Taysha Gene Therapies, Inc. (TSHA) — Institutional Holders, Q2 2026
209 institutional investment managers reported a TSHA position on SEC Form 13F-HR for the quarter ended June 30, 2026, with a combined reported value of $2.1B. Every filer is listed below, ranked by position value, 100 per page; this page shows ranks 1 to 100. Put and call option positions are excluded, and a firm filing several lots or share classes is shown once with its total.
TSHA in Q2 2026: what funds did
Funds that filed a 13F for both Q1 2026 and Q2 2026, by what they did with the common stock. Share counts are adjusted for any split between the two quarters; dollar figures are the change in shares at this quarter’s price.
Biggest buyers
- MPM BioImpactNew · +4,500,000 sh+$30.6M
- WELLINGTON MANAGEMENT GROUP LLPAdded · +3,349,244 sh+$22.8M
- Pictet Asset Management Holding SANew · +2,770,701 sh+$18.9M
- BlackRockAdded · +2,326,319 sh+$15.8M
- FARALLON CAPITAL MANAGEMENTNew · +2,250,000 sh+$15.3M
Biggest sellers
- DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)Sold out · -2,722,165 sh-$18.5M
- SG Americas SecuritiesTrimmed · -1,974,482 sh-$13.4M
- MORGAN STANLEYTrimmed · -1,477,892 sh-$10.1M
- BARCLAYS PLCTrimmed · -1,181,351 sh-$8.0M
- MILLENNIUM MANAGEMENTTrimmed · -1,154,982 sh-$7.9M
TSHA 13F holders ranked 1–100 of 209
| # | Institution | Shares | Value | % of portfolio | QoQShares vs Q1 2026 |
|---|---|---|---|---|---|
| 1 | Avoro Capital Advisors#1 · 23,888,888 sh | 23,888,888 | $162.7M | 1.46% | +10.1% |
| 2 | RA CAPITAL MANAGEMENT, L.P.#2 · 23,555,648 sh | 23,555,648 | $160.4M | 1.39% | 0.0% |
| 3 | GOLDMAN SACHS GROUP#3 · 22,713,118 sh | 22,713,118 | $154.7M | 0.01% | +1.5% |
| 4 | BlackRock#4 · 20,691,927 sh | 20,691,927 | $140.9M | <0.01% | +12.7% |
| 5 | Vestal Point Capital#5 · 19,415,000 sh | 19,415,000 | $132.2M | 3.09% | +7.9% |
| 6 | MORGAN STANLEY#6 · 16,487,479 sh | 16,487,479 | $112.3M | <0.01% | -8.2% |
| 7 | RTW INVESTMENTS#7 · 13,560,258 sh | 13,560,258 | $92.3M | 0.79% | -0.9% |
| 8 | FMR#8 · 13,336,413 sh | 13,336,413 | $90.8M | <0.01% | -6.9% |
| 9 | VANGUARD CAPITAL MANAGEMENT#9 · 12,478,595 sh | 12,478,595 | $85.0M | <0.01% | +22.0% |
| 10 | STATE STREET#10 · 11,421,920 sh | 11,421,920 | $77.8M | <0.01% | +1.9% |
| 11 | Siren, L.L.C.#11 · 9,846,579 sh | 9,846,579 | $67.1M | 1.36% | +11.5% |
| 12 | Octagon Capital Advisors#12 · 9,693,244 sh | 9,693,244 | $66.0M | 5.93% | +9.4% |
| 13 | GEODE CAPITAL MANAGEMENT#13 · 6,560,394 sh | 6,560,394 | $44.7M | <0.01% | +18.6% |
| 14 | Polar Capital Plc#14 · 5,117,133 sh | 5,117,133 | $34.8M | 0.08% | -9.5% |
| 15 | MPM BioImpact#15 · 4,500,000 sh | 4,500,000 | $30.6M | 1.87% | New |
| 16 | D. E. Shaw#16 · 4,398,652 sh | 4,398,652 | $30.0M | 0.01% | -0.6% |
| 17 | BAKER BROS. ADVISORS#17 · 4,004,756 sh | 4,004,756 | $27.3M | 0.14% | 0.0% |
| 18 | WELLINGTON MANAGEMENT GROUP LLP#18 · 3,975,605 sh | 3,975,605 | $27.1M | <0.01% | +534.7% |
| 19 | HEALTHCARE OF ONTARIO PENSION PLAN FUND#19 · 3,885,501 sh | 3,885,501 | $26.5M | 0.04% | +34.8% |
| 20 | GordonMD Global Investments#20 · 723,185 sh | 723,185 | $24.5M | 11.86% | -1.9% |
| 21 | Casdin Capital#21 · 3,250,000 sh | 3,250,000 | $22.1M | 1.11% | 0.0% |
| 22 | VANGUARD PORTFOLIO MANAGEMENT#22 · 3,140,009 sh | 3,140,009 | $21.4M | <0.01% | +55.3% |
| 23 | ADAR1 Capital Management#23 · 3,040,466 sh | 3,040,466 | $20.7M | 0.95% | +2.0% |
| 24 | Pictet Asset Management Holding SA#24 · 2,770,701 sh | 2,770,701 | $18.9M | 0.02% | New |
| 25 | abrdn plc#25 · 2,327,152 sh | 2,327,152 | $15.8M | 0.02% | +127.9% |
| 26 | FARALLON CAPITAL MANAGEMENT#26 · 2,250,000 sh | 2,250,000 | $15.3M | 0.07% | New |
| 27 | NORGES BANK#27 · 2,233,600 sh | 2,233,600 | $15.2M | <0.01% | — |
| 28 | NORTHERN#28 · 2,226,210 sh | 2,226,210 | $15.2M | <0.01% | +22.7% |
| 29 | CHARLES SCHWAB INVESTMENT MANAGEMENT#29 · 2,200,695 sh | 2,200,695 | $15.0M | <0.01% | +21.7% |
| 30 | MILLENNIUM MANAGEMENT#30 · 2,126,838 sh | 2,126,838 | $14.5M | <0.01% | -35.2% |
| 31 | ORBIMED ADVISORS#31 · 2,000,000 sh | 2,000,000 | $13.6M | 0.25% | New |
| 32 | RICE HALL JAMES & ASSOCIATES#32 · 1,992,229 sh | 1,992,229 | $13.6M | 0.66% | +2.4% |
| 33 | VANGUARD FIDUCIARY#33 · 1,896,474 sh | 1,896,474 | $12.9M | <0.01% | +23.9% |
| 34 | B Group#34 · 1,800,556 sh | 1,800,556 | $12.3M | 5.76% | 0.0% |
| 35 | Affinity Asset Advisors#35 · 1,750,000 sh | 1,750,000 | $11.9M | 0.54% | +75.0% |
| 36 | BARCLAYS PLC#36 · 1,630,659 sh | 1,630,659 | $11.1M | <0.01% | -42.0% |
| 37 | CITADEL ADVISORS#37 · 1,535,287 sh | 1,535,287 | $10.5M | <0.01% | +273.4% |
| 38 | HEIGHTS CAPITAL MANAGEMENT#38 · 1,500,000 sh | 1,500,000 | $10.2M | 2.36% | New |
| 39 | Seven Fleet Capital Management#39 · 1,504,400 sh | 1,504,400 | $9.9M | 1.64% | +140.4% |
| 40 | Palo Alto Investors#40 · 1,391,382 sh | 1,391,382 | $9.5M | 1.31% | 0.0% |
| 41 | BANK OF AMERICA#41 · 1,372,845 sh | 1,372,845 | $9.3M | <0.01% | -18.1% |
| 42 | Granahan Investment Management#42 · 1,305,177 sh | 1,305,177 | $8.9M | 0.32% | +47.8% |
| 43 | Quantum Private Wealth#43 · 812,027 sh | 812,027 | $5.5M | — | -4.4% |
| 44 | FIRST ADVISORS#44 · 791,169 sh | 791,169 | $5.4M | <0.01% | New |
| 45 | JPMORGAN CHASE#45 · 766,282 sh | 766,282 | $5.2M | <0.01% | +1.5% |
| 46 | Sands Capital Ventures#46 · 724,873 sh | 724,873 | $4.9M | 0.80% | 0.0% |
| 47 | Bank of New York Mellon#47 · 697,971 sh | 697,971 | $4.8M | <0.01% | +14.8% |
| 48 | BNP PARIBAS FINANCIAL MARKETS#48 · 640,035 sh | 640,035 | $4.4M | <0.01% | +432.5% |
| 49 | PANAGORA ASSET MANAGEMENT#49 · 590,387 sh | 590,387 | $4.0M | 0.01% | +224.1% |
| 50 | UBS Group AG#50 · 588,427 sh | 588,427 | $4.0M | <0.01% | +13.7% |
| 51 | AFFINITY WEALTH MANAGEMENT#51 · 576,808 sh | 576,808 | $3.9M | 0.51% | New |
| 52 | Squarepoint Ops#52 · 569,269 sh | 569,269 | $3.9M | <0.01% | +38.8% |
| 53 | ACUTA CAPITAL PARTNERS#53 · 561,808 sh | 561,808 | $3.8M | 2.67% | +27.8% |
| 54 | Nuveen#54 · 555,693 sh | 555,693 | $3.8M | <0.01% | +1.2% |
| 55 | ADAGE CAPITAL PARTNERS GP, L.L.C.#55 · 553,000 sh | 553,000 | $3.8M | <0.01% | New |
| 56 | DIADEMA PARTNERS#56 · 522,619 sh | 522,619 | $3.6M | 0.45% | New |
| 57 | Hennion & Walsh Asset Management#57 · 519,120 sh | 519,120 | $3.5M | — | +32.6% |
| 58 | Woodline Partners#58 · 513,828 sh | 513,828 | $3.5M | 0.01% | 0.0% |
| 59 | Holocene Advisors#59 · 510,000 sh | 510,000 | $3.5M | <0.01% | New |
| 60 | Ghisallo Capital Management#60 · 505,000 sh | 505,000 | $3.4M | 0.07% | New |
| 61 | Burkehill Global Management#61 · 500,000 sh | 500,000 | $3.4M | 0.12% | New |
| 62 | POLEN CAPITAL MANAGEMENT#62 · 489,219 sh | 489,219 | $3.3M | 0.03% | +53.0% |
| 63 | DIMENSIONAL FUND ADVISORS#63 · 464,771 sh | 464,771 | $3.2M | <0.01% | -5.2% |
| 64 | VOYA INVESTMENT MANAGEMENT#64 · 425,363 sh | 425,363 | $2.9M | <0.01% | -16.9% |
| 65 | Trexquant Investment#65 · 379,577 sh | 379,577 | $2.6M | 0.02% | New |
| 66 | Swiss National Bank#66 · 369,000 sh | 369,000 | $2.5M | <0.01% | +37.3% |
| 67 | MOORE CAPITAL MANAGEMENT#67 · 358,374 sh | 358,374 | $2.4M | 0.04% | +9.0% |
| 68 | WELLS FARGO & COMPANY#68 · 333,314 sh | 333,314 | $2.3M | <0.01% | +81.8% |
| 69 | LEUCADIA NATIONAL#69 · 328,800 sh | 328,800 | $2.2M | 0.01% | -31.4% |
| 70 | CITIGROUP#70 · 306,907 sh | 306,907 | $2.1M | <0.01% | +437.7% |
| 71 | RHUMBLINE ADVISERS#71 · 299,975 sh | 299,975 | $2.0M | <0.01% | +16.0% |
| 72 | ALPS ADVISORS#72 · 290,543 sh | 290,543 | $2.0M | <0.01% | +30.3% |
| 73 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AME#73 · 272,600 sh | 272,600 | $1.9M | <0.01% | +2.6% |
| 74 | Invesco Ltd.#74 · 264,379 sh | 264,379 | $1.8M | <0.01% | -28.2% |
| 75 | Ensign Peak Advisors#75 · 262,896 sh | 262,896 | $1.8M | <0.01% | -4.4% |
| 76 | Qube Research & Technologies Ltd#76 · 259,605 sh | 259,605 | $1.8M | <0.01% | New |
| 77 | SPHERA FUNDS MANAGEMENT LTD.#77 · 250,000 sh | 250,000 | $1.7M | 0.22% | New |
| 78 | DEUTSCHE BANK AG\#78 · 243,379 sh | 243,379 | $1.7M | <0.01% | +33.9% |
| 79 | TWO SIGMA INVESTMENTS#79 · 234,716 sh | 234,716 | $1.6M | <0.01% | -68.4% |
| 80 | JANE STREET GROUP#80 · 228,355 sh | 228,355 | $1.6M | <0.01% | New |
| 81 | SG Americas Securities#81 · 202,260 sh | 202,260 | $1.4M | <0.01% | -90.7% |
| 82 | Monashee Investment Management#82 · 200,000 sh | 200,000 | $1.4M | 2.29% | New |
| 83 | PRICE T ROWE ASSOCIATES#83 · 199,494 sh | 199,494 | $1.4M | <0.01% | +25.5% |
| 84 | Privium Fund Management B.V.#84 · 198,900 sh | 198,900 | $1.4M | 0.25% | +9.3% |
| 85 | VICTORY CAPITAL MANAGEMENT#85 · 197,578 sh | 197,578 | $1.3M | <0.01% | +0.9% |
| 86 | Chicago Partners Investment Group#86 · 222,347 sh | 222,347 | $1.3M | — | +30.2% |
| 87 | BALYASNY ASSET MANAGEMENT L.P.#87 · 189,332 sh | 189,332 | $1.3M | <0.01% | +128.1% |
| 88 | STATE OF WISCONSIN INVESTMENT BOARD#88 · 177,089 sh | 177,089 | $1.2M | <0.01% | -32.8% |
| 89 | RAYMOND JAMES FINANCIAL#89 · 166,042 sh | 166,042 | $1.1M | <0.01% | +653.7% |
| 90 | ALLIANCEBERNSTEIN L.P.#90 · 247,680 sh | 247,680 | $1.1M | <0.01% | +30.9% |
| 91 | WEXFORD CAPITAL#91 · 160,654 sh | 160,654 | $1.1M | 0.14% | 0.0% |
| 92 | Rafferty Asset Management#92 · 154,706 sh | 154,706 | $1.1M | <0.01% | -48.4% |
| 93 | Palumbo Wealth Management#93 · 149,173 sh | 149,173 | $1.0M | 0.21% | +1.7% |
| 94 | MetLife Investment Management#94 · 140,846 sh | 140,846 | $959.2K | <0.01% | +17.3% |
| 95 | Vanguard Global Advisers#95 · 133,821 sh | 133,821 | $911.3K | <0.01% | +14.7% |
| 96 | Persistent Asset Partners Ltd#96 · 133,411 sh | 133,411 | $908.5K | 0.27% | New |
| 97 | VANGUARD ASSET MANAGEMENT, Ltd#97 · 132,614 sh | 132,614 | $903.1K | <0.01% | +46.6% |
| 98 | AQR CAPITAL MANAGEMENT#98 · 128,764 sh | 128,764 | $876.9K | <0.01% | -27.4% |
| 99 | MIRAE ASSET GLOBAL ETFS Ltd.#99 · 127,915 sh | 127,915 | $869.7K | <0.01% | +2.6% |
| 100 | Mariner#100 · 116,582 sh | 116,582 | $793.9K | <0.01% | New |
Funds that sold out of TSHA in Q2 2026 (22)
Held TSHA at the end of Q1 2026 and filed a Q2 2026 13F without it. Not in the list above, because they no longer hold it. Largest prior position first.
| Institution | Shares sold | Value in Q1 2026 |
|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)2,722,165 sh | 2,722,165 | $12.2M |
| Point72 Asset Management, L.P.461,856 sh | 461,856 | $2.1M |
| RENAISSANCE TECHNOLOGIES413,203 sh | 413,203 | $1.8M |
| SUPERSTRING CAPITAL MANAGEMENT258,269 sh | 258,269 | $1.2M |
| TUDOR INVESTMENT ET AL143,575 sh | 143,575 | $641.8K |
| VARCOV58,511 sh | 58,511 | $261.5K |
| Abacus Wealth Partners58,241 sh | 58,241 | $260.3K |
| Legato Capital Management21,782 sh | 21,782 | $97.4K |
| Scientech Research21,040 sh | 21,040 | $94.0K |
| Catalyst Funds Management Pty Ltd15,100 sh | 15,100 | $67.5K |
| Virtu Financial13,346 sh | 13,346 | $60.0K |
| Allegheny Financial Group LTD12,000 sh | 12,000 | $53.6K |
| CIBC Asset Management11,959 sh | 11,959 | $53.5K |
| Y-Intercept (Hong Kong) Ltd11,486 sh | 11,486 | $51.3K |
| R Squared Ltd11,276 sh | 11,276 | $50.4K |
| Hudson Bay Capital Management10,740 sh | 10,740 | $48.0K |
| Quantbot Technologies524 sh | 524 | $2.3K |
| Sound Income Strategies325 sh | 325 | $1.4K |
| Root Financial Partners72 sh | 72 | $322.00 |
| MAI Capital Management13 sh | 13 | $59.00 |
| ASSETMARK8 sh | 8 | $36.00 |
| Ameritas Advisory Services1 sh | 1 | $4.00 |
Source: Form 13F-HR filings on SEC EDGAR, Q2 2026. Values are as reported by each manager at quarter end. “% of portfolio” is the position’s share of the manager’s total reported 13F value for the same quarter. “New” means the manager filed a 13F for Q1 2026 without this position; a dash means no comparison is available. Where a manager’s own filing is internally inconsistent its value is withheld and it is listed last. 13F data shows reported holdings, not recommendations.