Fulcrum Therapeutics, Inc. (FULC) — Institutional Holders, Q2 2026
155 institutional investment managers reported a FULC position on SEC Form 13F-HR for the quarter ended June 30, 2026, with a combined reported value of $291.3M. Every filer is listed below, ranked by position value, 100 per page; this page shows ranks 1 to 100. Put and call option positions are excluded, and a firm filing several lots or share classes is shown once with its total.
FULC in Q2 2026: what funds did
Funds that filed a 13F for both Q1 2026 and Q2 2026, by what they did with the common stock. Share counts are adjusted for any split between the two quarters; dollar figures are the change in shares at this quarter’s price.
Biggest buyers
- EcoR1 CapitalNew · +6,549,866 sh+$24.0M
- TANG CAPITAL MANAGEMENTNew · +6,521,412 sh+$23.9M
- BlackRockAdded · +3,433,666 sh+$12.6M
- Nantahala Capital ManagementAdded · +2,425,000 sh+$8.9M
- JANE STREET GROUPAdded · +1,907,081 sh+$7.0M
Biggest sellers
- RA CAPITAL MANAGEMENT, L.P.Sold out · -6,053,960 sh-$22.2M
- TCG Crossover ManagementSold out · -5,250,000 sh-$19.2M
- BRAIDWELLSold out · -3,134,922 sh-$11.5M
- SUVRETTA CAPITAL MANAGEMENTTrimmed · -2,880,190 sh-$10.5M
- Siren, L.L.C.Sold out · -2,350,000 sh-$8.6M
FULC 13F holders ranked 1–100 of 155
| # | Institution | Shares | Value | % of portfolio | QoQShares vs Q1 2026 |
|---|---|---|---|---|---|
| 1 | BlackRock#1 · 8,824,259 sh | 8,824,259 | $32.3M | <0.01% | +63.7% |
| 2 | EcoR1 Capital#2 · 6,549,866 sh | 6,549,866 | $24.0M | 1.17% | New |
| 3 | TANG CAPITAL MANAGEMENT#3 · 6,521,412 sh | 6,521,412 | $23.9M | 1.08% | New |
| 4 | Nantahala Capital Management#4 · 5,475,040 sh | 5,475,040 | $20.0M | 0.67% | +79.5% |
| 5 | SUVRETTA CAPITAL MANAGEMENT#5 · 3,680,921 sh | 3,680,921 | $13.5M | 0.25% | -43.9% |
| 6 | D. E. Shaw#6 · 3,044,385 sh | 3,044,385 | $11.1M | <0.01% | +87.5% |
| 7 | CITADEL ADVISORS#7 · 2,704,505 sh | 2,704,505 | $9.9M | <0.01% | +109.2% |
| 8 | VANGUARD CAPITAL MANAGEMENT#8 · 2,697,216 sh | 2,697,216 | $9.9M | <0.01% | +0.2% |
| 9 | JANE STREET GROUP#9 · 2,217,498 sh | 2,217,498 | $8.1M | <0.01% | +614.4% |
| 10 | STATE STREET#10 · 2,037,025 sh | 2,037,025 | $7.5M | <0.01% | +31.4% |
| 11 | ADAGE CAPITAL PARTNERS GP, L.L.C.#11 · 2,000,000 sh | 2,000,000 | $7.3M | 0.01% | +400.0% |
| 12 | GSK plc#12 · 1,785,714 sh | 1,785,714 | $6.5M | 1.09% | 0.0% |
| 13 | Qube Research & Technologies Ltd#13 · 1,748,467 sh | 1,748,467 | $6.4M | <0.01% | +79.4% |
| 14 | RENAISSANCE TECHNOLOGIES#14 · 1,647,800 sh | 1,647,800 | $6.0M | <0.01% | New |
| 15 | ADAR1 Capital Management#15 · 1,565,029 sh | 1,565,029 | $5.7M | 0.26% | +1098.7% |
| 16 | MILLENNIUM MANAGEMENT#16 · 1,485,803 sh | 1,485,803 | $5.4M | <0.01% | +316.8% |
| 17 | GEODE CAPITAL MANAGEMENT#17 · 1,432,133 sh | 1,432,133 | $5.2M | <0.01% | -3.7% |
| 18 | MARSHALL WACE, LLP#18 · 1,358,423 sh | 1,358,423 | $5.0M | <0.01% | New |
| 19 | UBS Group AG#19 · 1,253,909 sh | 1,253,909 | $4.6M | <0.01% | +297.8% |
| 20 | SUSQUEHANNA INTERNATIONAL GROUP, LLP#20 · 1,180,946 sh | 1,180,946 | $4.3M | <0.01% | +1065.4% |
| 21 | AQR CAPITAL MANAGEMENT#21 · 1,103,261 sh | 1,103,261 | $4.0M | <0.01% | +103.1% |
| 22 | GOLDMAN SACHS GROUP#22 · 1,094,425 sh | 1,094,425 | $4.0M | <0.01% | +91.4% |
| 23 | Ikarian Capital#23 · 1,049,161 sh | 1,049,161 | $3.8M | 0.41% | 0.0% |
| 24 | BANK OF AMERICA#24 · 1,043,029 sh | 1,043,029 | $3.8M | <0.01% | +724.1% |
| 25 | ACADIAN ASSET MANAGEMENT#25 · 1,038,797 sh | 1,038,797 | $3.8M | <0.01% | +42.8% |
| 26 | Jump Financial#26 · 1,005,000 sh | 1,005,000 | $3.7M | 0.03% | +171.8% |
| 27 | DIMENSIONAL FUND ADVISORS#27 · 960,547 sh | 960,547 | $3.5M | <0.01% | -15.0% |
| 28 | Assenagon Asset Management S.A.#28 · 835,204 sh | 835,204 | $3.1M | — | -30.0% |
| 29 | TWO SIGMA INVESTMENTS#29 · 812,766 sh | 812,766 | $3.0M | <0.01% | +484.7% |
| 30 | VANGUARD PORTFOLIO MANAGEMENT#30 · 782,144 sh | 782,144 | $2.9M | <0.01% | +30.5% |
| 31 | Connor, Clark & Lunn Investment Management Ltd.#31 · 745,317 sh | 745,317 | $2.7M | <0.01% | +1.2% |
| 32 | BALYASNY ASSET MANAGEMENT L.P.#32 · 692,372 sh | 692,372 | $2.5M | <0.01% | -61.1% |
| 33 | Y-Intercept (Hong Kong) Ltd#33 · 681,832 sh | 681,832 | $2.5M | — | +344.6% |
| 34 | Point72 Asset Management, L.P.#34 · 651,427 sh | 651,427 | $2.4M | <0.01% | -68.6% |
| 35 | NORTHERN#35 · 487,869 sh | 487,869 | $1.8M | <0.01% | +3.1% |
| 36 | CHARLES SCHWAB INVESTMENT MANAGEMENT#36 · 433,220 sh | 433,220 | $1.6M | <0.01% | +1.5% |
| 37 | VANGUARD FIDUCIARY#37 · 345,648 sh | 345,648 | $1.3M | <0.01% | +4.8% |
| 38 | BOOTHBAY FUND MANAGEMENT#38 · 303,988 sh | 303,988 | $1.1M | 0.01% | 0.0% |
| 39 | BESSEMER GROUP#39 · 286,988 sh | 286,988 | $1.1M | <0.01% | 0.0% |
| 40 | Peapod Lane Capital#40 · 285,798 sh | 285,798 | $1.0M | — | New |
| 41 | WELLINGTON MANAGEMENT GROUP LLP#41 · 285,084 sh | 285,084 | $1.0M | <0.01% | +140.4% |
| 42 | Engineers Gate Manager#42 · 242,000 sh | 242,000 | $885.7K | 0.01% | +91.9% |
| 43 | Hennion & Walsh Asset Management#43 · 233,851 sh | 233,851 | $855.9K | — | New |
| 44 | EntryPoint Capital#44 · 217,199 sh | 217,199 | $794.9K | 0.19% | +380.0% |
| 45 | XTX Topco Ltd#45 · 209,247 sh | 209,247 | $765.8K | <0.01% | +192.2% |
| 46 | Quadrature Capital Ltd#46 · 189,119 sh | 189,119 | $692.2K | <0.01% | New |
| 47 | MORGAN STANLEY#47 · 184,192 sh | 184,192 | $674.1K | 0.00% | +6.3% |
| 48 | ALLIANCEBERNSTEIN L.P.#48 · 83,370 sh | 83,370 | $639.4K | <0.01% | +141.2% |
| 49 | AMERICAN CENTURY COMPANIES#49 · 155,868 sh | 155,868 | $570.5K | <0.01% | -0.2% |
| 50 | Nuveen#50 · 154,871 sh | 154,871 | $566.8K | <0.01% | +19.5% |
| 51 | Bank of New York Mellon#51 · 154,513 sh | 154,513 | $565.5K | <0.01% | +3.0% |
| 52 | Simplify Asset Management#52 · 153,794 sh | 153,794 | $562.9K | <0.01% | +32.6% |
| 53 | GSA CAPITAL PARTNERS LLP#53 · 143,911 sh | 143,911 | $527.0K | 0.03% | +5.3% |
| 54 | FIDUCIARY#54 · 136,555 sh | 136,555 | $499.8K | <0.01% | 0.0% |
| 55 | Squarepoint Ops#55 · 126,558 sh | 126,558 | $463.2K | <0.01% | -28.1% |
| 56 | Verdad Advisers#56 · 125,224 sh | 125,224 | $458.3K | 0.44% | New |
| 57 | BNP PARIBAS FINANCIAL MARKETS#57 · 119,038 sh | 119,038 | $435.7K | <0.01% | +741.4% |
| 58 | HSBC PLC#58 · 109,353 sh | 109,353 | $426.5K | <0.01% | +86.5% |
| 59 | Rangeley Capital#59 · 114,890 sh | 114,890 | $420.5K | 0.38% | New |
| 60 | Invesco Ltd.#60 · 113,319 sh | 113,319 | $414.7K | 0.00% | +2.0% |
| 61 | Russell Investments Group, Ltd.#61 · 104,199 sh | 104,199 | $381.4K | <0.01% | +31.6% |
| 62 | CANADA PENSION PLAN INVESTMENT BOARD#62 · 102,400 sh | 102,400 | $374.8K | <0.01% | +456.5% |
| 63 | ALGERT GLOBAL#63 · 101,360 sh | 101,360 | $371.0K | <0.01% | +206.7% |
| 64 | PANAGORA ASSET MANAGEMENT#64 · 95,521 sh | 95,521 | $349.6K | <0.01% | -60.8% |
| 65 | PRICE T ROWE ASSOCIATES#65 · 94,235 sh | 94,235 | $345.0K | 0.00% | +17.5% |
| 66 | FMR#66 · 92,327 sh | 92,327 | $337.9K | 0.00% | +51.3% |
| 67 | Headlands Technologies#67 · 89,723 sh | 89,723 | $328.4K | 0.03% | New |
| 68 | Susquehanna Portfolio Strategies#68 · 85,580 sh | 85,580 | $313.2K | <0.01% | +342.9% |
| 69 | BARCLAYS PLC#69 · 83,373 sh | 83,373 | $305.1K | <0.01% | -5.7% |
| 70 | AXQ CAPITAL#70 · 81,483 sh | 81,483 | $298.2K | 0.03% | +269.7% |
| 71 | RHUMBLINE ADVISERS#71 · 73,443 sh | 73,443 | $268.8K | <0.01% | +11.0% |
| 72 | RBF Capital#72 · 70,000 sh | 70,000 | $256.2K | 0.01% | 0.0% |
| 73 | PRELUDE CAPITAL MANAGEMENT#73 · 67,857 sh | 67,857 | $248.4K | 0.02% | New |
| 74 | ALPS ADVISORS#74 · 67,632 sh | 67,632 | $247.5K | <0.01% | New |
| 75 | CITIGROUP#75 · 62,774 sh | 62,774 | $229.8K | <0.01% | +167.9% |
| 76 | FOX RUN MANAGEMENT, L.L.C.#76 · 56,446 sh | 56,446 | $206.6K | 0.03% | New |
| 77 | DEUTSCHE BANK AG\#77 · 52,381 sh | 52,381 | $191.7K | <0.01% | +7.3% |
| 78 | WELLS FARGO & COMPANY#78 · 49,696 sh | 49,696 | $181.9K | 0.00% | +120.4% |
| 79 | STRS OHIO#79 · 46,200 sh | 46,200 | $169.1K | <0.01% | -6.3% |
| 80 | JPMORGAN CHASE#80 · 41,371 sh | 41,371 | $154.3K | 0.00% | +38.9% |
| 81 | COMMONWEALTH EQUITY SERVICES#81 · 40,000 sh | 40,000 | $146.4K | <0.01% | -0.7% |
| 82 | Marquette Asset Management#82 · 38,552 sh | 38,552 | $141.1K | — | New |
| 83 | MetLife Investment Management#83 · 34,079 sh | 34,079 | $124.7K | <0.01% | +2.8% |
| 84 | FRANKLIN RESOURCES#84 · 34,063 sh | 34,063 | $124.7K | 0.00% | -37.7% |
| 85 | PROFUND ADVISORS#85 · 32,514 sh | 32,514 | $119.0K | <0.01% | +109.8% |
| 86 | State of Alaska, Department of Revenue#86 · 31,000 sh | 31,000 | $113.0K | — | New |
| 87 | SEI INVESTMENTS#87 · 30,681 sh | 30,681 | $112.3K | <0.01% | New |
| 88 | COUNTRY BANK#88 · 30,041 sh | 30,041 | $110.0K | <0.01% | 0.0% |
| 89 | LMR Partners LLP#89 · 30,000 sh | 30,000 | $109.8K | <0.01% | 0.0% |
| 90 | AIGEN INVESTMENT MANAGEMENT#90 · 29,512 sh | 29,512 | $108.0K | 0.03% | New |
| 91 | Scientech Research#91 · 28,584 sh | 28,584 | $104.6K | 0.08% | New |
| 92 | Mariner#92 · 28,104 sh | 28,104 | $102.9K | <0.01% | +20.8% |
| 93 | MIRAE ASSET GLOBAL ETFS Ltd.#93 · 27,325 sh | 27,325 | $100.0K | <0.01% | -2.7% |
| 94 | Graham Capital Management, L.P.#94 · 25,067 sh | 25,067 | $91.7K | <0.01% | -41.4% |
| 95 | STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM#95 · 25,052 sh | 25,052 | $91.7K | <0.01% | New |
| 96 | Rafferty Asset Management#96 · 24,538 sh | 24,538 | $89.8K | <0.01% | New |
| 97 | Creative Planning#97 · 21,373 sh | 21,373 | $78.2K | 0.00% | -66.7% |
| 98 | MERCER GLOBAL ADVISORS#98 · 21,370 sh | 21,370 | $78.2K | <0.01% | +96.7% |
| 99 | Castleview Partners#99 · 19,100 sh | 19,100 | $69.9K | — | New |
| 100 | Vanguard Global Advisers#100 · 18,858 sh | 18,858 | $69.0K | 0.00% | -51.0% |
Funds that sold out of FULC in Q2 2026 (42)
Held FULC at the end of Q1 2026 and filed a Q2 2026 13F without it. Not in the list above, because they no longer hold it. Largest prior position first.
| Institution | Shares sold | Value in Q1 2026 |
|---|---|---|
| RA CAPITAL MANAGEMENT, L.P.6,053,960 sh | 6,053,960 | $46.4M |
| TCG Crossover Management5,250,000 sh | 5,250,000 | $40.3M |
| BRAIDWELL3,134,922 sh | 3,134,922 | $24.0M |
| Siren, L.L.C.2,350,000 sh | 2,350,000 | $18.0M |
| First Turn Management2,256,109 sh | 2,256,109 | $17.3M |
| abrdn plc2,211,953 sh | 2,211,953 | $17.0M |
| Jones Hill Capital1,771,926 sh | 1,771,926 | $13.6M |
| Alyeska Investment Group, L.P.1,328,449 sh | 1,328,449 | $10.2M |
| Vestal Point Capital1,100,000 sh | 1,100,000 | $8.4M |
| Trexquant Investment453,529 sh | 453,529 | $3.5M |
| SILVERARC CAPITAL MANAGEMENT419,949 sh | 419,949 | $3.2M |
| DAFNA Capital Management205,000 sh | 205,000 | $1.6M |
| STATE OF WISCONSIN INVESTMENT BOARD154,435 sh | 154,435 | $1.2M |
| Atom Investors69,155 sh | 69,155 | $530.4K |
| Burkehill Global Management50,000 sh | 50,000 | $383.5K |
| Man Group plc46,119 sh | 46,119 | $353.7K |
| Marex Group plc42,000 sh | 42,000 | $322.1K |
| SIMPLEX TRADING41,940 sh | 41,940 | $321.7K |
| BIT Capital GmbH40,000 sh | 40,000 | $306.8K |
| Matisse Capital39,649 sh | 39,649 | $304.1K |
| Woodline Partners30,793 sh | 30,793 | $236.2K |
| Pale Fire Capital SE26,100 sh | 26,100 | $200.2K |
| Quantinno Capital Management25,669 sh | 25,669 | $196.9K |
| ExodusPoint Capital Management23,172 sh | 23,172 | $177.7K |
| Virtus Investment Advisers20,974 sh | 20,974 | $160.9K |
| DRW Securities16,414 sh | 16,414 | $125.9K |
| BAILARD11,781 sh | 11,781 | $90.4K |
| ProShare Advisors11,656 sh | 11,656 | $89.4K |
| Entropy Technologies10,819 sh | 10,819 | $83.0K |
| SUMMIT SECURITIES GROUP6,975 sh | 6,975 | $53.5K |
| MAI Capital Management1,866 sh | 1,866 | $14.3K |
| State of Wyoming1,815 sh | 1,815 | $13.9K |
| Versant Capital Management858 sh | 858 | $6.6K |
| MassMutual Private Wealth & , FSB581 sh | 581 | $4.5K |
| Larson Financial Group407 sh | 407 | $3.1K |
| Physician Wealth Advisors283 sh | 283 | $2.2K |
| TWIN PEAKS WEALTH ADVISORS38 sh | 38 | $291.00 |
| US BANCORP \DE\26 sh | 26 | $199.00 |
| JPL Wealth Management17 sh | 17 | $131.00 |
| Root Financial Partners14 sh | 14 | $107.00 |
| Keating Financial Advisory Services3 sh | 3 | $23.00 |
| Hughes Financial Services1 sh | 1 | $8.00 |
Source: Form 13F-HR filings on SEC EDGAR, Q2 2026. Values are as reported by each manager at quarter end. “% of portfolio” is the position’s share of the manager’s total reported 13F value for the same quarter. “New” means the manager filed a 13F for Q1 2026 without this position; a dash means no comparison is available. Where a manager’s own filing is internally inconsistent its value is withheld and it is listed last. 13F data shows reported holdings, not recommendations.