Zymeworks Inc. (ZYME) — Institutional Holders, Q2 2026

203 institutional investment managers reported a ZYME position on SEC Form 13F-HR for the quarter ended June 30, 2026, with a combined reported value of $1.8B. Every filer is listed below, ranked by position value, 100 per page; this page shows ranks 1 to 100. Put and call option positions are excluded, and a firm filing several lots or share classes is shown once with its total.

← ZYME stock profile

ZYME in Q2 2026: what funds did

Funds that filed a 13F for both Q1 2026 and Q2 2026, by what they did with the common stock. Share counts are adjusted for any split between the two quarters; dollar figures are the change in shares at this quarter’s price.

New positions

Added to

Trimmed

Sold out

Biggest buyers

NOMURA ASSET MANAGEMENT INTERNATIONALNew · +889,802 sh+$23.3M
PERCEPTIVE ADVISORSAdded · +672,875 sh+$17.6M
Assenagon Asset Management S.A.Added · +524,041 sh+$13.7M
FIRST ADVISORSNew · +340,363 sh+$8.9M
Pictet Asset Management Holding SAAdded · +298,931 sh+$7.8M

Biggest sellers

MPM BioImpactSold out · -565,249 sh-$14.8M
NuveenTrimmed · -532,273 sh-$13.9M
DEUTSCHE BANK AG\Trimmed · -524,060 sh-$13.7M
Capricorn Fund Managers LtdTrimmed · -520,681 sh-$13.6M
ARROWSTREET CAPITAL, LIMITED PARTNERSHIPTrimmed · -325,401 sh-$8.5M

ZYME 13F holders ranked 1–100 of 203

Institutional investors reporting a position in Zymeworks Inc. on SEC Form 13F-HR for Q2 2026, ranked by reported value.
#	Institution	Shares	Value	% of portfolio	QoQShares vs Q1 2026
1	EcoR1 Capital#1 · 22,970,388 sh	22,970,388	$600.4M	29.19%	0.0%
2	Rubric Capital Management#2 · 7,000,000 sh	7,000,000	$183.0M	1.68%	0.0%
3	BlackRock#3 · 4,251,030 sh	4,251,030	$111.1M	<0.01%	-6.7%
4	PERCEPTIVE ADVISORS#4 · 4,182,953 sh	4,182,953	$109.3M	1.64%	+19.2%
5	BVF#5 · 3,649,142 sh	3,649,142	$95.4M	2.44%	-2.3%
6	MORGAN STANLEY#6 · 2,231,260 sh	2,231,260	$58.3M	<0.01%	-10.1%
7	BNP Paribas Asset Management Holding S.A.#7 · 1,781,116 sh	1,781,116	$46.6M	0.05%	-6.7%
8	VANGUARD CAPITAL MANAGEMENT#8 · 1,558,998 sh	1,558,998	$40.8M	<0.01%	-8.6%
9	Assenagon Asset Management S.A.#9 · 1,252,027 sh	1,252,027	$32.7M	—	+72.0%
10	Nextech Invest, Ltd.#10 · 1,113,946 sh	1,113,946	$29.1M	1.38%	0.0%
11	STATE STREET#11 · 1,088,216 sh	1,088,216	$28.4M	<0.01%	+7.6%
12	DIMENSIONAL FUND ADVISORS#12 · 994,955 sh	994,955	$26.0M	<0.01%	-12.7%
13	CITADEL ADVISORS#13 · 914,136 sh	914,136	$23.9M	<0.01%	-20.5%
14	NOMURA ASSET MANAGEMENT INTERNATIONAL#14 · 889,802 sh	889,802	$23.3M	0.03%	New
15	FMR#15 · 702,568 sh	702,568	$18.4M	<0.01%	+5.3%
16	GEODE CAPITAL MANAGEMENT#16 · 692,410 sh	692,410	$18.1M	<0.01%	+4.9%
17	Prosight Management#17 · 674,434 sh	674,434	$17.6M	3.04%	+25.1%
18	Qube Research & Technologies Ltd#18 · 593,590 sh	593,590	$15.5M	0.01%	+15.9%
19	VANGUARD PORTFOLIO MANAGEMENT#19 · 510,032 sh	510,032	$13.3M	<0.01%	+2.0%
20	Redmile Group#20 · 491,654 sh	491,654	$12.9M	0.86%	0.0%
21	Capricorn Fund Managers Ltd#21 · 486,529 sh	486,529	$12.7M	1.00%	-51.7%
22	GOLDMAN SACHS GROUP#22 · 470,822 sh	470,822	$12.3M	<0.01%	-21.5%
23	ARROWSTREET CAPITAL, LIMITED PARTNERSHIP#23 · 418,497 sh	418,497	$10.9M	<0.01%	-43.7%
24	DEUTSCHE BANK AG\#24 · 397,190 sh	397,190	$10.4M	<0.01%	-56.9%
25	Hillsdale Investment Management#25 · 382,922 sh	382,922	$10.0M	0.23%	+10.8%
26	FIRST ADVISORS#26 · 340,363 sh	340,363	$8.9M	<0.01%	New
27	Granahan Investment Management#27 · 336,157 sh	336,157	$8.8M	0.31%	+34.0%
28	NORTHERN#28 · 321,073 sh	321,073	$8.4M	<0.01%	+0.3%
29	Pictet Asset Management Holding SA#29 · 308,187 sh	308,187	$7.4M	<0.01%	+3229.6%
30	PICTON MAHONEY ASSET MANAGEMENT#30 · 271,343 sh	271,343	$7.1M	0.05%	+5.7%
31	SILVERCREST ASSET MANAGEMENT GROUP#31 · 223,766 sh	223,766	$5.8M	0.04%	+36.7%
32	BANK OF AMERICA#32 · 219,071 sh	219,071	$5.7M	<0.01%	-7.5%
33	WELLS FARGO & COMPANY#33 · 217,199 sh	217,199	$5.7M	<0.01%	+14.5%
34	SummitTX Capital, L.P.#34 · 210,802 sh	210,802	$5.5M	0.14%	-34.4%
35	Man Group plc#35 · 210,779 sh	210,779	$5.5M	<0.01%	+11.0%
36	FEDERATED HERMES#36 · 187,995 sh	187,995	$4.9M	<0.01%	+3.1%
37	RAYMOND JAMES FINANCIAL#37 · 166,416 sh	166,416	$4.4M	<0.01%	-5.7%
38	STATE OF WISCONSIN INVESTMENT BOARD#38 · 155,579 sh	155,579	$4.1M	<0.01%	+135.3%
39	CHARLES SCHWAB INVESTMENT MANAGEMENT#39 · 152,416 sh	152,416	$4.0M	<0.01%	-17.7%
40	KENNEDY CAPITAL MANAGEMENT#40 · 145,386 sh	145,386	$3.8M	0.07%	-1.9%
41	D. E. Shaw#41 · 144,807 sh	144,807	$3.8M	<0.01%	-38.5%
42	DIADEMA PARTNERS#42 · 142,132 sh	142,132	$3.7M	0.47%	0.0%
43	CITIGROUP#43 · 131,441 sh	131,441	$3.4M	<0.01%	+15.0%
44	Bank of New York Mellon#44 · 131,106 sh	131,106	$3.4M	<0.01%	+5.6%
45	XTX Topco Ltd#45 · 125,877 sh	125,877	$3.3M	0.04%	-12.5%
46	Nuveen#46 · 119,389 sh	119,389	$3.1M	<0.01%	-81.7%
47	PANAGORA ASSET MANAGEMENT#47 · 118,603 sh	118,603	$3.1M	<0.01%	-42.7%
48	UBS Group AG#48 · 115,095 sh	115,095	$3.0M	<0.01%	-33.0%
49	Invesco Ltd.#49 · 112,212 sh	112,212	$2.9M	<0.01%	-10.7%
50	AQR CAPITAL MANAGEMENT#50 · 111,282 sh	111,282	$2.9M	<0.01%	+22.7%
51	WELLINGTON MANAGEMENT GROUP LLP#51 · 110,014 sh	110,014	$2.9M	<0.01%	-20.7%
52	Toroso Investments#52 · 105,615 sh	105,615	$2.8M	<0.01%	+0.7%
53	TEMA ETFS#53 · 105,615 sh	105,615	$2.8M	—	+0.7%
54	PLATINUM INVESTMENT MANAGEMENT LTD#54 · 105,184 sh	105,184	$2.7M	0.68%	0.0%
55	Manatuck Hill Partners#55 · 100,000 sh	100,000	$2.6M	0.87%	+150.0%
56	JPMORGAN CHASE#56 · 106,398 sh	106,398	$2.6M	<0.01%	-6.7%
57	KORNITZER CAPITAL MANAGEMENT#57 · 88,800 sh	88,800	$2.3M	0.05%	0.0%
58	MACKENZIE FINANCIAL#58 · 87,745 sh	87,745	$2.3M	<0.01%	+6.1%
59	PRINCIPAL FINANCIAL GROUP#59 · 84,990 sh	84,990	$2.2M	<0.01%	+8.2%
60	Y-Intercept (Hong Kong) Ltd#60 · 83,455 sh	83,455	$2.2M	—	New
61	LMR Partners LLP#61 · 82,500 sh	82,500	$2.2M	<0.01%	New
62	AMERIPRISE FINANCIAL#62 · 82,264 sh	82,264	$2.2M	<0.01%	+10.8%
63	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AME#63 · 81,359 sh	81,359	$2.1M	<0.01%	-74.5%
64	VANGUARD FIDUCIARY#64 · 80,120 sh	80,120	$2.1M	<0.01%	-5.1%
65	STIFEL FINANCIAL#65 · 77,214 sh	77,214	$2.0M	<0.01%	+0.6%
66	FRANKLIN RESOURCES#66 · 76,528 sh	76,528	$2.0M	<0.01%	-1.5%
67	RHUMBLINE ADVISERS#67 · 75,066 sh	75,066	$2.0M	<0.01%	-0.4%
68	Swiss National Bank#68 · 74,200 sh	74,200	$1.9M	<0.01%	0.0%
69	MARTINGALE ASSET MANAGEMENT L P#69 · 73,282 sh	73,282	$1.9M	0.05%	+123.7%
70	TWO SIGMA INVESTMENTS#70 · 71,874 sh	71,874	$1.9M	<0.01%	New
71	Dana Investment Advisors#71 · 71,660 sh	71,660	$1.9M	0.05%	+27.7%
72	CREDIT AGRICOLE S A#72 · 71,000 sh	71,000	$1.9M	<0.01%	-5.3%
73	Fisher Asset Management#73 · 70,775 sh	70,775	$1.9M	<0.01%	-30.2%
74	SEGALL BRYANT & HAMILL#74 · 66,836 sh	66,836	$1.7M	0.02%	New
75	Verdad Advisers#75 · 66,688 sh	66,688	$1.7M	1.67%	-19.4%
76	Susquehanna Portfolio Strategies#76 · 65,248 sh	65,248	$1.7M	0.03%	-34.6%
77	Campbell & Investment Adviser#77 · 60,874 sh	60,874	$1.6M	0.08%	+10.9%
78	ROYAL BANK OF CANADA#78 · 56,278 sh	56,278	$1.5M	<0.01%	+18.8%
79	ALLIANCEBERNSTEIN L.P.#79 · 55,896 sh	55,896	$1.4M	<0.01%	0.0%
80	Virtus Investment Advisers#80 · 50,825 sh	50,825	$1.3M	0.31%	+374.9%
81	ENVESTNET ASSET MANAGEMENT#81 · 48,675 sh	48,675	$1.3M	<0.01%	+20.4%
82	Russell Investments Group, Ltd.#82 · 47,867 sh	47,867	$1.3M	<0.01%	+0.9%
83	Quantinno Capital Management#83 · 47,642 sh	47,642	$1.2M	<0.01%	+20.2%
84	North Growth Management Ltd.#84 · 46,000 sh	46,000	$1.2M	—	0.0%
85	Legal & General Group Plc#85 · 43,160 sh	43,160	$1.1M	<0.01%	+64.7%
86	VICTORY CAPITAL MANAGEMENT#86 · 42,524 sh	42,524	$1.1M	<0.01%	+0.3%
87	MARSHALL WACE, LLP#87 · 40,948 sh	40,948	$1.1M	<0.01%	+27.1%
88	O'SHAUGHNESSY ASSET MANAGEMENT#88 · 39,534 sh	39,534	$1.0M	<0.01%	+6.5%
89	PRICE T ROWE ASSOCIATES#89 · 38,486 sh	38,486	$1.0M	<0.01%	+8.5%
90	JACOBS LEVY EQUITY MANAGEMENT#90 · 36,922 sh	36,922	$965.1K	<0.01%	-13.7%
91	TUDOR INVESTMENT ET AL#91 · 36,471 sh	36,471	$953.4K	<0.01%	-1.1%
92	HighTower Advisors#92 · 36,100 sh	36,100	$943.7K	<0.01%	-0.4%
93	Persistent Asset Partners Ltd#93 · 35,935 sh	35,935	$939.3K	0.28%	0.0%
94	HighVista Strategies#94 · 34,013 sh	34,013	$889.1K	0.20%	-0.2%
95	COMMONWEALTH EQUITY SERVICES#95 · 32,052 sh	32,052	$837.8K	<0.01%	+23.1%
96	MANUFACTURERS LIFE INSURANCE COMPANY, THE#96 · 30,886 sh	30,886	$807.4K	<0.01%	-2.2%
97	Creative Planning#97 · 29,731 sh	29,731	$777.2K	<0.01%	-8.2%
98	SBI Okasan Asset Management Ltd.#98 · 32,000 sh	32,000	$771.2K	0.03%	0.0%
99	MetLife Investment Management#99 · 27,884 sh	27,884	$728.9K	<0.01%	-6.0%
100	MASSACHUSETTS FINANCIAL SERVICES#100 · 27,670 sh	27,670	$723.3K	<0.01%	+1.2%

Funds that sold out of ZYME in Q2 2026 (30)

Held ZYME at the end of Q1 2026 and filed a Q2 2026 13F without it. Not in the list above, because they no longer hold it. Largest prior position first.

Institutions that held ZYME in Q1 2026 and reported no position in Q2 2026.
Institution	Shares sold	Value in Q1 2026
MPM BioImpact565,249 sh	565,249	$14.2M
ROYCE & ASSOCIATES299,202 sh	299,202	$7.5M
HRT FINANCIAL237,889 sh	237,889	$6.0M
AMERICAN CENTURY COMPANIES70,851 sh	70,851	$1.8M
Connor, Clark & Lunn Investment Management Ltd.37,919 sh	37,919	$949.5K
Engineers Gate Manager31,548 sh	31,548	$790.0K
OXFORD ASSET MANAGEMENT LLP27,812 sh	27,812	$696.4K
SCHRODER INVESTMENT MANAGEMENT GROUP28,349 sh	28,349	$686.3K
ExodusPoint Capital Management27,374 sh	27,374	$685.4K
SUSQUEHANNA INTERNATIONAL GROUP, LLP24,421 sh	24,421	$611.5K
Headlands Technologies22,845 sh	22,845	$572.0K
GSA CAPITAL PARTNERS LLP20,511 sh	20,511	$514.0K
Quadrature Capital Ltd16,735 sh	16,735	$419.0K
Amundi14,084 sh	14,084	$352.7K
Abacus Wealth Partners11,669 sh	11,669	$292.2K
LAZARD ASSET MANAGEMENT10,602 sh	10,602	$265.5K
Soleus Capital Management, L.P.10,000 sh	10,000	$250.4K
WINTON GROUP Ltd8,400 sh	8,400	$210.3K
Cygnus Capital Advisors8,197 sh	8,197	$205.0K
Global Wealth Strategies & Associates1,635 sh	1,635	$40.9K
Sofinnova Ventures1,610 sh	1,610	$40.3K
Aviso Financial1,146 sh	1,146	$28.7K
Walleye Capital78 sh	78	$2.0K
SIGNATUREFD77 sh	77	$1.9K
FIFTH THIRD BANCORP67 sh	67	$1.7K
TWIN PEAKS WEALTH ADVISORS20 sh	20	$501.00
Aster Capital Management (DIFC) Ltd42 sh	42	$500.00
CoreCap Advisors18 sh	18	$451.00
Root Financial Partners12 sh	12	$300.00
MAI Capital Management7 sh	7	$176.00

Source: Form 13F-HR filings on SEC EDGAR, Q2 2026. Values are as reported by each manager at quarter end. “% of portfolio” is the position’s share of the manager’s total reported 13F value for the same quarter. “New” means the manager filed a 13F for Q1 2026 without this position; a dash means no comparison is available. Where a manager’s own filing is internally inconsistent its value is withheld and it is listed last. 13F data shows reported holdings, not recommendations.