| Apr 7, 2026 | OVID | Grant or awardCode A · direct | 17,578 | $2.56 | $45K@ $2.56 | 17,578 | Form 4 |
| Mar 5, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · direct | 153 | $326.24 | $50K@ $326.24 | 20,569 | Form 4 |
| Mar 5, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · direct | 148 | $324.60 | $48K@ $324.60 | 20,722 | Form 4 |
| Mar 5, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · direct | 233 | $323.25 | $75K@ $323.25 | 20,870 | Form 4 |
| Mar 5, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · direct | 124 | $321.81 | $40K@ $321.81 | 21,103 | Form 4 |
| Mar 4, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · direct | 57 | $325.67 | $19K@ $325.67 | 21,227 | Form 4 |
| Mar 4, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · direct | 75 | $324.88 | $24K@ $324.88 | 21,284 | Form 4 |
| Mar 4, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · direct | 210 | $323.84 | $68K@ $323.84 | 21,359 | Form 4 |
| Mar 4, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · direct | 96 | $323.01 | $31K@ $323.01 | 21,569 | Form 4 |
| Mar 4, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · direct | 79 | $321.82 | $25K@ $321.82 | 21,665 | Form 4 |
| Mar 4, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · direct | 59 | $320.81 | $19K@ $320.81 | 21,744 | Form 4 |
| Mar 4, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · direct | 28 | $320.01 | $9K@ $320.01 | 21,803 | Form 4 |
| Mar 4, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · direct | 29 | $319.03 | $9K@ $319.03 | 21,831 | Form 4 |
| Mar 3, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · direct | 359 | $321.58 | $115K@ $321.58 | 21,860 | Form 4 |
| Mar 3, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · direct | 722 | $320.51 | $231K@ $320.51 | 22,219 | Form 4 |
| Mar 3, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · direct | 282 | $318.62 | $90K@ $318.62 | 22,941 | Form 4 |
| Mar 3, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · direct | 289 | $316.55 | $91K@ $316.55 | 23,223 | Form 4 |
| Mar 2, 2026 | ALNYCSO & EVP, Head of Research | Grant or awardCode A · direct | 8,105 | — | — | 8,105 | Form 4 |
| Mar 2, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · directAlso reported by Tanguler Tolga | 37 | $332.64 | $12K@ $332.64 | 23,512 | Form 4 |
| Mar 2, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · directAlso reported by Tanguler Tolga | 94 | $331.93 | $31K@ $331.93 | 23,549 | Form 4 |
| Mar 2, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · directAlso reported by Tanguler Tolga | 81 | $330.85 | $27K@ $330.85 | 23,643 | Form 4 |
| Mar 2, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · directAlso reported by Tanguler Tolga | 170 | $329.71 | $56K@ $329.71 | 23,724 | Form 4 |
| Mar 2, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · directAlso reported by Tanguler Tolga | 100 | $328.71 | $33K@ $328.71 | 23,894 | Form 4 |
| Mar 2, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · directAlso reported by Tanguler Tolga | 329 | $327.67 | $108K@ $327.67 | 23,994 | Form 4 |
| Mar 2, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · directAlso reported by Tanguler Tolga | 392 | $326.81 | $128K@ $326.81 | 24,323 | Form 4 |
| Mar 2, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · directAlso reported by Tanguler Tolga | 258 | $325.63 | $84K@ $325.63 | 24,715 | Form 4 |
| Mar 2, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · directAlso reported by Tanguler Tolga | 90 | $324.65 | $29K@ $324.65 | 24,973 | Form 4 |
| Mar 2, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · directAlso reported by Tanguler Tolga | 47 | $323.62 | $15K@ $323.62 | 25,063 | Form 4 |
| Mar 2, 2026 | ALNYCSO & EVP, Head of Research | Grant or awardCode A · direct | 3,688 | — | — | 25,110 | Form 4 |
| Feb 26, 2026 | OVID | Grant or awardCode A · direct | 65,000 | — | — | 65,000 | Form 4 |
| Feb 23, 2026 | ALNYCSO & EVP, Head of Research | Grant or awardCode A · direct | 158 | — | — | 21,422 | Form 4 |
| Feb 17, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · direct | 2,041 | $331.96 | $678K@ $331.96 | 21,264 | Form 4 |
| Feb 13, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · directAlso reported by Tanguler Tolga | 1,959 | $310.08 | $607K@ $310.08 | 23,305 | Form 4 |
| Feb 12, 2026 | ALNYCSO & EVP, Head of Research | Grant or awardCode A · direct | 4,000 | — | — | 25,264 | Form 4 |
| Jan 13, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · direct | 122 | $374.33 | $46K@ $374.33 | 21,264 | Form 4 |
| Jan 13, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · direct | 280 | $372.93 | $104K@ $372.93 | 21,386 | Form 4 |
| Jan 13, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · direct | 485 | $371.24 | $180K@ $371.24 | 21,666 | Form 4 |
| Jan 13, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · direct | 644 | $370.00 | $238K@ $370.00 | 22,151 | Form 4 |
| Jan 13, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · direct | 562 | $368.76 | $207K@ $368.76 | 22,795 | Form 4 |
| Jan 13, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · direct | 197 | $367.52 | $72K@ $367.52 | 23,357 | Form 4 |
| Jan 12, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · directAlso reported by Garg Pushkal, Tanguler Tolga | 15 | $377.82 | $6K@ $377.82 | 23,554 | Form 4 |
| Jan 12, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · directAlso reported by Garg Pushkal, Tanguler Tolga | 14 | $374.44 | $5K@ $374.44 | 23,588 | Form 4 |
| Jan 12, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · directAlso reported by Tanguler Tolga | 2 | $372.46 | $745@ $372.46 | 23,602 | Form 4 |
| Jan 12, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · directAlso reported by Tanguler Tolga | 19 | $370.87 | $7K@ $370.87 | 23,604 | Form 4 |
| Jan 12, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · directAlso reported by Garg Pushkal, Tanguler Tolga | 40 | $369.48 | $15K@ $369.48 | 23,623 | Form 4 |
| Jan 12, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · directAlso reported by Garg Pushkal, Tanguler Tolga | 92 | $368.62 | $34K@ $368.62 | 23,663 | Form 4 |
| Jan 12, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · directAlso reported by Garg Pushkal, Tanguler Tolga | 50 | $366.41 | $18K@ $366.41 | 23,796 | Form 4 |
| Jan 12, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · directAlso reported by Garg Pushkal, Tanguler Tolga | 220 | $365.56 | $80K@ $365.56 | 23,846 | Form 4 |
| Jan 12, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · directAlso reported by Garg Pushkal, Tanguler Tolga | 199 | $364.83 | $73K@ $364.83 | 24,066 | Form 4 |
| Jan 12, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · directAlso reported by Garg Pushkal, Tanguler Tolga | 47 | $363.55 | $17K@ $363.55 | 24,265 | Form 4 |
| Jan 12, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · directAlso reported by Garg Pushkal, Tanguler Tolga | 73 | $362.38 | $26K@ $362.38 | 24,312 | Form 4 |
| Jan 12, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · directAlso reported by Garg Pushkal, Tanguler Tolga | 98 | $361.45 | $35K@ $361.45 | 24,385 | Form 4 |
| Jan 12, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · directAlso reported by Garg Pushkal, Tanguler Tolga | 155 | $360.22 | $56K@ $360.22 | 24,483 | Form 4 |
| Jan 12, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · directAlso reported by Garg Pushkal, Tanguler Tolga | 85 | $359.14 | $31K@ $359.14 | 24,638 | Form 4 |
| Jan 12, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · directAlso reported by Garg Pushkal, Tanguler Tolga | 123 | $358.18 | $44K@ $358.18 | 24,723 | Form 4 |
| Jan 12, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · directAlso reported by Garg Pushkal, Tanguler Tolga | 96 | $357.17 | $34K@ $357.17 | 24,846 | Form 4 |
| Jan 12, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · directAlso reported by Garg Pushkal, Tanguler Tolga | 41 | $356.09 | $15K@ $356.09 | 24,942 | Form 4 |
| Jan 12, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · directAlso reported by Garg Pushkal, Tanguler Tolga | 42 | $355.16 | $15K@ $355.16 | 24,983 | Form 4 |
| Jan 12, 2026 | ALNYCSO & EVP, Head of Research | Open-market saleCode S · directAlso reported by Garg Pushkal, Tanguler Tolga | 39 | $353.95 | $14K@ $353.95 | 25,025 | Form 4 |
| Jan 11, 2026 | ALNYCSO & EVP, Head of Research | Grant or awardCode A · direct | 3,800 | — | — | 25,064 | Form 4 |