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Hedge Funds Similar to EcoR1 ,

13F Portfolio OverlapQ1 2026EcoR1 , portfolio →
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Most similar hedge funds by 13F overlap

EcoR1 Capital, LLC is an institutional investor managing $2.4B across 30 U.S. equity positions as of Q1 2026. Based on the overlap of conviction holdings in their latest 13F filings, the hedge funds with portfolios most similar to EcoR1 , are Foresite VI, First Light Asset ,, TCG Crossover ,, with shared positions in $CNTA, $CGON, $CRNX, $ZURA, $ANAB, $XNCR. The full ranking of 25 similar funds is below.

#1Foresite Capital Management VI LLCActive
Notable overlap · 4 shared positions
$CNTA$CGON$CRNX$ZURA
$460M
17 positions
#2First Light Asset Management, LLCActive
Notable overlap · 3 shared positions
$CNTA$CRNX$ANAB
$1.1B
35 positions
#3TCG Crossover Management, LLCActive
Notable overlap · 6 shared positions
$CNTA$CGON$XNCR$RLAY$MBX$SRZN
$3.5B
49 positions
#4NEA Management Company, LLCSmart money
Some overlap · 5 shared positions
$ORIC$CRSP$MBX$ZBIO$PHAT
$1.8B
26 positions
#5MPM BioImpact LLCActive
Some overlap · 5 shared positions
$AKTS$ORIC$ZYME$RLAY$STOK
$1.3B
41 positions
#6PERCEPTIVE ADVISORS LLCActive
Some overlap · 4 shared positions
$CNTA$ZYME$RLAY$JAZZ
$5.1B
94 positions
#7Affinity Asset Advisors, LLCActive
Some overlap · 4 shared positions
$CNTA$ANAB$ERAS$ZURA
$1.9B
105 positions
#8SR ONE CAPITAL MANAGEMENT, LPSmart money
Some overlap · 3 shared positions
$ORIC$CRSP$ZBIO
$915M
14 positions
#95AM Venture Management, LLCActive
Some overlap · 3 shared positions
$CNTA$ERAS$SRZN
$360M
20 positions
#10HighMark Wealth Management LLCActive
Some overlap · 3 shared positions
$CNTA$ANAB$CRNX
$246M
555 positions
#11Logos Global Management LPActive
Some overlap · 3 shared positions
$CNTA$CGON$ERAS
$2.0B
66 positions
#12PFM Health Sciences, LPActive
Some overlap · 3 shared positions
$JAZZ$CNTA$CGON
$1.1B
83 positions
#13Sofinnova Ventures IncActive
Some overlap · 3 shared positions
$JAZZ$ANAB$ORIC
$2.6B
74 positions
#14SILVERARC CAPITAL MANAGEMENT, LLCActive
Some overlap · 5 shared positions
$CNTA$ORIC$CGON$ZBIO$ERAS
$980M
73 positions
#15Prosight Management, LPActive
Some overlap · 3 shared positions
$ZYME$LKFT$CRNX
$610M
46 positions
#16Nextech Invest, Ltd.Smart money
Some overlap · 3 shared positions
$ORIC$ZYME$RLAY
$1.4B
17 positions
#17Spruce Street Capital LPActive
Some overlap · 4 shared positions
$CNTA$RLAY$ERAS$SRZN
$416M
28 positions
#18TANG CAPITAL MANAGEMENT LLCActive
Some overlap · 3 shared positions
$ANAB$LKFT$STOK
$2.0B
51 positions
#19BRAIDWELL LPPassive
Some overlap · 3 shared positions
$CNTA$CGON$MBX
$3.0B
88 positions
#20Palo Alto Investors LPActive
Some overlap · 3 shared positions
$ANAB$CRSP$STOK
$654M
51 positions
#21Octagon Capital Advisors LPActive
Some overlap · 3 shared positions
$CNTA$AKTS$BBOT
$904M
29 positions
#22RTW INVESTMENTS, LPActive
Some overlap · 5 shared positions
$CGON$XNCR$CNTA$ERAS$STOK
$10.0B
88 positions
#23Cormorant Asset Management, LPActive
Some overlap · 6 shared positions
$CNTA$BBOT$MBX$ERAS$CRNX$ZURA
$2.0B
47 positions
#24Siren, L.L.C.Active
Some overlap · 6 shared positions
$CRNX$CNTA$ORIC$ERAS$ZURA$STOK
$3.6B
100 positions
#25Elmind Capital, LPActive
Some overlap · 3 shared positions
$CGON$MBX$RLAY
$352M
34 positions

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Similarity is derived from each fund’s latest 13F-HR filing with the SEC. Funds are ranked by the overlap of distinctive conviction holdings; near-universal mega-cap positions are excluded so the ranking reflects shared strategy, not common index exposure. Data is informational only and not investment advice.