What hedge funds are most similar to Palo Alto Investors LP?

The funds with the most similar 13F portfolios to Palo Alto Investors LP are TANG, RTW INVESTMENTS,, Sofinnova Ventures, based on overlapping conviction holdings in the latest SEC filings.

How is hedge fund similarity measured?

Similarity is computed from each fund's top conviction holdings in their latest 13F filing. Funds are scored by the overlap of distinctive shared positions (the mega-caps that nearly every fund owns are excluded), so the ranking reflects genuinely shared strategy rather than common index exposure.

Hedge Funds Similar to Palo Alto Investors

13F Portfolio OverlapQ1 2026Palo Alto Investors portfolio →

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Most similar hedge funds by 13F overlap

Palo Alto Investors LP is an institutional investor managing $654M across 51 U.S. equity positions as of Q1 2026. Based on the overlap of conviction holdings in their latest 13F filings, the hedge funds with portfolios most similar to Palo Alto Investors are TANG, RTW INVESTMENTS,, Sofinnova Ventures, with shared positions in $PTCT, $MIRM, $ANAB, $INSM, $CMPX, $CAPR. The full ranking of 25 similar funds is below.

#1TANG CAPITAL MANAGEMENT LLCActive

Notable overlap · 10 shared positions

$PTCT $MIRM $ANAB $INSM $CMPX $CAPR

$2.0B

51 positions

#2RTW INVESTMENTS, LPActive

Notable overlap · 9 shared positions

$INSM $PTCT $ACAD $RARE $TSHA $ORKA

$10.0B

88 positions

#3Sofinnova Ventures IncActive

Notable overlap · 9 shared positions

$UTHR $INSM $BMRN $BIIB $RARE $DYN

$2.6B

74 positions

#4Eagle Health Investments LPActive

Notable overlap · 4 shared positions

$INSM $BMRN $RARE $ALKS

$572M

28 positions

#5Rock Springs Capital Management LPActive

Notable overlap · 11 shared positions

$MIRM $INSM $RARE $CLDX $AGIO $TVTX

$1.7B

100 positions

#6Vestal Point Capital, LPActive

Notable overlap · 10 shared positions

$BMRN $DYN $BCAX $IRON $UTHR $CLDX

$3.6B

90 positions

#7First Turn Management, LLCActive

Notable overlap · 5 shared positions

$UTHR $INSM $MIRM $XENE $CYTK

$895M

33 positions

#8Defilade Capital Management, L.P.Active

Notable overlap · 6 shared positions

$PTCT $INSM $BIIB $ALGN $DNLI $NBIX

$712M

31 positions

#9BAKER BROS. ADVISORS LPSmart money

Notable overlap · 6 shared positions

$INSM $ACAD $ALKS $STOK $DNLI $MIRM

$17.4B

84 positions

#10Ishara Investments LPActive

Notable overlap · 8 shared positions

$BMRN $ACAD $FOLD $RARE $TVTX $ANNX

$106M

37 positions

#11Soleus Capital Management, L.P.Active

Notable overlap · 8 shared positions

$UTHR $NVCR $SNDX $MIRM $BMRN $ALKS

$2.5B

93 positions

#12SPHERA FUNDS MANAGEMENT LTD.Passive

Notable overlap · 8 shared positions

$BIIB $SNDX $RARE $FOLD $BMRN $CLDX

$630M

96 positions

#13Artia Global Partners LPActive

Notable overlap · 6 shared positions

$INSM $BIIB $UTHR $TVTX $XENE $CYTK

$499M

50 positions

#14Eversept Partners, LPActive

Notable overlap · 5 shared positions

$UTHR $SNDX $CLDX $TVTX $BMRN

$1.9B

120 positions

#15Arrowpoint Investment Partners (Singapore) Pte. Ltd.Passive

Notable overlap · 7 shared positions

$BMRN $PTCT $INSM $BIIB $NBIX $CYTK

$113M

82 positions

#16BVF INC/ILActive

Notable overlap · 6 shared positions

$MIRM $IRON $ANNX $ALKS $CMPX $STOK

$3.1B

41 positions

#17SECTOR GAMMA ASActive

Notable overlap · 7 shared positions

$BIIB $BMRN $SNDX $PTCT $IOVA $DNLI

$423M

42 positions

#18Frazier Life Sciences Management, L.P.Smart money

Notable overlap · 8 shared positions

$MIRM $IRON $DYN $AGIO $ACAD $ALKS

$3.9B

38 positions

#19ARMISTICE CAPITAL, LLCActive

Notable overlap · 9 shared positions

$PTCT $DYN $IRON $AGIO $TVTX $ALGN

$5.6B

261 positions

#20Integral Health Asset Management, LLCActive

Notable overlap · 4 shared positions

$INSM $EW $NBIX $CYTK

$2.1B

90 positions

#21Logos Global Management LPActive

Notable overlap · 10 shared positions

$UTHR $BIIB $IRON $DYN $MIRM $ACAD

$2.0B

66 positions

#22Jones Hill Capital LPActive

Notable overlap · 6 shared positions

$BMRN $RARE $BCAX $CAPR $ORKA $NUVB

$466M

26 positions

#23DIADEMA PARTNERS LPPassive

Notable overlap · 4 shared positions

$UTHR $BMRN $CAPR $ALKS

$588M

144 positions

#24Knott David M JrActive

Notable overlap · 8 shared positions

$IOVA $SNDX $ALKS $AGIO $TVTX $BIIB

$168M

85 positions

#25Affinity Asset Advisors, LLCActive

Notable overlap · 7 shared positions

$INSM $ANAB $ALKS $CLDX $XENE $ORKA

$1.9B

105 positions

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Similarity is derived from each fund’s latest 13F-HR filing with the SEC. Funds are ranked by the overlap of distinctive conviction holdings; near-universal mega-cap positions are excluded so the ranking reflects shared strategy, not common index exposure. Data is informational only and not investment advice.