What is the 13F Pro Quality Score for PYXS?

13F Pro ranks Pyxis Oncology, Inc. (PYXS) on the 13F Pro Quality Score, a 0–100 composite of 32 fundamental signals including return on invested capital, free cash flow consistency, balance-sheet strength, earnings quality, growth durability, and valuation discipline. The score refreshes after each 10-K and 10-Q filing on SEC EDGAR. View PYXS's current score at https://13fpro.ai/company/PYXS (free sign-up required for the full ranking).

Where does 13F Pro source PYXS data?

All Pyxis Oncology, Inc. fundamentals and ownership data come directly from SEC EDGAR. Pyxis Oncology, Inc. files with the SEC under CIK 1782223. 13F Pro ingests XBRL financial facts from 10-K and 10-Q filings, Form 13F-HR institutional holdings, and Form 4 insider transactions, with no third-party rewrites or estimates.

What sector is PYXS in?

Pyxis Oncology, Inc. (PYXS) is classified in the Healthcare sector. 13F Pro publishes sector-level fund flow analysis and quality leaders at https://13fpro.ai/research/sector/healthcare.

How often is PYXS research updated on 13F Pro?

PYXS's fundamentals refresh within hours of each new 10-K or 10-Q filing on SEC EDGAR. Institutional ownership updates after each quarterly 13F filing window. Insider transactions update after each Form 4 filing. The 13F Pro Quality Score recalculates after every fundamentals refresh.

Pyxis Oncology, Inc.(PYXS)Stock Analysis

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13F Pro Quality Score

11.3/100

Rank #2,901 of 2,962 stocks

View Healthcare peers →

Rankings refresh quarterly once 80% of peers have filed (~45 days after quarter-end). Next update: ~Nov 14, 2026.

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Why PYXS Scores 11/100

exact factor attribution · 2026-09-11

PYXS's composite is driven by earnings growth, held back by revenue growth and free cash flow. Bars show each factor's exact push vs. a median company, using the same weights the ranking engine applies.

Earnings growth

+2.2 pts

95th pct

Institutional flow

-1.8 pts

15th pct

Earnings quality

-1.8 pts

32th pct

Shareholder dilution

-2.2 pts

6th pct

Capital efficiency

-4.6 pts

4th pct

Scale

-6.9 pts

4th pct

Profitability

-7.0 pts

3th pct

Free cash flow

-7.0 pts

3th pct

Revenue growth

-9.6 pts

2th pct

Factor percentiles are cross-sectional ranks across the ~2,800-stock scored universe, computed from SEC EDGAR filings. Not investment advice.

PYXS Stock Analysis & AI Quality Score

Data updated 2026-09-11

AI stock analysis and institutional research for Pyxis Oncology, Inc. (PYXS), a Healthcare sector company. 13F Pro's AI-powered ranking engine scores PYXS at 11.3/100 on a 32-signal composite quality model, placing it at rank #2,901 of 2,962 stocks — the bottom half of the AI-ranked universe. Top institutional holders of PYXS by reported 13-F value include GordonMD Global Investments, PFIZER, Laurion Capital Management, based on the most recent SEC filings. PYXS trades on the Nasdaq exchange and files with the SEC under CIK 1782223. 13F Pro's AI research platform runs 10 specialized AI analysts — value, growth, momentum, macro, and activist specialists — that debate PYXS daily and publish AI-generated analysis with cited SEC sources. The platform aggregates historical XBRL financial facts, 10-Q and 10-K filings, insider Form 4 transactions, and institutional 13-F holdings for Pyxis Oncology, Inc. directly from SEC EDGAR. Pyxis Oncology, Inc.'s 13F Pro composite quality score has ranged between 3 and 16 since 2026, currently 11.3 — an improving long-term trajectory across 31 quarterly and live scoring snapshots.

Net Income

Q2 2026

$-25.3M

Period

Revenue & Net Income

Earnings Per Share

Key Financials Over Time

Export Financial Table · Pro

Revenue

-14.2% YoY

$13.9MFY 2025

FY22 —FY23 —FY24 $16.1MFY25 $13.9M

Net Income

-3.0% YoY

$-79.6MFY 2025

FY22 $-120.7MFY23 $-73.8MFY24 $-77.3MFY25 $-79.6M

Operating Income

+5.6% YoY

$-84.4MFY 2025

FY22 $-123.5MFY23 $-82.2MFY24 $-89.5MFY25 $-84.4M

EPS (Diluted)

+3.0% YoY

$-1.28FY 2025

FY22 $-3.65FY23 $-1.85FY24 $-1.32FY25 $-1.28

Total Assets

-41.8% YoY

$91.5MFY 2025

FY22 $211.4MFY23 $173.7MFY24 $157.2MFY25 $91.5M

Op. Cash Flow

-10.1% YoY

$-63.5MFY 2025

FY22 $-89.3MFY23 $-70.7MFY24 $-57.7MFY25 $-63.5M

Free Cash Flow

-9.7% YoY

$-63.5MFY 2025

FY22 $-95.7MFY23 $-77.4MFY24 $-57.9MFY25 $-63.5M

Metric	FY 2025	FY 2024	FY 2023	FY 2022	FY 2021	FY 2020
Revenue	$13.9M -14.2%	$16.1M	—	—	—	—
Net Income	$-79.6M -3.0%	$-77.3M -4.8%	$-73.8M +38.9%	$-120.7M -58.9%	$-76.0M -492.3%	$-12.8M
Operating Income	$-84.4M +5.6%	$-89.5M -8.8%	$-82.2M +33.4%	$-123.5M -77.1%	$-69.7M -440.7%	$-12.9M
EPS (Diluted)	$-1.28 +3.0%	$-1.32 +28.6%	$-1.85 +49.3%	$-3.65 +59.2%	$-8.95	—
Total Assets	$91.5M -41.8%	$157.2M -9.5%	$173.7M -17.8%	$211.4M -24.5%	$280.0M +2658.6%	$10.2M
Operating Cash Flow	$-63.5M -10.1%	$-57.7M +18.4%	$-70.7M +20.8%	$-89.3M -152.9%	$-35.3M -250.3%	$-10.1M
Free Cash Flow	$-63.5M -9.7%	$-57.9M +25.2%	$-77.4M +19.1%	$-95.7M -166.9%	$-35.9M -210.1%	$-11.6M

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Available Research

13F Pro tracks comprehensive data for Pyxis Oncology, Inc. including:

SEC EDGAR filings (10-K, 10-Q, 8-K)

XBRL financial facts (revenue, EPS, margins)

Insider transactions (Form 4)

Institutional 13F holdings

Quality rankings (32 signals)

AI analyst debates & daily meetings

Historical financial trends

Peer comparison & sector analysis

Top Institutional Holders of PYXS

GordonMD Global Investments LP
$30.2M10,024,909 sh
PFIZER INC
$19.5M7,032,770 sh
Laurion Capital Management LP
$14.8M4,900,888 sh
VANGUARD CAPITAL MANAGEMENT LLC
$6.2M2,075,997 sh
HealthInvest Partners AB
$2.9M966,459 sh
BlackRock, Inc.
$2.6M867,934 sh
Palo Alto Investors LP
$2.6M864,277 sh
MARSHALL WACE, LLP
$2.5M830,544 sh
RENAISSANCE TECHNOLOGIES LLC
$2.3M772,232 sh
GEODE CAPITAL MANAGEMENT, LLC
$1.8M591,849 sh

Fund	Value	Shares
GordonMD Global Investments LP	$30.2M	10,024,909
PFIZER INC	$19.5M	7,032,770
Laurion Capital Management LP	$14.8M	4,900,888
VANGUARD CAPITAL MANAGEMENT LLC	$6.2M	2,075,997
HealthInvest Partners AB	$2.9M	966,459
BlackRock, Inc.	$2.6M	867,934
Palo Alto Investors LP	$2.6M	864,277
MARSHALL WACE, LLP	$2.5M	830,544
RENAISSANCE TECHNOLOGIES LLC	$2.3M	772,232
GEODE CAPITAL MANAGEMENT, LLC	$1.8M	591,849

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Is PYXS a good stock to buy?

13F Pro's AI-powered analysis of Pyxis Oncology, Inc. (PYXS) draws on SEC EDGAR-sourced fundamentals, institutional 13F holdings, and insider Form 4 transactions in the Healthcare sector (listed on Nasdaq). The 32-signal AI Quality Score, current rank, and full bull/bear verdict for PYXS are available on the PYXS stock profile dashboard — with the same data, AI insights, ratios, and institutional activity refreshed after every 10-K, 10-Q, 13F, and Form 4 filing. PYXS is classified as a small company.

Which hedge funds own PYXS?

Institutional investors are required to disclose their holdings quarterly via SEC Form 13F. 13F Pro aggregates these filings to show which hedge funds, mutual funds, and asset managers are buying or selling PYXS. Combined with insider transaction data from Form 4 filings and AI-powered analysis from 10 specialized research agents, 13F Pro provides a comprehensive view of Pyxis Oncology, Inc.'s investment landscape.