Septerna, Inc. (SEPN) — Institutional Holders, Q2 2026
154 institutional investment managers reported a SEPN position on SEC Form 13F-HR for the quarter ended June 30, 2026, with a combined reported value of $1.6B. Every filer is listed below, ranked by position value, 100 per page; this page shows ranks 1 to 100. Put and call option positions are excluded, and a firm filing several lots or share classes is shown once with its total.
SEPN in Q2 2026: what funds did
Funds that filed a 13F for both Q1 2026 and Q2 2026, by what they did with the common stock. Share counts are adjusted for any split between the two quarters; dollar figures are the change in shares at this quarter’s price.
Biggest buyers
- LOOMIS SAYLES & L PNew · +624,752 sh+$20.9M
- ALGERT GLOBALAdded · +376,452 sh+$12.6M
- Catalio Capital ManagementAdded · +241,792 sh+$8.1M
- First Light Asset ManagementAdded · +230,400 sh+$7.7M
- Longaeva Partners L.P.Added · +223,604 sh+$7.5M
Biggest sellers
- BVFSold out · -1,353,249 sh-$45.3M
- VR AdviserSold out · -506,056 sh-$16.9M
- ADAR1 Capital ManagementTrimmed · -149,071 sh-$5.0M
- Checkpoint Capital L.P.Sold out · -100,300 sh-$3.4M
- Siren, L.L.C.Trimmed · -100,000 sh-$3.3M
SEPN 13F holders ranked 1–100 of 154
| # | Institution | Shares | Value | % of portfolio | QoQShares vs Q1 2026 |
|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P.#1 · 6,995,858 sh | 6,995,858 | $234.3M | 2.04% | 0.0% |
| 2 | TRV GP V#2 · 6,215,591 sh | 6,215,591 | $208.2M | 41.78% | 0.0% |
| 3 | DRIEHAUS CAPITAL MANAGEMENT#3 · 4,433,058 sh | 4,433,058 | $148.5M | 0.86% | +0.9% |
| 4 | TRV GP VI#4 · 4,211,659 sh | 4,211,659 | $141.0M | 60.72% | 0.0% |
| 5 | Samsara BioCapital#5 · 3,149,128 sh | 3,149,128 | $105.5M | 8.66% | 0.0% |
| 6 | GOLDMAN SACHS GROUP#6 · 3,062,766 sh | 3,062,766 | $102.6M | <0.01% | +5.4% |
| 7 | BlackRock#7 · 1,932,088 sh | 1,932,088 | $64.7M | <0.01% | +6.0% |
| 8 | Siren, L.L.C.#8 · 1,900,000 sh | 1,900,000 | $63.6M | 1.29% | -5.0% |
| 9 | Avoro Capital Advisors#9 · 1,337,500 sh | 1,337,500 | $44.8M | 0.40% | 0.0% |
| 10 | Jupiter Topco#10 · 1,307,500 sh | 1,307,500 | $43.7M | 0.02% | — |
| 11 | VANGUARD CAPITAL MANAGEMENT#11 · 1,221,673 sh | 1,221,673 | $40.9M | <0.01% | +2.1% |
| 12 | PRIMECAP MANAGEMENT#12 · 1,167,382 sh | 1,167,382 | $39.1M | 0.02% | +11.3% |
| 13 | First Light Asset Management#13 · 963,260 sh | 963,260 | $32.3M | 1.96% | +31.4% |
| 14 | ADAR1 Capital Management#14 · 940,747 sh | 940,747 | $31.5M | 1.44% | -13.7% |
| 15 | GEODE CAPITAL MANAGEMENT#15 · 679,163 sh | 679,163 | $22.8M | <0.01% | +5.3% |
| 16 | STATE STREET#16 · 652,630 sh | 652,630 | $21.9M | <0.01% | +3.4% |
| 17 | LOOMIS SAYLES & L P#17 · 624,752 sh | 624,752 | $20.9M | 0.03% | New |
| 18 | Casdin Capital#18 · 553,268 sh | 553,268 | $18.5M | 0.93% | 0.0% |
| 19 | Catalio Capital Management#19 · 536,152 sh | 536,152 | $18.0M | 3.37% | +82.1% |
| 20 | ALGERT GLOBAL#20 · 397,487 sh | 397,487 | $13.3M | 0.16% | +1789.6% |
| 21 | BALYASNY ASSET MANAGEMENT L.P.#21 · 350,442 sh | 350,442 | $11.7M | 0.01% | +48.1% |
| 22 | Longaeva Partners L.P.#22 · 298,171 sh | 298,171 | $10.0M | 0.22% | +299.9% |
| 23 | Soleus Capital Management, L.P.#23 · 275,000 sh | 275,000 | $9.2M | 0.32% | 0.0% |
| 24 | VANGUARD PORTFOLIO MANAGEMENT#24 · 230,184 sh | 230,184 | $7.7M | <0.01% | +18.0% |
| 25 | Universal- Beteiligungs- und Servicegesellschaft mbH#25 · 222,702 sh | 222,702 | $7.5M | 0.01% | -0.6% |
| 26 | TWO SIGMA INVESTMENTS#26 · 220,885 sh | 220,885 | $7.4M | <0.01% | +193.1% |
| 27 | NORTHERN#27 · 201,131 sh | 201,131 | $6.7M | <0.01% | +22.2% |
| 28 | Kalehua Capital Management#28 · 194,544 sh | 194,544 | $6.5M | 4.67% | 0.0% |
| 29 | CHARLES SCHWAB INVESTMENT MANAGEMENT#29 · 187,041 sh | 187,041 | $6.3M | <0.01% | +3.0% |
| 30 | Woodline Partners#30 · 185,535 sh | 185,535 | $6.2M | 0.02% | New |
| 31 | VANGUARD FIDUCIARY#31 · 165,656 sh | 165,656 | $5.5M | <0.01% | +7.2% |
| 32 | MORGAN STANLEY#32 · 134,377 sh | 134,377 | $4.5M | <0.01% | +21.6% |
| 33 | UBS Group AG#33 · 89,874 sh | 89,874 | $3.0M | <0.01% | -23.2% |
| 34 | JPMORGAN CHASE#34 · 85,301 sh | 85,301 | $3.0M | <0.01% | +0.7% |
| 35 | FEDERATED HERMES#35 · 86,753 sh | 86,753 | $2.9M | <0.01% | -2.9% |
| 36 | LAZARD ASSET MANAGEMENT#36 · 75,425 sh | 75,425 | $2.5M | <0.01% | New |
| 37 | DIMENSIONAL FUND ADVISORS#37 · 75,309 sh | 75,309 | $2.5M | <0.01% | New |
| 38 | ARROWSTREET CAPITAL, LIMITED PARTNERSHIP#38 · 74,649 sh | 74,649 | $2.5M | <0.01% | New |
| 39 | JACOBS LEVY EQUITY MANAGEMENT#39 · 68,180 sh | 68,180 | $2.3M | <0.01% | +139.8% |
| 40 | HUSSMAN STRATEGIC ADVISORS#40 · 63,000 sh | 63,000 | $2.1M | 0.49% | -40.0% |
| 41 | AMERICAN CENTURY COMPANIES#41 · 60,973 sh | 60,973 | $2.0M | <0.01% | -0.5% |
| 42 | Bank of New York Mellon#42 · 56,176 sh | 56,176 | $1.9M | <0.01% | -4.3% |
| 43 | XTX Topco Ltd#43 · 54,489 sh | 54,489 | $1.8M | 0.02% | +48.4% |
| 44 | MILLENNIUM MANAGEMENT#44 · 50,562 sh | 50,562 | $1.7M | <0.01% | -59.3% |
| 45 | BARCLAYS PLC#45 · 49,821 sh | 49,821 | $1.7M | <0.01% | +119.3% |
| 46 | Elmind Capital#46 · 49,444 sh | 49,444 | $1.7M | 0.42% | New |
| 47 | Nuveen#47 · 48,229 sh | 48,229 | $1.6M | <0.01% | +65.3% |
| 48 | Sofinnova Ventures#48 · 47,506 sh | 47,506 | $1.6M | 0.08% | 0.0% |
| 49 | D. E. Shaw#49 · 46,483 sh | 46,483 | $1.6M | <0.01% | New |
| 50 | JANE STREET GROUP#50 · 45,552 sh | 45,552 | $1.5M | <0.01% | New |
| 51 | Voleon Capital Management#51 · 44,435 sh | 44,435 | $1.5M | 0.03% | New |
| 52 | HRT FINANCIAL#52 · 42,022 sh | 42,022 | $1.4M | <0.01% | New |
| 53 | RENAISSANCE TECHNOLOGIES#53 · 41,419 sh | 41,419 | $1.4M | <0.01% | +9.9% |
| 54 | Russell Investments Group, Ltd.#54 · 40,209 sh | 40,209 | $1.3M | <0.01% | +249.2% |
| 55 | Caption Management#55 · 38,006 sh | 38,006 | $1.3M | <0.01% | New |
| 56 | BANK OF AMERICA#56 · 35,875 sh | 35,875 | $1.2M | <0.01% | +38.1% |
| 57 | PRICE T ROWE ASSOCIATES#57 · 35,323 sh | 35,323 | $1.2M | <0.01% | +25.8% |
| 58 | Alyeska Investment Group, L.P.#58 · 35,000 sh | 35,000 | $1.2M | <0.01% | 0.0% |
| 59 | Brevan Howard Capital Management#59 · 29,452 sh | 29,452 | $986.3K | <0.01% | New |
| 60 | HighVista Strategies#60 · 29,337 sh | 29,337 | $982.5K | 0.22% | New |
| 61 | TUDOR INVESTMENT ET AL#61 · 28,966 sh | 28,966 | $970.1K | <0.01% | New |
| 62 | RHUMBLINE ADVISERS#62 · 27,636 sh | 27,636 | $925.5K | <0.01% | +3.9% |
| 63 | Trexquant Investment#63 · 25,645 sh | 25,645 | $858.9K | <0.01% | -27.4% |
| 64 | Invesco Ltd.#64 · 24,094 sh | 24,094 | $806.9K | <0.01% | -70.9% |
| 65 | Logos Global Management#65 · 23,548 sh | 23,548 | $788.6K | 0.03% | 0.0% |
| 66 | FMR#66 · 23,240 sh | 23,240 | $778.3K | 0.00% | -0.9% |
| 67 | FOX RUN MANAGEMENT, L.L.C.#67 · 22,038 sh | 22,038 | $738.1K | 0.12% | New |
| 68 | DEUTSCHE BANK AG\#68 · 21,873 sh | 21,873 | $732.5K | <0.01% | +29.9% |
| 69 | ALLIANCEBERNSTEIN L.P.#69 · 29,900 sh | 29,900 | $718.5K | <0.01% | +52.6% |
| 70 | Squarepoint Ops#70 · 21,219 sh | 21,219 | $710.6K | <0.01% | +17.3% |
| 71 | STRS OHIO#71 · 21,000 sh | 21,000 | $703.3K | <0.01% | +22.1% |
| 72 | FRED ALGER MANAGEMENT#72 · 20,958 sh | 20,958 | $701.9K | <0.01% | New |
| 73 | ACADIAN ASSET MANAGEMENT#73 · 20,996 sh | 20,996 | $701.0K | <0.01% | -32.2% |
| 74 | Jump Financial#74 · 20,200 sh | 20,200 | $676.5K | <0.01% | -61.9% |
| 75 | Swiss National Bank#75 · 19,800 sh | 19,800 | $663.1K | <0.01% | -10.4% |
| 76 | WELLS FARGO & COMPANY#76 · 19,684 sh | 19,684 | $659.2K | <0.01% | +99.5% |
| 77 | FRANKLIN RESOURCES#77 · 18,607 sh | 18,607 | $623.1K | <0.01% | New |
| 78 | CITIGROUP#78 · 17,808 sh | 17,808 | $596.4K | <0.01% | +93.7% |
| 79 | Aquatic Capital Management#79 · 17,427 sh | 17,427 | $583.6K | 0.02% | New |
| 80 | Engineers Gate Manager#80 · 17,350 sh | 17,350 | $581.1K | <0.01% | +5.0% |
| 81 | BNP PARIBAS FINANCIAL MARKETS#81 · 16,946 sh | 16,946 | $567.5K | <0.01% | +216.1% |
| 82 | LOS ANGELES CAPITAL MANAGEMENT#82 · 16,597 sh | 16,597 | $555.8K | <0.01% | +16.8% |
| 83 | State of Wyoming#83 · 16,379 sh | 16,379 | $548.5K | 0.06% | New |
| 84 | Vanguard Global Advisers#84 · 16,247 sh | 16,247 | $544.1K | <0.01% | 0.0% |
| 85 | AQR CAPITAL MANAGEMENT#85 · 15,397 sh | 15,397 | $515.6K | <0.01% | +0.1% |
| 86 | VIRGINIA RETIREMENT SYSTEMS ET Al#86 · 13,300 sh | 13,300 | $445.4K | <0.01% | New |
| 87 | Verdad Advisers#87 · 12,970 sh | 12,970 | $434.4K | 0.42% | New |
| 88 | MetLife Investment Management#88 · 12,880 sh | 12,880 | $431.4K | <0.01% | -5.9% |
| 89 | OSAIC#89 · 12,594 sh | 12,594 | $421.8K | <0.01% | -0.8% |
| 90 | Man Group plc#90 · 11,469 sh | 11,469 | $384.1K | <0.01% | -3.3% |
| 91 | China Universal Asset Management , Ltd.#91 · 10,774 sh | 10,774 | $360.8K | 0.02% | -9.8% |
| 92 | MIRAE ASSET GLOBAL ETFS Ltd.#92 · 10,193 sh | 10,193 | $341.4K | <0.01% | +1.7% |
| 93 | Legal & General Group Plc#93 · 10,062 sh | 10,062 | $337.0K | <0.01% | +75.4% |
| 94 | MASSACHUSETTS FINANCIAL SERVICES#94 · 9,982 sh | 9,982 | $334.3K | <0.01% | -3.9% |
| 95 | Gotham Asset Management#95 · 9,322 sh | 9,322 | $312.2K | <0.01% | New |
| 96 | Virtus Investment Advisers#96 · 9,102 sh | 9,102 | $304.8K | 0.07% | -15.1% |
| 97 | CANADA PENSION PLAN INVESTMENT BOARD#97 · 8,900 sh | 8,900 | $298.1K | <0.01% | New |
| 98 | NEW YORK STATE COMMON RETIREMENT FUND#98 · 8,500 sh | 8,500 | $284.7K | <0.01% | +51.8% |
| 99 | FIRST ADVISORS#99 · 7,739 sh | 7,739 | $259.2K | <0.01% | New |
| 100 | Creative Planning#100 · 7,636 sh | 7,636 | $255.7K | <0.01% | New |
Funds that sold out of SEPN in Q2 2026 (16)
Held SEPN at the end of Q1 2026 and filed a Q2 2026 13F without it. Not in the list above, because they no longer hold it. Largest prior position first.
| Institution | Shares sold | Value in Q1 2026 |
|---|---|---|
| BVF1,353,249 sh | 1,353,249 | $32.5M |
| VR Adviser506,056 sh | 506,056 | $12.2M |
| Checkpoint Capital L.P.100,300 sh | 100,300 | $2.4M |
| MARSHALL WACE, LLP39,840 sh | 39,840 | $957.4K |
| Y-Intercept (Hong Kong) Ltd25,770 sh | 25,770 | $619.3K |
| ADAGE CAPITAL PARTNERS GP, L.L.C.24,000 sh | 24,000 | $576.7K |
| VARCOV16,752 sh | 16,752 | $402.6K |
| Numerai GP15,082 sh | 15,082 | $362.4K |
| EntryPoint Capital12,776 sh | 12,776 | $307.0K |
| Verition Fund Management12,343 sh | 12,343 | $296.6K |
| Seven Fleet Capital Management11,445 sh | 11,445 | $275.0K |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO3,374 sh | 3,374 | $81.1K |
| QUADRANT CAPITAL GROUP14 sh | 14 | $49.1K |
| DIADEMA PARTNERS202 sh | 202 | $4.9K |
| Farther Finance Advisors7 sh | 7 | $171.00 |
| MAI Capital Management6 sh | 6 | $145.00 |
Source: Form 13F-HR filings on SEC EDGAR, Q2 2026. Values are as reported by each manager at quarter end. “% of portfolio” is the position’s share of the manager’s total reported 13F value for the same quarter. “New” means the manager filed a 13F for Q1 2026 without this position; a dash means no comparison is available. Where a manager’s own filing is internally inconsistent its value is withheld and it is listed last. 13F data shows reported holdings, not recommendations.