Structure Therapeutics Inc. (GPCR) — Institutional Holders, Q2 2026
193 institutional investment managers reported a GPCR position on SEC Form 13F-HR for the quarter ended June 30, 2026, with a combined reported value of $3.6B. Every filer is listed below, ranked by position value, 100 per page; this page shows ranks 1 to 100. Put and call option positions are excluded, and a firm filing several lots or share classes is shown once with its total.
GPCR in Q2 2026: what funds did
Funds that filed a 13F for both Q1 2026 and Q2 2026, by what they did with the common stock. Share counts are adjusted for any split between the two quarters; dollar figures are the change in shares at this quarter’s price.
Biggest buyers
- RTW INVESTMENTSNew · +1,607,507 sh+$86.3M
- ORBIMED ADVISORSAdded · +733,997 sh+$39.4M
- MORGAN STANLEYAdded · +501,183 sh+$26.9M
- Deep Track CapitalAdded · +460,224 sh+$24.7M
- BANK OF AMERICAAdded · +336,290 sh+$18.0M
Biggest sellers
- PRICE T ROWE ASSOCIATESTrimmed · -1,155,164 sh-$62.0M
- FMRTrimmed · -593,143 sh-$31.8M
- Paradigm Biocapital AdvisorsSold out · -545,287 sh-$29.3M
- Siren, L.L.C.Trimmed · -455,731 sh-$24.5M
- BALYASNY ASSET MANAGEMENT L.P.Sold out · -304,934 sh-$16.4M
GPCR 13F holders ranked 1–100 of 193
| # | Institution | Shares | Value | % of portfolio | QoQShares vs Q1 2026 |
|---|---|---|---|---|---|
| 1 | FMR#1 · 7,810,306 sh | 7,810,306 | $419.2M | 0.02% | -7.1% |
| 2 | WELLINGTON MANAGEMENT GROUP LLP#2 · 7,379,433 sh | 7,379,433 | $396.1M | 0.07% | +1.6% |
| 3 | Avoro Capital Advisors#3 · 6,555,555 sh | 6,555,555 | $351.8M | 3.16% | 0.0% |
| 4 | Jupiter Topco#4 · 5,204,212 sh | 5,204,212 | $279.3M | 0.11% | — |
| 5 | Deep Track Capital#5 · 4,740,072 sh | 4,740,072 | $254.4M | 3.70% | +10.8% |
| 6 | BVF#6 · 3,366,823 sh | 3,366,823 | $180.7M | 4.62% | -2.7% |
| 7 | MORGAN STANLEY#7 · 2,806,640 sh | 2,806,640 | $150.6M | <0.01% | +21.7% |
| 8 | ORBIMED ADVISORS#8 · 2,209,400 sh | 2,209,400 | $118.6M | 2.20% | +49.7% |
| 9 | PRINCIPAL FINANCIAL GROUP#9 · 1,752,753 sh | 1,752,753 | $94.1M | 0.05% | -0.1% |
| 10 | AMERICAN CENTURY COMPANIES#10 · 1,682,179 sh | 1,682,179 | $90.3M | 0.04% | +17.0% |
| 11 | RTW INVESTMENTS#11 · 1,607,507 sh | 1,607,507 | $86.3M | 0.74% | New |
| 12 | DRIEHAUS CAPITAL MANAGEMENT#12 · 1,553,219 sh | 1,553,219 | $83.4M | 0.48% | -1.5% |
| 13 | BAKER BROS. ADVISORS#13 · 1,432,529 sh | 1,432,529 | $76.9M | 0.39% | 0.0% |
| 14 | Casdin Capital#14 · 1,175,000 sh | 1,175,000 | $63.1M | 3.16% | 0.0% |
| 15 | DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)#15 · 1,086,000 sh | 1,086,000 | $58.3M | 0.61% | +41.4% |
| 16 | CAPITOLIS LIQUID GLOBAL MARKETS#16 · 1,041,100 sh | 1,041,100 | $55.9M | 0.24% | -9.6% |
| 17 | Siren, L.L.C.#17 · 872,967 sh | 872,967 | $46.9M | 0.95% | -34.3% |
| 18 | PRICE T ROWE ASSOCIATES#18 · 845,532 sh | 845,532 | $45.4M | <0.01% | -57.7% |
| 19 | PACIFIC HEIGHTS ASSET MANAGEMENT#19 · 800,000 sh | 800,000 | $42.9M | 1.36% | +6.7% |
| 20 | Rock Springs Capital Management#20 · 640,317 sh | 640,317 | $34.4M | 1.68% | 0.0% |
| 21 | abrdn plc#21 · 639,915 sh | 639,915 | $34.3M | 0.05% | +63.3% |
| 22 | FRANKLIN RESOURCES#22 · 578,839 sh | 578,839 | $31.1M | <0.01% | +8.9% |
| 23 | BANK OF AMERICA#23 · 563,422 sh | 563,422 | $30.2M | <0.01% | +148.1% |
| 24 | ALLIANCEBERNSTEIN L.P.#24 · 611,708 sh | 611,708 | $29.5M | <0.01% | -4.2% |
| 25 | BlackRock#25 · 511,149 sh | 511,149 | $27.4M | <0.01% | +15.7% |
| 26 | Logos Global Management#26 · 500,000 sh | 500,000 | $26.8M | 1.16% | 0.0% |
| 27 | Parkman Healthcare Partners#27 · 485,661 sh | 485,661 | $26.1M | 2.67% | +109.3% |
| 28 | Davern Capital Partners#28 · 446,059 sh | 446,059 | $23.9M | 4.08% | +252.7% |
| 29 | HEALTHCARE OF ONTARIO PENSION PLAN FUND#29 · 418,800 sh | 418,800 | $22.5M | 0.03% | -10.5% |
| 30 | UBS Group AG#30 · 378,986 sh | 378,986 | $20.3M | <0.01% | +78.0% |
| 31 | DEUTSCHE BANK AG\#31 · 331,867 sh | 331,867 | $17.8M | <0.01% | 0.0% |
| 32 | NEXTBio Capital Management#32 · 312,496 sh | 312,496 | $16.8M | 7.71% | +134.5% |
| 33 | Catalio Capital Management#33 · 276,550 sh | 276,550 | $14.8M | 2.79% | +8.3% |
| 34 | MARSHALL WACE, LLP#34 · 267,592 sh | 267,592 | $14.4M | 0.01% | +287.2% |
| 35 | SC CHINA HOLDING Ltd#35 · 266,062 sh | 266,062 | $14.3M | 1.19% | 0.0% |
| 36 | SEB Asset Management AB#36 · 245,043 sh | 245,043 | $13.2M | 0.05% | 0.0% |
| 37 | GOLDMAN SACHS GROUP#37 · 242,790 sh | 242,790 | $13.0M | <0.01% | -6.8% |
| 38 | AMERIPRISE FINANCIAL#38 · 230,514 sh | 230,514 | $12.4M | <0.01% | +5.0% |
| 39 | NATIONAL BANK OF CANADA#39 · 215,800 sh | 215,800 | $11.6M | <0.01% | -29.3% |
| 40 | TWO SIGMA INVESTMENTS#40 · 204,156 sh | 204,156 | $11.0M | <0.01% | +12.5% |
| 41 | Eversept Partners#41 · 196,302 sh | 196,302 | $10.5M | 0.55% | +42.2% |
| 42 | Schonfeld Strategic Advisors#42 · 190,685 sh | 190,685 | $10.2M | 0.04% | +15.3% |
| 43 | Woodline Partners#43 · 153,808 sh | 153,808 | $8.3M | 0.03% | -19.4% |
| 44 | NOMURA ASSET MANAGEMENT INTERNATIONAL#44 · 153,119 sh | 153,119 | $8.2M | 0.01% | +14.3% |
| 45 | ArrowMark Colorado#45 · 150,579 sh | 150,579 | $8.1M | 0.34% | -20.0% |
| 46 | Susquehanna Portfolio Strategies#46 · 148,948 sh | 148,948 | $8.0M | 0.13% | +146.1% |
| 47 | CenterBook Partners#47 · 148,030 sh | 148,030 | $7.9M | 0.39% | +597.0% |
| 48 | Rhenman & Partners Asset Management AB#48 · 145,100 sh | 145,100 | $7.8M | 0.74% | +13.3% |
| 49 | B Group#49 · 140,000 sh | 140,000 | $7.5M | 3.53% | +9.8% |
| 50 | HighVista Strategies#50 · 130,784 sh | 130,784 | $7.0M | 1.60% | +5.5% |
| 51 | Universal- Beteiligungs- und Servicegesellschaft mbH#51 · 125,689 sh | 125,689 | $6.7M | 0.01% | +14.6% |
| 52 | Squarepoint Ops#52 · 125,575 sh | 125,575 | $6.7M | <0.01% | +454.5% |
| 53 | SUSQUEHANNA INTERNATIONAL GROUP, LLP#53 · 122,344 sh | 122,344 | $6.6M | <0.01% | +119.1% |
| 54 | D. E. Shaw#54 · 115,300 sh | 115,300 | $6.2M | <0.01% | -43.7% |
| 55 | VOLORIDGE INVESTMENT MANAGEMENT#55 · 112,300 sh | 112,300 | $6.0M | 0.03% | -56.0% |
| 56 | Soleus Capital Management, L.P.#56 · 107,000 sh | 107,000 | $5.7M | 0.20% | +33.8% |
| 57 | Avidity Partners Management#57 · 98,000 sh | 98,000 | $5.3M | 0.84% | +104.2% |
| 58 | GEODE CAPITAL MANAGEMENT#58 · 97,183 sh | 97,183 | $5.2M | <0.01% | +43.2% |
| 59 | Qube Research & Technologies Ltd#59 · 93,403 sh | 93,403 | $5.0M | <0.01% | +26.9% |
| 60 | PEREGRINE CAPITAL MANAGEMENT#60 · 92,229 sh | 92,229 | $4.9M | 0.16% | -5.0% |
| 61 | PFM Health Sciences#61 · 91,550 sh | 91,550 | $4.9M | 0.42% | -27.6% |
| 62 | PLATINUM INVESTMENT MANAGEMENT LTD#62 · 90,363 sh | 90,363 | $4.8M | 1.19% | +35.1% |
| 63 | MILLENNIUM MANAGEMENT#63 · 89,568 sh | 89,568 | $4.8M | <0.01% | -47.0% |
| 64 | ExodusPoint Capital Management#64 · 78,266 sh | 78,266 | $4.2M | 0.03% | New |
| 65 | ADAGE CAPITAL PARTNERS GP, L.L.C.#65 · 75,000 sh | 75,000 | $4.0M | <0.01% | New |
| 66 | Cormorant Asset Management#66 · 75,000 sh | 75,000 | $4.0M | 0.21% | -57.1% |
| 67 | Boxer Capital Management#67 · 75,000 sh | 75,000 | $4.0M | 0.30% | 0.0% |
| 68 | ALPS ADVISORS#68 · 71,833 sh | 71,833 | $3.9M | 0.02% | +24.6% |
| 69 | TD ASSET MANAGEMENT#69 · 68,962 sh | 68,962 | $3.7M | <0.01% | -66.3% |
| 70 | Brevan Howard Capital Management#70 · 60,336 sh | 60,336 | $3.3M | 0.02% | +27.7% |
| 71 | Burkehill Global Management#71 · 60,000 sh | 60,000 | $3.2M | 0.12% | 0.0% |
| 72 | RAYMOND JAMES FINANCIAL#72 · 59,357 sh | 59,357 | $3.2M | <0.01% | +31.5% |
| 73 | TUDOR INVESTMENT ET AL#73 · 53,656 sh | 53,656 | $2.9M | <0.01% | -28.7% |
| 74 | ANTIPODES PARTNERS Ltd#74 · 51,262 sh | 51,262 | $2.8M | 0.05% | +13.0% |
| 75 | SEVEN GRAND MANAGERS#75 · 50,000 sh | 50,000 | $2.7M | 0.11% | 0.0% |
| 76 | Buckland Partners Management#76 · 50,000 sh | 50,000 | $2.7M | 1.31% | 0.0% |
| 77 | DAFNA Capital Management#77 · 46,500 sh | 46,500 | $2.5M | 0.48% | 0.0% |
| 78 | Mariner#78 · 46,285 sh | 46,285 | $2.5M | <0.01% | +34.2% |
| 79 | OSAIC#79 · 44,786 sh | 44,786 | $2.4M | <0.01% | +0.8% |
| 80 | STATE STREET#80 · 44,629 sh | 44,629 | $2.4M | <0.01% | -6.2% |
| 81 | VOYA INVESTMENT MANAGEMENT#81 · 44,410 sh | 44,410 | $2.4M | <0.01% | 0.0% |
| 82 | BANQUE PICTET & CIE SA#82 · 43,332 sh | 43,332 | $2.3M | — | -12.2% |
| 83 | Jump Financial#83 · 42,658 sh | 42,658 | $2.3M | 0.02% | -60.4% |
| 84 | BANK OF MONTREAL#84 · 42,570 sh | 42,570 | $2.3M | <0.01% | +6.5% |
| 85 | Cinctive Capital Management#85 · 40,877 sh | 40,877 | $2.2M | 0.08% | +369.1% |
| 86 | LEUCADIA NATIONAL#86 · 40,625 sh | 40,625 | $2.2M | 0.01% | -35.1% |
| 87 | Jones Hill Capital#87 · 40,567 sh | 40,567 | $2.2M | 0.46% | -59.7% |
| 88 | StemPoint Capital#88 · 38,178 sh | 38,178 | $2.0M | 0.35% | -80.9% |
| 89 | MANUFACTURERS LIFE INSURANCE COMPANY, THE#89 · 38,108 sh | 38,108 | $2.0M | <0.01% | -66.8% |
| 90 | CAPITAL FUND MANAGEMENT S.A.#90 · 37,281 sh | 37,281 | $2.0M | <0.01% | +14.9% |
| 91 | PSquared Asset Management AG#91 · 37,200 sh | 37,200 | $2.0M | 0.65% | +6.3% |
| 92 | TrueMark Investments#92 · 33,600 sh | 33,600 | $1.8M | 0.23% | -2.3% |
| 93 | FLAX POND CAPITAL#93 · 37,000 sh | 37,000 | $1.8M | 1.41% | +2.8% |
| 94 | NOMURA ASSET MANAGEMENT LTD#94 · 32,790 sh | 32,790 | $1.8M | <0.01% | 0.0% |
| 95 | DCF Advisers#95 · 32,100 sh | 32,100 | $1.7M | 0.30% | +16.7% |
| 96 | EXCHANGE TRADED CONCEPTS#96 · 30,773 sh | 30,773 | $1.7M | <0.01% | +21.3% |
| 97 | Private Capital Advisors#97 · 29,760 sh | 29,760 | $1.6M | — | -13.5% |
| 98 | GSA CAPITAL PARTNERS LLP#98 · 28,665 sh | 28,665 | $1.5M | 0.10% | +107.6% |
| 99 | SPHERA FUNDS MANAGEMENT LTD.#99 · 28,600 sh | 28,600 | $1.5M | 0.20% | -43.7% |
| 100 | Verition Fund Management#100 · 28,519 sh | 28,519 | $1.5M | <0.01% | +1.6% |
Funds that sold out of GPCR in Q2 2026 (31)
Held GPCR at the end of Q1 2026 and filed a Q2 2026 13F without it. Not in the list above, because they no longer hold it. Largest prior position first.
| Institution | Shares sold | Value in Q1 2026 |
|---|---|---|
| Paradigm Biocapital Advisors545,287 sh | 545,287 | $26.3M |
| BALYASNY ASSET MANAGEMENT L.P.304,934 sh | 304,934 | $14.7M |
| Pentwater Capital Management245,000 sh | 245,000 | $11.8M |
| Sio Capital Management209,093 sh | 209,093 | $10.1M |
| Holocene Advisors159,009 sh | 159,009 | $7.7M |
| TCG Crossover Management140,411 sh | 140,411 | $6.8M |
| Trexquant Investment107,884 sh | 107,884 | $5.2M |
| DIADEMA PARTNERS72,234 sh | 72,234 | $3.5M |
| RENAISSANCE TECHNOLOGIES55,800 sh | 55,800 | $2.7M |
| Monashee Investment Management50,000 sh | 50,000 | $2.4M |
| Pier Capital47,551 sh | 47,551 | $2.3M |
| Headlands Technologies37,156 sh | 37,156 | $1.8M |
| XTX Topco Ltd30,921 sh | 30,921 | $1.5M |
| Walleye Capital21,360 sh | 21,360 | $1.0M |
| Persistent Asset Partners Ltd18,263 sh | 18,263 | $880.3K |
| Aquatic Capital Management14,814 sh | 14,814 | $714.0K |
| Russell Investments Group, Ltd.10,701 sh | 10,701 | $515.8K |
| AXQ CAPITAL7,916 sh | 7,916 | $381.6K |
| Scientech Research6,958 sh | 6,958 | $335.4K |
| Advisory Services Network5,879 sh | 5,879 | $283.4K |
| Jain Global5,772 sh | 5,772 | $278.2K |
| Toroso Investments4,643 sh | 4,643 | $223.8K |
| Penserra Capital Management1,738 sh | 1,738 | $83.0K |
| SOA Wealth Advisors200 sh | 200 | $9.6K |
| EverSource Wealth Advisors63 sh | 63 | $5.6K |
| FARMERS & MERCHANTS INVESTMENTS100 sh | 100 | $4.8K |
| Basecamp Wealth Advisors84 sh | 84 | $4.0K |
| Ancora Advisors10 sh | 10 | $482.00 |
| US BANCORP \DE\10 sh | 10 | $482.00 |
| Allworth Financial9 sh | 9 | $434.00 |
| TrueNorth2 sh | 2 | $96.00 |
Source: Form 13F-HR filings on SEC EDGAR, Q2 2026. Values are as reported by each manager at quarter end. “% of portfolio” is the position’s share of the manager’s total reported 13F value for the same quarter. “New” means the manager filed a 13F for Q1 2026 without this position; a dash means no comparison is available. Where a manager’s own filing is internally inconsistent its value is withheld and it is listed last. 13F data shows reported holdings, not recommendations.