RHYTHM PHARMACEUTICALS, INC. (RYTM) — Institutional Holders, Q2 2026

307 institutional investment managers reported a RYTM position on SEC Form 13F-HR for the quarter ended June 30, 2026, with a combined reported value of $8.5B. Every filer is listed below, ranked by position value, 100 per page; this page shows ranks 1 to 100. Put and call option positions are excluded, and a firm filing several lots or share classes is shown once with its total.

← RYTM stock profile

RYTM in Q2 2026: what funds did

Funds that filed a 13F for both Q1 2026 and Q2 2026, by what they did with the common stock. Share counts are adjusted for any split between the two quarters; dollar figures are the change in shares at this quarter’s price.

New positions

Added to

107

Trimmed

101

Sold out

Biggest buyers

JPMORGAN CHASEAdded · +1,099,102 sh+$122.0M
PRICE T ROWE ASSOCIATESAdded · +911,295 sh+$101.2M
FEDERATED HERMESAdded · +499,413 sh+$55.4M
Capital Research Global InvestorsAdded · +416,843 sh+$46.3M
Siren, L.L.C.Added · +410,764 sh+$45.6M

Biggest sellers

FMRTrimmed · -663,831 sh-$73.7M
Point72 Asset Management, L.P.Trimmed · -432,591 sh-$48.0M
LORD, ABBETTSold out · -348,953 sh-$38.7M
ADAGE CAPITAL PARTNERS GP, L.L.C.Trimmed · -328,744 sh-$36.5M
Logos Global ManagementTrimmed · -325,000 sh-$36.1M

RYTM 13F holders ranked 1–100 of 307

Institutional investors reporting a position in RHYTHM PHARMACEUTICALS, INC. on SEC Form 13F-HR for Q2 2026, ranked by reported value.
#	Institution	Shares	Value	% of portfolio	QoQShares vs Q1 2026
1	RA CAPITAL MANAGEMENT, L.P.#1 · 6,666,837 sh	6,666,837	$740.2M	6.43%	0.0%
2	BlackRock#2 · 6,156,902 sh	6,156,902	$683.6M	0.01%	-1.3%
3	BAKER BROS. ADVISORS#3 · 5,604,483 sh	5,604,483	$622.3M	3.12%	0.0%
4	PRIMECAP MANAGEMENT#4 · 3,168,853 sh	3,168,853	$351.8M	0.21%	-7.3%
5	VANGUARD PORTFOLIO MANAGEMENT#5 · 3,136,895 sh	3,136,895	$348.3M	0.02%	+3.2%
6	VANGUARD CAPITAL MANAGEMENT#6 · 3,005,977 sh	3,005,977	$333.8M	<0.01%	+1.3%
7	JPMORGAN CHASE#7 · 2,652,746 sh	2,652,746	$292.2M	0.02%	+70.7%
8	PERCEPTIVE ADVISORS#8 · 2,586,295 sh	2,586,295	$287.2M	4.31%	+9.0%
9	STATE STREET#9 · 2,573,529 sh	2,573,529	$285.7M	<0.01%	+13.3%
10	PRICE T ROWE ASSOCIATES#10 · 2,566,171 sh	2,566,171	$284.9M	0.03%	+55.1%
11	WESTFIELD CAPITAL MANAGEMENT#11 · 2,208,595 sh	2,208,595	$245.2M	0.80%	+14.5%
12	GOLDMAN SACHS GROUP#12 · 2,126,502 sh	2,126,502	$236.1M	0.02%	+8.2%
13	FEDERATED HERMES#13 · 1,785,716 sh	1,785,716	$198.3M	0.29%	+38.8%
14	Polar Capital Plc#14 · 1,663,632 sh	1,663,632	$184.7M	0.44%	+3.0%
15	GEODE CAPITAL MANAGEMENT#15 · 1,533,698 sh	1,533,698	$170.3M	<0.01%	+8.3%
16	Capital Research Global Investors#16 · 1,532,303 sh	1,532,303	$170.1M	0.02%	+37.4%
17	CITADEL ADVISORS#17 · 1,263,652 sh	1,263,652	$140.3M	0.02%	-10.9%
18	Checkpoint Capital L.P.#18 · 1,186,000 sh	1,186,000	$131.7M	33.79%	-3.4%
19	Siren, L.L.C.#19 · 1,136,275 sh	1,136,275	$126.2M	2.55%	+56.6%
20	MORGAN STANLEY#20 · 1,112,240 sh	1,112,240	$123.5M	<0.01%	+58.0%
21	FMR#21 · 1,025,840 sh	1,025,840	$113.9M	<0.01%	-39.3%
22	Pictet Asset Management Holding SA#22 · 957,785 sh	957,785	$106.3M	0.10%	+43.6%
23	Jupiter Topco#23 · 925,490 sh	925,490	$102.8M	0.04%	—
24	Woodline Partners#24 · 758,891 sh	758,891	$84.3M	0.26%	0.0%
25	ALLIANCEBERNSTEIN L.P.#25 · 894,723 sh	894,723	$77.8M	0.03%	-1.7%
26	Clearbridge Investments#26 · 696,473 sh	696,473	$77.3M	0.06%	+14.3%
27	Rock Springs Capital Management#27 · 692,598 sh	692,598	$76.9M	3.75%	+0.4%
28	NORGES BANK#28 · 685,844 sh	685,844	$76.1M	<0.01%	—
29	FRANKLIN RESOURCES#29 · 577,033 sh	577,033	$64.1M	0.01%	-7.9%
30	CHARLES SCHWAB INVESTMENT MANAGEMENT#30 · 552,738 sh	552,738	$61.4M	<0.01%	+5.0%
31	Integral Health Asset Management#31 · 550,000 sh	550,000	$61.1M	2.41%	-8.3%
32	Invesco Ltd.#32 · 543,271 sh	543,271	$60.3M	<0.01%	+49.1%
33	NORTHERN#33 · 540,332 sh	540,332	$60.0M	<0.01%	+8.4%
34	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AME#34 · 514,850 sh	514,850	$57.2M	0.01%	-4.9%
35	WELLINGTON MANAGEMENT GROUP LLP#35 · 488,747 sh	488,747	$54.3M	<0.01%	+78.5%
36	VANGUARD FIDUCIARY#36 · 445,723 sh	445,723	$49.5M	0.01%	+5.6%
37	LOOMIS SAYLES & L P#37 · 434,102 sh	434,102	$48.2M	0.06%	-6.7%
38	Candriam S.C.A.#38 · 433,025 sh	433,025	$48.0M	0.22%	-6.7%
39	Squarepoint Ops#39 · 422,921 sh	422,921	$47.0M	0.05%	+60.8%
40	Point72 Asset Management, L.P.#40 · 414,210 sh	414,210	$46.0M	0.05%	-51.1%
41	Sofinnova Ventures#41 · 408,027 sh	408,027	$45.3M	2.34%	-9.3%
42	AMERIPRISE FINANCIAL#42 · 401,634 sh	401,634	$44.6M	<0.01%	+4.6%
43	ADAGE CAPITAL PARTNERS GP, L.L.C.#43 · 397,000 sh	397,000	$44.1M	0.06%	-45.3%
44	Bank of New York Mellon#44 · 394,044 sh	394,044	$43.8M	<0.01%	+34.3%
45	BRAIDWELL#45 · 381,128 sh	381,128	$42.3M	1.57%	+22.7%
46	Artisan Partners Limited Partnership#46 · 354,816 sh	354,816	$39.4M	0.06%	-9.2%
47	BANK OF AMERICA#47 · 325,470 sh	325,470	$36.1M	<0.01%	-48.2%
48	ORBIMED ADVISORS#48 · 322,900 sh	322,900	$35.9M	0.66%	+2.8%
49	MILLENNIUM MANAGEMENT#49 · 316,719 sh	316,719	$35.2M	0.01%	-29.9%
50	SILVERARC CAPITAL MANAGEMENT#50 · 311,461 sh	311,461	$34.6M	3.59%	+1.8%
51	VOYA INVESTMENT MANAGEMENT#51 · 272,974 sh	272,974	$30.3M	0.03%	+16.8%
52	Capital World Investors#52 · 221,450 sh	221,450	$24.6M	<0.01%	+91.4%
53	Duquesne Family Office#53 · 203,618 sh	203,618	$22.6M	0.43%	New
54	Nuveen#54 · 203,078 sh	203,078	$22.5M	<0.01%	+73.0%
55	BNP PARIBAS FINANCIAL MARKETS#55 · 197,374 sh	197,374	$21.9M	<0.01%	-20.4%
56	KENNEDY CAPITAL MANAGEMENT#56 · 193,215 sh	193,215	$21.5M	0.38%	+193.6%
57	Assenagon Asset Management S.A.#57 · 186,491 sh	186,491	$20.7M	—	New
58	SCHRODER INVESTMENT MANAGEMENT GROUP#58 · 160,518 sh	160,518	$17.7M	0.01%	+21.9%
59	First Turn Management#59 · 154,018 sh	154,018	$17.1M	1.83%	New
60	NEW YORK STATE COMMON RETIREMENT FUND#60 · 148,152 sh	148,152	$16.4M	0.02%	+18.3%
61	UBS Group AG#61 · 144,378 sh	144,378	$16.0M	<0.01%	-37.7%
62	Nicholas Investment Partners#62 · 139,270 sh	139,270	$15.5M	0.87%	New
63	ADAR1 Capital Management#63 · 136,158 sh	136,158	$15.1M	0.69%	-35.6%
64	Connor, Clark & Lunn Investment Management Ltd.#64 · 135,867 sh	135,867	$15.1M	0.03%	-10.5%
65	Qube Research & Technologies Ltd#65 · 134,410 sh	134,410	$14.9M	0.01%	-51.6%
66	NEXTBio Capital Management#66 · 131,758 sh	131,758	$14.6M	6.73%	+4.5%
67	DRIEHAUS CAPITAL MANAGEMENT#67 · 129,285 sh	129,285	$14.4M	0.08%	-70.4%
68	SummitTX Capital, L.P.#68 · 126,401 sh	126,401	$14.0M	0.36%	-23.7%
69	Logos Global Management#69 · 125,000 sh	125,000	$13.9M	0.60%	-72.2%
70	Opaleye Management#70 · 122,500 sh	122,500	$13.6M	1.23%	-0.4%
71	SEGALL BRYANT & HAMILL#71 · 121,866 sh	121,866	$13.5M	0.16%	New
72	DEUTSCHE BANK AG\#72 · 115,232 sh	115,232	$12.8M	<0.01%	-18.6%
73	Longaeva Partners L.P.#73 · 110,074 sh	110,074	$12.2M	0.27%	New
74	Swiss National Bank#74 · 109,700 sh	109,700	$12.2M	<0.01%	-2.2%
75	PFM Health Sciences#75 · 101,550 sh	101,550	$11.3M	0.97%	-25.7%
76	abrdn plc#76 · 94,946 sh	94,946	$10.5M	0.01%	+19.6%
77	AXIOM INVESTORS#77 · 86,880 sh	86,880	$9.6M	0.08%	-5.3%
78	Russell Investments Group, Ltd.#78 · 86,709 sh	86,709	$9.6M	<0.01%	-25.1%
79	First Light Asset Management#79 · 85,765 sh	85,765	$9.5M	0.58%	-1.6%
80	ALGERT GLOBAL#80 · 83,431 sh	83,431	$9.3M	0.11%	+42.6%
81	Granahan Investment Management#81 · 83,270 sh	83,270	$9.2M	0.33%	+7.2%
82	Neuberger Berman Group#82 · 83,035 sh	83,035	$9.2M	<0.01%	+13.1%
83	SPHERA FUNDS MANAGEMENT LTD.#83 · 80,400 sh	80,400	$8.9M	1.16%	New
84	WCM INVESTMENT MANAGEMENT#84 · 80,552 sh	80,552	$8.9M	0.02%	-0.1%
85	Atom Investors#85 · 73,465 sh	73,465	$8.2M	0.73%	+28.9%
86	SILVERCREST ASSET MANAGEMENT GROUP#86 · 73,432 sh	73,432	$8.2M	0.05%	+56.6%
87	RHUMBLINE ADVISERS#87 · 73,333 sh	73,333	$8.1M	<0.01%	+5.0%
88	WELLS FARGO & COMPANY#88 · 72,147 sh	72,147	$8.0M	<0.01%	+111.5%
89	PRUDENTIAL FINANCIAL#89 · 69,145 sh	69,145	$7.7M	<0.01%	+129.0%
90	CAPITAL FUND MANAGEMENT S.A.#90 · 68,548 sh	68,548	$7.6M	0.03%	New
91	RENAISSANCE TECHNOLOGIES#91 · 68,281 sh	68,281	$7.6M	0.01%	-73.5%
92	PICTON MAHONEY ASSET MANAGEMENT#92 · 65,880 sh	65,880	$7.3M	0.05%	+30.8%
93	Blue Owl Capital#93 · 61,455 sh	61,455	$6.8M	1.03%	0.0%
94	ExodusPoint Capital Management#94 · 61,147 sh	61,147	$6.8M	0.04%	+244.0%
95	AQR CAPITAL MANAGEMENT#95 · 59,208 sh	59,208	$6.6M	<0.01%	-0.1%
96	CITIGROUP#96 · 58,347 sh	58,347	$6.5M	<0.01%	+373.0%
97	RAYMOND JAMES FINANCIAL#97 · 58,069 sh	58,069	$6.4M	<0.01%	+16.3%
98	MANUFACTURERS LIFE INSURANCE COMPANY, THE#98 · 57,170 sh	57,170	$6.3M	<0.01%	+12.6%
99	Trexquant Investment#99 · 56,248 sh	56,248	$6.2M	0.04%	New
100	VANGUARD ASSET MANAGEMENT, Ltd#100 · 53,279 sh	53,279	$5.9M	<0.01%	+7.2%

Funds that sold out of RYTM in Q2 2026 (41)

Held RYTM at the end of Q1 2026 and filed a Q2 2026 13F without it. Not in the list above, because they no longer hold it. Largest prior position first.

Institutions that held RYTM in Q1 2026 and reported no position in Q2 2026.
Institution	Shares sold	Value in Q1 2026
LORD, ABBETT348,953 sh	348,953	$30.3M
Hood River Capital Management239,912 sh	239,912	$20.9M
M&G Plc138,567 sh	138,567	$12.1M
BALYASNY ASSET MANAGEMENT L.P.52,967 sh	52,967	$4.6M
CASTLEARK MANAGEMENT52,279 sh	52,279	$4.5M
Harvest Investment Services48,468 sh	48,468	$4.2M
Utah Retirement Systems42,177 sh	42,177	$3.7M
Alyeska Investment Group, L.P.32,589 sh	32,589	$2.8M
HARBOR CAPITAL ADVISORS30,353 sh	30,353	$2.6M
PDT Partners27,232 sh	27,232	$2.4M
HSBC PLC14,307 sh	14,307	$1.2M
Hudson Bay Capital Management9,120 sh	9,120	$793.2K
HighTower Advisors9,058 sh	9,058	$787.8K
PRELUDE CAPITAL MANAGEMENT8,372 sh	8,372	$728.1K
IMC-Chicago6,697 sh	6,697	$582.4K
TEXAS TREASURY SAFEKEEPING6,154 sh	6,154	$535.0K
Campbell & Investment Adviser5,958 sh	5,958	$518.2K
Blueshift Asset Management5,787 sh	5,787	$503.3K
Centiva Capital4,000 sh	4,000	$347.9K
FOX RUN MANAGEMENT, L.L.C.4,499 sh	4,499	$347.5K
BANK OF MONTREAL3,801 sh	3,801	$330.6K
Brevan Howard Capital Management3,777 sh	3,777	$328.5K
Chicago Partners Investment Group3,125 sh	3,125	$266.2K
Ethic3,003 sh	3,003	$261.2K
MAI Capital Management2,710 sh	2,710	$235.7K
Blackstone2,600 sh	2,600	$226.1K
DRW Securities2,562 sh	2,562	$222.8K
TWO SIGMA SECURITIES2,545 sh	2,545	$221.3K
CORNERSTONE PARTNERS CAPITAL MANAGEMENT2,462 sh	2,462	$214.1K
Verdad Advisers2,445 sh	2,445	$212.6K
Quantbot Technologies1,363 sh	1,363	$118.5K
Sound Income Strategies114 sh	114	$10.0K
EASTERN BANK59 sh	59	$5.1K
Advisory Services Network37 sh	37	$3.2K
Golden State Equity Partners37 sh	37	$3.2K
Root Financial Partners31 sh	31	$2.7K
JFS WEALTH ADVISORS10 sh	10	$870.00
TWIN PEAKS WEALTH ADVISORS6 sh	6	$522.00
TORONTO DOMINION BANK6 sh	6	$522.00
HFM Investment Advisors1 sh	1	$87.00
Bay Harbor Wealth Management1 sh	1	$86.00

Source: Form 13F-HR filings on SEC EDGAR, Q2 2026. Values are as reported by each manager at quarter end. “% of portfolio” is the position’s share of the manager’s total reported 13F value for the same quarter. “New” means the manager filed a 13F for Q1 2026 without this position; a dash means no comparison is available. Where a manager’s own filing is internally inconsistent its value is withheld and it is listed last. 13F data shows reported holdings, not recommendations.