevin Joseph | 42 | $355.16 | $15K@ $355.16 | 31,157 | Form 4 |
| Jan 12, 2026 | ALNYEVP, Chief Commercial Officer | Open-market saleCode S · directAlso reported by Garg Pushkal, Fitzgerald Kevin Joseph | 39 | $353.95 | $14K@ $353.95 | 31,199 | Form 4 |
| Jan 11, 2026 | ALNYEVP, Chief Commercial Officer | Grant or awardCode A · direct | 3,800 | — | — | 31,238 | Form 4 |