Denali Therapeutics Inc. (DNLI) — Institutional Holders, Q2 2026
294 institutional investment managers reported a DNLI position on SEC Form 13F-HR for the quarter ended June 30, 2026, with a combined reported value of $4.0B. Every filer is listed below, ranked by position value, 100 per page; this page shows ranks 1 to 100. Put and call option positions are excluded, and a firm filing several lots or share classes is shown once with its total.
DNLI in Q2 2026: what funds did
Funds that filed a 13F for both Q1 2026 and Q2 2026, by what they did with the common stock. Share counts are adjusted for any split between the two quarters; dollar figures are the change in shares at this quarter’s price.
Biggest buyers
- T. Rowe Price Investment ManagementAdded · +7,659,771 sh+$197.0M
- NOMURA ASSET MANAGEMENT INTERNATIONALAdded · +2,093,739 sh+$53.9M
- BNP Paribas Asset Management Holding S.A.Added · +1,059,011 sh+$27.2M
- BlackRockAdded · +991,979 sh+$25.5M
- STATE STREETAdded · +777,303 sh+$20.0M
Biggest sellers
- Lynx1 Capital ManagementTrimmed · -1,868,645 sh-$48.1M
- Vestal Point CapitalSold out · -1,773,326 sh-$45.6M
- Alyeska Investment Group, L.P.Trimmed · -1,721,789 sh-$44.3M
- UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMETrimmed · -1,270,342 sh-$32.7M
- Defilade Capital Management, L.P.Trimmed · -968,103 sh-$24.9M
DNLI 13F holders ranked 1–100 of 294
| # | Institution | Shares | Value | % of portfolio | QoQShares vs Q1 2026 |
|---|---|---|---|---|---|
| 1 | T. Rowe Price Investment Management#1 · 16,178,963 sh | 16,178,963 | $416.1M | 0.27% | +89.9% |
| 2 | BlackRock#2 · 14,026,413 sh | 14,026,413 | $360.8M | <0.01% | +7.6% |
| 3 | BAILLIE GIFFORD#3 · 11,960,230 sh | 11,960,230 | $307.6M | 0.28% | -0.9% |
| 4 | STATE STREET#4 · 7,049,304 sh | 7,049,304 | $181.3M | <0.01% | +12.4% |
| 5 | Temasek (Private) Ltd#5 · 7,012,974 sh | 7,012,974 | $180.4M | 0.48% | 0.0% |
| 6 | VANGUARD PORTFOLIO MANAGEMENT#6 · 6,477,057 sh | 6,477,057 | $166.6M | <0.01% | +5.8% |
| 7 | VANGUARD CAPITAL MANAGEMENT#7 · 6,275,729 sh | 6,275,729 | $161.4M | <0.01% | +2.1% |
| 8 | FMR#8 · 4,535,836 sh | 4,535,836 | $116.7M | <0.01% | -0.9% |
| 9 | GOLDMAN SACHS GROUP#9 · 4,155,895 sh | 4,155,895 | $106.9M | <0.01% | -5.7% |
| 10 | GEODE CAPITAL MANAGEMENT#10 · 3,973,342 sh | 3,973,342 | $102.2M | <0.01% | +6.6% |
| 11 | Holocene Advisors#11 · 3,905,225 sh | 3,905,225 | $100.4M | 0.23% | +22.2% |
| 12 | BAKER BROS. ADVISORS#12 · 3,734,336 sh | 3,734,336 | $96.0M | 0.48% | +0.1% |
| 13 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AME#13 · 3,161,972 sh | 3,161,972 | $81.3M | 0.01% | -28.7% |
| 14 | PRICE T ROWE ASSOCIATES#14 · 3,136,149 sh | 3,136,149 | $80.7M | <0.01% | +27.3% |
| 15 | UBS Group AG#15 · 3,120,592 sh | 3,120,592 | $80.3M | 0.01% | +21.4% |
| 16 | DIMENSIONAL FUND ADVISORS#16 · 2,860,604 sh | 2,860,604 | $73.6M | 0.01% | +6.3% |
| 17 | NORGES BANK#17 · 2,824,746 sh | 2,824,746 | $72.7M | <0.01% | — |
| 18 | Pictet Asset Management Holding SA#18 · 2,791,206 sh | 2,791,206 | $71.9M | 0.07% | +9.1% |
| 19 | Capital Research Global Investors#19 · 2,565,817 sh | 2,565,817 | $66.0M | <0.01% | +2.0% |
| 20 | Fisher Asset Management#20 · 2,414,162 sh | 2,414,162 | $62.1M | 0.02% | -0.9% |
| 21 | ALLIANCEBERNSTEIN L.P.#21 · 2,984,807 sh | 2,984,807 | $57.3M | 0.02% | +3.2% |
| 22 | NOMURA ASSET MANAGEMENT INTERNATIONAL#22 · 2,208,263 sh | 2,208,263 | $56.8M | 0.09% | +1828.2% |
| 23 | Casdin Capital#23 · 2,045,000 sh | 2,045,000 | $52.6M | 2.63% | +11.1% |
| 24 | Crestline Management#24 · 1,910,732 sh | 1,910,732 | $49.1M | 91.90% | -13.6% |
| 25 | PRINCIPAL FINANCIAL GROUP#25 · 1,420,083 sh | 1,420,083 | $36.5M | 0.02% | -4.0% |
| 26 | Foresite Capital Management VI#26 · 1,396,771 sh | 1,396,771 | $35.9M | 5.59% | +15.4% |
| 27 | Siren, L.L.C.#27 · 1,396,513 sh | 1,396,513 | $35.9M | 0.73% | 0.0% |
| 28 | NORTHERN#28 · 1,389,765 sh | 1,389,765 | $35.7M | <0.01% | +6.0% |
| 29 | BNP Paribas Asset Management Holding S.A.#29 · 1,355,514 sh | 1,355,514 | $34.9M | 0.03% | +357.2% |
| 30 | abrdn plc#30 · 1,345,481 sh | 1,345,481 | $34.6M | 0.05% | -27.4% |
| 31 | CHARLES SCHWAB INVESTMENT MANAGEMENT#31 · 1,244,955 sh | 1,244,955 | $32.0M | <0.01% | +3.1% |
| 32 | BANK OF AMERICA#32 · 1,230,957 sh | 1,230,957 | $31.7M | <0.01% | +8.5% |
| 33 | Artisan Partners Limited Partnership#33 · 1,224,497 sh | 1,224,497 | $31.5M | 0.05% | +11.3% |
| 34 | Candriam S.C.A.#34 · 1,189,886 sh | 1,189,886 | $30.6M | 0.14% | +8.2% |
| 35 | MILLENNIUM MANAGEMENT#35 · 1,125,748 sh | 1,125,748 | $29.0M | 0.01% | -10.5% |
| 36 | ADAR1 Capital Management#36 · 1,029,080 sh | 1,029,080 | $26.5M | 1.21% | -45.0% |
| 37 | VANGUARD FIDUCIARY#37 · 991,904 sh | 991,904 | $25.5M | <0.01% | +4.4% |
| 38 | MORGAN STANLEY#38 · 961,050 sh | 961,050 | $24.7M | <0.01% | -13.0% |
| 39 | Bank of New York Mellon#39 · 800,283 sh | 800,283 | $20.6M | <0.01% | +4.2% |
| 40 | DAFNA Capital Management#40 · 739,014 sh | 739,014 | $19.0M | 3.62% | +132.0% |
| 41 | AMERICAN CENTURY COMPANIES#41 · 712,526 sh | 712,526 | $18.3M | <0.01% | -23.9% |
| 42 | Cercano Management#42 · 625,000 sh | 625,000 | $16.1M | 1.55% | 0.0% |
| 43 | Nuveen#43 · 608,967 sh | 608,967 | $15.7M | <0.01% | +106.0% |
| 44 | Ensign Peak Advisors#44 · 582,669 sh | 582,669 | $15.0M | 0.02% | +13.0% |
| 45 | MARSHALL WACE, LLP#45 · 549,830 sh | 549,830 | $14.1M | 0.01% | -44.5% |
| 46 | SEGALL BRYANT & HAMILL#46 · 519,483 sh | 519,483 | $13.4M | 0.16% | 0.0% |
| 47 | CITIGROUP#47 · 487,278 sh | 487,278 | $12.5M | <0.01% | +1140.6% |
| 48 | Defilade Capital Management, L.P.#48 · 391,866 sh | 391,866 | $10.1M | 1.35% | -71.2% |
| 49 | AQR CAPITAL MANAGEMENT#49 · 388,469 sh | 388,469 | $10.0M | <0.01% | +278.7% |
| 50 | Woodline Partners#50 · 364,082 sh | 364,082 | $9.4M | 0.03% | 0.0% |
| 51 | Invesco Ltd.#51 · 343,898 sh | 343,898 | $8.8M | <0.01% | +10.9% |
| 52 | ExodusPoint Capital Management#52 · 336,567 sh | 336,567 | $8.7M | 0.06% | New |
| 53 | Marex Group plc#53 · 295,631 sh | 295,631 | $7.6M | 0.03% | +3.0% |
| 54 | JPMORGAN CHASE#54 · 287,019 sh | 287,019 | $7.6M | <0.01% | -11.4% |
| 55 | Swiss National Bank#55 · 270,500 sh | 270,500 | $7.0M | <0.01% | -1.2% |
| 56 | TD ASSET MANAGEMENT#56 · 231,644 sh | 231,644 | $6.0M | <0.01% | -9.4% |
| 57 | GROUPAMA ASSET MANAGMENT#57 · 229,939 sh | 229,939 | $5.9M | 0.07% | +11.0% |
| 58 | Privium Fund Management B.V.#58 · 229,857 sh | 229,857 | $5.9M | 1.09% | -9.8% |
| 59 | XTX Topco Ltd#59 · 226,953 sh | 226,953 | $5.8M | 0.08% | +188.9% |
| 60 | Alyeska Investment Group, L.P.#60 · 219,334 sh | 219,334 | $5.6M | 0.01% | -88.7% |
| 61 | Susquehanna Portfolio Strategies#61 · 211,474 sh | 211,474 | $5.4M | 0.09% | +33.9% |
| 62 | MASTERS CAPITAL MANAGEMENT#62 · 200,000 sh | 200,000 | $5.1M | 0.13% | -66.7% |
| 63 | Burkehill Global Management#63 · 200,000 sh | 200,000 | $5.1M | 0.19% | 0.0% |
| 64 | SCS Capital Management#64 · 197,998 sh | 197,998 | $5.1M | 0.05% | 0.0% |
| 65 | RHUMBLINE ADVISERS#65 · 194,787 sh | 194,787 | $5.0M | <0.01% | +5.7% |
| 66 | WELLS FARGO & COMPANY#66 · 189,865 sh | 189,865 | $4.9M | <0.01% | +76.4% |
| 67 | Universal- Beteiligungs- und Servicegesellschaft mbH#67 · 179,195 sh | 179,195 | $4.6M | <0.01% | +80.1% |
| 68 | Rhenman & Partners Asset Management AB#68 · 179,000 sh | 179,000 | $4.6M | 0.43% | -10.1% |
| 69 | NEW YORK STATE COMMON RETIREMENT FUND#69 · 171,712 sh | 171,712 | $4.4M | <0.01% | +34.0% |
| 70 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY#70 · 166,181 sh | 166,181 | $4.3M | 0.03% | 0.0% |
| 71 | EDMOND DE ROTHSCHILD HOLDING S.A.#71 · 165,080 sh | 165,080 | $4.2M | 0.06% | -26.9% |
| 72 | ALPS ADVISORS#72 · 160,378 sh | 160,378 | $4.1M | 0.02% | +24.2% |
| 73 | E. Ohman J:or Asset Management AB#73 · 160,000 sh | 160,000 | $4.1M | — | New |
| 74 | DEUTSCHE BANK AG\#74 · 149,804 sh | 149,804 | $3.9M | <0.01% | +24.5% |
| 75 | GREAT LAKES ADVISORS#75 · 145,045 sh | 145,045 | $3.7M | 0.03% | -36.1% |
| 76 | VANGUARD ASSET MANAGEMENT, Ltd#76 · 141,153 sh | 141,153 | $3.6M | <0.01% | +12.7% |
| 77 | Man Group plc#77 · 139,065 sh | 139,065 | $3.6M | <0.01% | 0.0% |
| 78 | Hudson Bay Capital Management#78 · 130,000 sh | 130,000 | $3.3M | <0.01% | -62.5% |
| 79 | Odyssean#79 · 125,062 sh | 125,062 | $3.2M | 0.52% | New |
| 80 | SUSQUEHANNA INTERNATIONAL GROUP, LLP#80 · 123,258 sh | 123,258 | $3.2M | <0.01% | +144.2% |
| 81 | MANUFACTURERS LIFE INSURANCE COMPANY, THE#81 · 117,348 sh | 117,348 | $3.0M | <0.01% | -6.5% |
| 82 | Zurcher Kantonalbank (Zurich Cantonalbank)#82 · 115,775 sh | 115,775 | $3.0M | <0.01% | +3.7% |
| 83 | B. Metzler seel. Sohn & AG#83 · 112,300 sh | 112,300 | $2.9M | 0.03% | 0.0% |
| 84 | Legal & General Group Plc#84 · 111,953 sh | 111,953 | $2.9M | <0.01% | +1.5% |
| 85 | Integrated Wealth Concepts#85 · 102,241 sh | 102,241 | $2.6M | 0.01% | +2.7% |
| 86 | PFM Health Sciences#86 · 100,966 sh | 100,966 | $2.6M | 0.22% | New |
| 87 | Integral Health Asset Management#87 · 100,000 sh | 100,000 | $2.6M | 0.10% | New |
| 88 | Ghisallo Capital Management#88 · 100,000 sh | 100,000 | $2.6M | 0.05% | 0.0% |
| 89 | Lumbard & Kellner#89 · 98,282 sh | 98,282 | $2.5M | 0.77% | +3.7% |
| 90 | Rafferty Asset Management#90 · 96,342 sh | 96,342 | $2.5M | <0.01% | -36.1% |
| 91 | D.A. DAVIDSON#91 · 87,741 sh | 87,741 | $2.3M | 0.01% | -20.4% |
| 92 | Russell Investments Group, Ltd.#92 · 86,032 sh | 86,032 | $2.2M | <0.01% | +512.0% |
| 93 | MetLife Investment Management#93 · 85,621 sh | 85,621 | $2.2M | 0.01% | +10.4% |
| 94 | BARCLAYS PLC#94 · 84,892 sh | 84,892 | $2.2M | <0.01% | +63.0% |
| 95 | STATE OF WISCONSIN INVESTMENT BOARD#95 · 84,652 sh | 84,652 | $2.2M | <0.01% | +2.8% |
| 96 | Creative Planning#96 · 84,644 sh | 84,644 | $2.2M | <0.01% | +14.3% |
| 97 | AMERIPRISE FINANCIAL#97 · 82,650 sh | 82,650 | $2.1M | <0.01% | -7.7% |
| 98 | MIRAE ASSET GLOBAL ETFS Ltd.#98 · 78,937 sh | 78,937 | $2.0M | <0.01% | -17.1% |
| 99 | Phocas Financial#99 · 71,197 sh | 71,197 | $1.8M | 0.25% | New |
| 100 | Knights of Columbus Asset Advisors#100 · 67,591 sh | 67,591 | $1.7M | 0.09% | +20.0% |
Funds that sold out of DNLI in Q2 2026 (26)
Held DNLI at the end of Q1 2026 and filed a Q2 2026 13F without it. Not in the list above, because they no longer hold it. Largest prior position first.
| Institution | Shares sold | Value in Q1 2026 |
|---|---|---|
| Vestal Point Capital1,773,326 sh | 1,773,326 | $34.0M |
| StemPoint Capital426,561 sh | 426,561 | $8.2M |
| BRAIDWELL296,324 sh | 296,324 | $5.7M |
| SCHRODER INVESTMENT MANAGEMENT GROUP285,820 sh | 285,820 | $5.2M |
| Palo Alto Investors234,582 sh | 234,582 | $4.5M |
| BALYASNY ASSET MANAGEMENT L.P.195,108 sh | 195,108 | $3.7M |
| SECTOR GAMMA AS162,710 sh | 162,710 | $3.1M |
| Y-Intercept (Hong Kong) Ltd78,007 sh | 78,007 | $1.5M |
| POLEN CAPITAL MANAGEMENT65,301 sh | 65,301 | $1.3M |
| Virtu Financial43,362 sh | 43,362 | $833.0K |
| Seven Fleet Capital Management35,286 sh | 35,286 | $677.5K |
| JANE STREET GROUP32,147 sh | 32,147 | $617.2K |
| TWINBEECH CAPITAL23,000 sh | 23,000 | $441.6K |
| Amundi18,604 sh | 18,604 | $357.2K |
| Headlands Technologies10,557 sh | 10,557 | $202.7K |
| QUADRANT CAPITAL GROUP1,516 sh | 1,516 | $63.5K |
| Advisory Services Network848 sh | 848 | $16.3K |
| Quantbot Technologies512 sh | 512 | $9.8K |
| EASTERN BANK282 sh | 282 | $5.4K |
| Root Financial Partners188 sh | 188 | $3.6K |
| Aster Capital Management (DIFC) Ltd246 sh | 246 | $3.3K |
| Golden State Equity Partners130 sh | 130 | $2.5K |
| Your Advocates Ltd., LLP100 sh | 100 | $1.9K |
| Wealth Preservation Advisors43 sh | 43 | $826.00 |
| Vermillion Wealth Management1 sh | 1 | $19.00 |
| CURIO WEALTH1 sh | 1 | $19.00 |
Source: Form 13F-HR filings on SEC EDGAR, Q2 2026. Values are as reported by each manager at quarter end. “% of portfolio” is the position’s share of the manager’s total reported 13F value for the same quarter. “New” means the manager filed a 13F for Q1 2026 without this position; a dash means no comparison is available. Where a manager’s own filing is internally inconsistent its value is withheld and it is listed last. 13F data shows reported holdings, not recommendations.