Stonepine Capital Management, LLC
Sector Allocation
- Healthcare99.7%$167.2M
- Technology0.2%$276,502
- Materials0.1%$247,836
AUM History
13fpro.ai/research/fund/stonepine-capital-management-llc-1440771
Conviction and streaks
Diversifying · top 10 = 50.3%From the fund's last 12 quarters of 13F filings: positions held longest at size, and names it added to or trimmed several quarters running.
Largest positions — Q2 2026
VSTM
$12.8MEOLS
$11.0MAYTU
$9.6MTENX
$9.6MNKTR
$8.4MAZTR
$8.0MCNSP
$6.4MELOX
$6.2MADMA
$6.2MCAMP
$6.1MKZIA
$4.9MSRZN
$4.7MINDV
$4.1MCRBP
$4.0MMSLE
$3.7MZVRA
$3.7MABEO
$3.4MEDSA
$3.2MCRIS
$3.2MCABA
$2.9M
Top 20 stock positions. Options are left out: 13F reports them at the underlying's value.
13fpro.ai/research/fund/stonepine-capital-management-llc-1440771
Stonepine Capital Management, LLC 13F holdings — Q2 2026
$213.6M portfolio (-14.5% QoQ) · 97 holdings · Q2 2026 13F · top 10 are 50% of the stock portfolio
Includes $45.9M of put/call options ($0 puts, $45.9M calls), which 13F rules report at the value of the underlying shares, not the premium at risk. Stocks alone: $167.7M. Weights use the stock portfolio.
$12.8M
7.6% of stocks
+1%This quarter+52.0%Since filed5+ qtrsHeldAIQuality31.1#2,447Est. buyEstimated buy price is Pro: unlock with a free trialAdded 4 qtrs in a row$11.0M
6.6% of stocks
-10%This quarter-12.1%Since filed5+ qtrsHeld$9.6M
5.7% of stocks
+530%This quarter-18.9%Since filed5+ qtrsHeld$9.6M
5.7% of stocks
-32%This quarter-8.9%Since filed3 qtrsHeld$8.4M
5.0% of stocks
+42%This quarter-48.7%Since filed5+ qtrsHeld$8.0M
4.8% of stocks
NewThis quarter+9.8%Since filedNew this quarterHeld$6.4M
3.8% of stocks
+2106%This quarter-16.2%Since filed3 qtrsHeldAIQualityAI quality score is Pro: unlock with a free trialEst. buyEstimated buy price is Pro: unlock with a free trialAdded 3 qtrs in a row$6.2M
3.7% of stocks
NewThis quarter-29.8%Since filedNew this quarterHeld$6.2M
3.7% of stocks
No changeThis quarter+16.8%Since filed5+ qtrsHeld$6.1M
3.6% of stocks
No changeThis quarter-41.0%Since filed3 qtrsHeld
All holdings — Stonepine Capital Management, LLC (Q2 2026)
97 disclosed positions from the Form 13F-HR on SEC EDGAR, with quarter-over-quarter share changes. Largest by value first; the ten above are not repeated.
| # | Company | Held | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 11 | ADMA BIOLOGICS, INC. | Healthcare | $8.0M | — | 650K | -43% | — | — | 13F | |
| 12 | INSMED Inc | Healthcare | $5.6M | — | 40K | New | — | — | 13F | |
| 13 | Ultragenyx Pharmaceutical Inc. | Healthcare | $5.5M | — | 200K | New | — | — | 13F | |
| 14 | KAZIA THERAPEUTICS LTDadr | Healthcare | $4.9M | 2.9% | 345K | — | 3 qtrs | AI quality score is Pro: unlock with a free trial | 13F | |
| 15 | Surrozen, Inc./DE | Healthcare | $4.7M | 2.8% | 68K | +106% | 5+ qtrs | AI quality score is Pro: unlock with a free trial | 13F | |
| 16 | Medtronic plc | Healthcare | $4.4M | — | 50K | New | — | — | 13F | |
| 17 | Indivior Pharmaceuticals, Inc. | Healthcare | $4.1M | 2.5% | 100K | New | 1 qtr | AI quality score is Pro: unlock with a free trial | 13F | |
| 18 | Corbus Pharmaceuticals Holdings, Inc. | Healthcare | $4.0M | 2.4% | 425K | +11% | 3 qtrs | AI quality score is Pro: unlock with a free trial | 13F | |
| 19 | ABBOTT LABORATORIES | Healthcare | $3.8M | — | 40K | New | — | — | 13F | |
| 20 | Satellos Bioscience Inc. | Healthcare | $3.7M | 2.2% | 492K | +392% | 2 qtrsAdded 2 qtrs in a row | AI quality score is Pro: unlock with a free trial | 13F | |
| 21 | ZEVRA THERAPEUTICS, INC. | Healthcare | $3.7M | 2.2% | 259K | -46% | 5+ qtrsTrimmed 3 qtrs in a row | AI quality score is Pro: unlock with a free trial | 13F | |
| 22 | ABEONA THERAPEUTICS INC. | Healthcare | $3.4M | 2.0% | 557K | -25% | 5+ qtrs | AI quality score is Pro: unlock with a free trial | 13F | |
| 23 | BOSTON SCIENTIFIC CORP | Healthcare | $3.3M | — | 50K | New | — | — | 13F | |
| 24 | Edesa Biotech, Inc. | Healthcare | $3.2M | 1.9% | 456K | +1421% | 4 qtrs | AI quality score is Pro: unlock with a free trial | 13F | |
| 25 | CURIS INC | Healthcare | $3.2M | 1.9% | 14.31M | +284% | 3 qtrsAdded 3 qtrs in a row | AI quality score is Pro: unlock with a free trial | 13F | |
| 26 | $EOLS CALL | Evolus, Inc. | Healthcare | $3.1M | — | 420K | — | |||
| 27 | $BMRN CALL | BIOMARIN PHARMACEUTICAL INC | Healthcare | $3.1M | — | 50K | New | |||
| 28 | $CABA | Cabaletta Bio, Inc. | Healthcare | $2.9M | 1.7% | 917K | +1734% | |||
| 29 | $ANTX | AN2 Therapeutics, Inc. | Healthcare | $2.7M | 1.6% | 552K | -23% | |||
| 30 | $IKT | Inhibikase Therapeutics, Inc. | Healthcare | $2.4M | 1.4% | 2.47M | +158% | |||
| 31 | $INAB | IN8BIO, INC. | Healthcare | $2.3M | 1.4% | 1.62M | +145% | |||
| 32 | $XLO | Xilio Therapeutics, Inc. | Healthcare | $2.2M | 1.3% | 226K | +252% | |||
| 33 | $ACET | Adicet Bio, Inc. | Healthcare | $2.1M | 1.3% | 246K | +11% | |||
| 34 | $XERS CALL | Xeris Biopharma Holdings, Inc. | Healthcare | $2.1M | — | 280K | — | |||
| 35 | $QNRX | Quoin Pharmaceuticals Ltd. | Healthcare | $2.0M | 1.2% | 766K | +1332% | |||
| 36 | $TELA | TELA Bio, Inc. | Healthcare | $2.0M | 1.2% | 2.66M | +2% | |||
| 37 | $ADIL | ADIAL PHARMACEUTICALS, INC. | Healthcare | $1.6M | 0.9% | 728K | New | |||
| 38 | $SPRB | SPRUCE BIOSCIENCES, INC. | Healthcare | $1.6M | 0.9% | 29K | New | |||
| 39 | $HRTX CALL | HERON THERAPEUTICS, INC. /DE/ | Healthcare | $1.5M | — | 1.00M | — | |||
| 40 | $SIBN CALL | SI-BONE, Inc. | Healthcare | $1.5M | — | 100K | — | |||
| 41 | $OKYO | OKYO Pharma Ltd | Healthcare | $1.3M | 0.8% | 863K | +2% | |||
| 42 | $CALC | CalciMedica, Inc. | Healthcare | $1.3M | 0.8% | 2.13M | New | |||
| 43 | $NMRA CALL | Neumora Therapeutics, Inc. | Healthcare | $1.3M | — | 500K | — | |||
| 44 | $KTTA | Pasithea Therapeutics Corp. | Healthcare | $1.1M | 0.7% | 2.20M | +165% | |||
| 45 | $SLGL | Sol-Gel Technologies Ltd. | Healthcare | $1.1M | 0.6% | 14K | -48% | |||
| 46 | $LUNG | Pulmonx Corp | Healthcare | $1.1M | 0.6% | 815K | +6% | |||
| 47 | $XFOR | X4 Pharmaceuticals, Inc | Healthcare | $1.1M | 0.6% | 225K | -33% | |||
| 48 | $ARDX CALL | ARDELYX, INC. | Healthcare | $1.1M | — | 150K | — | |||
| 49 | $DCTH CALL | DELCATH SYSTEMS, INC. | Healthcare | $1.0M | — | 100K | — | |||
| 50 | $MLTX | MoonLake Immunotherapeutics | Healthcare | $974K | 0.6% | 50K | New | |||
| 51 | $HELP | Helus Pharma Inc. | Healthcare | $966K | 0.6% | 331K | +147% | |||
| 52 | $MXCT | MAXCYTE, INC. | Healthcare | $924K | 0.6% | 752K | -25% | |||
| 53 | $PHAT | Phathom Pharmaceuticals, Inc. | Healthcare | $922K | 0.6% | 85K | +70% | |||
| 54 | $CNTB | Connect Biopharma Holdings Ltd | Healthcare | $867K | 0.5% | 364K | +18% | |||
| 55 | $RARE | Ultragenyx Pharmaceutical Inc. | Healthcare | $835K | 0.5% | 25K | New | |||
| 56 | $RADX | Radiopharm Theranostics Ltd | Healthcare | $794K | 0.5% | 102.00M | +100% | |||
| 57 | $ZNTL | Zentalis Pharmaceuticals, Inc. | Healthcare | $784K | 0.5% | 162K | -40% | |||
| 58 | $CTMX | CytomX Therapeutics, Inc. | Healthcare | $769K | 0.5% | 205K | +3% | |||
| 59 | $MNKD CALL | MANNKIND CORP | Healthcare | $750K | — | 250K | -50% | |||
| 60 | $NGEN | NERVGEN PHARMA CORP. | Healthcare | $740K | 0.4% | 572K | New | |||
| 61 | $NVCT | Nuvectis Pharma, Inc. | Healthcare | $736K | 0.4% | 40K | New | |||
| 62 | $CBIO | CRESCENT BIOPHARMA, INC. | Healthcare | $720K | 0.4% | 40K | -53% | |||
| 63 | $PMVP | PMV Pharmaceuticals, Inc. | Healthcare | $718K | 0.4% | 536K | -24% | |||
| 64 | $ORKA | Oruka Therapeutics, Inc. | Healthcare | $714K | 0.4% | 7,500 | New | |||
| 65 | $OKUR | OnKure Therapeutics, Inc. | Healthcare | $596K | 0.4% | 131K | -1% | |||
| 66 | $SINT | Sintx Technologies, Inc. | Healthcare | $558K | 0.3% | 628K | New | |||
| 67 | $IMA | ImageneBio, Inc. | Healthcare | $539K | 0.3% | 96K | New | |||
| 68 | $ARVN | ARVINAS, INC. | Healthcare | $499K | 0.3% | 60K | +118% | |||
| 69 | $BIOA | BioAge Labs, Inc. | Healthcare | $490K | 0.3% | 20K | -60% | |||
| 70 | $IRD | Opus Genetics, Inc. | Healthcare | $414K | 0.3% | 101K | +47% | |||
| 71 | $QTI | QT IMAGING HOLDINGS, INC. | Healthcare | $407K | 0.2% | 100K | New | |||
| 72 | $BOLD | Boundless Bio, Inc. | Healthcare | $386K | 0.2% | 155K | -74% | |||
| 73 | $MLSS | MILESTONE SCIENTIFIC INC. | Healthcare | $349K | 0.2% | 667K | New | |||
| 74 | $CLRB | Cellectar Biosciences, Inc. | Healthcare | $291K | 0.2% | 105K | New | |||
| 75 | $EPRX | EUPRAXIA PHARMACEUTICALS INC. | Healthcare | $287K | 0.2% | 43K | New | |||
| 76 | $SABS | SAB Biotherapeutics, Inc. | Healthcare | $286K | 0.2% | 73K | +47% | |||
| 77 | $ANL | Adlai Nortye Group Ltd. | Healthcare | $279K | 0.2% | 24K | New | |||
| 78 | $SENS | Senseonics Holdings, Inc. | Technology | $277K | 0.2% | 49K | New | |||
| 79 | $PLRX | PLIANT THERAPEUTICS, INC. | Healthcare | $263K | 0.2% | 231K | +3% | |||
| 80 | $CDXS | CODEXIS, INC. | Materials | $248K | 0.1% | 110K | -74% | |||
| 81 | $VRCA | Verrica Pharmaceuticals Inc. | Healthcare | $241K | 0.1% | 88K | -11% | |||
| 82 | $POCI | PRECISION OPTICS CORPORATION, INC. | Healthcare | $237K | 0.1% | 46K | -54% | |||
| 83 | $UPB | Upstream Bio, Inc. | Healthcare | $231K | 0.1% | 33K | -4% | |||
| 84 | $RNTX | Rein Therapeutics, Inc. | Healthcare | $227K | 0.1% | 218K | New | |||
| 85 | $INO | INOVIO PHARMACEUTICALS, INC. | Healthcare | $210K | 0.1% | 1.35M | New | |||
| 86 | $HRTX | HERON THERAPEUTICS, INC. /DE/ | Healthcare | $209K | 0.1% | 491K | -65% | |||
| 87 | $HUMA | Humacyte, Inc. | Healthcare | $181K | 0.1% | 231K | New | |||
| 88 | $DTIL | PRECISION BIOSCIENCES INC | Healthcare | $128K | 0.1% | 40K | New | |||
| 89 | $KLRS | Kalaris Therapeutics, Inc. | Healthcare | $123K | 0.1% | 30K | +48% | |||
| 90 | $TNYA | Tenaya Therapeutics, Inc. | Healthcare | $107K | 0.1% | 352K | New | |||
| 91 | $PCSA | Processa Pharmaceuticals, Inc. | Healthcare | $106K | 0.1% | 55K | — | |||
| 92 | $BCAB | BioAtla, Inc. | Healthcare | $68K | 0.0% | 16K | -75% | |||
| 93 | $CGEN | COMPUGEN LTD | Healthcare | $67K | 0.0% | 31K | -70% | |||
| 94 | $GRCE | Grace Therapeutics, Inc. | Healthcare | $62K | 0.0% | 295K | New | |||
| 95 | $OVID | Ovid Therapeutics Inc. | Healthcare | $57K | 0.0% | 21K | -47% | |||
| 96 | $EVAX | Evaxion A/S | Healthcare | $54K | 0.0% | 18K | -11% | |||
| 97 | $APRE | Aprea Therapeutics, Inc. | Healthcare | $0 | 0.0% | 137K | New |
What changed in Q2 2026
Against the previous quarter's 13F: 32 new, 29 added to, 25 trimmed, 18 sold out. Share-count changes; largest moves by dollar size first.
New positions (32)
$AZTRAzitra, Inc.$8.0M
first bought this quarter
$ELOXEloxx Pharmaceuticals, Inc.$6.2M
first bought this quarter
$INSMCALLINSMED Inc$5.6M
first bought this quarter
$RARECALLUltragenyx Pharmaceutical Inc.$5.5M
first bought this quarter
$MDTCALLMedtronic plc$4.4M
first bought this quarter
$INDVIndivior Pharmaceuticals, Inc.$4.1M
first bought this quarter
+26 more in the Excel export
Added to (29)
$AYTUAYTU BIOPHARMA, INC+530%
now $9.6M · held 5+ qtrs
$CNSPCNS Pharmaceuticals, Inc.+2106%
now $6.4M · held 3 qtrs, 3 adds in a row
$EDSAEdesa Biotech, Inc.+1421%
now $3.2M · held 4 qtrs
$MSLESatellos Bioscience Inc.+392%
now $3.7M · held 2 qtrs, 2 adds in a row
$CABACabaletta Bio, Inc.+1734%
now $2.9M · held 3 qtrs
$NKTRNEKTAR THERAPEUTICS+42%
now $8.4M · held 5+ qtrs
+23 more in the Excel export
Trimmed (25)
$ADMACALLADMA BIOLOGICS, INC.-43%
now $8.0M
$TENXTENAX THERAPEUTICS, INC.-32%
now $9.6M · held 3 qtrs
$ZVRAZEVRA THERAPEUTICS, INC.-46%
now $3.7M · held 5+ qtrs, 3 trims in a row
$EOLSEvolus, Inc.-10%
now $11.0M · held 5+ qtrs
$ABEOABEONA THERAPEUTICS INC.-25%
now $3.4M · held 5+ qtrs
$BOLDBoundless Bio, Inc.-74%
now $386K · held 5+ qtrs, 2 trims in a row
+19 more in the Excel export
Holdings by quarter
Every 13F Stonepine Capital Management, LLC has filed, 37 earlier quarters. Pick one to see what it held then.
Is it too late to follow Stonepine Capital Management?
Q2 2026 13F filed with the SEC on Aug 14, 2026. Prices are closing prices as of Oct 26, 2026.
Average quality of Stonepine Capital Management's top 20 holdings: 36/100 (our AI quality score, weighted by position size; 9 of the 20 are scored)
Top 10 since filing
-5.9%
Value-weighted move of the 10 largest stock positions
Turnover
16%
Last quarter; 107% over the last 4
Top 10 weight
50%
Share of the stock portfolio in its 10 largest positions
Held 4+ quarters
47%
Share of portfolio value in positions held a year or more
Highest-quality names it owns(among its 100 largest positions)
The 8 highest-scoring companies in this portfolio are a Pro feature.
How these are measured
- Moves since the quarter-end and since the filing date use our own daily closing prices, from the close on (or just before) each date to the latest close.
- Turnover is the lesser of shares bought or sold in a quarter, valued at the quarter-end prices in the 13F, divided by the average of the two quarters' stock portfolio values.
- Quarters held and add/trim streaks count back only through quarters whose filed holdings add up to the filing's own cover-page total (back to Q2 2025 for this fund). A change counts as an add or a trim when the split-adjusted share count moves by more than 1%.
- Estimate, not the fund's reported cost. For each quarter in the current holding period in which the fund's share count rose (split-adjusted), we take that quarter's average daily close and weight it by the shares added; sales do not change an average cost. Quarters where the stock's price history and the 13F's own implied price disagree by more than 2x are left out.
- Put and call option rows report the value of the underlying shares, not a position the fund paid for, so they are left out of all of the above.
Portfolio Overview
Stonepine Capital Management, LLC disclosed 97 positions worth $213.6M in its Form 13F-HR for Q2 2026 — $167.7M in common stock plus $45.9M of put/call option positions (reported at underlying notional value, not premium at risk), led by $VSTM (Verastem, Inc.) at 7.6% of the equity portfolio, followed by $EOLS and $AYTU. During the quarter the fund opened 32 new positions and exited 18 — including a new stake in $AZTR. The portfolio is most concentrated in Healthcare (99.7% of disclosed assets). All figures are sourced directly from Stonepine Capital Management, LLC’s Form 13F-HR filing with the SEC under CIK 1440771.
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AI-Powered Hedge Fund Analysis: Stonepine Capital Management, LLC
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Every holding in Stonepine Capital Management, LLC's portfolio is scored on an AI quality ranking built from its SEC filings (ROIC, FCF margin, revenue growth, institutional flow, earnings quality, shareholder dilution, and more). Track accumulation and distribution quarter over quarter, identify conviction positions, and see AI stock analysis for each position — alongside 8,700+ other institutional filers and 2,800+ AI-ranked companies.