Xenon Pharmaceuticals Inc. (XENE) — Institutional Holders, Q2 2026
317 institutional investment managers reported a XENE position on SEC Form 13F-HR for the quarter ended June 30, 2026, with a combined reported value of $6.1B. Every filer is listed below, ranked by position value, 100 per page; this page shows ranks 1 to 100. Put and call option positions are excluded, and a firm filing several lots or share classes is shown once with its total.
XENE in Q2 2026: what funds did
Funds that filed a 13F for both Q1 2026 and Q2 2026, by what they did with the common stock. Share counts are adjusted for any split between the two quarters; dollar figures are the change in shares at this quarter’s price.
Biggest buyers
- PRICE T ROWE ASSOCIATESAdded · +1,918,628 sh+$115.8M
- BlackRockAdded · +1,882,364 sh+$113.6M
- T. Rowe Price Investment ManagementAdded · +1,216,626 sh+$73.4M
- TWO SIGMA INVESTMENTSAdded · +1,036,763 sh+$62.6M
- Invesco Ltd.Added · +844,355 sh+$51.0M
Biggest sellers
- WELLINGTON MANAGEMENT GROUP LLPTrimmed · -3,404,149 sh-$205.5M
- Holocene AdvisorsSold out · -1,518,686 sh-$91.7M
- CITADEL ADVISORSTrimmed · -1,251,748 sh-$75.6M
- FMRTrimmed · -1,170,493 sh-$70.7M
- JENNISON ASSOCIATESTrimmed · -1,110,754 sh-$67.0M
XENE 13F holders ranked 1–100 of 317
| # | Institution | Shares | Value | % of portfolio | QoQShares vs Q1 2026 |
|---|---|---|---|---|---|
| 1 | FMR#1 · 9,647,998 sh | 9,647,998 | $582.4M | 0.03% | -10.8% |
| 2 | BlackRock#2 · 7,522,482 sh | 7,522,482 | $454.1M | <0.01% | +33.4% |
| 3 | Avoro Capital Advisors#3 · 5,777,777 sh | 5,777,777 | $348.7M | 3.13% | 0.0% |
| 4 | Polar Capital Plc#4 · 4,570,556 sh | 4,570,556 | $275.9M | 0.65% | +3.8% |
| 5 | DRIEHAUS CAPITAL MANAGEMENT#5 · 4,418,557 sh | 4,418,557 | $266.7M | 1.55% | -1.6% |
| 6 | Jupiter Topco#6 · 4,186,519 sh | 4,186,519 | $252.7M | 0.10% | — |
| 7 | PRICE T ROWE ASSOCIATES#7 · 3,248,219 sh | 3,248,219 | $196.1M | 0.02% | +144.3% |
| 8 | JPMORGAN CHASE#8 · 2,617,360 sh | 2,617,360 | $157.4M | <0.01% | +36.1% |
| 9 | Capital International Investors#9 · 2,361,639 sh | 2,361,639 | $142.5M | 0.03% | -11.7% |
| 10 | T. Rowe Price Investment Management#10 · 2,168,581 sh | 2,168,581 | $130.9M | 0.09% | +127.8% |
| 11 | STATE STREET#11 · 1,969,629 sh | 1,969,629 | $118.9M | <0.01% | +14.5% |
| 12 | TWO SIGMA INVESTMENTS#12 · 1,642,848 sh | 1,642,848 | $99.2M | 0.07% | +171.1% |
| 13 | DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)#13 · 1,615,696 sh | 1,615,696 | $97.5M | 1.02% | 0.0% |
| 14 | Affinity Asset Advisors#14 · 1,595,000 sh | 1,595,000 | $96.3M | 4.35% | -4.8% |
| 15 | WESTFIELD CAPITAL MANAGEMENT#15 · 1,507,294 sh | 1,507,294 | $91.0M | 0.30% | +7.5% |
| 16 | ALLIANCEBERNSTEIN L.P.#16 · 1,562,276 sh | 1,562,276 | $90.8M | 0.03% | +11.3% |
| 17 | FRANKLIN RESOURCES#17 · 1,437,712 sh | 1,437,712 | $86.8M | 0.02% | +12.3% |
| 18 | WELLINGTON MANAGEMENT GROUP LLP#18 · 1,425,492 sh | 1,425,492 | $86.0M | 0.01% | -70.5% |
| 19 | CITADEL ADVISORS#19 · 1,401,242 sh | 1,401,242 | $84.6M | <0.01% | -47.2% |
| 20 | GEODE CAPITAL MANAGEMENT#20 · 1,370,114 sh | 1,370,114 | $82.7M | <0.01% | +25.4% |
| 21 | Siren, L.L.C.#21 · 1,318,564 sh | 1,318,564 | $79.6M | 1.61% | 0.0% |
| 22 | BNP Paribas Asset Management Holding S.A.#22 · 1,290,731 sh | 1,290,731 | $77.9M | 0.08% | -3.8% |
| 23 | Pictet Asset Management Holding SA#23 · 1,187,723 sh | 1,187,723 | $71.6M | 0.07% | +74.7% |
| 24 | BRAIDWELL#24 · 1,131,452 sh | 1,131,452 | $68.3M | 2.53% | -15.5% |
| 25 | Nuveen#25 · 993,126 sh | 993,126 | $59.9M | 0.01% | +297.2% |
| 26 | Invesco Ltd.#26 · 903,458 sh | 903,458 | $54.5M | <0.01% | +1428.6% |
| 27 | ORBIMED ADVISORS#27 · 892,471 sh | 892,471 | $53.9M | 1.00% | -15.8% |
| 28 | Caligan Partners#28 · 889,944 sh | 889,944 | $53.7M | 2.53% | -36.1% |
| 29 | AMERICAN CENTURY COMPANIES#29 · 884,319 sh | 884,319 | $53.4M | 0.02% | +30.2% |
| 30 | FEDERATED HERMES#30 · 883,737 sh | 883,737 | $53.3M | 0.08% | -9.1% |
| 31 | Capital World Investors#31 · 862,775 sh | 862,775 | $52.1M | <0.01% | +2.7% |
| 32 | GOLDMAN SACHS GROUP#32 · 773,625 sh | 773,625 | $46.7M | <0.01% | +0.5% |
| 33 | VANGUARD PORTFOLIO MANAGEMENT#33 · 749,651 sh | 749,651 | $45.2M | <0.01% | +38.0% |
| 34 | Vestal Point Capital#34 · 700,000 sh | 700,000 | $42.3M | 0.99% | +9.4% |
| 35 | Alyeska Investment Group, L.P.#35 · 697,692 sh | 697,692 | $42.1M | 0.11% | -46.3% |
| 36 | MARSHALL WACE, LLP#36 · 689,342 sh | 689,342 | $41.6M | 0.03% | New |
| 37 | Rock Springs Capital Management#37 · 683,907 sh | 683,907 | $41.3M | 2.01% | -10.4% |
| 38 | NORTHERN#38 · 671,566 sh | 671,566 | $40.5M | <0.01% | +27.2% |
| 39 | PANAGORA ASSET MANAGEMENT#39 · 664,031 sh | 664,031 | $40.1M | 0.12% | New |
| 40 | First Turn Management#40 · 600,200 sh | 600,200 | $36.2M | 3.88% | -23.7% |
| 41 | TUDOR INVESTMENT ET AL#41 · 545,387 sh | 545,387 | $32.9M | 0.05% | +10.0% |
| 42 | LOOMIS SAYLES & L P#42 · 527,273 sh | 527,273 | $31.8M | 0.04% | -6.7% |
| 43 | Octagon Capital Advisors#43 · 490,000 sh | 490,000 | $29.6M | 2.66% | 0.0% |
| 44 | Novo A/S#44 · 485,438 sh | 485,438 | $29.3M | 1.70% | 0.0% |
| 45 | Candriam S.C.A.#45 · 462,768 sh | 462,768 | $27.9M | 0.13% | -2.9% |
| 46 | TimesSquare Capital Management#46 · 451,593 sh | 451,593 | $27.3M | 0.40% | +25.7% |
| 47 | Logos Global Management#47 · 450,000 sh | 450,000 | $27.2M | 1.17% | 0.0% |
| 48 | Trails Edge Capital Partners#48 · 440,000 sh | 440,000 | $26.6M | 4.22% | 0.0% |
| 49 | Bank of New York Mellon#49 · 421,518 sh | 421,518 | $25.4M | <0.01% | +6.4% |
| 50 | ALGERT GLOBAL#50 · 419,773 sh | 419,773 | $25.3M | 0.30% | +58.9% |
| 51 | abrdn plc#51 · 408,736 sh | 408,736 | $24.7M | 0.03% | -33.0% |
| 52 | MORGAN STANLEY#52 · 406,257 sh | 406,257 | $24.5M | <0.01% | -14.2% |
| 53 | Fiera Capital#53 · 405,638 sh | 405,638 | $24.5M | 0.09% | -42.8% |
| 54 | BANK OF AMERICA#54 · 404,067 sh | 404,067 | $24.4M | <0.01% | +52.3% |
| 55 | Parkman Healthcare Partners#55 · 397,379 sh | 397,379 | $24.0M | 2.46% | -20.1% |
| 56 | Nicholas Investment Partners#56 · 395,844 sh | 395,844 | $23.9M | 1.35% | +60.2% |
| 57 | MILLENNIUM MANAGEMENT#57 · 376,777 sh | 376,777 | $22.7M | <0.01% | +86.7% |
| 58 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AME#58 · 374,748 sh | 374,748 | $22.6M | <0.01% | -0.1% |
| 59 | BAKER BROS. ADVISORS#59 · 370,208 sh | 370,208 | $22.3M | 0.11% | 0.0% |
| 60 | Jones Hill Capital#60 · 367,900 sh | 367,900 | $22.2M | 4.72% | New |
| 61 | AMERIPRISE FINANCIAL#61 · 318,548 sh | 318,548 | $19.2M | <0.01% | +303.7% |
| 62 | Man Group plc#62 · 310,617 sh | 310,617 | $18.7M | 0.03% | New |
| 63 | ADAGE CAPITAL PARTNERS GP, L.L.C.#63 · 300,000 sh | 300,000 | $18.1M | 0.03% | -36.2% |
| 64 | Soleus Capital Management, L.P.#64 · 267,000 sh | 267,000 | $16.1M | 0.56% | -8.6% |
| 65 | Jump Financial#65 · 260,730 sh | 260,730 | $15.7M | 0.13% | +67.4% |
| 66 | DAFNA Capital Management#66 · 250,772 sh | 250,772 | $15.1M | 2.89% | 0.0% |
| 67 | CHARLES SCHWAB INVESTMENT MANAGEMENT#67 · 249,473 sh | 249,473 | $15.1M | <0.01% | +31.9% |
| 68 | STATE OF WISCONSIN INVESTMENT BOARD#68 · 248,821 sh | 248,821 | $15.0M | 0.03% | -2.2% |
| 69 | NAN FUNG TRINITY (HK) Ltd#69 · 247,765 sh | 247,765 | $15.0M | 1.48% | 0.0% |
| 70 | Duquesne Family Office#70 · 238,600 sh | 238,600 | $14.4M | 0.28% | 0.0% |
| 71 | Allspring Global Investments#71 · 234,412 sh | 234,412 | $14.1M | 0.02% | -4.8% |
| 72 | Redmile Group#72 · 229,374 sh | 229,374 | $13.8M | 0.93% | -12.7% |
| 73 | Schonfeld Strategic Advisors#73 · 227,330 sh | 227,330 | $13.7M | 0.05% | -30.0% |
| 74 | D. E. Shaw#74 · 223,922 sh | 223,922 | $13.5M | <0.01% | +1082.3% |
| 75 | Patient Square Capital#75 · 220,000 sh | 220,000 | $13.3M | 2.06% | -3.1% |
| 76 | NEW YORK STATE COMMON RETIREMENT FUND#76 · 210,471 sh | 210,471 | $12.7M | 0.02% | +11.7% |
| 77 | JENNISON ASSOCIATES#77 · 208,060 sh | 208,060 | $12.6M | <0.01% | -84.2% |
| 78 | Neuberger Berman Group#78 · 206,604 sh | 206,604 | $12.5M | <0.01% | +58.4% |
| 79 | Trexquant Investment#79 · 202,455 sh | 202,455 | $12.2M | 0.07% | +200.6% |
| 80 | DnB Asset Management AS#80 · 200,451 sh | 200,451 | $12.1M | 0.03% | +10.7% |
| 81 | Integral Health Asset Management#81 · 200,000 sh | 200,000 | $12.1M | 0.48% | 0.0% |
| 82 | Eversept Partners#82 · 196,532 sh | 196,532 | $11.9M | 0.62% | +51.7% |
| 83 | BALYASNY ASSET MANAGEMENT L.P.#83 · 193,407 sh | 193,407 | $11.7M | 0.01% | -17.3% |
| 84 | DEUTSCHE BANK AG\#84 · 191,126 sh | 191,126 | $11.5M | <0.01% | +17.5% |
| 85 | RENAISSANCE TECHNOLOGIES#85 · 187,110 sh | 187,110 | $11.3M | 0.02% | -37.7% |
| 86 | SILVERARC CAPITAL MANAGEMENT#86 · 186,821 sh | 186,821 | $11.3M | 1.17% | -5.5% |
| 87 | BOOTHBAY FUND MANAGEMENT#87 · 183,343 sh | 183,343 | $11.1M | 0.15% | -32.2% |
| 88 | NEXTBio Capital Management#88 · 183,225 sh | 183,225 | $11.1M | 5.09% | 0.0% |
| 89 | WELLS FARGO & COMPANY#89 · 173,945 sh | 173,945 | $10.5M | <0.01% | +50.4% |
| 90 | ADAR1 Capital Management#90 · 166,550 sh | 166,550 | $10.1M | 0.46% | -27.2% |
| 91 | PEREGRINE CAPITAL MANAGEMENT#91 · 164,894 sh | 164,894 | $10.0M | 0.32% | +15.2% |
| 92 | Swiss National Bank#92 · 162,700 sh | 162,700 | $9.8M | <0.01% | +3.2% |
| 93 | Foresite Capital Management IV#93 · 160,000 sh | 160,000 | $9.7M | 3.33% | 0.0% |
| 94 | Woodline Partners#94 · 155,302 sh | 155,302 | $9.4M | 0.03% | +3.3% |
| 95 | Russell Investments Group, Ltd.#95 · 153,227 sh | 153,227 | $9.2M | <0.01% | +18.4% |
| 96 | HSBC PLC#96 · 151,474 sh | 151,474 | $9.1M | <0.01% | +24.6% |
| 97 | Susquehanna Portfolio Strategies#97 · 133,059 sh | 133,059 | $8.0M | 0.13% | +620.5% |
| 98 | Point72 Asset Management, L.P.#98 · 130,378 sh | 130,378 | $7.9M | <0.01% | New |
| 99 | Granahan Investment Management#99 · 129,443 sh | 129,443 | $7.8M | 0.28% | +23.9% |
| 100 | KBC Group NV#100 · 129,010 sh | 129,010 | $7.8M | — | 0.0% |
Funds that sold out of XENE in Q2 2026 (22)
Held XENE at the end of Q1 2026 and filed a Q2 2026 13F without it. Not in the list above, because they no longer hold it. Largest prior position first.
| Institution | Shares sold | Value in Q1 2026 |
|---|---|---|
| Holocene Advisors1,518,686 sh | 1,518,686 | $88.3M |
| Commodore Capital825,000 sh | 825,000 | $48.0M |
| MPM BioImpact588,706 sh | 588,706 | $34.2M |
| Sofinnova Ventures305,216 sh | 305,216 | $17.7M |
| Y-Intercept (Hong Kong) Ltd85,388 sh | 85,388 | $5.0M |
| Atika Capital Management59,900 sh | 59,900 | $3.5M |
| LMR Partners LLP56,200 sh | 56,200 | $3.3M |
| Qube Research & Technologies Ltd44,044 sh | 44,044 | $2.6M |
| Calamos Advisors30,374 sh | 30,374 | $1.8M |
| SummitTX Capital, L.P.26,186 sh | 26,186 | $1.5M |
| SANDERS MORRIS HARRIS21,500 sh | 21,500 | $1.3M |
| Neo Ivy Capital Management13,710 sh | 13,710 | $797.2K |
| Covalis Capital LLP10,000 sh | 10,000 | $581.5K |
| Longaeva Partners L.P.6,250 sh | 6,250 | $363.4K |
| DRW Securities5,461 sh | 5,461 | $317.6K |
| SEEDS INVESTOR3,423 sh | 3,423 | $203.2K |
| JANE STREET GROUP3,468 sh | 3,468 | $201.7K |
| ACADIAN ASSET MANAGEMENT677 sh | 677 | $39.0K |
| MAI Capital Management392 sh | 392 | $22.8K |
| Root Financial Partners40 sh | 40 | $2.3K |
| Golden State Equity Partners35 sh | 35 | $2.0K |
| TWIN PEAKS WEALTH ADVISORS32 sh | 32 | $1.9K |
Source: Form 13F-HR filings on SEC EDGAR, Q2 2026. Values are as reported by each manager at quarter end. “% of portfolio” is the position’s share of the manager’s total reported 13F value for the same quarter. “New” means the manager filed a 13F for Q1 2026 without this position; a dash means no comparison is available. Where a manager’s own filing is internally inconsistent its value is withheld and it is listed last. 13F data shows reported holdings, not recommendations.