IONIS PHARMACEUTICALS INC (IONS) — Institutional Holders, Q2 2026

533 institutional investment managers reported a IONS position on SEC Form 13F-HR for the quarter ended June 30, 2026, with a combined reported value of $15.2B. Every filer is listed below, ranked by position value, 100 per page; this page shows ranks 1 to 100. Put and call option positions are excluded, and a firm filing several lots or share classes is shown once with its total.

← IONS stock profile

IONS in Q2 2026: what funds did

Funds that filed a 13F for both Q1 2026 and Q2 2026, by what they did with the common stock. Share counts are adjusted for any split between the two quarters; dollar figures are the change in shares at this quarter’s price.

New positions

Added to

199

Trimmed

160

Sold out

Biggest buyers

ROYAL BANK OF CANADAAdded · +2,380,664 sh+$188.8M
BARCLAYS PLCAdded · +1,313,262 sh+$104.1M
WELLINGTON MANAGEMENT GROUP LLPAdded · +1,259,599 sh+$99.9M
Alyeska Investment Group, L.P.Added · +944,766 sh+$74.9M
Capital International InvestorsNew · +823,764 sh+$65.3M

Biggest sellers

T. Rowe Price Investment ManagementTrimmed · -2,199,655 sh-$174.4M
Bellevue Group AGTrimmed · -846,407 sh-$67.1M
MILLENNIUM MANAGEMENTTrimmed · -762,634 sh-$60.5M
CITADEL ADVISORSTrimmed · -706,250 sh-$56.0M
SUMMIT PARTNERS PUBLIC ASSET MANAGEMENTTrimmed · -616,770 sh-$48.9M

IONS 13F holders ranked 1–100 of 533

Institutional investors reporting a position in IONIS PHARMACEUTICALS INC on SEC Form 13F-HR for Q2 2026, ranked by reported value.
#	Institution	Shares	Value	% of portfolio	QoQShares vs Q1 2026
1	FMR#1 · 31,635,956 sh	31,635,956	$2.0B	0.09%	+0.3%
2	Capital World Investors#2 · 21,669,226 sh	21,669,226	$1.7B	0.20%	+2.3%
3	BlackRock#3 · 22,129,660 sh	22,129,660	$866.5M	0.01%	-25.3%
4	WELLINGTON MANAGEMENT GROUP LLP#4 · 19,218,415 sh	19,218,415	$624.6M	0.11%	-5.1%
5	VANGUARD PORTFOLIO MANAGEMENT#5 · 7,859,529 sh	7,859,529	$623.2M	0.03%	+0.6%
6	VANGUARD CAPITAL MANAGEMENT#6 · 7,211,497 sh	7,211,497	$571.8M	0.01%	+1.3%
7	TWO SIGMA INVESTMENTS#7 · 6,252,342 sh	6,252,342	$495.7M	0.36%	+6.7%
8	ROYAL BANK OF CANADA#8 · 6,282,479 sh	6,282,479	$490.4M	0.07%	+5.4%
9	STATE STREET#9 · 19,359,848 sh	19,359,848	$367.1M	0.01%	+21.8%
10	T. Rowe Price Investment Management#10 · 3,959,372 sh	3,959,372	$313.9M	0.21%	-35.7%
11	GEODE CAPITAL MANAGEMENT#11 · 3,584,024 sh	3,584,024	$294.8M	0.02%	-10.0%
12	PRICE T ROWE ASSOCIATES#12 · 3,184,500 sh	3,184,500	$252.5M	0.03%	+5.3%
13	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)#13 · 61,979,669 sh	61,979,669	$250.1M	2.61%	0.0%
14	JPMORGAN CHASE#14 · 3,224,717 sh	3,224,717	$217.1M	0.01%	-58.0%
15	Artisan Partners Limited Partnership#15 · 2,640,024 sh	2,640,024	$209.3M	0.33%	+28.3%
16	Tweedy, Browne#16 · 2,280,311 sh	2,280,311	$180.8M	13.70%	+0.2%
17	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AME#17 · 42,554,672 sh	42,554,672	$179.2M	0.03%	+2783.8%
18	Deep Track Capital#18 · 2,200,000 sh	2,200,000	$174.4M	2.54%	+12.8%
19	GOLDMAN SACHS GROUP#19 · 2,109,945 sh	2,109,945	$167.3M	0.01%	-49.3%
20	BAKER BROS. ADVISORS#20 · 2,047,727 sh	2,047,727	$162.4M	0.81%	0.0%
21	AMERICAN CENTURY COMPANIES#21 · 1,947,076 sh	1,947,076	$154.4M	0.07%	+17.0%
22	CITADEL ADVISORS#22 · 86,703,284 sh	86,703,284	$153.5M	0.02%	+47.1%
23	TENOR CAPITAL MANAGEMENT , L.P.#23 · 94,682,000 sh	94,682,000	$147.8M	2.08%	+336.1%
24	FRANKLIN RESOURCES#24 · 1,623,377 sh	1,623,377	$128.7M	0.03%	+3.1%
25	BARCLAYS PLC#25 · 1,849,136 sh	1,849,136	$127.5M	0.02%	+0.1%
26	CHARLES SCHWAB INVESTMENT MANAGEMENT#26 · 1,605,054 sh	1,605,054	$127.3M	0.02%	+1.4%
27	Pictet Asset Management Holding SA#27 · 1,596,998 sh	1,596,998	$127.0M	0.12%	+11.3%
28	VOYA INVESTMENT MANAGEMENT#28 · 76,721,303 sh	76,721,303	$124.7M	0.11%	-10.1%
29	Polar Capital Plc#29 · 1,454,021 sh	1,454,021	$115.3M	0.27%	+75.3%
30	Alyeska Investment Group, L.P.#30 · 1,417,916 sh	1,417,916	$112.4M	0.29%	+199.7%
31	NOMURA ASSET MANAGEMENT INTERNATIONAL#31 · 1,300,392 sh	1,300,392	$103.1M	0.15%	+65.6%
32	MORGAN STANLEY#32 · 1,281,444 sh	1,281,444	$101.6M	<0.01%	+14.4%
33	DLD Asset Management#33 · 60,000,000 sh	60,000,000	$93.7M	6.19%	+9.1%
34	Invesco Ltd.#34 · 1,120,707 sh	1,120,707	$88.9M	<0.01%	-12.3%
35	VANGUARD FIDUCIARY#35 · 1,060,845 sh	1,060,845	$84.1M	0.02%	+3.6%
36	Bellevue Group AG#36 · 972,258 sh	972,258	$77.1M	1.62%	-46.5%
37	GROUPAMA ASSET MANAGMENT#37 · 937,083 sh	937,083	$75.2M	0.95%	+13.6%
38	NORTHERN#38 · 913,610 sh	913,610	$72.4M	<0.01%	+5.2%
39	Capital International Investors#39 · 823,764 sh	823,764	$65.3M	0.01%	New
40	LMR Partners LLP#40 · 40,030,800 sh	40,030,800	$64.5M	0.24%	+7.3%
41	Davern Capital Partners#41 · 798,709 sh	798,709	$63.3M	10.80%	+106.4%
42	BNP Paribas Asset Management Holding S.A.#42 · 3,869,219 sh	3,869,219	$63.1M	0.06%	-4.3%
43	BANK OF AMERICA#43 · 790,990 sh	790,990	$62.7M	<0.01%	-56.6%
44	SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT#44 · 787,263 sh	787,263	$62.4M	1.10%	-43.9%
45	GW&K Investment Management#45 · 746,966 sh	746,966	$59.2M	0.46%	-4.2%
46	Nuveen#46 · 726,282 sh	726,282	$57.6M	0.01%	+12.0%
47	Connor, Clark & Lunn Investment Management Ltd.#47 · 684,236 sh	684,236	$54.3M	0.10%	-21.7%
48	Eversept Partners#48 · 664,684 sh	664,684	$52.7M	2.73%	+5.2%
49	VOLORIDGE INVESTMENT MANAGEMENT#49 · 655,454 sh	655,454	$52.0M	0.22%	-2.6%
50	MASSACHUSETTS FINANCIAL SERVICES#50 · 651,816 sh	651,816	$51.7M	0.02%	-2.1%
51	Neuberger Berman Group#51 · 633,533 sh	633,533	$50.2M	0.03%	+42.9%
52	ARROWSTREET CAPITAL, LIMITED PARTNERSHIP#52 · 632,028 sh	632,028	$50.1M	0.02%	-14.3%
53	UBS Group AG#53 · 756,874 sh	756,874	$49.8M	<0.01%	-18.5%
54	TimesSquare Capital Management#54 · 614,070 sh	614,070	$48.7M	0.72%	+122.8%
55	EVENTIDE ASSET MANAGEMENT#55 · 575,000 sh	575,000	$45.6M	0.61%	0.0%
56	PERCEPTIVE ADVISORS#56 · 566,000 sh	566,000	$44.9M	0.67%	+12.3%
57	RENAISSANCE TECHNOLOGIES#57 · 559,414 sh	559,414	$44.4M	0.06%	+83.1%
58	Bank of New York Mellon#58 · 542,454 sh	542,454	$43.0M	<0.01%	+5.4%
59	TEACHER RETIREMENT SYSTEM OF TEXAS#59 · 522,317 sh	522,317	$41.4M	0.11%	-0.3%
60	BOONE CAPITAL MANAGEMENT#60 · 519,977 sh	519,977	$41.2M	9.64%	+3.9%
61	JANE STREET GROUP#61 · 503,647 sh	503,647	$39.9M	<0.01%	+162.6%
62	NEW YORK STATE COMMON RETIREMENT FUND#62 · 500,050 sh	500,050	$39.6M	0.05%	+42.7%
63	BNP PARIBAS FINANCIAL MARKETS#63 · 471,649 sh	471,649	$36.1M	0.01%	-93.4%
64	Candriam S.C.A.#64 · 445,019 sh	445,019	$35.3M	0.16%	-8.1%
65	NOMURA#65 · 438,169 sh	438,169	$34.7M	0.04%	+120.0%
66	FIRST ADVISORS#66 · 427,197 sh	427,197	$33.9M	0.02%	-8.8%
67	PINNACLE ASSOCIATES LTD#67 · 419,752 sh	419,752	$33.3M	—	-3.8%
68	Handelsbanken Fonder AB#68 · 383,211 sh	383,211	$30.4M	0.09%	+79.1%
69	C WorldWide Group Holding A/S#69 · 366,000 sh	366,000	$29.0M	0.70%	0.0%
70	BALYASNY ASSET MANAGEMENT L.P.#70 · 17,500,000 sh	17,500,000	$27.2M	0.03%	-50.0%
71	TD ASSET MANAGEMENT#71 · 340,548 sh	340,548	$27.0M	0.02%	-35.7%
72	Freestone Grove Partners#72 · 339,967 sh	339,967	$27.0M	0.17%	New
73	Qube Research & Technologies Ltd#73 · 333,952 sh	333,952	$26.5M	0.02%	+679.2%
74	Capital Research Global Investors#74 · 331,936 sh	331,936	$26.3M	<0.01%	+2.8%
75	CAPITAL FUND MANAGEMENT S.A.#75 · 329,554 sh	329,554	$26.1M	0.12%	+131.8%
76	ALLIANCEBERNSTEIN L.P.#76 · 340,450 sh	340,450	$25.6M	<0.01%	-15.0%
77	Carmignac Gestion#77 · 321,000 sh	321,000	$25.5M	0.33%	+505.7%
78	Privium Fund Management B.V.#78 · 319,924 sh	319,924	$25.4M	4.66%	+10.3%
79	Swiss National Bank#79 · 315,000 sh	315,000	$25.0M	0.01%	+3.4%
80	Jump Financial#80 · 306,330 sh	306,330	$24.3M	0.20%	+48.2%
81	ARK Investment Management#81 · 300,770 sh	300,770	$23.8M	0.15%	+4.2%
82	Universal- Beteiligungs- und Servicegesellschaft mbH#82 · 3,607,499 sh	3,607,499	$23.8M	0.04%	-26.3%
83	Legal & General Group Plc#83 · 299,184 sh	299,184	$23.7M	<0.01%	+1.5%
84	D. E. Shaw#84 · 297,041 sh	297,041	$23.6M	0.01%	-30.9%
85	MILLENNIUM MANAGEMENT#85 · 288,872 sh	288,872	$22.9M	<0.01%	-72.5%
86	DAVENPORT#86 · 283,960 sh	283,960	$22.5M	—	+19.2%
87	abrdn plc#87 · 277,400 sh	277,400	$22.0M	0.03%	+143.7%
88	CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM#88 · 270,843 sh	270,843	$21.5M	0.01%	+6.0%
89	TOCQUEVILLE ASSET MANAGEMENT L.P.#89 · 251,215 sh	251,215	$19.9M	0.26%	+14.6%
90	Focus Partners Wealth#90 · 5,323,917 sh	5,323,917	$19.8M	0.02%	-2.2%
91	WELLS FARGO & COMPANY#91 · 861,213 sh	861,213	$18.9M	<0.01%	-83.3%
92	RAYMOND JAMES FINANCIAL#92 · 237,348 sh	237,348	$18.8M	<0.01%	+0.9%
93	Empowered Funds#93 · 223,142 sh	223,142	$17.7M	0.09%	+116.3%
94	Orion Investment#94 · 220,335 sh	220,335	$17.5M	5.10%	-2.1%
95	Life Cycle Investment Partners Ltd#95 · 219,896 sh	219,896	$17.4M	0.08%	New
96	ALGERT GLOBAL#96 · 206,853 sh	206,853	$16.4M	0.19%	+77.5%
97	STIFEL FINANCIAL#97 · 202,983 sh	202,983	$16.1M	0.01%	+3.2%
98	Corient Private Wealth#98 · 196,661 sh	196,661	$15.6M	0.02%	0.0%
99	Eagle Health Investments#99 · 194,577 sh	194,577	$15.4M	2.56%	New
100	HSBC PLC#100 · 188,402 sh	188,402	$15.0M	<0.01%	+1.3%

Funds that sold out of IONS in Q2 2026 (45)

Held IONS at the end of Q1 2026 and filed a Q2 2026 13F without it. Not in the list above, because they no longer hold it. Largest prior position first.

Institutions that held IONS in Q1 2026 and reported no position in Q2 2026.
Institution	Shares sold	Value in Q1 2026
Zurich Insurance Group Ltd239,645 sh	239,645	$18.0M
Ikarian Capital127,038 sh	127,038	$9.5M
Integral Health Asset Management125,000 sh	125,000	$9.4M
WINTON GROUP Ltd106,532 sh	106,532	$8.0M
Lisanti Capital Growth75,699 sh	75,699	$5.7M
TUDOR INVESTMENT ET AL48,244 sh	48,244	$3.6M
PRELUDE CAPITAL MANAGEMENT29,658 sh	29,658	$2.2M
StemPoint Capital26,385 sh	26,385	$2.0M
FLORIDA FINANCIAL ADVISORS25,886 sh	25,886	$1.9M
Informed Momentum20,608 sh	20,608	$1.5M
READYSTATE ASSET MANAGEMENT20,436 sh	20,436	$1.5M
LANDSCAPE CAPITAL MANAGEMENT, L.L.C.20,146 sh	20,146	$1.5M
Legato Capital Management19,840 sh	19,840	$1.5M
HIGHLAND CAPITAL MANAGEMENT12,819 sh	12,819	$962.6K
Capstone Capital Management Ltd21,447 sh	21,447	$832.4K
AIGEN INVESTMENT MANAGEMENT8,790 sh	8,790	$660.0K
Ground Swell Capital7,285 sh	7,285	$547.0K
PRINCIPAL FINANCIAL GROUP7,019 sh	7,019	$527.1K
Cynosure Management5,614 sh	5,614	$421.6K
Virtu Financial5,342 sh	5,342	$401.0K
Lighthouse Investment Partners4,970 sh	4,970	$373.2K
FARALLON CAPITAL MANAGEMENT4,800 sh	4,800	$360.4K
Vise Technologies4,305 sh	4,305	$340.6K
Inspire Advisors4,120 sh	4,120	$309.4K
Optas4,034 sh	4,034	$302.9K
CONGRESS ASSET MANAGEMENT3,946 sh	3,946	$296.3K
EntryPoint Capital2,963 sh	2,963	$222.5K
Fideuram Asset Management (Ireland) dac2,213 sh	2,213	$181.6K
Advisors Asset Management1,878 sh	1,878	$141.0K
QUADRANT CAPITAL GROUP1,232 sh	1,232	$95.2K
STEPHENS26,761 sh	26,761	$91.4K
MAI Capital Management940 sh	940	$70.6K
Root Financial Partners681 sh	681	$51.1K
Advisory Services Network604 sh	604	$45.4K
Bayforest Capital Ltd413 sh	413	$31.0K
Destiny Wealth Partners375 sh	375	$28.2K
Employees Retirement System of Texas378 sh	378	$28.0K
Sound Income Strategies300 sh	300	$22.5K
TWIN PEAKS WEALTH ADVISORS215 sh	215	$16.1K
Wealth Preservation Advisors150 sh	150	$11.3K
CLEAR INVESTMENT RESEARCH71 sh	71	$5.3K
Crewe Advisors48 sh	48	$3.6K
Aspect Partners20 sh	20	$1.5K
Dunhill Financial2 sh	2	$201.00
Elequin Securities208 sh	208	—

Source: Form 13F-HR filings on SEC EDGAR, Q2 2026. Values are as reported by each manager at quarter end. “% of portfolio” is the position’s share of the manager’s total reported 13F value for the same quarter. “New” means the manager filed a 13F for Q1 2026 without this position; a dash means no comparison is available. Where a manager’s own filing is internally inconsistent its value is withheld and it is listed last. 13F data shows reported holdings, not recommendations.