Amylyx Pharmaceuticals, Inc. (AMLX) — Institutional Holders, Q2 2026
207 institutional investment managers reported a AMLX position on SEC Form 13F-HR for the quarter ended June 30, 2026, with a combined reported value of $2.1B. Every filer is listed below, ranked by position value, 100 per page; this page shows ranks 1 to 100. Put and call option positions are excluded, and a firm filing several lots or share classes is shown once with its total.
AMLX in Q2 2026: what funds did
Funds that filed a 13F for both Q1 2026 and Q2 2026, by what they did with the common stock. Share counts are adjusted for any split between the two quarters; dollar figures are the change in shares at this quarter’s price.
Biggest buyers
- JPMORGAN CHASEAdded · +1,703,987 sh+$30.6M
- Alyeska Investment Group, L.P.New · +1,053,015 sh+$18.9M
- MORGAN STANLEYAdded · +955,261 sh+$17.2M
- abrdn plcNew · +737,670 sh+$13.2M
- FRANKLIN RESOURCESAdded · +688,656 sh+$12.4M
Biggest sellers
- ADAGE CAPITAL PARTNERS GP, L.L.C.Trimmed · -1,660,764 sh-$29.8M
- Almitas CapitalTrimmed · -1,147,716 sh-$20.6M
- GREAT POINT PARTNERSTrimmed · -1,050,000 sh-$18.9M
- BARCLAYS PLCTrimmed · -915,596 sh-$16.4M
- DEUTSCHE BANK AG\Trimmed · -709,848 sh-$12.7M
AMLX 13F holders ranked 1–100 of 207
| # | Institution | Shares | Value | % of portfolio | QoQShares vs Q1 2026 |
|---|---|---|---|---|---|
| 1 | FMR#1 · 16,727,909 sh | 16,727,909 | $300.4M | 0.01% | +0.6% |
| 2 | BlackRock#2 · 8,827,085 sh | 8,827,085 | $158.5M | <0.01% | 0.0% |
| 3 | PERCEPTIVE ADVISORS#3 · 8,334,882 sh | 8,334,882 | $149.7M | 2.25% | +0.6% |
| 4 | TCG Crossover Management#4 · 6,243,812 sh | 6,243,812 | $112.1M | 2.70% | 0.0% |
| 5 | Commodore Capital#5 · 5,650,000 sh | 5,650,000 | $101.5M | 6.04% | 0.0% |
| 6 | Jupiter Topco#6 · 5,236,102 sh | 5,236,102 | $94.0M | 0.04% | — |
| 7 | Saturn V Capital Management#7 · 4,624,101 sh | 4,624,101 | $83.0M | 11.91% | +6.3% |
| 8 | VANGUARD CAPITAL MANAGEMENT#8 · 4,224,224 sh | 4,224,224 | $75.9M | <0.01% | +2.0% |
| 9 | MORGAN STANLEY#9 · 3,130,808 sh | 3,130,808 | $56.2M | <0.01% | +43.9% |
| 10 | DRIEHAUS CAPITAL MANAGEMENT#10 · 3,036,970 sh | 3,036,970 | $54.5M | 0.32% | +1.7% |
| 11 | First Light Asset Management#11 · 3,023,256 sh | 3,023,256 | $54.3M | 3.30% | -5.2% |
| 12 | FRANKLIN RESOURCES#12 · 2,950,225 sh | 2,950,225 | $53.0M | 0.01% | +30.5% |
| 13 | GOLDMAN SACHS GROUP#13 · 2,858,239 sh | 2,858,239 | $51.3M | <0.01% | +8.8% |
| 14 | STATE STREET#14 · 2,603,337 sh | 2,603,337 | $46.8M | <0.01% | +10.2% |
| 15 | GEODE CAPITAL MANAGEMENT#15 · 2,335,315 sh | 2,335,315 | $41.9M | <0.01% | +5.6% |
| 16 | JPMORGAN CHASE#16 · 1,863,650 sh | 1,863,650 | $34.9M | <0.01% | +1067.2% |
| 17 | ADAGE CAPITAL PARTNERS GP, L.L.C.#17 · 1,900,000 sh | 1,900,000 | $34.1M | 0.05% | -46.6% |
| 18 | Siren, L.L.C.#18 · 1,480,586 sh | 1,480,586 | $26.6M | 0.54% | +20.4% |
| 19 | EVENTIDE ASSET MANAGEMENT#19 · 1,327,536 sh | 1,327,536 | $23.8M | 0.32% | -12.3% |
| 20 | 683 Capital Management#20 · 1,279,512 sh | 1,279,512 | $23.0M | 1.13% | -16.4% |
| 21 | VANGUARD PORTFOLIO MANAGEMENT#21 · 1,061,534 sh | 1,061,534 | $19.1M | <0.01% | +12.4% |
| 22 | Alyeska Investment Group, L.P.#22 · 1,053,015 sh | 1,053,015 | $18.9M | 0.05% | New |
| 23 | Almitas Capital#23 · 974,881 sh | 974,881 | $17.5M | 4.20% | -54.1% |
| 24 | DIMENSIONAL FUND ADVISORS#24 · 902,463 sh | 902,463 | $16.2M | <0.01% | -0.1% |
| 25 | Jones Hill Capital#25 · 894,058 sh | 894,058 | $16.1M | 3.41% | -44.1% |
| 26 | Woodline Partners#26 · 846,387 sh | 846,387 | $15.2M | 0.05% | +0.1% |
| 27 | NORTHERN#27 · 831,740 sh | 831,740 | $14.9M | <0.01% | +6.6% |
| 28 | BANK OF AMERICA#28 · 821,841 sh | 821,841 | $14.8M | <0.01% | -38.2% |
| 29 | Boxer Capital Management#29 · 800,000 sh | 800,000 | $14.4M | 1.08% | 0.0% |
| 30 | abrdn plc#30 · 737,670 sh | 737,670 | $13.2M | 0.02% | New |
| 31 | CHARLES SCHWAB INVESTMENT MANAGEMENT#31 · 725,030 sh | 725,030 | $13.0M | <0.01% | +1.2% |
| 32 | Connor, Clark & Lunn Investment Management Ltd.#32 · 721,002 sh | 721,002 | $12.9M | 0.02% | -17.0% |
| 33 | GREAT POINT PARTNERS#33 · 700,000 sh | 700,000 | $12.6M | 2.38% | -60.0% |
| 34 | BALYASNY ASSET MANAGEMENT L.P.#34 · 684,974 sh | 684,974 | $12.3M | 0.02% | -38.1% |
| 35 | Qube Research & Technologies Ltd#35 · 681,389 sh | 681,389 | $12.2M | 0.01% | -3.0% |
| 36 | VANGUARD FIDUCIARY#36 · 623,078 sh | 623,078 | $11.2M | <0.01% | +6.3% |
| 37 | TWO SIGMA INVESTMENTS#37 · 593,435 sh | 593,435 | $10.7M | <0.01% | +266.4% |
| 38 | DEUTSCHE BANK AG\#38 · 557,937 sh | 557,937 | $10.0M | <0.01% | -56.0% |
| 39 | Rock Springs Capital Management#39 · 499,764 sh | 499,764 | $9.0M | 0.44% | 0.0% |
| 40 | ADAR1 Capital Management#40 · 494,378 sh | 494,378 | $8.9M | 0.41% | -50.6% |
| 41 | Nantahala Capital Management#41 · 486,684 sh | 486,684 | $8.7M | 0.29% | -9.1% |
| 42 | FEDERATED HERMES#42 · 462,205 sh | 462,205 | $8.3M | 0.01% | +27.1% |
| 43 | Nearwater Capital Markets, Ltd#43 · 425,000 sh | 425,000 | $7.6M | 0.13% | New |
| 44 | Parkman Healthcare Partners#44 · 398,782 sh | 398,782 | $7.2M | 0.73% | -35.8% |
| 45 | HighVista Strategies#45 · 386,080 sh | 386,080 | $6.9M | 1.58% | +9.7% |
| 46 | StemPoint Capital#46 · 384,304 sh | 384,304 | $6.9M | 1.19% | -42.6% |
| 47 | Logos Global Management#47 · 350,000 sh | 350,000 | $6.3M | 0.27% | -50.0% |
| 48 | Trexquant Investment#48 · 349,439 sh | 349,439 | $6.3M | 0.04% | New |
| 49 | Nuveen#49 · 330,521 sh | 330,521 | $5.9M | <0.01% | +24.8% |
| 50 | Ensign Peak Advisors#50 · 305,441 sh | 305,441 | $5.5M | <0.01% | New |
| 51 | iA Global Asset Management#51 · 303,786 sh | 303,786 | $5.5M | 0.06% | -0.3% |
| 52 | JANE STREET GROUP#52 · 299,565 sh | 299,565 | $5.4M | <0.01% | New |
| 53 | TFG Asset Management GP Ltd#53 · 297,926 sh | 297,926 | $5.4M | 0.84% | -6.3% |
| 54 | JUPITER ASSET MANAGEMENT LTD#54 · 274,944 sh | 274,944 | $4.9M | 0.02% | -53.6% |
| 55 | Bank of New York Mellon#55 · 274,435 sh | 274,435 | $4.9M | <0.01% | +9.3% |
| 56 | UBS Group AG#56 · 271,881 sh | 271,881 | $4.9M | <0.01% | -16.2% |
| 57 | FIRST ADVISORS#57 · 254,587 sh | 254,587 | $4.6M | <0.01% | New |
| 58 | SummitTX Capital, L.P.#58 · 227,690 sh | 227,690 | $4.1M | 0.11% | +0.3% |
| 59 | WELLINGTON MANAGEMENT GROUP LLP#59 · 212,842 sh | 212,842 | $3.8M | <0.01% | -11.9% |
| 60 | Cormorant Asset Management#60 · 200,000 sh | 200,000 | $3.6M | 0.18% | -42.9% |
| 61 | Aldebaran Capital#61 · 195,892 sh | 195,892 | $3.5M | 2.64% | -1.0% |
| 62 | Walleye Capital#62 · 186,588 sh | 186,588 | $3.4M | 0.01% | +202.4% |
| 63 | ORBIMED ADVISORS#63 · 183,400 sh | 183,400 | $3.3M | 0.06% | New |
| 64 | CITADEL ADVISORS#64 · 178,686 sh | 178,686 | $3.2M | <0.01% | -56.6% |
| 65 | D. E. Shaw#65 · 174,285 sh | 174,285 | $3.1M | <0.01% | +134.8% |
| 66 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AME#66 · 173,407 sh | 173,407 | $3.1M | <0.01% | +10.4% |
| 67 | ACUTA CAPITAL PARTNERS#67 · 168,115 sh | 168,115 | $3.0M | 2.10% | +11.3% |
| 68 | NORGES BANK#68 · 159,900 sh | 159,900 | $2.9M | <0.01% | — |
| 69 | Alpha Wave Global#69 · 155,422 sh | 155,422 | $2.8M | 0.04% | +9.2% |
| 70 | PRICE T ROWE ASSOCIATES#70 · 145,133 sh | 145,133 | $2.6M | <0.01% | +19.5% |
| 71 | Swiss National Bank#71 · 144,200 sh | 144,200 | $2.6M | <0.01% | +10.7% |
| 72 | PFM Health Sciences#72 · 143,700 sh | 143,700 | $2.6M | 0.22% | -1.1% |
| 73 | Invesco Ltd.#73 · 139,942 sh | 139,942 | $2.5M | <0.01% | -18.5% |
| 74 | WELLS FARGO & COMPANY#74 · 128,164 sh | 128,164 | $2.3M | <0.01% | +70.7% |
| 75 | AMERIPRISE FINANCIAL#75 · 125,484 sh | 125,484 | $2.3M | <0.01% | New |
| 76 | Lighthouse Investment Partners#76 · 122,909 sh | 122,909 | $2.2M | 0.06% | New |
| 77 | Ikarian Capital#77 · 117,500 sh | 117,500 | $2.1M | 0.23% | New |
| 78 | RHUMBLINE ADVISERS#78 · 112,920 sh | 112,920 | $2.0M | <0.01% | +4.1% |
| 79 | ALPS ADVISORS#79 · 112,447 sh | 112,447 | $2.0M | <0.01% | +25.0% |
| 80 | Elmind Capital#80 · 112,000 sh | 112,000 | $2.0M | 0.51% | 0.0% |
| 81 | Campbell & Investment Adviser#81 · 100,963 sh | 100,963 | $1.8M | 0.10% | +85.5% |
| 82 | Affinity Asset Advisors#82 · 98,999 sh | 98,999 | $1.8M | 0.08% | New |
| 83 | Russell Investments Group, Ltd.#83 · 87,574 sh | 87,574 | $1.6M | <0.01% | +47.6% |
| 84 | Quantinno Capital Management#84 · 80,850 sh | 80,850 | $1.5M | <0.01% | New |
| 85 | ALLIANCEBERNSTEIN L.P.#85 · 104,400 sh | 104,400 | $1.5M | <0.01% | +29.2% |
| 86 | 1492 Capital Management#86 · 79,751 sh | 79,751 | $1.4M | 0.42% | New |
| 87 | CITIGROUP#87 · 68,684 sh | 68,684 | $1.2M | <0.01% | +116.1% |
| 88 | Schonfeld Strategic Advisors#88 · 66,804 sh | 66,804 | $1.2M | <0.01% | -14.1% |
| 89 | Optimize Financial#89 · 63,780 sh | 63,780 | $1.1M | 0.21% | +99.3% |
| 90 | STATE OF WISCONSIN INVESTMENT BOARD#90 · 61,278 sh | 61,278 | $1.1M | <0.01% | -15.0% |
| 91 | Corient Private Wealth#91 · 59,322 sh | 59,322 | $1.1M | <0.01% | New |
| 92 | MOODY ALDRICH PARTNERS#92 · 57,802 sh | 57,802 | $1.0M | 0.19% | New |
| 93 | VANGUARD ASSET MANAGEMENT, Ltd#93 · 56,948 sh | 56,948 | $1.0M | <0.01% | +31.6% |
| 94 | Legal & General Group Plc#94 · 56,477 sh | 56,477 | $1.0M | <0.01% | +1.3% |
| 95 | BARCLAYS PLC#95 · 56,258 sh | 56,258 | $1.0M | <0.01% | -94.2% |
| 96 | MetLife Investment Management#96 · 55,700 sh | 55,700 | $1.0M | <0.01% | +8.0% |
| 97 | SG Americas Securities#97 · 55,321 sh | 55,321 | $994.0K | <0.01% | New |
| 98 | Hudson Bay Capital Management#98 · 50,000 sh | 50,000 | $898.0K | <0.01% | New |
| 99 | Vanguard Global Advisers#99 · 47,851 sh | 47,851 | $859.4K | <0.01% | 0.0% |
| 100 | FOX RUN MANAGEMENT, L.L.C.#100 · 44,817 sh | 44,817 | $804.9K | 0.13% | New |
Funds that sold out of AMLX in Q2 2026 (13)
Held AMLX at the end of Q1 2026 and filed a Q2 2026 13F without it. Not in the list above, because they no longer hold it. Largest prior position first.
| Institution | Shares sold | Value in Q1 2026 |
|---|---|---|
| Squarepoint Ops114,877 sh | 114,877 | $1.6M |
| Point72 Asset Management, L.P.106,535 sh | 106,535 | $1.5M |
| Informed Momentum53,256 sh | 53,256 | $740.3K |
| Integrated Quantitative Investments27,234 sh | 27,234 | $378.6K |
| Headlands Technologies19,814 sh | 19,814 | $275.4K |
| Verition Fund Management13,264 sh | 13,264 | $184.4K |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C.12,226 sh | 12,226 | $169.9K |
| MAI Capital Management9,014 sh | 9,014 | $125.3K |
| ACT CAPITAL MANAGEMENT9,000 sh | 9,000 | $125.1K |
| MEEDER ASSET MANAGEMENT661 sh | 661 | $9.2K |
| Dunhill Financial600 sh | 600 | $8.3K |
| Stone House Investment Management73 sh | 73 | $1.0K |
| Ameritas Advisory Services3 sh | 3 | $42.00 |
Source: Form 13F-HR filings on SEC EDGAR, Q2 2026. Values are as reported by each manager at quarter end. “% of portfolio” is the position’s share of the manager’s total reported 13F value for the same quarter. “New” means the manager filed a 13F for Q1 2026 without this position; a dash means no comparison is available. Where a manager’s own filing is internally inconsistent its value is withheld and it is listed last. 13F data shows reported holdings, not recommendations.