INSMED Inc (INSM) — Institutional Holders, Q2 2026

669 institutional investment managers reported a INSM position on SEC Form 13F-HR for the quarter ended June 30, 2026, with a combined reported value of $23.8B. Every filer is listed below, ranked by position value, 100 per page; this page shows ranks 1 to 100. Put and call option positions are excluded, and a firm filing several lots or share classes is shown once with its total.

← INSM stock profile

INSM in Q2 2026: what funds did

Funds that filed a 13F for both Q1 2026 and Q2 2026, by what they did with the common stock. Share counts are adjusted for any split between the two quarters; dollar figures are the change in shares at this quarter’s price.

New positions

115

Added to

245

Trimmed

230

Sold out

120

Biggest buyers

Orbis Allan Gray LtdAdded · +4,203,663 sh+$448.2M
AMERIPRISE FINANCIALAdded · +3,121,853 sh+$332.9M
FMRAdded · +2,983,416 sh+$318.1M
Capital International InvestorsAdded · +2,642,930 sh+$281.8M
MAVERICK CAPITAL LTDNew · +2,150,762 sh+$229.3M

Biggest sellers

JPMORGAN CHASETrimmed · -13,722,329 sh-$1.5B
Darwin Global Management, Ltd.Trimmed · -10,374,021 sh-$1.1B
Invesco Ltd.Trimmed · -1,620,707 sh-$172.8M
Capital World InvestorsSold out · -1,362,291 sh-$145.2M
Artisan Partners Limited PartnershipTrimmed · -1,085,583 sh-$115.7M

INSM 13F holders ranked 1–100 of 669

Institutional investors reporting a position in INSMED Inc on SEC Form 13F-HR for Q2 2026, ranked by reported value.
#	Institution	Shares	Value	% of portfolio	QoQShares vs Q1 2026
1	FMR#1 · 16,143,583 sh	16,143,583	$1.7B	0.07%	+22.7%
2	BlackRock#2 · 15,807,984 sh	15,807,984	$1.7B	0.03%	-5.2%
3	VANGUARD PORTFOLIO MANAGEMENT#3 · 10,407,962 sh	10,407,962	$1.1B	0.05%	+0.3%
4	JPMORGAN CHASE#4 · 10,428,170 sh	10,428,170	$1.1B	0.06%	-56.8%
5	VANGUARD CAPITAL MANAGEMENT#5 · 9,790,865 sh	9,790,865	$1.0B	0.02%	+1.5%
6	BAKER BROS. ADVISORS#6 · 8,796,111 sh	8,796,111	$937.8M	4.70%	+18.5%
7	Capital International Investors#7 · 8,238,124 sh	8,238,124	$878.3M	0.18%	+47.2%
8	Darwin Global Management, Ltd.#8 · 6,431,163 sh	6,431,163	$673.6M	17.91%	-61.7%
9	AMERIPRISE FINANCIAL#9 · 6,179,571 sh	6,179,571	$658.9M	0.13%	+102.1%
10	Orbis Allan Gray Ltd#10 · 6,076,487 sh	6,076,487	$647.9M	2.23%	+224.5%
11	STATE STREET#11 · 6,052,174 sh	6,052,174	$645.3M	0.02%	+9.0%
12	D. E. Shaw#12 · 5,877,959 sh	5,877,959	$626.7M	0.30%	+4.5%
13	Artisan Partners Limited Partnership#13 · 5,441,718 sh	5,441,718	$580.2M	0.92%	-16.6%
14	RTW INVESTMENTS#14 · 4,842,880 sh	4,842,880	$516.3M	4.41%	0.0%
15	GEODE CAPITAL MANAGEMENT#15 · 4,220,155 sh	4,220,155	$448.8M	0.02%	-5.2%
16	PRICE T ROWE ASSOCIATES#16 · 3,405,290 sh	3,405,290	$363.1M	0.04%	+10.1%
17	NORGES BANK#17 · 3,377,641 sh	3,377,641	$360.1M	0.04%	—
18	Jupiter Topco#18 · 2,605,181 sh	2,605,181	$277.8M	0.11%	—
19	UBS Group AG#19 · 2,584,446 sh	2,584,446	$275.6M	0.04%	+48.7%
20	CITADEL ADVISORS#20 · 2,556,973 sh	2,556,973	$272.6M	0.03%	+17.2%
21	FRANKLIN RESOURCES#21 · 2,273,222 sh	2,273,222	$242.4M	0.05%	-13.1%
22	MAVERICK CAPITAL LTD#22 · 2,150,762 sh	2,150,762	$229.3M	2.03%	New
23	MILLENNIUM MANAGEMENT#23 · 2,048,005 sh	2,048,005	$218.4M	0.08%	+76.9%
24	Qube Research & Technologies Ltd#24 · 1,682,334 sh	1,682,334	$179.4M	0.17%	+1032.8%
25	WESTFIELD CAPITAL MANAGEMENT#25 · 1,629,561 sh	1,629,561	$173.7M	0.57%	+11.0%
26	T. Rowe Price Investment Management#26 · 1,622,675 sh	1,622,675	$173.0M	0.11%	New
27	Integral Health Asset Management#27 · 1,600,000 sh	1,600,000	$170.6M	6.74%	+6.7%
28	Duquesne Family Office#28 · 1,424,690 sh	1,424,690	$151.9M	2.92%	+23.4%
29	GOLDMAN SACHS GROUP#29 · 1,409,885 sh	1,409,885	$150.3M	0.01%	+49.6%
30	VANGUARD FIDUCIARY#30 · 1,401,552 sh	1,401,552	$149.4M	0.03%	+3.5%
31	Bellevue Group AG#31 · 1,393,418 sh	1,393,418	$148.6M	3.13%	New
32	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AME#32 · 1,335,071 sh	1,335,071	$142.3M	0.03%	+9.9%
33	BALYASNY ASSET MANAGEMENT L.P.#33 · 1,326,430 sh	1,326,430	$141.4M	0.18%	+498.3%
34	Paradigm Biocapital Advisors#34 · 1,325,977 sh	1,325,977	$141.4M	2.65%	+5.7%
35	NORTHERN#35 · 1,315,325 sh	1,315,325	$140.2M	0.02%	+1.6%
36	Bank of New York Mellon#36 · 1,312,756 sh	1,312,756	$140.0M	0.02%	+4.0%
37	TWO SIGMA INVESTMENTS#37 · 1,242,222 sh	1,242,222	$132.4M	0.10%	+424.1%
38	MORGAN STANLEY#38 · 1,233,498 sh	1,233,498	$131.5M	<0.01%	-7.4%
39	Pictet Asset Management Holding SA#39 · 1,220,353 sh	1,220,353	$129.8M	0.12%	+10.7%
40	CHARLES SCHWAB INVESTMENT MANAGEMENT#40 · 1,213,963 sh	1,213,963	$129.4M	0.02%	+13.5%
41	Hood River Capital Management#41 · 1,056,871 sh	1,056,871	$112.7M	0.82%	+53.5%
42	BANK OF AMERICA#42 · 1,023,114 sh	1,023,114	$109.1M	<0.01%	-31.9%
43	SEI INVESTMENTS#43 · 1,015,870 sh	1,015,870	$108.3M	0.10%	-27.2%
44	NWI MANAGEMENT#44 · 1,014,000 sh	1,014,000	$108.1M	5.00%	0.0%
45	Castle Hook Partners#45 · 993,310 sh	993,310	$105.9M	0.49%	-21.8%
46	JENNISON ASSOCIATES#46 · 905,094 sh	905,094	$96.5M	0.06%	+49.7%
47	Polar Capital Plc#47 · 890,872 sh	890,872	$95.0M	0.22%	+142.0%
48	FIL Ltd#48 · 856,214 sh	856,214	$91.3M	0.07%	+3.3%
49	PRINCIPAL FINANCIAL GROUP#49 · 856,126 sh	856,126	$91.3M	0.04%	-6.6%
50	ADAGE CAPITAL PARTNERS GP, L.L.C.#50 · 850,000 sh	850,000	$90.6M	0.13%	-5.6%
51	Fiera Capital#51 · 843,042 sh	843,042	$89.9M	0.33%	-17.5%
52	Legal & General Group Plc#52 · 826,431 sh	826,431	$88.1M	0.02%	+5.0%
53	FRONTIER CAPITAL MANAGEMENT#53 · 795,242 sh	795,242	$84.8M	0.79%	+69.4%
54	AMERICAN CENTURY COMPANIES#54 · 759,735 sh	759,735	$81.0M	0.04%	-17.9%
55	SAMLYN CAPITAL#55 · 732,568 sh	732,568	$78.1M	1.27%	+75.6%
56	SUSQUEHANNA INTERNATIONAL GROUP, LLP#56 · 729,354 sh	729,354	$77.8M	<0.01%	+320.1%
57	TimesSquare Capital Management#57 · 728,096 sh	728,096	$77.6M	1.14%	+24.5%
58	Clearbridge Investments#58 · 715,922 sh	715,922	$76.3M	0.06%	+11.3%
59	ALLIANCEBERNSTEIN L.P.#59 · 462,796 sh	462,796	$75.7M	0.03%	-32.8%
60	Ensign Peak Advisors#60 · 702,951 sh	702,951	$74.9M	0.12%	+40.7%
61	DEUTSCHE BANK AG\#61 · 690,590 sh	690,590	$73.6M	0.02%	+22.8%
62	HRT FINANCIAL#62 · 709,681 sh	709,681	$73.6M	0.18%	New
63	RAYMOND JAMES FINANCIAL#63 · 660,601 sh	660,601	$70.4M	0.02%	-14.8%
64	Affinity Asset Advisors#64 · 650,000 sh	650,000	$69.3M	3.13%	+35.4%
65	WILLIAM BLAIR INVESTMENT MANAGEMENT#65 · 629,831 sh	629,831	$67.2M	0.20%	-30.2%
66	GW&K Investment Management#66 · 629,760 sh	629,760	$67.1M	0.52%	+1.1%
67	Squarepoint Ops#67 · 616,464 sh	616,464	$65.7M	0.07%	+1468.0%
68	AQR CAPITAL MANAGEMENT#68 · 612,832 sh	612,832	$65.3M	0.02%	-9.3%
69	Railway Pension Investments Ltd#69 · 604,700 sh	604,700	$64.5M	0.81%	New
70	Swiss National Bank#70 · 593,512 sh	593,512	$63.3M	0.03%	-5.2%
71	Nuveen#71 · 591,844 sh	591,844	$63.1M	0.02%	+10.7%
72	Artia Global Partners#72 · 589,052 sh	589,052	$62.8M	11.59%	-6.3%
73	EVENTIDE ASSET MANAGEMENT#73 · 583,665 sh	583,665	$62.2M	0.83%	+6.8%
74	abrdn plc#74 · 577,437 sh	577,437	$61.6M	0.09%	+108.4%
75	Davern Capital Partners#75 · 559,824 sh	559,824	$59.7M	10.18%	+206.6%
76	Candriam S.C.A.#76 · 555,131 sh	555,131	$59.1M	0.27%	+38.2%
77	WELLINGTON MANAGEMENT GROUP LLP#77 · 543,893 sh	543,893	$58.0M	0.01%	+36.3%
78	Point72 Asset Management, L.P.#78 · 536,997 sh	536,997	$57.3M	0.06%	New
79	Long Focus Capital Management#79 · 528,000 sh	528,000	$56.3M	1.44%	+264.1%
80	MARSHALL WACE, LLP#80 · 501,930 sh	501,930	$53.5M	0.04%	+60.6%
81	Amundi#81 · 487,525 sh	487,525	$52.0M	0.01%	-39.4%
82	BNP Paribas Asset Management Holding S.A.#82 · 475,307 sh	475,307	$50.7M	0.05%	+1.6%
83	Bridgewater Associates#83 · 455,392 sh	455,392	$48.6M	0.20%	+54.1%
84	Sumitomo Mitsui#84 · 437,713 sh	437,713	$46.7M	0.03%	-12.7%
85	ROYAL BANK OF CANADA#85 · 416,487 sh	416,487	$44.4M	<0.01%	-20.4%
86	VANGUARD ASSET MANAGEMENT, Ltd#86 · 416,108 sh	416,108	$44.4M	0.03%	+15.6%
87	Palo Alto Investors#87 · 413,980 sh	413,980	$44.1M	6.10%	-0.3%
88	DIMENSIONAL FUND ADVISORS#88 · 408,388 sh	408,388	$43.5M	<0.01%	+1.9%
89	BNP PARIBAS FINANCIAL MARKETS#89 · 400,765 sh	400,765	$42.7M	0.01%	-33.7%
90	Eagle Health Investments#90 · 384,130 sh	384,130	$41.0M	6.79%	+71.3%
91	Neuberger Berman Group#91 · 378,816 sh	378,816	$40.4M	0.03%	+39.9%
92	Prosight Management#92 · 375,609 sh	375,609	$40.0M	6.90%	New
93	Invesco Ltd.#93 · 368,261 sh	368,261	$39.3M	<0.01%	-81.5%
94	GATEWAY INVESTMENT ADVISERS#94 · 365,000 sh	365,000	$38.9M	—	0.0%
95	Rock Springs Capital Management#95 · 362,150 sh	362,150	$38.6M	1.88%	+15.2%
96	ENVESTNET ASSET MANAGEMENT#96 · 336,997 sh	336,997	$35.9M	<0.01%	+12.4%
97	VICTORY CAPITAL MANAGEMENT#97 · 306,651 sh	306,651	$32.7M	0.02%	-22.6%
98	NEW YORK STATE COMMON RETIREMENT FUND#98 · 304,236 sh	304,236	$32.4M	0.04%	+3.6%
99	SCHRODER INVESTMENT MANAGEMENT GROUP#99 · 298,372 sh	298,372	$31.8M	0.02%	+148.7%
100	Mitsubishi UFJ Asset Management , Ltd.#100 · 289,594 sh	289,594	$30.9M	0.02%	+13.5%

Funds that sold out of INSM in Q2 2026 (120)

Held INSM at the end of Q1 2026 and filed a Q2 2026 13F without it. Not in the list above, because they no longer hold it. Largest prior position first.

Institutions that held INSM in Q1 2026 and reported no position in Q2 2026.
Institution	Shares sold	Value in Q1 2026
Capital World Investors1,362,291 sh	1,362,291	$222.7M
SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT653,445 sh	653,445	$106.9M
LORD, ABBETT397,261 sh	397,261	$65.0M
Nearwater Capital Markets, Ltd300,000 sh	300,000	$49.1M
AXIOM INVESTORS239,447 sh	239,447	$39.2M
Evergreen Quality Fund GP, Ltd.232,500 sh	232,500	$38.0M
Susquehanna Portfolio Strategies207,527 sh	207,527	$33.9M
LOOMIS SAYLES & L P194,982 sh	194,982	$31.9M
Patient Square Capital157,500 sh	157,500	$25.8M
NEOS Investment Management110,426 sh	110,426	$18.1M
DRIEHAUS CAPITAL MANAGEMENT105,414 sh	105,414	$17.2M
PARNASSUS INVESTMENTS69,515 sh	69,515	$11.4M
HEALTHCARE OF ONTARIO PENSION PLAN FUND56,529 sh	56,529	$9.2M
VOLORIDGE INVESTMENT MANAGEMENT32,190 sh	32,190	$5.3M
1832 Asset Management L.P.28,900 sh	28,900	$4.7M
SHELTON CAPITAL MANAGEMENT24,217 sh	24,217	$4.0M
Elo Mutual Pension Insurance24,125 sh	24,125	$3.9M
Mariner22,072 sh	22,072	$3.6M
ASR Vermogensbeheer N.V.21,496 sh	21,496	$3.5M
RENAISSANCE TECHNOLOGIES20,300 sh	20,300	$3.3M
Baird Financial Group17,688 sh	17,688	$2.9M
Harvest Fund Management , Ltd15,921 sh	15,921	$2.6M
Louisiana State Employees Retirement System14,200 sh	14,200	$2.3M
Draper Asset Management11,321 sh	11,321	$1.9M
AG2R LA MONDIALE GESTION D'ACTIFS11,244 sh	11,244	$1.8M
SIMPLEX TRADING10,715 sh	10,715	$1.8M
FORMULA GROWTH LTD9,000 sh	9,000	$1.5M
FIG FINANCIAL ADVISORY SERVICES8,308 sh	8,308	$1.4M
Norinchukin Bank, The8,078 sh	8,078	$1.3M
Ameritas Investment Partners7,788 sh	7,788	$1.3M
PRELUDE CAPITAL MANAGEMENT6,775 sh	6,775	$1.1M
ING GROEP NV5,996 sh	5,996	$980.5K
PINKERTON WEALTH5,248 sh	5,248	$913.4K
J. Goldman5,545 sh	5,545	$906.7K
Ikarian Capital4,214 sh	4,214	$689.1K
DRW Securities3,698 sh	3,698	$604.7K
ICICI Prudential Asset Management Ltd3,572 sh	3,572	$584.1K
PIER 88 INVESTMENT PARTNERS3,200 sh	3,200	$523.3K
Whalen Wealth Management2,969 sh	2,969	$485.5K
Callan Family Office2,968 sh	2,968	$485.3K
Cynosure Management2,947 sh	2,947	$481.9K
Everhart Financial Group2,934 sh	2,934	$479.8K
Gilbert & Cook2,841 sh	2,841	$464.6K
Cambridge Investment Research Advisors2,719 sh	2,719	$445.0K
Edgestream Partners, L.P.2,499 sh	2,499	$408.6K
Centiva Capital2,347 sh	2,347	$383.8K
Abacus Wealth Partners2,338 sh	2,338	$382.3K
CHOREO2,161 sh	2,161	$353.4K
Cooper Financial Group2,141 sh	2,141	$350.1K
SIH Partners, LLLP2,138 sh	2,138	$349.6K
Alphadyne Asset Management2,119 sh	2,119	$346.5K
REGIONS FINANCIAL2,076 sh	2,076	$339.5K
Metis Global Partners2,041 sh	2,041	$333.7K
Summit Financial2,040 sh	2,040	$333.6K
Cravens & Advisors2,020 sh	2,020	$330.3K
Marex Group plc2,010 sh	2,010	$328.7K
GTS SECURITIES1,991 sh	1,991	$325.6K
Lido Advisors1,980 sh	1,980	$324.0K
Ellevest1,966 sh	1,966	$321.5K
GLENMEDE NA1,916 sh	1,916	$313.3K
Merit Financial Group1,908 sh	1,908	$312.0K
Savant Capital1,789 sh	1,789	$292.5K
HB Wealth Management1,786 sh	1,786	$292.0K
Frank, Rimerman Advisors1,697 sh	1,697	$277.5K
NORDEN GROUP1,594 sh	1,594	$260.7K
Meridian Wealth Management1,529 sh	1,529	$250.0K
ANB BANK1,507 sh	1,507	$246.4K
EVERPAR ADVISORS1,503 sh	1,503	$245.8K
Stratos Wealth Partners, LTD.1,502 sh	1,502	$245.6K
Knollwood Investment Advisory1,501 sh	1,501	$245.4K
CreativeOne Wealth1,485 sh	1,485	$242.8K
Allegheny Financial Group LTD1,479 sh	1,479	$241.8K
Independent Advisor Alliance1,434 sh	1,434	$234.5K
Dynasty Wealth Management1,422 sh	1,422	$232.5K
WEALTH ALLIANCE1,421 sh	1,421	$232.4K
DIVERSIFY WEALTH MANAGEMENT1,704 sh	1,704	$230.1K
FIDUCIARY1,389 sh	1,389	$227.1K
OpenArc Corporate Advisory1,334 sh	1,334	$218.1K
Fidelis Capital Partners1,325 sh	1,325	$216.7K
Kestra Advisory Services1,307 sh	1,307	$213.7K
JGP Global Gestao de Recursos Ltda.1,296 sh	1,296	$211.9K
Charter Capital Management, \DE1,275 sh	1,275	$208.5K
Leonteq Securities AG1,270 sh	1,270	$207.7K
Coastal Bridge Advisors1,264 sh	1,264	$206.7K
Brucke Financial1,253 sh	1,253	$204.9K
KRS Capital Management1,244 sh	1,244	$203.4K
MAI Capital Management1,227 sh	1,227	$200.6K
Harel Insurance Investments & Financial Services Ltd.1,084 sh	1,084	$177.0K
Golden State Equity Partners743 sh	743	$121.5K
QUADRANT CAPITAL GROUP42 sh	42	$52.4K
Timothy G. Youngquist 2020 Irrevocable240 sh	240	$39.2K
ACADIAN ASSET MANAGEMENT240 sh	240	$39.0K
Destiny Wealth Partners175 sh	175	$28.6K
CX Institutional150 sh	150	$25.0K
V-Square Quantitative Management143 sh	143	$23.4K
Parallax Volatility Advisers, L.P.150 sh	150	$21.1K
Sound Income Strategies79 sh	79	$13.0K
Catalyst Capital Advisors77 sh	77	$12.6K
TWIN PEAKS WEALTH ADVISORS68 sh	68	$11.1K
SWISS RE LTD62 sh	62	$10.1K

And 20 smaller positions.

Source: Form 13F-HR filings on SEC EDGAR, Q2 2026. Values are as reported by each manager at quarter end. “% of portfolio” is the position’s share of the manager’s total reported 13F value for the same quarter. “New” means the manager filed a 13F for Q1 2026 without this position; a dash means no comparison is available. Where a manager’s own filing is internally inconsistent its value is withheld and it is listed last. 13F data shows reported holdings, not recommendations.