Protagonist Therapeutics, Inc (PTGX) — Institutional Holders, Q2 2026

349 institutional investment managers reported a PTGX position on SEC Form 13F-HR for the quarter ended June 30, 2026, with a combined reported value of $9.3B. Every filer is listed below, ranked by position value, 100 per page; this page shows ranks 1 to 100. Put and call option positions are excluded, and a firm filing several lots or share classes is shown once with its total.

← PTGX stock profile

PTGX in Q2 2026: what funds did

Funds that filed a 13F for both Q1 2026 and Q2 2026, by what they did with the common stock. Share counts are adjusted for any split between the two quarters; dollar figures are the change in shares at this quarter’s price.

New positions

Added to

134

Trimmed

Sold out

Biggest buyers

VANGUARD PORTFOLIO MANAGEMENTNew · +3,629,298 sh+$444.9M
VANGUARD CAPITAL MANAGEMENTNew · +2,853,394 sh+$349.8M
BlackRockAdded · +528,468 sh+$64.8M
PRICE T ROWE ASSOCIATESAdded · +484,165 sh+$59.3M
VANGUARD FIDUCIARYNew · +437,747 sh+$53.7M

Biggest sellers

UBS Group AGTrimmed · -1,778,575 sh-$218.0M
CITADEL ADVISORSSold out · -1,551,900 sh-$190.2M
Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A.Sold out · -571,825 sh-$70.1M
MARSHALL WACE, LLPTrimmed · -519,058 sh-$63.6M
Rubric Capital ManagementSold out · -427,998 sh-$52.5M

PTGX 13F holders ranked 1–100 of 349

Institutional investors reporting a position in Protagonist Therapeutics, Inc on SEC Form 13F-HR for Q2 2026, ranked by reported value.
#	Institution	Shares	Value	% of portfolio	QoQShares vs Q1 2026
1	BlackRock#1 · 10,307,837 sh	10,307,837	$1.3B	0.02%	+5.4%
2	FARALLON CAPITAL MANAGEMENT#2 · 6,348,906 sh	6,348,906	$778.2M	3.59%	0.0%
3	RTW INVESTMENTS#3 · 5,061,175 sh	5,061,175	$620.4M	5.30%	0.0%
4	VANGUARD PORTFOLIO MANAGEMENT#4 · 3,629,298 sh	3,629,298	$444.9M	0.02%	New
5	WELLINGTON MANAGEMENT GROUP LLP#5 · 3,416,781 sh	3,416,781	$418.8M	0.07%	-5.1%
6	UBS Group AG#6 · 3,399,221 sh	3,399,221	$416.7M	0.05%	-34.4%
7	STATE STREET#7 · 3,321,554 sh	3,321,554	$407.2M	0.01%	+6.6%
8	VANGUARD CAPITAL MANAGEMENT#8 · 2,853,394 sh	2,853,394	$349.8M	<0.01%	New
9	JOHNSON & JOHNSON#9 · 2,449,183 sh	2,449,183	$300.2M	—	0.0%
10	Invesco Ltd.#10 · 2,340,667 sh	2,340,667	$286.9M	0.02%	+8.1%
11	PRICE T ROWE ASSOCIATES#11 · 2,149,662 sh	2,149,662	$263.5M	0.03%	+29.1%
12	Jupiter Topco#12 · 2,129,780 sh	2,129,780	$261.0M	0.11%	—
13	GEODE CAPITAL MANAGEMENT#13 · 1,741,209 sh	1,741,209	$213.5M	0.01%	+4.3%
14	Woodline Partners#14 · 1,414,173 sh	1,414,173	$173.3M	0.54%	0.0%
15	BANK OF AMERICA#15 · 1,324,498 sh	1,324,498	$162.4M	0.01%	+2.2%
16	JENNISON ASSOCIATES#16 · 1,151,681 sh	1,151,681	$141.2M	0.08%	+7.4%
17	PERCEPTIVE ADVISORS#17 · 981,879 sh	981,879	$120.4M	1.81%	-20.2%
18	ADAR1 Capital Management#18 · 960,863 sh	960,863	$117.8M	5.39%	-3.3%
19	MORGAN STANLEY#19 · 905,992 sh	905,992	$111.1M	<0.01%	-11.0%
20	Alyeska Investment Group, L.P.#20 · 889,298 sh	889,298	$109.0M	0.28%	+49.9%
21	Hood River Capital Management#21 · 882,738 sh	882,738	$108.2M	0.78%	+6.4%
22	GOLDMAN SACHS GROUP#22 · 812,852 sh	812,852	$99.6M	<0.01%	+4.4%
23	DRIEHAUS CAPITAL MANAGEMENT#23 · 731,053 sh	731,053	$89.6M	0.52%	+1.4%
24	Clearbridge Investments#24 · 725,335 sh	725,335	$88.9M	0.07%	+16.6%
25	FMR#25 · 672,186 sh	672,186	$82.4M	<0.01%	+1.5%
26	NORTHERN#26 · 666,105 sh	666,105	$81.7M	<0.01%	+13.3%
27	AMERICAN CENTURY COMPANIES#27 · 598,600 sh	598,600	$73.4M	0.03%	+11.4%
28	CHARLES SCHWAB INVESTMENT MANAGEMENT#28 · 583,774 sh	583,774	$71.6M	<0.01%	+5.6%
29	VOYA INVESTMENT MANAGEMENT#29 · 571,618 sh	571,618	$70.1M	0.06%	+25.8%
30	Pictet Asset Management Holding SA#30 · 567,990 sh	567,990	$69.6M	0.07%	-2.3%
31	FRANKLIN RESOURCES#31 · 520,032 sh	520,032	$63.7M	0.01%	+277.2%
32	VANGUARD FIDUCIARY#32 · 437,747 sh	437,747	$53.7M	0.01%	New
33	LORD, ABBETT#33 · 398,994 sh	398,994	$48.9M	0.14%	+144.1%
34	PRINCIPAL FINANCIAL GROUP#34 · 385,262 sh	385,262	$47.2M	0.02%	+4.7%
35	Bank of New York Mellon#35 · 358,300 sh	358,300	$43.9M	<0.01%	+4.9%
36	Neuberger Berman Group#36 · 302,427 sh	302,427	$37.1M	0.02%	+113.8%
37	BNP PARIBAS FINANCIAL MARKETS#37 · 301,472 sh	301,472	$37.0M	0.01%	+55.0%
38	683 Capital Management#38 · 290,000 sh	290,000	$35.5M	1.75%	-18.3%
39	Nuveen#39 · 284,085 sh	284,085	$34.8M	<0.01%	+122.1%
40	Stephens Investment Management Group#40 · 281,832 sh	281,832	$34.5M	0.37%	New
41	BNP Paribas Asset Management Holding S.A.#41 · 259,972 sh	259,972	$31.9M	0.03%	-15.1%
42	Eagle Health Investments#42 · 248,322 sh	248,322	$30.4M	5.05%	+38.5%
43	NEXTBio Capital Management#43 · 219,333 sh	219,333	$26.9M	12.37%	-4.5%
44	SEGALL BRYANT & HAMILL#44 · 214,724 sh	214,724	$26.3M	0.31%	-0.6%
45	SEB Asset Management AB#45 · 209,963 sh	209,963	$25.7M	0.10%	-9.7%
46	Duquesne Family Office#46 · 208,900 sh	208,900	$25.6M	0.49%	+30.8%
47	PUBLIC SECTOR PENSION INVESTMENT BOARD#47 · 207,688 sh	207,688	$25.5M	0.07%	-1.2%
48	CITIGROUP#48 · 198,668 sh	198,668	$24.4M	<0.01%	+25.2%
49	JPMORGAN CHASE#49 · 183,098 sh	183,098	$22.6M	<0.01%	+5.8%
50	DIMENSIONAL FUND ADVISORS#50 · 178,152 sh	178,152	$21.8M	<0.01%	-64.9%
51	Affinity Asset Advisors#51 · 172,125 sh	172,125	$21.1M	0.95%	0.0%
52	Fisher Asset Management#52 · 170,524 sh	170,524	$20.9M	<0.01%	-2.0%
53	Boxer Capital Management#53 · 170,000 sh	170,000	$20.8M	1.57%	0.0%
54	RAYMOND JAMES FINANCIAL#54 · 168,270 sh	168,270	$20.6M	<0.01%	-5.1%
55	NAN FUNG TRINITY (HK) Ltd#55 · 160,670 sh	160,670	$19.7M	1.94%	0.0%
56	AMERIPRISE FINANCIAL#56 · 143,810 sh	143,810	$17.6M	<0.01%	-1.3%
57	DEUTSCHE BANK AG\#57 · 141,838 sh	141,838	$17.4M	<0.01%	+13.1%
58	RHUMBLINE ADVISERS#58 · 141,279 sh	141,279	$17.3M	0.01%	-10.2%
59	NOMURA ASSET MANAGEMENT INTERNATIONAL#59 · 141,081 sh	141,081	$17.3M	0.03%	New
60	TD ASSET MANAGEMENT#60 · 134,950 sh	134,950	$16.5M	0.01%	-26.5%
61	KENNEDY CAPITAL MANAGEMENT#61 · 134,019 sh	134,019	$16.4M	0.29%	-2.2%
62	Legal & General Group Plc#62 · 132,351 sh	132,351	$16.2M	<0.01%	-2.2%
63	Russell Investments Group, Ltd.#63 · 115,425 sh	115,425	$14.1M	0.01%	+185.9%
64	MARSHALL WACE, LLP#64 · 109,017 sh	109,017	$13.4M	0.01%	-82.6%
65	MANUFACTURERS LIFE INSURANCE COMPANY, THE#65 · 108,555 sh	108,555	$13.3M	0.01%	-15.1%
66	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AME#66 · 107,094 sh	107,094	$13.1M	<0.01%	-0.3%
67	Catalio Capital Management#67 · 106,799 sh	106,799	$13.1M	2.46%	New
68	Swiss National Bank#68 · 102,400 sh	102,400	$12.6M	<0.01%	+3.5%
69	Universal- Beteiligungs- und Servicegesellschaft mbH#69 · 102,002 sh	102,002	$12.5M	0.02%	-3.3%
70	Opaleye Management#70 · 100,000 sh	100,000	$12.3M	1.11%	0.0%
71	ASSETMARK#71 · 98,687 sh	98,687	$12.1M	—	+112.5%
72	SEI INVESTMENTS#72 · 92,749 sh	92,749	$11.4M	0.01%	+11.5%
73	ALGERT GLOBAL#73 · 87,698 sh	87,698	$10.8M	0.13%	+11.8%
74	PRUDENTIAL FINANCIAL#74 · 85,180 sh	85,180	$10.4M	0.01%	-10.6%
75	VICTORY CAPITAL MANAGEMENT#75 · 83,883 sh	83,883	$10.3M	<0.01%	+0.4%
76	AXIOM INVESTORS#76 · 81,683 sh	81,683	$10.0M	0.09%	-4.4%
77	WELLS FARGO & COMPANY#77 · 71,944 sh	71,944	$8.8M	<0.01%	+139.2%
78	ALLIANCEBERNSTEIN L.P.#78 · 79,563 sh	79,563	$8.4M	<0.01%	+7.8%
79	NORDEA INVESTMENT MANAGEMENT AB#79 · 64,964 sh	64,964	$7.9M	<0.01%	+25.4%
80	SCHRODER INVESTMENT MANAGEMENT GROUP#80 · 64,991 sh	64,991	$7.9M	<0.01%	-35.1%
81	Knott David M Jr#81 · 63,000 sh	63,000	$7.7M	4.08%	0.0%
82	Atika Capital Management#82 · 62,100 sh	62,100	$7.6M	0.50%	0.0%
83	MOODY ALDRICH PARTNERS#83 · 59,601 sh	59,601	$7.3M	1.31%	+10.6%
84	Eversept Partners#84 · 58,504 sh	58,504	$7.2M	0.37%	New
85	Twin Lakes Capital Management#85 · 58,059 sh	58,059	$7.1M	2.72%	-0.2%
86	SUSQUEHANNA INTERNATIONAL GROUP, LLP#86 · 57,062 sh	57,062	$7.0M	<0.01%	-65.9%
87	GREAT LAKES ADVISORS#87 · 56,904 sh	56,904	$7.0M	0.05%	-19.9%
88	Creative Planning#88 · 56,185 sh	56,185	$6.9M	<0.01%	+17.1%
89	Bellevue Group AG#89 · 55,682 sh	55,682	$6.8M	0.14%	+285.4%
90	FIRST ADVISORS#90 · 54,865 sh	54,865	$6.7M	<0.01%	-37.6%
91	KVP Capital Advisors#91 · 53,000 sh	53,000	$6.5M	4.77%	0.0%
92	BESSEMER GROUP#92 · 52,074 sh	52,074	$6.4M	<0.01%	-3.9%
93	VANGUARD ASSET MANAGEMENT, Ltd#93 · 51,639 sh	51,639	$6.3M	<0.01%	New
94	CASTLEARK MANAGEMENT#94 · 50,570 sh	50,570	$6.2M	0.17%	New
95	Granahan Investment Management#95 · 49,809 sh	49,809	$6.1M	0.22%	+81.8%
96	NEW YORK STATE TEACHERS RETIREMENT SYSTEM#96 · 49,550 sh	49,550	$6.1M	—	+4.5%
97	NORTHWESTERN MUTUAL WEALTH MANAGEMENT#97 · 48,894 sh	48,894	$6.0M	<0.01%	-0.3%
98	GREAT WEST LIFE ASSURANCE#98 · 48,045 sh	48,045	$5.9M	<0.01%	+1.3%
99	SILVERCREST ASSET MANAGEMENT GROUP#99 · 45,668 sh	45,668	$5.6M	0.04%	-4.7%
100	Seven Fleet Capital Management#100 · 45,400 sh	45,400	$5.6M	0.92%	+1035.0%

Funds that sold out of PTGX in Q2 2026 (36)

Held PTGX at the end of Q1 2026 and filed a Q2 2026 13F without it. Not in the list above, because they no longer hold it. Largest prior position first.

Institutions that held PTGX in Q1 2026 and reported no position in Q2 2026.
Institution	Shares sold	Value in Q1 2026
CITADEL ADVISORS1,551,900 sh	1,551,900	$163.6M
Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A.571,825 sh	571,825	$60.3M
Rubric Capital Management427,998 sh	427,998	$45.1M
Vestal Point Capital326,159 sh	326,159	$34.4M
ADAGE CAPITAL PARTNERS GP, L.L.C.282,436 sh	282,436	$29.8M
Integral Health Asset Management50,000 sh	50,000	$5.3M
ROYCE & ASSOCIATES14,349 sh	14,349	$1.5M
HUSSMAN STRATEGIC ADVISORS10,500 sh	10,500	$1.1M
NOMURA10,479 sh	10,479	$1.1M
Advisors Asset Management4,644 sh	4,644	$489.5K
Cynosure Management4,635 sh	4,635	$488.5K
DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD.4,600 sh	4,600	$484.8K
Vident Advisory4,481 sh	4,481	$472.3K
Abacus Wealth Partners4,094 sh	4,094	$431.5K
Hudson Bay Capital Management3,760 sh	3,760	$396.3K
Headlands Technologies2,957 sh	2,957	$311.7K
Sumitomo Mitsui2,760 sh	2,760	$290.9K
Vise Technologies2,996 sh	2,996	$261.7K
GTS SECURITIES2,416 sh	2,416	$254.6K
PRELUDE CAPITAL MANAGEMENT2,012 sh	2,012	$212.1K
QUADRANT CAPITAL GROUP2,858 sh	2,858	$199.6K
FEDERATED HERMES1,001 sh	1,001	$105.5K
CFG Wealth Management Services611 sh	611	$64.4K
TORONTO DOMINION BANK349 sh	349	$36.8K
Ameritas Advisory Services334 sh	334	$35.2K
Allworth Financial313 sh	313	$33.0K
TWIN PEAKS WEALTH ADVISORS173 sh	173	$18.2K
Sound Income Strategies156 sh	156	$16.2K
Annis Gardner Whiting Capital Advisors76 sh	76	$8.0K
MCF Advisors40 sh	40	$4.2K
Golden State Equity Partners27 sh	27	$2.8K
PICTON MAHONEY ASSET MANAGEMENT25 sh	25	$2.6K
PENSION & WEALTH MANAGEMENT ADVISORS20 sh	20	$2.1K
Advisory Services Network18 sh	18	$1.9K
MAI Capital Management14 sh	14	$1.5K
Root Financial Partners3 sh	3	$316.00

Source: Form 13F-HR filings on SEC EDGAR, Q2 2026. Values are as reported by each manager at quarter end. “% of portfolio” is the position’s share of the manager’s total reported 13F value for the same quarter. “New” means the manager filed a 13F for Q1 2026 without this position; a dash means no comparison is available. Where a manager’s own filing is internally inconsistent its value is withheld and it is listed last. 13F data shows reported holdings, not recommendations.