LEXICON PHARMACEUTICALS, INC. (LXRX) — Institutional Holders, Q2 2026
150 institutional investment managers reported a LXRX position on SEC Form 13F-HR for the quarter ended June 30, 2026, with a combined reported value of $875.0M. Every filer is listed below, ranked by position value, 100 per page; this page shows ranks 1 to 100. Put and call option positions are excluded, and a firm filing several lots or share classes is shown once with its total.
LXRX in Q2 2026: what funds did
Funds that filed a 13F for both Q1 2026 and Q2 2026, by what they did with the common stock. Share counts are adjusted for any split between the two quarters; dollar figures are the change in shares at this quarter’s price.
Biggest buyers
- Artal Group S.A.Added · +20,421,735 sh+$49.0M
- BlackRockAdded · +14,026,522 sh+$33.7M
- FMRAdded · +6,725,707 sh+$16.1M
- STATE STREETAdded · +3,953,731 sh+$9.5M
- GEODE CAPITAL MANAGEMENTAdded · +3,075,261 sh+$7.4M
Biggest sellers
- MILLENNIUM MANAGEMENTTrimmed · -3,810,502 sh-$9.1M
- JANE STREET GROUPSold out · -2,665,938 sh-$6.4M
- MARSHALL WACE, LLPSold out · -2,376,304 sh-$5.7M
- UBS Group AGTrimmed · -1,798,469 sh-$4.3M
- CIBC Bancorp USATrimmed · -1,786,260 sh-$4.3M
LXRX 13F holders ranked 1–100 of 150
| # | Institution | Shares | Value | % of portfolio | QoQShares vs Q1 2026 |
|---|---|---|---|---|---|
| 1 | Artal Group S.A.#1 · 175,156,062 sh | 175,156,062 | $420.4M | 45.15% | +13.2% |
| 2 | FMR#2 · 51,782,045 sh | 51,782,045 | $124.3M | <0.01% | +14.9% |
| 3 | Siren, L.L.C.#3 · 44,303,518 sh | 44,303,518 | $106.3M | 2.15% | 0.0% |
| 4 | Sessa Capital IM, L.P.#4 · 18,960,836 sh | 18,960,836 | $45.5M | 0.76% | +5.8% |
| 5 | BlackRock#5 · 17,348,741 sh | 17,348,741 | $41.6M | <0.01% | +422.2% |
| 6 | VANGUARD CAPITAL MANAGEMENT#6 · 9,901,208 sh | 9,901,208 | $23.8M | <0.01% | +4.0% |
| 7 | Point72 Asset Management, L.P.#7 · 8,251,325 sh | 8,251,325 | $19.8M | 0.02% | +5.6% |
| 8 | GEODE CAPITAL MANAGEMENT#8 · 6,244,372 sh | 6,244,372 | $15.0M | <0.01% | +97.0% |
| 9 | STATE STREET#9 · 4,917,769 sh | 4,917,769 | $11.8M | <0.01% | +410.1% |
| 10 | VANGUARD PORTFOLIO MANAGEMENT#10 · 2,357,749 sh | 2,357,749 | $5.7M | <0.01% | +331.3% |
| 11 | NORTHERN#11 · 1,968,619 sh | 1,968,619 | $4.7M | <0.01% | +298.0% |
| 12 | CHARLES SCHWAB INVESTMENT MANAGEMENT#12 · 1,956,775 sh | 1,956,775 | $4.7M | <0.01% | +49.2% |
| 13 | VANGUARD FIDUCIARY#13 · 1,634,571 sh | 1,634,571 | $3.9M | <0.01% | +22.7% |
| 14 | CITADEL ADVISORS#14 · 1,601,182 sh | 1,601,182 | $3.8M | <0.01% | +46.2% |
| 15 | Ishara Investments#15 · 1,271,000 sh | 1,271,000 | $3.1M | 2.24% | +40.9% |
| 16 | MILLENNIUM MANAGEMENT#16 · 1,134,229 sh | 1,134,229 | $2.7M | <0.01% | -77.1% |
| 17 | RENAISSANCE TECHNOLOGIES#17 · 1,127,000 sh | 1,127,000 | $2.7M | <0.01% | -29.6% |
| 18 | MACKENZIE FINANCIAL#18 · 963,354 sh | 963,354 | $2.3M | <0.01% | +24.7% |
| 19 | ADAR1 Capital Management#19 · 750,000 sh | 750,000 | $1.8M | 0.08% | 0.0% |
| 20 | SUSQUEHANNA INTERNATIONAL GROUP, LLP#20 · 696,776 sh | 696,776 | $1.7M | <0.01% | -67.2% |
| 21 | ACADIAN ASSET MANAGEMENT#21 · 696,617 sh | 696,617 | $1.7M | <0.01% | +56.4% |
| 22 | UBS Group AG#22 · 684,713 sh | 684,713 | $1.6M | <0.01% | -72.4% |
| 23 | TWO SIGMA INVESTMENTS#23 · 643,444 sh | 643,444 | $1.5M | <0.01% | -46.4% |
| 24 | Nuveen#24 · 586,664 sh | 586,664 | $1.4M | <0.01% | New |
| 25 | Bank of New York Mellon#25 · 568,706 sh | 568,706 | $1.4M | <0.01% | +1971.1% |
| 26 | Invesco Ltd.#26 · 508,071 sh | 508,071 | $1.2M | <0.01% | -0.8% |
| 27 | GOLDMAN SACHS GROUP#27 · 485,546 sh | 485,546 | $1.2M | <0.01% | -54.6% |
| 28 | Compagnie Lombard Odier SCmA#28 · 480,000 sh | 480,000 | $1.2M | 0.01% | -5.9% |
| 29 | BANK OF AMERICA#29 · 421,299 sh | 421,299 | $1.0M | <0.01% | -19.9% |
| 30 | GSA CAPITAL PARTNERS LLP#30 · 397,219 sh | 397,219 | $953.0K | 0.06% | -57.3% |
| 31 | BARCLAYS PLC#31 · 387,483 sh | 387,483 | $930.0K | <0.01% | +267.3% |
| 32 | XTX Topco Ltd#32 · 357,877 sh | 357,877 | $858.9K | 0.01% | +13.8% |
| 33 | Janney Montgomery Scott#33 · 295,548 sh | 295,548 | $709.0K | <0.01% | New |
| 34 | CANADA PENSION PLAN INVESTMENT BOARD#34 · 257,900 sh | 257,900 | $619.0K | <0.01% | New |
| 35 | RHUMBLINE ADVISERS#35 · 256,885 sh | 256,885 | $616.5K | <0.01% | New |
| 36 | DEUTSCHE BANK AG\#36 · 247,528 sh | 247,528 | $594.1K | <0.01% | New |
| 37 | WELLS FARGO & COMPANY#37 · 230,470 sh | 230,470 | $553.1K | <0.01% | +2870.0% |
| 38 | PRICE T ROWE ASSOCIATES#38 · 204,391 sh | 204,391 | $491.0K | 0.00% | New |
| 39 | WELLINGTON MANAGEMENT GROUP LLP#39 · 179,700 sh | 179,700 | $431.3K | <0.01% | New |
| 40 | CITIGROUP#40 · 175,205 sh | 175,205 | $420.5K | <0.01% | +5.3% |
| 41 | GROUP ONE TRADING, L.P.#41 · 175,013 sh | 175,013 | $420.0K | <0.01% | -5.4% |
| 42 | Virtus Investment Advisers#42 · 170,415 sh | 170,415 | $409.0K | 0.10% | New |
| 43 | Headlands Technologies#43 · 167,198 sh | 167,198 | $401.3K | 0.04% | -12.6% |
| 44 | Ikarian Capital#44 · 164,674 sh | 164,674 | $395.2K | 0.04% | 0.0% |
| 45 | Quarry#45 · 156,186 sh | 156,186 | $374.8K | 0.03% | +42.0% |
| 46 | MetLife Investment Management#46 · 146,410 sh | 146,410 | $351.4K | <0.01% | New |
| 47 | MORGAN STANLEY#47 · 132,902 sh | 132,902 | $319.0K | 0.00% | -39.6% |
| 48 | PANAGORA ASSET MANAGEMENT#48 · 132,042 sh | 132,042 | $316.9K | <0.01% | New |
| 49 | JPMORGAN CHASE#49 · 109,839 sh | 109,839 | $290.0K | 0.00% | New |
| 50 | State of Wyoming#50 · 119,090 sh | 119,090 | $285.8K | 0.03% | +1004.8% |
| 51 | MIRAE ASSET GLOBAL ETFS Ltd.#51 · 114,114 sh | 114,114 | $273.9K | <0.01% | New |
| 52 | Cornerstone Investment Partners#52 · 113,739 sh | 113,739 | $273.0K | <0.01% | New |
| 53 | Cerity Partners#53 · 98,400 sh | 98,400 | $236.2K | <0.01% | -10.9% |
| 54 | ALGERT GLOBAL#54 · 92,150 sh | 92,150 | $221.2K | <0.01% | New |
| 55 | BANK OF NOVA SCOTIA#55 · 86,607 sh | 86,607 | $207.9K | <0.01% | +17.5% |
| 56 | LPL Financial#56 · 84,916 sh | 84,916 | $203.8K | 0.00% | +21.7% |
| 57 | Vanguard Global Advisers#57 · 77,946 sh | 77,946 | $187.1K | <0.01% | -16.8% |
| 58 | AQR CAPITAL MANAGEMENT#58 · 75,230 sh | 75,230 | $180.6K | <0.01% | -21.8% |
| 59 | Police & Firemen's Retirement System of New Jersey#59 · 73,402 sh | 73,402 | $176.2K | <0.01% | New |
| 60 | UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT#60 · 71,427 sh | 71,427 | $171.4K | 0.02% | +100.0% |
| 61 | PRUDENTIAL FINANCIAL#61 · 71,345 sh | 71,345 | $171.2K | <0.01% | +111.1% |
| 62 | MANUFACTURERS LIFE INSURANCE COMPANY, THE#62 · 69,747 sh | 69,747 | $167.4K | <0.01% | New |
| 63 | NEW YORK STATE COMMON RETIREMENT FUND#63 · 68,400 sh | 68,400 | $164.2K | <0.01% | New |
| 64 | TWO SIGMA SECURITIES#64 · 66,375 sh | 66,375 | $159.3K | 0.01% | New |
| 65 | SEI INVESTMENTS#65 · 63,937 sh | 63,937 | $153.4K | <0.01% | New |
| 66 | Straight Path Wealth Management#66 · 62,666 sh | 62,666 | $150.4K | — | 0.0% |
| 67 | R Squared Ltd#67 · 54,985 sh | 54,985 | $132.0K | 0.07% | -18.6% |
| 68 | Vanguard Personalized Indexing Management#68 · 54,334 sh | 54,334 | $130.4K | <0.01% | -1.1% |
| 69 | Fortis Group Advisors#69 · 50,000 sh | 50,000 | $120.0K | 0.02% | 0.0% |
| 70 | Schonfeld Strategic Advisors#70 · 49,435 sh | 49,435 | $118.6K | <0.01% | -34.2% |
| 71 | SCOTIA CAPITAL#71 · 48,871 sh | 48,871 | $117.3K | <0.01% | -69.4% |
| 72 | PROFUND ADVISORS#72 · 48,586 sh | 48,586 | $116.6K | <0.01% | New |
| 73 | VOYA INVESTMENT MANAGEMENT#73 · 47,771 sh | 47,771 | $114.7K | <0.01% | New |
| 74 | AXQ CAPITAL#74 · 45,727 sh | 45,727 | $109.7K | 0.01% | +126.9% |
| 75 | BOOTHBAY FUND MANAGEMENT#75 · 44,315 sh | 44,315 | $106.4K | <0.01% | 0.0% |
| 76 | ALLIANCEBERNSTEIN L.P.#76 · 67,800 sh | 67,800 | $105.8K | 0.00% | New |
| 77 | WINTON GROUP Ltd#77 · 43,200 sh | 43,200 | $103.7K | <0.01% | +69.4% |
| 78 | INTECH INVESTMENT MANAGEMENT#78 · 42,491 sh | 42,491 | $102.0K | <0.01% | New |
| 79 | LMR Partners LLP#79 · 41,091 sh | 41,091 | $98.6K | <0.01% | +76.3% |
| 80 | BANK OF MONTREAL#80 · 40,000 sh | 40,000 | $96.0K | 0.00% | -42.9% |
| 81 | BNP PARIBAS FINANCIAL MARKETS#81 · 37,780 sh | 37,780 | $90.7K | 0.00% | +115.3% |
| 82 | Rafferty Asset Management#82 · 34,090 sh | 34,090 | $81.8K | <0.01% | New |
| 83 | ProShare Advisors#83 · 32,588 sh | 32,588 | $78.2K | <0.01% | New |
| 84 | Leonteq Securities AG#84 · 30,000 sh | 30,000 | $72.0K | <0.01% | 0.0% |
| 85 | Pathstone#85 · 29,969 sh | 29,969 | $71.9K | <0.01% | +0.7% |
| 86 | PINNACLE ASSOCIATES LTD#86 · 29,015 sh | 29,015 | $69.6K | — | 0.0% |
| 87 | SECURITY NATIONAL BANK OF SIOUX CITY IOWA#87 · 26,650 sh | 26,650 | $64.0K | 0.03% | 0.0% |
| 88 | VICTORY CAPITAL MANAGEMENT#88 · 24,223 sh | 24,223 | $58.1K | 0.00% | +6.8% |
| 89 | Legal & General Group Plc#89 · 24,185 sh | 24,185 | $58.0K | 0.00% | New |
| 90 | XPONANCE#90 · 23,763 sh | 23,763 | $57.0K | <0.01% | New |
| 91 | Graham Capital Management, L.P.#91 · 23,541 sh | 23,541 | $56.5K | <0.01% | -30.8% |
| 92 | Ameritas Investment Partners#92 · 22,986 sh | 22,986 | $55.2K | <0.01% | New |
| 93 | D. E. Shaw#93 · 22,200 sh | 22,200 | $53.3K | 0.00% | New |
| 94 | Quadrature Capital Ltd#94 · 21,998 sh | 21,998 | $52.8K | <0.01% | -80.1% |
| 95 | WEDBUSH SECURITIES#95 · 20,000 sh | 20,000 | $48.0K | — | -51.0% |
| 96 | DIKER MANAGEMENT#96 · 20,000 sh | 20,000 | $48.0K | 0.04% | 0.0% |
| 97 | Invera Wealth Advisors#97 · 20,000 sh | 20,000 | $48.0K | 0.03% | 0.0% |
| 98 | TIAA-CREF INDIVIDUAL & INSTITUTIONAL SERVICES#98 · 20,000 sh | 20,000 | $48.0K | <0.01% | 0.0% |
| 99 | Russell Investments Group, Ltd.#99 · 19,902 sh | 19,902 | $47.8K | 0.00% | New |
| 100 | Tower Research Capital (TRC)#100 · 19,486 sh | 19,486 | $46.8K | <0.01% | New |
Funds that sold out of LXRX in Q2 2026 (30)
Held LXRX at the end of Q1 2026 and filed a Q2 2026 13F without it. Not in the list above, because they no longer hold it. Largest prior position first.
| Institution | Shares sold | Value in Q1 2026 |
|---|---|---|
| JANE STREET GROUP2,665,938 sh | 2,665,938 | $4.2M |
| MARSHALL WACE, LLP2,376,304 sh | 2,376,304 | $3.7M |
| Hennion & Walsh Asset Management848,138 sh | 848,138 | $1.3M |
| TANG CAPITAL MANAGEMENT399,700 sh | 399,700 | $623.5K |
| Catalyst Funds Management Pty Ltd207,900 sh | 207,900 | $324.3K |
| Brevan Howard Capital Management160,499 sh | 160,499 | $250.4K |
| Jain Global154,800 sh | 154,800 | $241.5K |
| Hudson Bay Capital Management152,616 sh | 152,616 | $238.1K |
| JACOBS LEVY EQUITY MANAGEMENT130,020 sh | 130,020 | $202.8K |
| Bridgewater Advisors82,209 sh | 82,209 | $200.6K |
| HRT FINANCIAL122,780 sh | 122,780 | $191.0K |
| Man Group plc108,806 sh | 108,806 | $169.7K |
| OMERS ADMINISTRATION106,800 sh | 106,800 | $166.6K |
| LEUCADIA NATIONAL68,734 sh | 68,734 | $107.2K |
| Diametric Capital67,841 sh | 67,841 | $105.8K |
| EntryPoint Capital48,498 sh | 48,498 | $75.7K |
| Jump Financial40,246 sh | 40,246 | $62.8K |
| ExodusPoint Capital Management37,430 sh | 37,430 | $58.4K |
| KWB Wealth40,640 sh | 40,640 | $46.7K |
| OPPENHEIMER23,500 sh | 23,500 | $36.7K |
| Cambridge Investment Research Advisors21,505 sh | 21,505 | $34.0K |
| Quantessence Capital18,581 sh | 18,581 | $29.0K |
| CTC Alternative Strategies, Ltd.17,544 sh | 17,544 | $27.4K |
| PRELUDE CAPITAL MANAGEMENT17,173 sh | 17,173 | $26.8K |
| Chemistry Wealth Management12,000 sh | 12,000 | $18.7K |
| Fortress Wealth Group11,350 sh | 11,350 | $18.0K |
| Talisman Wealth Advisors10,000 sh | 10,000 | $15.6K |
| Advisory Services Network3,242 sh | 3,242 | $5.1K |
| EverSource Wealth Advisors12 sh | 12 | $230.00 |
| True Wealth Design2 sh | 2 | $4.00 |
Source: Form 13F-HR filings on SEC EDGAR, Q2 2026. Values are as reported by each manager at quarter end. “% of portfolio” is the position’s share of the manager’s total reported 13F value for the same quarter. “New” means the manager filed a 13F for Q1 2026 without this position; a dash means no comparison is available. Where a manager’s own filing is internally inconsistent its value is withheld and it is listed last. 13F data shows reported holdings, not recommendations.