Tyra Biosciences, Inc. (TYRA) — Institutional Holders, Q2 2026

170 institutional investment managers reported a TYRA position on SEC Form 13F-HR for the quarter ended June 30, 2026, with a combined reported value of $2.2B. Every filer is listed below, ranked by position value, 100 per page; this page shows ranks 1 to 100. Put and call option positions are excluded, and a firm filing several lots or share classes is shown once with its total.

← TYRA stock profile

TYRA in Q2 2026: what funds did

Funds that filed a 13F for both Q1 2026 and Q2 2026, by what they did with the common stock. Share counts are adjusted for any split between the two quarters; dollar figures are the change in shares at this quarter’s price.

New positions

Added to

Trimmed

Sold out

Biggest buyers

PRICE T ROWE ASSOCIATESAdded · +1,796,506 sh+$57.4M
FMRAdded · +1,172,865 sh+$37.5M
Hood River Capital ManagementNew · +1,016,775 sh+$32.5M
STATE STREETAdded · +924,290 sh+$29.5M
BlackRockAdded · +814,043 sh+$26.0M

Biggest sellers

FARALLON CAPITAL MANAGEMENTSold out · -3,580,818 sh-$114.4M
Logos Global ManagementSold out · -850,000 sh-$27.1M
BARCLAYS PLCTrimmed · -813,124 sh-$26.0M
Commodore CapitalTrimmed · -600,000 sh-$19.2M
Nextech Invest, Ltd.Trimmed · -502,276 sh-$16.0M

TYRA 13F holders ranked 1–100 of 170

Institutional investors reporting a position in Tyra Biosciences, Inc. on SEC Form 13F-HR for Q2 2026, ranked by reported value.
#	Institution	Shares	Value	% of portfolio	QoQShares vs Q1 2026
1	RA CAPITAL MANAGEMENT, L.P.#1 · 12,198,625 sh	12,198,625	$389.6M	3.39%	0.0%
2	FMR#2 · 8,920,513 sh	8,920,513	$284.9M	0.01%	+15.1%
3	Jupiter Topco#3 · 4,352,448 sh	4,352,448	$139.2M	0.06%	—
4	Alta Partners Management Company, L.P.#4 · 3,823,425 sh	3,823,425	$122.1M	95.92%	0.0%
5	Nextech Invest, Ltd.#5 · 3,553,585 sh	3,553,585	$113.5M	5.39%	-12.4%
6	TCG Crossover Management#6 · 3,248,980 sh	3,248,980	$103.8M	2.49%	0.0%
7	BlackRock#7 · 3,031,972 sh	3,031,972	$96.8M	<0.01%	+36.7%
8	PRICE T ROWE ASSOCIATES#8 · 2,782,567 sh	2,782,567	$88.9M	<0.01%	+182.2%
9	STATE STREET#9 · 2,140,368 sh	2,140,368	$68.4M	<0.01%	+76.0%
10	Commodore Capital#10 · 1,875,000 sh	1,875,000	$59.9M	3.57%	-24.2%
11	Paradigm Biocapital Advisors#11 · 1,828,607 sh	1,828,607	$58.4M	1.09%	-11.0%
12	VANGUARD CAPITAL MANAGEMENT#12 · 1,508,447 sh	1,508,447	$48.2M	<0.01%	+34.0%
13	BVF#13 · 1,476,196 sh	1,476,196	$47.1M	1.21%	-25.3%
14	5AM Venture Management#14 · 1,029,298 sh	1,029,298	$32.9M	11.42%	0.0%
15	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)#15 · 1,017,000 sh	1,017,000	$32.5M	0.34%	+85.2%
16	Hood River Capital Management#16 · 1,016,775 sh	1,016,775	$32.5M	0.24%	New
17	GEODE CAPITAL MANAGEMENT#17 · 970,734 sh	970,734	$31.0M	<0.01%	+47.4%
18	Caligan Partners#18 · 806,986 sh	806,986	$25.8M	1.21%	-36.8%
19	Canaan Partners XI#19 · 750,000 sh	750,000	$24.0M	—	0.0%
20	Siren, L.L.C.#20 · 725,000 sh	725,000	$23.2M	0.47%	New
21	Sio Capital Management#21 · 695,315 sh	695,315	$22.2M	3.68%	+14.8%
22	StemPoint Capital#22 · 632,754 sh	632,754	$20.2M	3.48%	+227.6%
23	MARSHALL WACE, LLP#23 · 583,133 sh	583,133	$18.6M	0.01%	+194.9%
24	GOLDMAN SACHS GROUP#24 · 463,477 sh	463,477	$14.8M	<0.01%	-15.8%
25	JENNISON ASSOCIATES#25 · 450,964 sh	450,964	$14.4M	<0.01%	-28.7%
26	TWO SIGMA INVESTMENTS#26 · 449,808 sh	449,808	$14.4M	0.01%	+342.6%
27	VANGUARD PORTFOLIO MANAGEMENT#27 · 403,019 sh	403,019	$12.9M	<0.01%	+63.0%
28	Defilade Capital Management, L.P.#28 · 376,870 sh	376,870	$12.0M	1.61%	New
29	BANK OF AMERICA#29 · 349,732 sh	349,732	$11.2M	<0.01%	+66.6%
30	Walleye Capital#30 · 347,898 sh	347,898	$11.1M	0.04%	+1758.9%
31	Woodline Partners#31 · 320,040 sh	320,040	$10.2M	0.03%	+6.3%
32	NORTHERN#32 · 310,084 sh	310,084	$9.9M	<0.01%	+41.9%
33	MORGAN STANLEY#33 · 300,322 sh	300,322	$9.6M	<0.01%	+149.3%
34	CITADEL ADVISORS#34 · 278,307 sh	278,307	$8.9M	<0.01%	+1707.7%
35	CHARLES SCHWAB INVESTMENT MANAGEMENT#35 · 267,699 sh	267,699	$8.6M	<0.01%	+34.4%
36	Qube Research & Technologies Ltd#36 · 266,934 sh	266,934	$8.5M	<0.01%	New
37	BNP PARIBAS FINANCIAL MARKETS#37 · 240,227 sh	240,227	$7.7M	<0.01%	+26.4%
38	ALGERT GLOBAL#38 · 239,120 sh	239,120	$7.6M	0.09%	+27.2%
39	VANGUARD FIDUCIARY#39 · 224,805 sh	224,805	$7.2M	<0.01%	+42.5%
40	DIMENSIONAL FUND ADVISORS#40 · 217,078 sh	217,078	$6.9M	<0.01%	+136.4%
41	Affinity Asset Advisors#41 · 200,012 sh	200,012	$6.4M	0.29%	-22.3%
42	FRANKLIN RESOURCES#42 · 192,340 sh	192,340	$6.1M	<0.01%	+1383.0%
43	HighVista Strategies#43 · 184,774 sh	184,774	$5.9M	1.35%	+40.7%
44	RAYMOND JAMES FINANCIAL#44 · 180,881 sh	180,881	$5.8M	<0.01%	-26.8%
45	JPMORGAN CHASE#45 · 178,263 sh	178,263	$5.7M	<0.01%	+166.9%
46	MILLENNIUM MANAGEMENT#46 · 177,672 sh	177,672	$5.7M	<0.01%	-19.8%
47	BOOTHBAY FUND MANAGEMENT#47 · 173,559 sh	173,559	$5.5M	0.07%	-36.5%
48	ADAGE CAPITAL PARTNERS GP, L.L.C.#48 · 162,000 sh	162,000	$5.2M	<0.01%	New
49	Jump Financial#49 · 157,000 sh	157,000	$5.0M	0.04%	+279.5%
50	VICTORY CAPITAL MANAGEMENT#50 · 152,585 sh	152,585	$4.9M	<0.01%	+901.9%
51	Ensign Peak Advisors#51 · 146,537 sh	146,537	$4.7M	<0.01%	+97.9%
52	Trexquant Investment#52 · 132,740 sh	132,740	$4.2M	0.03%	-9.9%
53	UBS Group AG#53 · 129,945 sh	129,945	$4.2M	<0.01%	+111.1%
54	BNP Paribas Asset Management Holding S.A.#54 · 123,420 sh	123,420	$3.9M	<0.01%	-4.2%
55	LORD, ABBETT#55 · 121,833 sh	121,833	$3.9M	0.01%	New
56	Bank of New York Mellon#56 · 103,720 sh	103,720	$3.3M	<0.01%	+43.6%
57	Russell Investments Group, Ltd.#57 · 102,703 sh	102,703	$3.3M	<0.01%	+45.8%
58	ORBIMED ADVISORS#58 · 102,000 sh	102,000	$3.3M	0.06%	New
59	JACOBS LEVY EQUITY MANAGEMENT#59 · 89,205 sh	89,205	$2.8M	0.01%	-45.0%
60	OPPENHEIMER#60 · 83,783 sh	83,783	$2.7M	—	-0.5%
61	XTX Topco Ltd#61 · 81,320 sh	81,320	$2.6M	0.03%	-3.1%
62	Nuveen#62 · 78,829 sh	78,829	$2.5M	<0.01%	+55.1%
63	Kalehua Capital Management#63 · 74,465 sh	74,465	$2.4M	1.70%	0.0%
64	SEI INVESTMENTS#64 · 66,607 sh	66,607	$2.1M	<0.01%	New
65	Squarepoint Ops#65 · 63,805 sh	63,805	$2.0M	<0.01%	+211.3%
66	CITIGROUP#66 · 62,279 sh	62,279	$2.0M	<0.01%	+939.5%
67	Fisher Asset Management#67 · 60,230 sh	60,230	$1.9M	<0.01%	+109.1%
68	ALPS ADVISORS#68 · 60,159 sh	60,159	$1.9M	<0.01%	+37.2%
69	WELLINGTON MANAGEMENT GROUP LLP#69 · 59,601 sh	59,601	$1.9M	<0.01%	-22.8%
70	ALLIANCEBERNSTEIN L.P.#70 · 48,420 sh	48,420	$1.9M	<0.01%	+51.4%
71	RHUMBLINE ADVISERS#71 · 52,039 sh	52,039	$1.7M	<0.01%	+31.2%
72	TD ASSET MANAGEMENT#72 · 50,000 sh	50,000	$1.6M	<0.01%	0.0%
73	Arkadios Wealth Advisors#73 · 49,336 sh	49,336	$1.6M	0.02%	+3.7%
74	STATE OF WISCONSIN INVESTMENT BOARD#74 · 46,697 sh	46,697	$1.5M	<0.01%	+40.4%
75	Susquehanna Portfolio Strategies#75 · 44,878 sh	44,878	$1.4M	0.02%	-4.6%
76	Swiss National Bank#76 · 44,700 sh	44,700	$1.4M	<0.01%	+69.3%
77	MANUFACTURERS LIFE INSURANCE COMPANY, THE#77 · 44,327 sh	44,327	$1.4M	<0.01%	+10.2%
78	ExodusPoint Capital Management#78 · 41,026 sh	41,026	$1.3M	<0.01%	+191.7%
79	Rafferty Asset Management#79 · 38,702 sh	38,702	$1.2M	<0.01%	+11.0%
80	DEUTSCHE BANK AG\#80 · 36,935 sh	36,935	$1.2M	<0.01%	+80.2%
81	Verdad Advisers#81 · 36,003 sh	36,003	$1.1M	1.10%	New
82	WELLS FARGO & COMPANY#82 · 33,561 sh	33,561	$1.1M	<0.01%	+187.5%
83	Sofinnova Ventures#83 · 32,267 sh	32,267	$1.0M	0.05%	-84.2%
84	Engineers Gate Manager#84 · 31,958 sh	31,958	$1.0M	0.01%	New
85	AQR CAPITAL MANAGEMENT#85 · 29,853 sh	29,853	$953.5K	<0.01%	+1.5%
86	Toroso Investments#86 · 29,519 sh	29,519	$942.8K	<0.01%	New
87	TEMA ETFS#87 · 29,519 sh	29,519	$942.8K	—	New
88	SG Americas Securities#88 · 29,444 sh	29,444	$940.0K	<0.01%	+308.1%
89	PDT Partners#89 · 25,684 sh	25,684	$820.3K	0.04%	-39.3%
90	Invesco Ltd.#90 · 24,893 sh	24,893	$795.1K	<0.01%	-77.2%
91	STRS OHIO#91 · 22,100 sh	22,100	$705.9K	<0.01%	+22.1%
92	Creative Planning#92 · 21,803 sh	21,803	$696.4K	<0.01%	-9.0%
93	MetLife Investment Management#93 · 21,723 sh	21,723	$693.8K	<0.01%	+55.2%
94	MIRAE ASSET GLOBAL ETFS Ltd.#94 · 21,364 sh	21,364	$683.1K	<0.01%	+46.1%
95	LMR Partners LLP#95 · 21,151 sh	21,151	$675.6K	<0.01%	New
96	Auour Investments#96 · 21,020 sh	21,020	$671.4K	0.19%	0.0%
97	VOYA INVESTMENT MANAGEMENT#97 · 20,282 sh	20,282	$647.8K	<0.01%	-47.1%
98	BARCLAYS PLC#98 · 20,275 sh	20,275	$647.6K	<0.01%	-97.6%
99	D. E. Shaw#99 · 20,189 sh	20,189	$644.8K	<0.01%	New
100	Vanguard Global Advisers#100 · 20,154 sh	20,154	$643.7K	<0.01%	+30.2%

Funds that sold out of TYRA in Q2 2026 (25)

Held TYRA at the end of Q1 2026 and filed a Q2 2026 13F without it. Not in the list above, because they no longer hold it. Largest prior position first.

Institutions that held TYRA in Q1 2026 and reported no position in Q2 2026.
Institution	Shares sold	Value in Q1 2026
FARALLON CAPITAL MANAGEMENT3,580,818 sh	3,580,818	$137.1M
Logos Global Management850,000 sh	850,000	$32.6M
BALYASNY ASSET MANAGEMENT L.P.351,479 sh	351,479	$13.5M
Seven Fleet Capital Management195,685 sh	195,685	$7.5M
Schonfeld Strategic Advisors79,592 sh	79,592	$3.0M
Catalio Capital Management67,285 sh	67,285	$2.6M
Vestal Point Capital54,000 sh	54,000	$2.1M
AMERICAN CENTURY COMPANIES47,929 sh	47,929	$1.8M
Point72 Asset Management, L.P.38,850 sh	38,850	$1.5M
Brevan Howard Capital Management38,606 sh	38,606	$1.5M
Eversept Partners27,055 sh	27,055	$1.0M
Quadrature Capital Ltd18,203 sh	18,203	$697.2K
TUDOR INVESTMENT ET AL16,284 sh	16,284	$623.7K
PSP Research16,000 sh	16,000	$612.8K
SUSQUEHANNA INTERNATIONAL GROUP, LLP15,543 sh	15,543	$595.3K
JANE STREET GROUP10,169 sh	10,169	$389.5K
Soleus Capital Management, L.P.10,000 sh	10,000	$383.0K
Arrowpoint Investment Partners (Singapore) Pte. Ltd.8,075 sh	8,075	$309.3K
Bridgefront Capital7,911 sh	7,911	$303.0K
Graham Capital Management, L.P.5,756 sh	5,756	$220.5K
Persistent Asset Partners Ltd4,518 sh	4,518	$173.0K
Quantbot Technologies243 sh	243	$9.3K
US BANCORP \DE\11 sh	11	$421.00
TWIN PEAKS WEALTH ADVISORS7 sh	7	$268.00
MAI Capital Management4 sh	4	$154.00

Source: Form 13F-HR filings on SEC EDGAR, Q2 2026. Values are as reported by each manager at quarter end. “% of portfolio” is the position’s share of the manager’s total reported 13F value for the same quarter. “New” means the manager filed a 13F for Q1 2026 without this position; a dash means no comparison is available. Where a manager’s own filing is internally inconsistent its value is withheld and it is listed last. 13F data shows reported holdings, not recommendations.