5AM Venture Management, LLC
Sector Allocation
- Healthcare100.0%$287.9M
AUM History
13fpro.ai/research/fund/5am-venture-management-llc-1799883
Conviction and streaks
Concentrating · top 10 = 85.6%From the fund's last 12 quarters of 13F filings: positions held longest at size, and names it added to or trimmed several quarters running.
Largest positions — Q2 2026
MPLT
$34.0MTYRA
$32.9MTRDA
$29.9MPHVS
$27.6MCAMP
$25.6MARTV
$22.8MTECX
$20.9MZNTL
$19.1MCLDX
$18.5MEYPT
$15.0MBHVN
$11.0MSRZN
$7.0MSKYE
$6.7MALXO
$6.3MTARA
$5.2MSLN
$5.2M
Top 20 stock positions. Options are left out: 13F reports them at the underlying's value.
13fpro.ai/research/fund/5am-venture-management-llc-1799883
5AM Venture Management, LLC 13F holdings — Q2 2026
$287.9M portfolio (-20.1% QoQ) · 16 holdings · Q2 2026 13F · top 10 are 86% of the stock portfolio
$34.0M
11.8% of stocks
No changeThis quarter-34.8%Since filed3 qtrsHeld$32.9M
11.4% of stocks
No changeThis quarter-19.3%Since filed10+ qtrsHeld$29.9M
10.4% of stocks
No changeThis quarter-36.3%Since filed10+ qtrsHeld$27.6M
9.6% of stocks
No changeThis quarter-10.2%Since filed10+ qtrsHeld$25.6M
8.9% of stocks
No changeThis quarter-41.0%Since filed7 qtrsHeld$22.8M
7.9% of stocks
No changeThis quarter-46.2%Since filed8 qtrsHeld$20.9M
7.2% of stocks
No changeThis quarter-42.9%Since filed9 qtrsHeld$19.1M
6.7% of stocks
No changeThis quarter-41.9%Since filed10+ qtrsHeld$18.5M
6.4% of stocks
No changeThis quarter-29.7%Since filed10+ qtrsHeld$15.0M
5.2% of stocks
No changeThis quarter—Since filed9 qtrsHeld
All holdings — 5AM Venture Management, LLC (Q2 2026)
16 disclosed positions from the Form 13F-HR on SEC EDGAR, with quarter-over-quarter share changes. Largest by value first; the ten above are not repeated.
| # | Company | Held | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 11 | Biohaven Ltd. | Healthcare | $11.0M | 3.8% | 739K | — | 10+ qtrs | AI quality score is Pro: unlock with a free trial | 13F | |
| 12 | Surrozen, Inc./DE | Healthcare | $7.0M | 2.4% | 271K | -30% | 6 qtrs | AI quality score is Pro: unlock with a free trial | 13F | |
| 13 | Skye Bioscience, Inc. | Healthcare | $6.7M | 2.3% | 9.68M | — | 9 qtrs | AI quality score is Pro: unlock with a free trial | 13F | |
| 14 | ALX ONCOLOGY HOLDINGS INC | Healthcare | $6.3M | 2.2% | 3.06M | — | 2 qtrs | AI quality score is Pro: unlock with a free trial | 13F | |
| 15 | Protara Therapeutics, Inc. | Healthcare | $5.2M | 1.8% | 1.37M | — | 7 qtrs | AI quality score is Pro: unlock with a free trial | 13F | |
| 16 | Silence Therapeutics plcadr | Healthcare | $5.2M | 1.8% | 476K | — | 10+ qtrs | AI quality score is Pro: unlock with a free trial | 13F |
What changed in Q2 2026
Against the previous quarter's 13F: 0 new, 0 added to, 1 trimmed, 4 sold out. Share-count changes; largest moves by dollar size first.
New positions (0)
No new positions this quarter.
Added to (0)
No positions added to this quarter.
Trimmed (1)
now $7.0M · held 6 qtrs
Holdings by quarter
Every 13F 5AM Venture Management, LLC has filed, 26 earlier quarters. Pick one to see what it held then.
Is it too late to follow 5AM Venture Management?
Q2 2026 13F filed with the SEC on Aug 14, 2026. Prices are closing prices as of Oct 26, 2026.
Average quality of 5AM Venture Management's top 20 holdings: 12/100 (our AI quality score, weighted by position size; 6 of the 20 are scored)
Top 10 since filing
-32.6%
Value-weighted move of the 10 largest stock positions
Turnover
0%
Last quarter; 17% over the last 4
Top 10 weight
86%
Share of the stock portfolio in its 10 largest positions
Held 4+ quarters
86%
Share of portfolio value in positions held a year or more
Highest-quality names it owns(among its 100 largest positions)
The 6 highest-scoring companies in this portfolio are a Pro feature.
How these are measured
- Moves since the quarter-end and since the filing date use our own daily closing prices, from the close on (or just before) each date to the latest close.
- Turnover is the lesser of shares bought or sold in a quarter, valued at the quarter-end prices in the 13F, divided by the average of the two quarters' stock portfolio values.
- Quarters held and add/trim streaks count back only through quarters whose filed holdings add up to the filing's own cover-page total (back to Q1 2024 for this fund). A change counts as an add or a trim when the split-adjusted share count moves by more than 1%.
- Estimate, not the fund's reported cost. For each quarter in the current holding period in which the fund's share count rose (split-adjusted), we take that quarter's average daily close and weight it by the shares added; sales do not change an average cost. Quarters where the stock's price history and the 13F's own implied price disagree by more than 2x are left out.
- Put and call option rows report the value of the underlying shares, not a position the fund paid for, so they are left out of all of the above.
Portfolio Overview
5AM Venture Management, LLC disclosed 16 positions worth $287.9M in its Form 13F-HR for Q2 2026, led by $MPLT (MapLight Therapeutics, Inc.) at 11.8% of the equity portfolio, followed by $TYRA and $TRDA. During the quarter the fund opened 0 new positions and exited 4 and a full exit from $ERAS. The portfolio is most concentrated in Healthcare (100.0% of disclosed assets). All figures are sourced directly from 5AM Venture Management, LLC’s Form 13F-HR filing with the SEC under CIK 1799883.
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AI-Powered Hedge Fund Analysis: 5AM Venture Management, LLC
13F Pro is an AI hedge fund tracker and stock research platform. For 5AM Venture Management, LLC (SEC CIK: 1799883), the platform ingests every quarterly Form 13F filing and applies AI-powered analysis on top — 10 specialized AI analysts (value, growth, momentum, macro, activist, and more) debate the fund's top positions and publish AI-generated analysis with cited SEC sources.
Every holding in 5AM Venture Management, LLC's portfolio is scored on an AI quality ranking built from its SEC filings (ROIC, FCF margin, revenue growth, institutional flow, earnings quality, shareholder dilution, and more). Track accumulation and distribution quarter over quarter, identify conviction positions, and see AI stock analysis for each position — alongside 8,700+ other institutional filers and 2,800+ AI-ranked companies.