EcoR1 Capital, LLC
13F Reported Value
ⓘ$2.1B
incl. option notional
Equity Holdings
ⓘ$2.0B
Option Notional
ⓘ$40.0M
$0 puts / $40.0M calls
Holdings
33
Latest Filing
2026-06-30
Filing Quarter
Q2 2026
Portfolio Overview
EcoR1 Capital, LLC disclosed 33 positions worth $2.1B in its Form 13F-HR for Q2 2026 — $2.0B in common stock plus $40.0M of put/call option positions (reported at underlying notional value, not premium at risk), led by $ZYME (Zymeworks Inc.) at 29.8% of the equity portfolio, followed by $ANAB and $AKTS. During the quarter the fund opened 11 new positions and exited 8 — including a new stake in $TRAX and a full exit from $JAZZ. The portfolio is most concentrated in Healthcare (97.4% of disclosed assets). All figures are sourced directly from EcoR1 Capital, LLC’s Form 13F-HR filing with the SEC under CIK 1587114.
AI Fund Analysis
DiversifyingSector Allocation
AUM History
Top Equity Holdings by Value
Option Positions
13F rules report options at the value of the underlying shares (notional) — not the premium paid or capital at risk. Shown separately from the equity sleeve above.
Quarterly Activity — Q2 2026
Click any card to unlockTop Holdings
- 8.7#2,926
Quality
$600.4M22,970,388 sh - 48.4#1,725
Quality
$531.9M7,880,094 sh - —
Quality
$155.5M4,824,469 sh - 27.0
Quality
$106.2M1,494,300 sh - 67.5
Quality
$78.6M2,171,938 sh - 9.7
Quality
$75.8M1,389,276 sh - —
Quality
$72.9M6,728,116 sh - $63.9M3,174,519 sh
LAKEFRONT BIOTHERAPEUTICS NV - SPON ADR
—Quality
$50.0M1,667,119 sh- 27.4
Quality
$40.0M1,271,342 sh
| Company | Quality | Value | Shares |
|---|---|---|---|
 Zymeworks Inc.$ZYME | 8.7#2,926 | $600.4M | 22,970,388 |
 ANAPTYSBIO, INC$ANAB | 48.4#1,725 | $531.9M | 7,880,094 |
 Aktis Oncology, Inc.$AKTS | — | $155.5M | 4,824,469 |
 CG Oncology, Inc.$CGON | 27.0 | $106.2M | 1,494,300 |
 Eton Pharmaceuticals, Inc.$ETON | 67.5 | $78.6M | 2,171,938 |
 CRISPR Therapeutics AG$CRSP | 9.7 | $75.8M | 1,389,276 |
 Oric Pharmaceuticals, Inc.$ORIC | — | $72.9M | 6,728,116 |
 First Tracks Biotherapeutics, Inc.$TRAX | — | $63.9M | 3,174,519 |
| LAKEFRONT BIOTHERAPEUTICS NV - SPON ADR | — | $50.0M | 1,667,119 |
 Neurogene Inc.$NGNE | 27.4 | $40.0M | 1,271,342 |
Unlock AI quality scores for every holding
32-signal composite ranking on each of EcoR1 Capital, LLC's 33 positions.
Showing top 10 of 33 holdings.
Sector Allocation
Healthcare
$2.0B
Other
$52.1M
Full Holdings — EcoR1 Capital, LLC (Q2 2026)
All 33 disclosed positions from the latest Form 13F-HR, with quarter-over-quarter share changes and 13F Pro quality scores. Sourced from SEC EDGAR.
| # | Ticker | Company | Value | Weight | QoQ | Quality |
|---|---|---|---|---|---|---|
| 1 | $ZYME | Zymeworks Inc. | $600.4M | 29.8% | +0% | 8.7 |
| 2 | $ANAB | ANAPTYSBIO, INC | $531.9M | 26.4% | +0% | 48.4 |
| 3 | $AKTS | Aktis Oncology, Inc. | $155.5M | 7.7% | +0% | — |
| 4 | $CGON | CG Oncology, Inc. | $106.2M | 5.3% | +36% | 27 |
| 5 | $ETON | Eton Pharmaceuticals, Inc. | $78.6M | 3.9% | +0% | 67.5 |
| 6 | $CRSP | CRISPR Therapeutics AG | $75.8M | 3.8% | +0% | 9.7 |
| 7 | $ORIC | Oric Pharmaceuticals, Inc. | $72.9M | 3.6% | +0% | — |
| 8 | $TRAX | First Tracks Biotherapeutics, Inc. | $63.9M | 3.2% | NEW | — |
| 9 | — | LAKEFRONT BIOTHERAPEUTICS NV - SPON ADR | $50.0M | 2.5% | +0% | — |
| 10 | $NGNE | Neurogene Inc. | $40.0M | 2.0% | +0% | 27.4 |
| 11 | $CGONCALL | CG Oncology, Inc. | $39.9M | — | NEW | 27 |
| 12 |  $STOK | Stoke Therapeutics, Inc. | $24.0M | 1.2% | +635% | 24.9 |
| 13 |  $FULC | Fulcrum Therapeutics, Inc. | $24.0M | 1.2% | NEW | 32.9 |
| 14 |  $LEGN | Legend Biotech Corp | $23.1M | 1.1% | NEW | 47.8 |
| 15 |  $BBOT | BridgeBio Oncology Therapeutics, Inc. | $21.5M | 1.1% | +0% | — |
| 16 |  $MBX | MBX Biosciences, Inc. | $21.4M | 1.1% | -50% | — |
| 17 |  $ZBIO | Zenas BioPharma, Inc. | $20.0M | 1.0% | +0% | 7.4 |
| 18 |  $ATRA | Atara Biotherapeutics, Inc. | $17.8M | 0.9% | +1458% | 8.1 |
| 19 |  $RLAY | Relay Therapeutics, Inc. | $13.1M | 0.7% | -63% | 19.5 |
| 20 |  $AURA | Aura Biosciences, Inc. | $11.8M | 0.6% | NEW | — |
| 21 |  $ODTX | Odyssey Therapeutics, Inc. | $10.4M | 0.5% | NEW | — |
| 22 |  $EIKN | Eikon Therapeutics, Inc. | $9.6M | 0.5% | +0% | — |
| 23 |  $PHVS | Pharvaris N.V. | $8.1M | 0.4% | NEW | — |
| 24 |  $ZURA | Zura Bio Ltd | $7.0M | 0.3% | +0% | — |
| 25 |  $PHAT | Phathom Pharmaceuticals, Inc. | $6.8M | 0.3% | +0% | 40.9 |
| 26 |  $NRIX | Nurix Therapeutics, Inc. | $6.6M | 0.3% | NEW | 6.4 |
| 27 |  $ERAS | Erasca, Inc. | $6.0M | 0.3% | -63% | — |
| 28 |  $ELOX | Eloxx Pharmaceuticals, Inc. | $5.6M | 0.3% | NEW | — |
| 29 |  $AARD | Aardvark Therapeutics, Inc. | $2.3M | 0.1% | NEW | — |
| 30 | — | HELIX ACQUISITION CORP III USD - CL A ORD SHS | $2.1M | 0.1% | +0% | — |
| 31 |  $MREO | Mereo BioPharma Group plc | $317,700 | 0.0% | -93% | — |
| 32 |  $SRZN | Surrozen, Inc./DE | $115,322 | 0.0% | +0% | — |
| 33 | $AARDCALL | Aardvark Therapeutics, Inc. | $84,672 | — | NEW | — |
New Positions (11)
$TRAX First Tracks Biotherapeutics, Inc.$63.9M$CGONCALL CG Oncology, Inc.$39.9M$FULC Fulcrum Therapeutics, Inc.$24.0M$LEGN Legend Biotech Corp$23.1M$AURA Aura Biosciences, Inc.$11.8M$ODTX Odyssey Therapeutics, Inc.$10.4M$PHVS Pharvaris N.V.$8.1M$NRIX Nurix Therapeutics, Inc.$6.6M$ELOX Eloxx Pharmaceuticals, Inc.$5.6M$AARD Aardvark Therapeutics, Inc.$2.3M$AARDCALL Aardvark Therapeutics, Inc.$84,672
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