IONIS PHARMACEUTICALS INC(IONS)— Stock Profile, AI Score & Financials

Healthcare · Nasdaq · AI-powered stock analysis, 32-signal quality score, SEC EDGAR financials, and institutional holdings. Updated .

IONIS PHARMACEUTICALS INC (IONS) stock profile, AI quality score, and SEC EDGAR financial data, a Healthcare sector company. 13F Pro's AI-powered ranking engine scores IONS at 23.4/100 on a 32-signal composite quality model, placing it at rank #2,720 of 2,961 stocks — the bottom half of the AI-ranked universe. Areas of concern include free cash flow (8.2) and profitability (9.0), which score below median versus the broader universe. Shareholder dilution risk is elevated at 12.3/100, reflecting ongoing share issuance or stock-based compensation. Based on the latest XBRL financial filings (Q2 2026), IONIS PHARMACEUTICALS INC reports quarterly revenue of $267.9M, net income of $-114.6M, an operating margin of -38.2%. Top institutional holders of IONS by reported 13-F value include FMR, Capital World Investors, BlackRock, based on the most recent SEC filings. IONS trades on the Nasdaq exchange and files with the SEC under CIK 874015. 13F Pro's AI research platform runs 10 specialized AI analysts — value, growth, momentum, macro, and activist specialists — that debate IONS daily and publish AI-generated analysis with cited SEC sources. The platform aggregates historical XBRL financial facts, 10-Q and 10-K filings, insider Form 4 transactions, and institutional 13-F holdings for IONIS PHARMACEUTICALS INC directly from SEC EDGAR.

AI Quality Score

23.4/100

AI Rank

#2,720

Revenue

$267.9M

Net Income

$-114.6M

Free Cash Flow

$549.5M

Operating Margin

-38.2%

IONS key financials by period

IONIS PHARMACEUTICALS INC reported revenue, net income and margins by fiscal period, from SEC filings.
PeriodFormRevenueNet incomeOperating margin
FY 202510-K$943.7M$-381.4M-40.5%
FY 202410-K$705.1M$-453.9M-67.4%
FY 202310-K$787.6M$-366.3M-44.9%
FY 202210-K$587.4M$-269.7M-69.8%
FY 202110-K$810.5M$-28.6M-3.7%
FY 202010-K$729.3M$-444.3M-23.6%

Institutions holding IONS

Institutional investors reporting a position in IONIS PHARMACEUTICALS INC on SEC Form 13F.
InstitutionSharesValueReported
FMR24,631,956$2.0B2026-06-30
Capital World Investors21,669,226$1.7B2026-06-30
BlackRock10,704,660$848.8M2026-06-30
VANGUARD PORTFOLIO MANAGEMENT7,859,529$623.2M2026-06-30
WELLINGTON MANAGEMENT GROUP LLP7,651,415$606.7M2026-06-30
VANGUARD CAPITAL MANAGEMENT7,211,497$571.8M2026-06-30
TWO SIGMA INVESTMENTS6,252,342$495.7M2026-06-30
ROYAL BANK OF CANADA6,182,479$490.2M2026-06-30
STATE STREET4,334,848$343.7M2026-06-30
T. Rowe Price Investment Management3,959,372$313.9M2026-06-30
IONS

IONIS PHARMACEUTICALS INC

IONS
NasdaqMid CapHealthcare

13F Pro Quality Score

23.4/100

Rank #2,720 of 2,961 stocks

View Healthcare peers →

Rankings refresh quarterly once 80% of peers have filed (~45 days after quarter-end). Next update: ~Nov 14, 2026.

Revenue Growth

37.3/100

Profitability

9.0/100

Balance Sheet

11.6/100

Earnings Quality

14.9/100

Free Cash Flow

8.2/100

Institutional Flow

46.8/100

Revenue Scale

47.9/100

Dilution Risk

12.3/100

Price Chart

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Key Metrics

Revenue

Q2 2026
EDGAR

$267.95M

Net Income

Q2 2026
EDGAR

$-114.65M

EPS (Diluted)

Q2 2026
EDGAR

$-0.69

Operating Margin

Q2 2026
EDGAR

-38.2%

Free Cash Flow

Q2 2026
EDGAR

$549.45M

Top Institutional Holders

as of Q2 2026
$15.81B total

Financial Trends

Revenue & Net Income

Earnings Per Share

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