Praxis Precision Medicines, Inc. (PRAX) — Institutional Holders, Q2 2026

311 institutional investment managers reported a PRAX position on SEC Form 13F-HR for the quarter ended June 30, 2026, with a combined reported value of $11.3B. Every filer is listed below, ranked by position value, 100 per page; this page shows ranks 1 to 100. Put and call option positions are excluded, and a firm filing several lots or share classes is shown once with its total.

← PRAX stock profile

PRAX in Q2 2026: what funds did

Funds that filed a 13F for both Q1 2026 and Q2 2026, by what they did with the common stock. Share counts are adjusted for any split between the two quarters; dollar figures are the change in shares at this quarter’s price.

New positions

Added to

121

Trimmed

Sold out

Biggest buyers

VANGUARD PORTFOLIO MANAGEMENTAdded · +578,437 sh+$193.7M
Invesco Ltd.Added · +476,151 sh+$159.4M
PRICE T ROWE ASSOCIATESAdded · +312,147 sh+$104.5M
Polar Capital PlcNew · +279,131 sh+$93.5M
WESTFIELD CAPITAL MANAGEMENTNew · +218,898 sh+$73.3M

Biggest sellers

Orbis Allan Gray LtdTrimmed · -942,692 sh-$315.6M
RA CAPITAL MANAGEMENT, L.P.Sold out · -373,787 sh-$125.1M
Cormorant Asset ManagementTrimmed · -245,500 sh-$82.2M
GOLDMAN SACHS GROUPTrimmed · -161,904 sh-$54.2M
Soleus Capital Management, L.P.Trimmed · -153,000 sh-$51.2M

PRAX 13F holders ranked 1–100 of 311

Institutional investors reporting a position in Praxis Precision Medicines, Inc. on SEC Form 13F-HR for Q2 2026, ranked by reported value.
#	Institution	Shares	Value	% of portfolio	QoQShares vs Q1 2026
1	Jupiter Topco#1 · 3,421,374 sh	3,421,374	$1.1B	0.47%	—
2	FMR#2 · 2,316,907 sh	2,316,907	$775.7M	0.03%	+7.2%
3	BlackRock#3 · 2,292,585 sh	2,292,585	$767.5M	0.01%	-1.4%
4	PERCEPTIVE ADVISORS#4 · 2,035,986 sh	2,035,986	$681.6M	10.23%	0.0%
5	BAKER BROS. ADVISORS#5 · 1,753,198 sh	1,753,198	$587.0M	2.94%	0.0%
6	Orbis Allan Gray Ltd#6 · 1,529,788 sh	1,529,788	$512.2M	1.76%	-38.1%
7	VANGUARD PORTFOLIO MANAGEMENT#7 · 1,335,185 sh	1,335,185	$447.0M	0.02%	+76.4%
8	VANGUARD CAPITAL MANAGEMENT#8 · 1,235,299 sh	1,235,299	$413.6M	<0.01%	+1.1%
9	STATE STREET#9 · 1,026,443 sh	1,026,443	$343.7M	0.01%	+16.1%
10	ADAGE CAPITAL PARTNERS GP, L.L.C.#10 · 1,015,480 sh	1,015,480	$340.0M	0.48%	+24.5%
11	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)#11 · 963,351 sh	963,351	$322.5M	3.36%	0.0%
12	DRIEHAUS CAPITAL MANAGEMENT#12 · 959,048 sh	959,048	$321.1M	1.86%	+1.0%
13	PRICE T ROWE ASSOCIATES#13 · 942,999 sh	942,999	$315.7M	0.03%	+49.5%
14	MORGAN STANLEY#14 · 854,112 sh	854,112	$285.9M	0.02%	+2.5%
15	GEODE CAPITAL MANAGEMENT#15 · 748,039 sh	748,039	$250.5M	0.01%	+14.9%
16	Cormorant Asset Management#16 · 640,000 sh	640,000	$214.3M	10.98%	-27.7%
17	GOLDMAN SACHS GROUP#17 · 548,830 sh	548,830	$183.7M	0.02%	-22.8%
18	BANK OF AMERICA#18 · 546,930 sh	546,930	$183.1M	0.01%	+2.3%
19	Invesco Ltd.#19 · 537,548 sh	537,548	$180.0M	0.01%	+775.5%
20	Hood River Capital Management#20 · 425,167 sh	425,167	$142.3M	1.03%	+18.6%
21	NORGES BANK#21 · 346,969 sh	346,969	$116.2M	0.01%	—
22	FRANKLIN RESOURCES#22 · 327,124 sh	327,124	$109.5M	0.02%	+18.5%
23	Pictet Asset Management Holding SA#23 · 291,689 sh	291,689	$98.0M	0.09%	+1.8%
24	Polar Capital Plc#24 · 279,131 sh	279,131	$93.5M	0.22%	New
25	Vivo Capital#25 · 271,116 sh	271,116	$90.8M	8.29%	-20.0%
26	Logos Global Management#26 · 260,000 sh	260,000	$87.0M	3.75%	-8.8%
27	NORTHERN#27 · 240,887 sh	240,887	$80.6M	<0.01%	+5.7%
28	AMERICAN CENTURY COMPANIES#28 · 237,315 sh	237,315	$79.5M	0.04%	+85.0%
29	ORBIMED ADVISORS#29 · 230,100 sh	230,100	$77.0M	1.43%	+33.4%
30	CHARLES SCHWAB INVESTMENT MANAGEMENT#30 · 220,008 sh	220,008	$73.7M	<0.01%	+2.1%
31	WESTFIELD CAPITAL MANAGEMENT#31 · 218,898 sh	218,898	$73.3M	0.24%	New
32	Woodline Partners#32 · 200,013 sh	200,013	$67.0M	0.21%	0.0%
33	BNP PARIBAS FINANCIAL MARKETS#33 · 188,409 sh	188,409	$63.1M	0.02%	+31.7%
34	VANGUARD FIDUCIARY#34 · 188,161 sh	188,161	$63.0M	0.01%	+10.7%
35	Affinity Asset Advisors#35 · 185,000 sh	185,000	$61.9M	2.80%	+8.8%
36	Soleus Capital Management, L.P.#36 · 177,517 sh	177,517	$59.4M	2.05%	-46.3%
37	abrdn plc#37 · 166,399 sh	166,399	$55.7M	0.08%	-3.5%
38	T. Rowe Price Investment Management#38 · 160,477 sh	160,477	$53.7M	0.04%	-8.4%
39	Qube Research & Technologies Ltd#39 · 152,475 sh	152,475	$51.0M	0.05%	+18.9%
40	MARSHALL WACE, LLP#40 · 137,008 sh	137,008	$45.9M	0.04%	+203.5%
41	UBS Group AG#41 · 131,046 sh	131,046	$43.9M	<0.01%	+20.8%
42	WELLINGTON MANAGEMENT GROUP LLP#42 · 125,867 sh	125,867	$42.1M	<0.01%	-27.8%
43	VOYA INVESTMENT MANAGEMENT#43 · 122,227 sh	122,227	$40.9M	0.04%	+334.4%
44	Nuveen#44 · 108,032 sh	108,032	$36.2M	<0.01%	+50.0%
45	MASSACHUSETTS FINANCIAL SERVICES#45 · 107,409 sh	107,409	$36.0M	0.01%	+1353.8%
46	MetLife Investment Management#46 · 90,543 sh	90,543	$30.3M	0.14%	+11.9%
47	Neuberger Berman Group#47 · 89,468 sh	89,468	$30.0M	0.02%	+244.6%
48	Velan Capital Investment Management#48 · 88,781 sh	88,781	$29.7M	18.10%	-11.9%
49	Bank of New York Mellon#49 · 85,376 sh	85,376	$28.6M	<0.01%	-1.9%
50	First Turn Management#50 · 83,528 sh	83,528	$28.0M	2.99%	+96.8%
51	ACUTA CAPITAL PARTNERS#51 · 82,796 sh	82,796	$27.7M	19.32%	-2.5%
52	Alyeska Investment Group, L.P.#52 · 80,846 sh	80,846	$27.1M	0.07%	+12.0%
53	ADAR1 Capital Management#53 · 74,253 sh	74,253	$24.9M	1.14%	+4850.2%
54	FRONTIER CAPITAL MANAGEMENT#54 · 74,207 sh	74,207	$24.8M	0.23%	+39.1%
55	Ensign Peak Advisors#55 · 72,952 sh	72,952	$24.4M	0.04%	+6.7%
56	Ikarian Capital#56 · 72,842 sh	72,842	$24.4M	2.63%	+1.8%
57	ALLIANCEBERNSTEIN L.P.#57 · 71,518 sh	71,518	$23.0M	<0.01%	+158.2%
58	72 Investment#58 · 65,933 sh	65,933	$22.1M	44.18%	0.0%
59	SILVERARC CAPITAL MANAGEMENT#59 · 65,679 sh	65,679	$22.0M	2.29%	-8.2%
60	AMERIPRISE FINANCIAL#60 · 64,295 sh	64,295	$21.5M	<0.01%	+105.9%
61	DEUTSCHE BANK AG\#61 · 64,263 sh	64,263	$21.5M	<0.01%	+11.2%
62	RAYMOND JAMES FINANCIAL#62 · 61,980 sh	61,980	$20.8M	<0.01%	+1065.0%
63	Candriam S.C.A.#63 · 60,856 sh	60,856	$20.4M	0.09%	-4.4%
64	AQR CAPITAL MANAGEMENT#64 · 58,446 sh	58,446	$19.6M	<0.01%	-0.4%
65	HEALTHCARE OF ONTARIO PENSION PLAN FUND#65 · 56,840 sh	56,840	$19.0M	0.03%	New
66	Russell Investments Group, Ltd.#66 · 51,033 sh	51,033	$17.1M	0.01%	+120.8%
67	Universal- Beteiligungs- und Servicegesellschaft mbH#67 · 48,118 sh	48,118	$16.1M	0.02%	+1.4%
68	JPMORGAN CHASE#68 · 44,085 sh	44,085	$15.8M	<0.01%	-45.0%
69	Boxer Capital Management#69 · 46,457 sh	46,457	$15.6M	1.17%	0.0%
70	Swiss National Bank#70 · 46,100 sh	46,100	$15.4M	<0.01%	-1.3%
71	ArrowMark Colorado#71 · 46,030 sh	46,030	$15.4M	0.64%	-60.9%
72	CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM#72 · 45,370 sh	45,370	$15.2M	<0.01%	+7.6%
73	KVP Capital Advisors#73 · 42,900 sh	42,900	$14.4M	10.54%	0.0%
74	SEB Asset Management AB#74 · 42,705 sh	42,705	$14.3M	0.05%	New
75	Squarepoint Ops#75 · 42,501 sh	42,501	$14.2M	0.02%	+2014.5%
76	SEI INVESTMENTS#76 · 40,117 sh	40,117	$13.4M	0.01%	+35.9%
77	Integral Health Asset Management#77 · 40,000 sh	40,000	$13.4M	0.53%	0.0%
78	EVENTIDE ASSET MANAGEMENT#78 · 38,684 sh	38,684	$13.0M	0.17%	+0.1%
79	PFM Health Sciences#79 · 38,575 sh	38,575	$12.9M	1.11%	+8.9%
80	StemPoint Capital#80 · 37,243 sh	37,243	$12.5M	2.15%	-33.8%
81	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AME#81 · 36,187 sh	36,187	$12.1M	<0.01%	-5.1%
82	Burkehill Global Management#82 · 35,000 sh	35,000	$11.7M	0.42%	0.0%
83	University of Wisconsin Foundation#83 · 34,730 sh	34,730	$11.6M	9.21%	+37.7%
84	B Group#84 · 33,237 sh	33,237	$11.1M	5.22%	0.0%
85	RHUMBLINE ADVISERS#85 · 32,347 sh	32,347	$10.8M	<0.01%	-1.6%
86	DIMENSIONAL FUND ADVISORS#86 · 31,574 sh	31,574	$10.6M	<0.01%	+1.3%
87	HighVista Strategies#87 · 30,210 sh	30,210	$10.1M	2.31%	+14.8%
88	LORD, ABBETT#88 · 29,662 sh	29,662	$9.9M	0.03%	+0.1%
89	Clearbridge Investments#89 · 27,981 sh	27,981	$9.4M	<0.01%	New
90	WELLS FARGO & COMPANY#90 · 27,889 sh	27,889	$9.3M	<0.01%	+140.1%
91	MIRAE ASSET GLOBAL ETFS Ltd.#91 · 27,185 sh	27,185	$9.1M	0.01%	-2.0%
92	Exome Asset Management#92 · 27,205 sh	27,205	$9.1M	5.62%	-40.2%
93	TD ASSET MANAGEMENT#93 · 27,162 sh	27,162	$9.1M	<0.01%	-22.7%
94	CAPITAL FUND MANAGEMENT S.A.#94 · 27,058 sh	27,058	$9.1M	0.04%	New
95	MANUFACTURERS LIFE INSURANCE COMPANY, THE#95 · 26,147 sh	26,147	$8.8M	<0.01%	-13.1%
96	WCM INVESTMENT MANAGEMENT#96 · 24,739 sh	24,739	$8.7M	0.02%	New
97	PEREGRINE CAPITAL MANAGEMENT#97 · 25,790 sh	25,790	$8.6M	0.28%	New
98	CASTLEARK MANAGEMENT#98 · 24,390 sh	24,390	$8.2M	0.22%	New
99	CITIGROUP#99 · 23,599 sh	23,599	$7.9M	<0.01%	+318.0%
100	VANGUARD ASSET MANAGEMENT, Ltd#100 · 22,634 sh	22,634	$7.6M	<0.01%	+2.9%

Funds that sold out of PRAX in Q2 2026 (38)

Held PRAX at the end of Q1 2026 and filed a Q2 2026 13F without it. Not in the list above, because they no longer hold it. Largest prior position first.

Institutions that held PRAX in Q1 2026 and reported no position in Q2 2026.
Institution	Shares sold	Value in Q1 2026
RA CAPITAL MANAGEMENT, L.P.373,787 sh	373,787	$120.4M
CANADA PENSION PLAN INVESTMENT BOARD40,130 sh	40,130	$12.9M
Ally Bridge Group (NY)32,810 sh	32,810	$10.6M
CONGRESS ASSET MANAGEMENT24,839 sh	24,839	$8.0M
Informed Momentum18,995 sh	18,995	$6.1M
TFG Asset Management GP Ltd15,952 sh	15,952	$5.1M
ExodusPoint Capital Management14,742 sh	14,742	$4.7M
BRAIDWELL9,976 sh	9,976	$3.2M
PRELUDE CAPITAL MANAGEMENT9,064 sh	9,064	$2.9M
Trexquant Investment6,626 sh	6,626	$2.1M
SIMPLEX TRADING1,660 sh	1,660	$534.8K
Hudson Bay Capital Management1,640 sh	1,640	$528.4K
MARTINGALE ASSET MANAGEMENT L P1,615 sh	1,615	$520.3K
Centiva Capital1,501 sh	1,501	$483.6K
PSP Research1,500 sh	1,500	$483.3K
Fieldview Capital Management1,223 sh	1,223	$394.0K
FOX RUN MANAGEMENT, L.L.C.1,393 sh	1,393	$385.1K
AlphaGrep UK Ltd1,134 sh	1,134	$365.4K
Persistent Asset Partners Ltd1,131 sh	1,131	$364.4K
QP WEALTH MANAGEMENT995 sh	995	$320.6K
CTC Alternative Strategies, Ltd.925 sh	925	$298.0K
GTS SECURITIES837 sh	837	$269.7K
Pinnacle Wealth Management Advisory Group744 sh	744	$239.7K
PINNACLE ASSOCIATES LTD744 sh	744	$239.7K
COMMONWEALTH EQUITY SERVICES660 sh	660	$212.7K
MML INVESTORS SERVICES639 sh	639	$205.9K
Caitong International Asset Management , Ltd472 sh	472	$152.1K
ABS Direct Equity Fund400 sh	400	$135.0K
QUADRANT CAPITAL GROUP2 sh	2	$49.3K
Parallel Advisors124 sh	124	$40.0K
MAI Capital Management106 sh	106	$34.2K
Aster Capital Management (DIFC) Ltd260 sh	260	$9.8K
Golden State Equity Partners24 sh	24	$7.7K
AdvisorNet Financial20 sh	20	$6.4K
Root Financial Partners7 sh	7	$2.3K
Wealth Preservation Advisors5 sh	5	$1.6K
TWIN PEAKS WEALTH ADVISORS5 sh	5	$1.6K
NATIONAL BANK OF CANADA2 sh	2	$641.00

Source: Form 13F-HR filings on SEC EDGAR, Q2 2026. Values are as reported by each manager at quarter end. “% of portfolio” is the position’s share of the manager’s total reported 13F value for the same quarter. “New” means the manager filed a 13F for Q1 2026 without this position; a dash means no comparison is available. Where a manager’s own filing is internally inconsistent its value is withheld and it is listed last. 13F data shows reported holdings, not recommendations.