| Jun 8, 2026 | CRVODirector | Grant or awardCode A · direct | 8,150 | — | — | 8,150 | Form 4 |
| Mar 4, 2026 | ALNYEVP, Chief Financial Officer | Open-market saleCode S · direct | 223 | $325.67 | $73K@ $325.67 | 61,805 | Form 4 |
| Mar 4, 2026 | ALNYEVP, Chief Financial Officer | Open-market saleCode S · direct | 291 | $324.88 | $95K@ $324.88 | 62,028 | Form 4 |
| Mar 4, 2026 | ALNYEVP, Chief Financial Officer | Open-market saleCode S · direct | 818 | $323.84 | $265K@ $323.84 | 62,319 | Form 4 |
| Mar 4, 2026 | ALNYEVP, Chief Financial Officer | Open-market saleCode S · direct | 374 | $323.01 | $121K@ $323.01 | 63,137 | Form 4 |
| Mar 4, 2026 | ALNYEVP, Chief Financial Officer | Open-market saleCode S · direct | 309 | $321.82 | $99K@ $321.82 | 63,511 | Form 4 |
| Mar 4, 2026 | ALNYEVP, Chief Financial Officer | Open-market saleCode S · direct | 230 | $320.81 | $74K@ $320.81 | 63,820 | Form 4 |
| Mar 4, 2026 | ALNYEVP, Chief Financial Officer | Open-market saleCode S · direct | 109 | $320.01 | $35K@ $320.01 | 64,050 | Form 4 |
| Mar 4, 2026 | ALNYEVP, Chief Financial Officer | Open-market saleCode S · direct | 114 | $319.03 | $36K@ $319.03 | 64,159 | Form 4 |
| Mar 2, 2026 | ALNYEVP, Chief Financial Officer | Grant or awardCode A · direct | 10,480 | — | — | 10,480 | Form 4 |
| Mar 2, 2026 | ALNYEVP, Chief Financial Officer | Open-market saleCode S · direct | 53 | $332.64 | $18K@ $332.64 | 64,273 | Form 4 |
| Mar 2, 2026 | ALNYEVP, Chief Financial Officer | Open-market saleCode S · direct | 129 | $331.93 | $43K@ $331.93 | 64,326 | Form 4 |
| Mar 2, 2026 | ALNYEVP, Chief Financial Officer | Open-market saleCode S · direct | 112 | $330.85 | $37K@ $330.85 | 64,455 | Form 4 |
| Mar 2, 2026 | ALNYEVP, Chief Financial Officer | Open-market saleCode S · direct | 234 | $329.71 | $77K@ $329.71 | 64,567 | Form 4 |
| Mar 2, 2026 | ALNYEVP, Chief Financial Officer | Open-market saleCode S · direct | 138 | $328.71 | $45K@ $328.71 | 64,801 | Form 4 |
| Mar 2, 2026 | ALNYEVP, Chief Financial Officer | Open-market saleCode S · direct | 454 | $327.67 | $149K@ $327.67 | 64,939 | Form 4 |
| Mar 2, 2026 | ALNYEVP, Chief Financial Officer | Open-market saleCode S · direct | 541 | $326.81 | $177K@ $326.81 | 65,393 | Form 4 |
| Mar 2, 2026 | ALNYEVP, Chief Financial Officer | Open-market saleCode S · direct | 356 | $325.63 | $116K@ $325.63 | 65,934 | Form 4 |
| Mar 2, 2026 | ALNYEVP, Chief Financial Officer | Open-market saleCode S · direct | 124 | $324.65 | $40K@ $324.65 | 66,290 | Form 4 |
| Mar 2, 2026 | ALNYEVP, Chief Financial Officer | Open-market saleCode S · direct | 65 | $323.62 | $21K@ $323.62 | 66,414 | Form 4 |
| Mar 2, 2026 | ALNYEVP, Chief Financial Officer | Grant or awardCode A · direct | 4,769 | — | — | 66,479 | Form 4 |
| Feb 27, 2026 | ALNYEVP, Chief Financial Officer | Option exerciseCode M · direct | 1,908 | — | — | 61,710 | Form 4 |
| Feb 13, 2026 | ALNYEVP, Chief Financial Officer | Open-market saleCode S · directAlso reported by Garg Pushkal | 2,242 | $310.08 | $695K@ $310.08 | 59,802 | Form 4 |
| Feb 12, 2026 | ALNYEVP, Chief Financial Officer | Grant or awardCode A · direct | 4,579 | — | — | 62,044 | Form 4 |
| Jan 12, 2026 | ALNYEVP, Chief Financial Officer | Open-market saleCode S · direct | 27 | $377.82 | $10K@ $377.82 | 57,465 | Form 4 |
| Jan 12, 2026 | ALNYEVP, Chief Financial Officer | Open-market saleCode S · direct | 34 | $375.65 | $13K@ $375.65 | 57,492 | Form 4 |
| Jan 12, 2026 | ALNYEVP, Chief Financial Officer | Open-market saleCode S · direct | 25 | $374.44 | $9K@ $374.44 | 57,526 | Form 4 |
| Jan 12, 2026 | ALNYEVP, Chief Financial Officer | Open-market saleCode S · direct | 6 | $372.46 | $2K@ $372.46 | 57,551 | Form 4 |
| Jan 12, 2026 | ALNYEVP, Chief Financial Officer | Open-market saleCode S · direct | 36 | $370.87 | $13K@ $370.87 | 57,557 | Form 4 |
| Jan 12, 2026 | ALNYEVP, Chief Financial Officer | Open-market saleCode S · direct | 73 | $369.48 | $27K@ $369.48 | 57,593 | Form 4 |
| Jan 12, 2026 | ALNYEVP, Chief Financial Officer | Open-market saleCode S · direct | 170 | $368.62 | $63K@ $368.62 | 57,666 | Form 4 |
| Jan 12, 2026 | ALNYEVP, Chief Financial Officer | Open-market saleCode S · direct | 92 | $366.41 | $34K@ $366.41 | 57,912 | Form 4 |
| Jan 12, 2026 | ALNYEVP, Chief Financial Officer | Open-market saleCode S · direct | 405 | $365.56 | $148K@ $365.56 | 58,004 | Form 4 |
| Jan 12, 2026 | ALNYEVP, Chief Financial Officer | Open-market saleCode S · direct | 365 | $364.83 | $133K@ $364.83 | 58,409 | Form 4 |
| Jan 12, 2026 | ALNYEVP, Chief Financial Officer | Open-market saleCode S · direct | 87 | $363.55 | $32K@ $363.55 | 58,774 | Form 4 |
| Jan 12, 2026 | ALNYEVP, Chief Financial Officer | Open-market saleCode S · direct | 135 | $362.38 | $49K@ $362.38 | 58,861 | Form 4 |
| Jan 12, 2026 | ALNYEVP, Chief Financial Officer | Open-market saleCode S · direct | 181 | $361.45 | $65K@ $361.45 | 58,996 | Form 4 |
| Jan 12, 2026 | ALNYEVP, Chief Financial Officer | Open-market saleCode S · direct | 284 | $360.22 | $102K@ $360.22 | 59,177 | Form 4 |
| Jan 12, 2026 | ALNYEVP, Chief Financial Officer | Open-market saleCode S · direct | 156 | $359.14 | $56K@ $359.14 | 59,461 | Form 4 |
| Jan 12, 2026 | ALNYEVP, Chief Financial Officer | Open-market saleCode S · direct | 226 | $358.18 | $81K@ $358.18 | 59,617 | Form 4 |
| Jan 12, 2026 | ALNYEVP, Chief Financial Officer | Open-market saleCode S · direct | 176 | $357.17 | $63K@ $357.17 | 59,843 | Form 4 |
| Jan 12, 2026 | ALNYEVP, Chief Financial Officer | Open-market saleCode S · direct | 76 | $356.09 | $27K@ $356.09 | 60,019 | Form 4 |
| Jan 12, 2026 | ALNYEVP, Chief Financial Officer | Open-market saleCode S · direct | 78 | $355.16 | $28K@ $355.16 | 60,095 | Form 4 |
| Jan 12, 2026 | ALNYEVP, Chief Financial Officer | Open-market saleCode S · direct | 72 | $353.95 | $25K@ $353.95 | 60,173 | Form 4 |
| Jan 11, 2026 | ALNYEVP, Chief Financial Officer | Grant or awardCode A · direct | 6,193 | — | — | 60,245 | Form 4 |