Summit Therapeutics Inc. (SMMT) — Institutional Holders, Q2 2026

246 institutional investment managers reported a SMMT position on SEC Form 13F-HR for the quarter ended June 30, 2026, with a combined reported value of $2.0B. Every filer is listed below, ranked by position value, 100 per page; this page shows ranks 1 to 100. Put and call option positions are excluded, and a firm filing several lots or share classes is shown once with its total.

← SMMT stock profile

SMMT in Q2 2026: what funds did

Funds that filed a 13F for both Q1 2026 and Q2 2026, by what they did with the common stock. Share counts are adjusted for any split between the two quarters; dollar figures are the change in shares at this quarter’s price.

New positions

Added to

Trimmed

Sold out

Biggest buyers

GOLDMAN SACHS GROUPAdded · +4,202,671 sh+$61.2M
Point72 Asset Management, L.P.Added · +2,913,617 sh+$42.5M
STATE STREETAdded · +2,508,636 sh+$36.6M
MILLENNIUM MANAGEMENTAdded · +2,222,808 sh+$32.4M
ADAGE CAPITAL PARTNERS GP, L.L.C.New · +1,989,591 sh+$29.0M

Biggest sellers

PRICE T ROWE ASSOCIATESTrimmed · -4,384,039 sh-$63.9M
BAKER BROS. ADVISORSTrimmed · -3,604,715 sh-$52.5M
D. E. ShawTrimmed · -998,673 sh-$14.6M
SUPERSTRING CAPITAL MANAGEMENTSold out · -892,873 sh-$13.0M
FMRTrimmed · -809,252 sh-$11.8M

SMMT 13F holders ranked 1–100 of 246

Institutional investors reporting a position in Summit Therapeutics Inc. on SEC Form 13F-HR for Q2 2026, ranked by reported value.
#	Institution	Shares	Value	% of portfolio	QoQShares vs Q1 2026
1	BAKER BROS. ADVISORS#1 · 32,786,348 sh	32,786,348	$477.7M	2.39%	-9.9%
2	FMR#2 · 10,043,947 sh	10,043,947	$146.3M	<0.01%	-7.5%
3	STATE STREET#3 · 9,536,796 sh	9,536,796	$139.0M	<0.01%	+35.7%
4	BlackRock#4 · 9,529,041 sh	9,529,041	$138.8M	<0.01%	-1.3%
5	VANGUARD CAPITAL MANAGEMENT#5 · 5,734,484 sh	5,734,484	$83.6M	<0.01%	+0.4%
6	UBS Group AG#6 · 5,233,798 sh	5,233,798	$76.3M	<0.01%	+42.2%
7	VANGUARD PORTFOLIO MANAGEMENT#7 · 5,042,190 sh	5,042,190	$73.5M	<0.01%	-3.7%
8	GOLDMAN SACHS GROUP#8 · 4,513,399 sh	4,513,399	$65.8M	<0.01%	+1352.5%
9	PRICE T ROWE ASSOCIATES#9 · 3,893,820 sh	3,893,820	$56.7M	<0.01%	-53.0%
10	Point72 Asset Management, L.P.#10 · 3,697,803 sh	3,697,803	$53.9M	0.06%	+371.5%
11	GEODE CAPITAL MANAGEMENT#11 · 3,427,263 sh	3,427,263	$50.0M	<0.01%	+3.4%
12	MILLENNIUM MANAGEMENT#12 · 2,349,081 sh	2,349,081	$34.2M	0.01%	+1760.3%
13	ADAGE CAPITAL PARTNERS GP, L.L.C.#13 · 1,989,591 sh	1,989,591	$29.0M	0.04%	New
14	BALYASNY ASSET MANAGEMENT L.P.#14 · 1,904,254 sh	1,904,254	$27.7M	0.03%	+247.3%
15	CITADEL ADVISORS#15 · 1,725,716 sh	1,725,716	$25.1M	<0.01%	+290.7%
16	abrdn plc#16 · 1,693,626 sh	1,693,626	$24.7M	0.03%	+154.5%
17	Squarepoint Ops#17 · 1,590,736 sh	1,590,736	$23.2M	0.03%	+159.1%
18	MORGAN STANLEY#18 · 1,450,019 sh	1,450,019	$21.1M	<0.01%	-12.2%
19	NORGES BANK#19 · 1,382,519 sh	1,382,519	$20.1M	<0.01%	—
20	Logos Global Management#20 · 1,350,000 sh	1,350,000	$19.7M	0.85%	New
21	Octagon Capital Advisors#21 · 1,250,000 sh	1,250,000	$18.2M	1.64%	New
22	D. E. Shaw#22 · 1,243,556 sh	1,243,556	$18.1M	<0.01%	-44.5%
23	Kynam Capital Management#23 · 1,200,000 sh	1,200,000	$17.5M	0.97%	New
24	Pictet Asset Management Holding SA#24 · 1,134,299 sh	1,134,299	$16.4M	0.02%	-14.3%
25	CHARLES SCHWAB INVESTMENT MANAGEMENT#25 · 976,851 sh	976,851	$14.2M	<0.01%	+1.7%
26	VANGUARD FIDUCIARY#26 · 966,585 sh	966,585	$14.1M	<0.01%	+3.4%
27	APEIRON CAPITAL Ltd#27 · 961,866 sh	961,866	$14.0M	9.00%	-26.5%
28	BANK OF AMERICA#28 · 864,983 sh	864,983	$12.6M	<0.01%	+44.5%
29	SCHRODER INVESTMENT MANAGEMENT GROUP#29 · 835,963 sh	835,963	$12.0M	<0.01%	+232.5%
30	Rock Springs Capital Management#30 · 715,000 sh	715,000	$10.4M	0.51%	+0.7%
31	CITIGROUP#31 · 714,000 sh	714,000	$10.4M	<0.01%	+258.6%
32	TWO SIGMA INVESTMENTS#32 · 696,714 sh	696,714	$10.2M	<0.01%	-29.0%
33	NORTHERN#33 · 633,794 sh	633,794	$9.2M	<0.01%	+9.0%
34	MARSHALL WACE, LLP#34 · 577,190 sh	577,190	$8.4M	<0.01%	+21.5%
35	AQR CAPITAL MANAGEMENT#35 · 542,178 sh	542,178	$7.9M	<0.01%	+22.2%
36	Candriam S.C.A.#36 · 532,432 sh	532,432	$7.8M	0.03%	-1.5%
37	SUSQUEHANNA INTERNATIONAL GROUP, LLP#37 · 521,339 sh	521,339	$7.6M	<0.01%	-13.7%
38	Elmind Capital#38 · 493,820 sh	493,820	$7.2M	1.81%	New
39	WELLINGTON MANAGEMENT GROUP LLP#39 · 441,934 sh	441,934	$6.4M	<0.01%	+21.8%
40	Bank of New York Mellon#40 · 431,299 sh	431,299	$6.3M	<0.01%	+6.6%
41	WORLDQUANT MILLENNIUM ADVISORS#41 · 431,028 sh	431,028	$6.3M	0.02%	+639.7%
42	TD ASSET MANAGEMENT#42 · 426,084 sh	426,084	$6.2M	<0.01%	-55.5%
43	Invesco Ltd.#43 · 416,847 sh	416,847	$6.1M	<0.01%	-20.8%
44	Jump Financial#44 · 389,618 sh	389,618	$5.7M	0.05%	+236.6%
45	QVT Financial#45 · 360,524 sh	360,524	$5.3M	0.31%	0.0%
46	Ghisallo Capital Management#46 · 350,000 sh	350,000	$5.1M	0.10%	New
47	HOHIMER WEALTH MANAGEMENT#47 · 339,100 sh	339,100	$4.9M	0.49%	New
48	MANUFACTURERS LIFE INSURANCE COMPANY, THE#48 · 298,000 sh	298,000	$4.3M	<0.01%	-49.7%
49	Nuveen#49 · 294,867 sh	294,867	$4.3M	<0.01%	+20.9%
50	BNP PARIBAS FINANCIAL MARKETS#50 · 274,894 sh	274,894	$4.0M	<0.01%	+460.6%
51	DARK FOREST CAPITAL MANAGEMENT#51 · 243,607 sh	243,607	$3.5M	0.23%	+201.6%
52	DEUTSCHE BANK AG\#52 · 239,347 sh	239,347	$3.5M	<0.01%	+0.7%
53	Polymer Capital Management (HK) LTD#53 · 224,853 sh	224,853	$3.3M	0.17%	+69.0%
54	SECTORAL ASSET MANAGEMENT#54 · 220,180 sh	220,180	$3.2M	2.24%	+216.3%
55	Woodline Partners#55 · 214,507 sh	214,507	$3.1M	<0.01%	0.0%
56	BARCLAYS PLC#56 · 210,207 sh	210,207	$3.1M	<0.01%	+328.1%
57	WELLS FARGO & COMPANY#57 · 208,413 sh	208,413	$3.0M	<0.01%	+73.2%
58	Rafferty Asset Management#58 · 206,625 sh	206,625	$3.0M	<0.01%	-20.2%
59	VOYA INVESTMENT MANAGEMENT#59 · 199,390 sh	199,390	$2.9M	<0.01%	+53.1%
60	HRT FINANCIAL#60 · 244,553 sh	244,553	$2.9M	<0.01%	New
61	GRIFFIN ASSET MANAGEMENT#61 · 193,582 sh	193,582	$2.8M	—	+0.9%
62	ADAR1 Capital Management#62 · 191,869 sh	191,869	$2.8M	0.13%	+108.9%
63	Trexquant Investment#63 · 184,013 sh	184,013	$2.7M	0.02%	New
64	Focus Partners Wealth#64 · 170,338 sh	170,338	$2.5M	<0.01%	+103.0%
65	China Universal Asset Management , Ltd.#65 · 133,527 sh	133,527	$1.9M	0.12%	-3.0%
66	DIMENSIONAL FUND ADVISORS#66 · 127,978 sh	127,978	$1.9M	<0.01%	+44.6%
67	RHUMBLINE ADVISERS#67 · 126,895 sh	126,895	$1.8M	<0.01%	-2.0%
68	HSBC PLC#68 · 120,560 sh	120,560	$1.8M	<0.01%	New
69	Toroso Investments#69 · 121,097 sh	121,097	$1.8M	<0.01%	+0.7%
70	TEMA ETFS#70 · 121,097 sh	121,097	$1.8M	—	+1.3%
71	Cerity Partners#71 · 114,505 sh	114,505	$1.7M	<0.01%	+0.6%
72	Quantinno Capital Management#72 · 113,452 sh	113,452	$1.7M	<0.01%	+53.7%
73	NOMURA#73 · 112,359 sh	112,359	$1.6M	<0.01%	-64.2%
74	BANK OF MONTREAL#74 · 104,625 sh	104,625	$1.5M	<0.01%	-3.1%
75	PROFUND ADVISORS#75 · 100,549 sh	100,549	$1.5M	0.04%	-11.0%
76	Caption Management#76 · 100,000 sh	100,000	$1.5M	<0.01%	New
77	Beacon Pointe Advisors#77 · 98,114 sh	98,114	$1.4M	<0.01%	+3.9%
78	LMR Partners LLP#78 · 96,177 sh	96,177	$1.4M	<0.01%	+181.9%
79	STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM#79 · 94,229 sh	94,229	$1.4M	<0.01%	-1.9%
80	AXQ CAPITAL#80 · 93,624 sh	93,624	$1.4M	0.15%	+98.1%
81	Schonfeld Strategic Advisors#81 · 91,557 sh	91,557	$1.3M	<0.01%	+306.8%
82	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AME#82 · 90,338 sh	90,338	$1.3M	<0.01%	+13.4%
83	Wealth Management Partners#83 · 89,274 sh	89,274	$1.3M	—	+40.0%
84	XTX Topco Ltd#84 · 81,402 sh	81,402	$1.2M	0.02%	New
85	Seven Fleet Capital Management#85 · 73,300 sh	73,300	$1.1M	0.18%	New
86	JPMORGAN CHASE#86 · 68,169 sh	68,169	$1.1M	<0.01%	+5.6%
87	NICOLET BANKSHARES#87 · 72,593 sh	72,593	$1.1M	0.03%	New
88	Engineers Gate Manager#88 · 67,871 sh	67,871	$988.9K	0.01%	New
89	GUGGENHEIM CAPITAL#89 · 67,835 sh	67,835	$988.4K	<0.01%	+2.2%
90	VARCOV#90 · 63,957 sh	63,957	$931.9K	0.35%	+172.1%
91	Illinois Municipal Retirement Fund#91 · 62,734 sh	62,734	$914.0K	0.01%	-43.9%
92	Bridgefront Capital#92 · 60,416 sh	60,416	$880.3K	0.23%	New
93	Police & Firemen's Retirement System of New Jersey#93 · 60,337 sh	60,337	$879.1K	<0.01%	+14.7%
94	DIADEMA PARTNERS#94 · 60,000 sh	60,000	$874.2K	0.11%	New
95	Assenagon Asset Management S.A.#95 · 59,621 sh	59,621	$868.7K	—	0.0%
96	Vanguard Global Advisers#96 · 59,105 sh	59,105	$861.2K	<0.01%	-3.3%
97	Treasurer of the State of North Carolina#97 · 57,527 sh	57,527	$838.0K	<0.01%	+15.0%
98	Entropy Technologies#98 · 57,017 sh	57,017	$830.7K	0.03%	+161.7%
99	Handelsbanken Fonder AB#99 · 55,500 sh	55,500	$809.0K	<0.01%	+24.4%
100	Hudson Bay Capital Management#100 · 54,950 sh	54,950	$800.6K	<0.01%	New

Funds that sold out of SMMT in Q2 2026 (36)

Held SMMT at the end of Q1 2026 and filed a Q2 2026 13F without it. Not in the list above, because they no longer hold it. Largest prior position first.

Institutions that held SMMT in Q1 2026 and reported no position in Q2 2026.
Institution	Shares sold	Value in Q1 2026
SUPERSTRING CAPITAL MANAGEMENT892,873 sh	892,873	$16.9M
TUDOR INVESTMENT ET AL384,988 sh	384,988	$7.3M
ExodusPoint Capital Management256,255 sh	256,255	$4.9M
Y-Intercept (Hong Kong) Ltd119,655 sh	119,655	$2.3M
LEUCADIA NATIONAL100,000 sh	100,000	$1.9M
CANADA PENSION PLAN INVESTMENT BOARD91,000 sh	91,000	$1.7M
NEXTBio Capital Management89,717 sh	89,717	$1.7M
Longaeva Partners L.P.57,282 sh	57,282	$1.1M
BOOTHBAY FUND MANAGEMENT53,964 sh	53,964	$1.0M
SG Americas Securities53,523 sh	53,523	$1.0M
Fieldview Capital Management49,204 sh	49,204	$932.9K
Capstone Capital Management Ltd23,146 sh	23,146	$438.8K
WINTON GROUP Ltd22,400 sh	22,400	$424.7K
PRELUDE CAPITAL MANAGEMENT20,000 sh	20,000	$379.2K
Arrowpoint Investment Partners (Singapore) Pte. Ltd.12,136 sh	12,136	$230.1K
Lighthouse Investment Partners11,991 sh	11,991	$227.3K
DRW Securities11,533 sh	11,533	$218.7K
Jain Global10,786 sh	10,786	$204.5K
EVOKE WEALTH10,668 sh	10,668	$202.3K
PSP Research10,223 sh	10,223	$193.8K
Eurizon Capital SGR S.p.A.6,908 sh	6,908	$131.0K
Versant Capital Management831 sh	831	$15.8K
Sound Income Strategies410 sh	410	$7.8K
Western Wealth Management198 sh	198	$3.8K
Aster Capital Management (DIFC) Ltd91 sh	91	$1.8K
ZRC WEALTH MANAGEMENT91 sh	91	$1.7K
TOTH FINANCIAL ADVISORY90 sh	90	$1.7K
Marquette Asset Management44 sh	44	$835.00
Golden State Equity Partners40 sh	40	$758.00
Horizon Investments28 sh	28	$531.00
TWIN PEAKS WEALTH ADVISORS12 sh	12	$228.00
Hughes Financial Services6 sh	6	$114.00
MassMutual Private Wealth & , FSB5 sh	5	$95.00
Activest Wealth Management3 sh	3	$57.00
Cassaday & Wealth Management2 sh	2	$38.00
Root Financial Partners1 sh	1	$19.00

Source: Form 13F-HR filings on SEC EDGAR, Q2 2026. Values are as reported by each manager at quarter end. “% of portfolio” is the position’s share of the manager’s total reported 13F value for the same quarter. “New” means the manager filed a 13F for Q1 2026 without this position; a dash means no comparison is available. Where a manager’s own filing is internally inconsistent its value is withheld and it is listed last. 13F data shows reported holdings, not recommendations.