CASTLE BIOSCIENCES INC (CSTL) — Institutional Holders, Q2 2026

178 institutional investment managers reported a CSTL position on SEC Form 13F-HR for the quarter ended June 30, 2026, with a combined reported value of $651.9M. Every filer is listed below, ranked by position value, 100 per page; this page shows ranks 1 to 100. Put and call option positions are excluded, and a firm filing several lots or share classes is shown once with its total.

← CSTL stock profile

CSTL in Q2 2026: what funds did

Funds that filed a 13F for both Q1 2026 and Q2 2026, by what they did with the common stock. Share counts are adjusted for any split between the two quarters; dollar figures are the change in shares at this quarter’s price.

New positions

Added to

Trimmed

Sold out

Biggest buyers

MACKENZIE FINANCIALAdded · +719,396 sh+$17.2M
LEUCADIA NATIONALNew · +647,391 sh+$15.4M
ACADIAN ASSET MANAGEMENTAdded · +434,227 sh+$10.4M
Point72 Asset Management, L.P.New · +357,317 sh+$8.5M
KENNEDY CAPITAL MANAGEMENTNew · +348,371 sh+$8.3M

Biggest sellers

Portolan Capital ManagementTrimmed · -1,021,465 sh-$24.4M
EVENTIDE ASSET MANAGEMENTSold out · -386,425 sh-$9.2M
PALISADE CAPITAL MANAGEMENTTrimmed · -303,953 sh-$7.2M
SCHRODER INVESTMENT MANAGEMENT GROUPSold out · -298,941 sh-$7.1M
NuveenTrimmed · -290,401 sh-$6.9M

CSTL 13F holders ranked 1–100 of 178

Institutional investors reporting a position in CASTLE BIOSCIENCES INC on SEC Form 13F-HR for Q2 2026, ranked by reported value.
#	Institution	Shares	Value	% of portfolio	QoQShares vs Q1 2026
1	BlackRock#1 · 3,291,963 sh	3,291,963	$78.5M	<0.01%	+10.4%
2	RTW INVESTMENTS#2 · 2,778,335 sh	2,778,335	$66.3M	0.57%	+0.7%
3	PRINCIPAL FINANCIAL GROUP#3 · 1,726,648 sh	1,726,648	$41.2M	0.02%	-2.4%
4	VANGUARD CAPITAL MANAGEMENT#4 · 1,226,497 sh	1,226,497	$29.3M	<0.01%	+4.2%
5	ACADIAN ASSET MANAGEMENT#5 · 918,668 sh	918,668	$21.9M	0.03%	+89.6%
6	VANGUARD PORTFOLIO MANAGEMENT#6 · 840,785 sh	840,785	$20.1M	<0.01%	-2.4%
7	Allianz Asset Management GmbH#7 · 811,324 sh	811,324	$19.9M	0.02%	0.0%
8	SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT#8 · 824,872 sh	824,872	$19.7M	0.35%	-12.3%
9	STATE STREET#9 · 822,079 sh	822,079	$19.6M	<0.01%	+6.9%
10	GEODE CAPITAL MANAGEMENT#10 · 795,912 sh	795,912	$19.0M	<0.01%	+9.3%
11	MACKENZIE FINANCIAL#11 · 793,507 sh	793,507	$18.9M	0.02%	+970.7%
12	DIMENSIONAL FUND ADVISORS#12 · 791,085 sh	791,085	$18.9M	<0.01%	-23.9%
13	LEUCADIA NATIONAL#13 · 647,391 sh	647,391	$15.4M	0.10%	New
14	Qube Research & Technologies Ltd#14 · 589,300 sh	589,300	$14.1M	0.01%	+5.3%
15	AIGH Capital Management#15 · 545,101 sh	545,101	$13.0M	0.82%	-7.7%
16	RENAISSANCE TECHNOLOGIES#16 · 371,200 sh	371,200	$8.9M	0.01%	-30.3%
17	GOLDMAN SACHS GROUP#17 · 358,397 sh	358,397	$8.5M	<0.01%	+5.0%
18	Point72 Asset Management, L.P.#18 · 357,317 sh	357,317	$8.5M	<0.01%	New
19	KENNEDY CAPITAL MANAGEMENT#19 · 348,371 sh	348,371	$8.3M	0.15%	New
20	Connor, Clark & Lunn Investment Management Ltd.#20 · 331,727 sh	331,727	$7.9M	0.01%	-12.0%
21	MORGAN STANLEY#21 · 329,684 sh	329,684	$7.9M	<0.01%	-23.1%
22	Portolan Capital Management#22 · 328,818 sh	328,818	$7.8M	0.29%	-75.6%
23	PANAGORA ASSET MANAGEMENT#23 · 301,040 sh	301,040	$7.2M	0.02%	+35.4%
24	Allspring Global Investments#24 · 292,470 sh	292,470	$7.0M	0.01%	+82.0%
25	NORTHERN#25 · 285,158 sh	285,158	$6.8M	<0.01%	+4.4%
26	WASATCH ADVISORS#26 · 279,349 sh	279,349	$6.7M	—	-38.6%
27	CITADEL ADVISORS#27 · 265,353 sh	265,353	$6.3M	<0.01%	+119.3%
28	KORNITZER CAPITAL MANAGEMENT#28 · 264,235 sh	264,235	$6.3M	0.13%	-0.1%
29	SILVERCREST ASSET MANAGEMENT GROUP#29 · 256,095 sh	256,095	$6.1M	0.04%	-4.6%
30	CHARLES SCHWAB INVESTMENT MANAGEMENT#30 · 254,535 sh	254,535	$6.1M	<0.01%	+5.2%
31	Advisors Capital Management#31 · 238,204 sh	238,204	$5.7M	0.06%	-4.1%
32	NEW YORK STATE COMMON RETIREMENT FUND#32 · 234,746 sh	234,746	$5.6M	<0.01%	+0.7%
33	PALISADE CAPITAL MANAGEMENT#33 · 231,931 sh	231,931	$5.5M	0.24%	-56.7%
34	Nuveen#34 · 231,726 sh	231,726	$5.5M	<0.01%	-55.6%
35	BRIDGEWAY CAPITAL MANAGEMENT#35 · 221,338 sh	221,338	$5.3M	0.09%	-13.3%
36	Trexquant Investment#36 · 206,111 sh	206,111	$4.9M	0.03%	+58.0%
37	MILLENNIUM MANAGEMENT#37 · 205,369 sh	205,369	$4.9M	<0.01%	-41.9%
38	VANGUARD FIDUCIARY#38 · 197,494 sh	197,494	$4.7M	<0.01%	+4.9%
39	AQR CAPITAL MANAGEMENT#39 · 166,567 sh	166,567	$4.0M	<0.01%	+156.7%
40	FIRST ADVISORS#40 · 145,064 sh	145,064	$3.5M	<0.01%	New
41	Parkman Healthcare Partners#41 · 144,791 sh	144,791	$3.5M	0.35%	+14.8%
42	Empowered Funds#42 · 142,338 sh	142,338	$3.4M	0.02%	+7.7%
43	HRT FINANCIAL#43 · 115,853 sh	115,853	$2.8M	<0.01%	+630.6%
44	D. E. Shaw#44 · 112,789 sh	112,789	$2.7M	<0.01%	-46.8%
45	Man Group plc#45 · 108,761 sh	108,761	$2.6M	<0.01%	+130.7%
46	TWO SIGMA INVESTMENTS#46 · 100,374 sh	100,374	$2.4M	<0.01%	-59.7%
47	BANK OF AMERICA#47 · 98,745 sh	98,745	$2.4M	<0.01%	+45.6%
48	Bank of New York Mellon#48 · 98,018 sh	98,018	$2.3M	<0.01%	+10.6%
49	FRANKLIN RESOURCES#49 · 97,733 sh	97,733	$2.3M	<0.01%	+7.5%
50	ARROWSTREET CAPITAL, LIMITED PARTNERSHIP#50 · 92,736 sh	92,736	$2.2M	<0.01%	+241.7%
51	UBS Group AG#51 · 89,368 sh	89,368	$2.1M	<0.01%	+81.8%
52	JPMORGAN CHASE#52 · 84,804 sh	84,804	$2.1M	<0.01%	-4.5%
53	SummitTX Capital, L.P.#53 · 79,018 sh	79,018	$1.9M	0.05%	+17.9%
54	SEI INVESTMENTS#54 · 74,433 sh	74,433	$1.8M	<0.01%	+112.4%
55	ALGERT GLOBAL#55 · 70,478 sh	70,478	$1.7M	0.02%	+102.7%
56	Orion Porfolio Solutions#56 · 69,654 sh	69,654	$1.7M	0.01%	-7.0%
57	BNP PARIBAS FINANCIAL MARKETS#57 · 69,571 sh	69,571	$1.7M	<0.01%	-43.0%
58	AMERICAN CENTURY COMPANIES#58 · 65,413 sh	65,413	$1.6M	<0.01%	-17.3%
59	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AME#59 · 64,346 sh	64,346	$1.5M	<0.01%	-1.0%
60	NORGES BANK#60 · 60,100 sh	60,100	$1.4M	<0.01%	—
61	FMR#61 · 55,871 sh	55,871	$1.3M	<0.01%	+10.8%
62	ENVESTNET ASSET MANAGEMENT#62 · 55,157 sh	55,157	$1.3M	<0.01%	-10.8%
63	Invesco Ltd.#63 · 54,888 sh	54,888	$1.3M	<0.01%	-10.0%
64	Swiss National Bank#64 · 53,700 sh	53,700	$1.3M	<0.01%	-6.3%
65	PRICE T ROWE ASSOCIATES#65 · 53,242 sh	53,242	$1.3M	<0.01%	+40.9%
66	JANE STREET GROUP#66 · 44,793 sh	44,793	$1.1M	<0.01%	+5.2%
67	XTX Topco Ltd#67 · 39,923 sh	39,923	$952.2K	0.01%	+96.8%
68	RHUMBLINE ADVISERS#68 · 39,010 sh	39,010	$930.4K	<0.01%	+1.6%
69	KBC Group NV#69 · 36,042 sh	36,042	$860.0K	—	-2.4%
70	Russell Investments Group, Ltd.#70 · 31,679 sh	31,679	$761.4K	<0.01%	+240.1%
71	Y-Intercept (Hong Kong) Ltd#71 · 31,916 sh	31,916	$761.2K	—	+35.8%
72	HARBOR CAPITAL ADVISORS#72 · 31,748 sh	31,748	$757.0K	—	+23.9%
73	STRS OHIO#73 · 30,500 sh	30,500	$727.4K	<0.01%	+22.0%
74	BARCLAYS PLC#74 · 30,330 sh	30,330	$723.4K	<0.01%	+13.1%
75	DEUTSCHE BANK AG\#75 · 30,139 sh	30,139	$718.8K	<0.01%	+24.7%
76	WELLS FARGO & COMPANY#76 · 29,543 sh	29,543	$704.6K	<0.01%	+129.2%
77	Engineers Gate Manager#77 · 29,480 sh	29,480	$703.1K	<0.01%	+61.5%
78	Inspire Investing#78 · 29,047 sh	29,047	$692.8K	—	+38.0%
79	ALLIANCEBERNSTEIN L.P.#79 · 27,100 sh	27,100	$665.3K	<0.01%	+7.2%
80	Universal- Beteiligungs- und Servicegesellschaft mbH#80 · 25,221 sh	25,221	$601.5K	<0.01%	-26.7%
81	TRUIST FINANCIAL#81 · 23,786 sh	23,786	$567.3K	<0.01%	0.0%
82	Toroso Investments#82 · 22,186 sh	22,186	$529.1K	<0.01%	New
83	Legal & General Group Plc#83 · 20,548 sh	20,548	$490.1K	<0.01%	-11.4%
84	Schonfeld Strategic Advisors#84 · 19,930 sh	19,930	$475.3K	<0.01%	-53.0%
85	First Bank#85 · 18,591 sh	18,591	$443.4K	—	+12.6%
86	VANGUARD ASSET MANAGEMENT, Ltd#86 · 17,653 sh	17,653	$421.0K	<0.01%	0.0%
87	MetLife Investment Management#87 · 17,008 sh	17,008	$405.6K	<0.01%	+1.7%
88	Counterpoint Mutual Funds#88 · 16,510 sh	16,510	$393.8K	—	New
89	Campbell & Investment Adviser#89 · 16,476 sh	16,476	$393.0K	0.02%	-88.9%
90	Quantinno Capital Management#90 · 16,428 sh	16,428	$391.8K	<0.01%	-63.9%
91	Diversify Advisory Services#91 · 15,932 sh	15,932	$389.4K	—	New
92	DIVERSIFY WEALTH MANAGEMENT#92 · 15,932 sh	15,932	$389.4K	—	+1.1%
93	CITIGROUP#93 · 16,144 sh	16,144	$385.0K	<0.01%	+300.9%
94	PERKINS CAPITAL MANAGEMENT#94 · 16,140 sh	16,140	$384.9K	0.29%	+4.7%
95	Zurcher Kantonalbank (Zurich Cantonalbank)#95 · 15,579 sh	15,579	$371.6K	<0.01%	+3.7%
96	Jupiter Topco#96 · 15,037 sh	15,037	$358.2K	<0.01%	—
97	TUDOR INVESTMENT ET AL#97 · 14,462 sh	14,462	$344.9K	<0.01%	-93.5%
98	LPL Financial#98 · 14,220 sh	14,220	$339.1K	<0.01%	+46.6%
99	MIRAE ASSET GLOBAL ETFS Ltd.#99 · 13,785 sh	13,785	$328.8K	<0.01%	+0.8%
100	Creative Planning#100 · 13,681 sh	13,681	$326.3K	<0.01%	+9.6%

Funds that sold out of CSTL in Q2 2026 (30)

Held CSTL at the end of Q1 2026 and filed a Q2 2026 13F without it. Not in the list above, because they no longer hold it. Largest prior position first.

Institutions that held CSTL in Q1 2026 and reported no position in Q2 2026.
Institution	Shares sold	Value in Q1 2026
EVENTIDE ASSET MANAGEMENT386,425 sh	386,425	$9.5M
SCHRODER INVESTMENT MANAGEMENT GROUP298,941 sh	298,941	$7.0M
SG Americas Securities244,886 sh	244,886	$6.0M
FORMULA GROWTH LTD46,000 sh	46,000	$1.1M
NOMURA35,748 sh	35,748	$877.6K
ExodusPoint Capital Management32,608 sh	32,608	$800.5K
Corient Private Wealth31,870 sh	31,870	$782.4K
FOX RUN MANAGEMENT, L.L.C.26,247 sh	26,247	$618.1K
Magnetar Financial23,332 sh	23,332	$572.8K
Brevan Howard Capital Management18,560 sh	18,560	$455.6K
Dynamic Technology Lab Private Ltd15,913 sh	15,913	$390.7K
Jump Financial12,300 sh	12,300	$302.0K
GSA CAPITAL PARTNERS LLP12,236 sh	12,236	$300.0K
CANADA PENSION PLAN INVESTMENT BOARD11,400 sh	11,400	$279.9K
Jackson Creek Investment Advisors11,214 sh	11,214	$275.0K
Graham Capital Management, L.P.11,133 sh	11,133	$273.3K
SUSQUEHANNA INTERNATIONAL GROUP, LLP9,520 sh	9,520	$233.7K
GLOBEFLEX CAPITAL L P3,759 sh	3,759	$92.3K
QUADRANT CAPITAL GROUP672 sh	672	$57.2K
GROUP ONE TRADING, L.P.292 sh	292	$7.2K
Advisory Services Network287 sh	287	$7.1K
MassMutual Private Wealth & , FSB202 sh	202	$5.0K
Destiny Wealth Partners88 sh	88	$2.2K
SIGNATUREFD45 sh	45	$1.1K
MAI Capital Management19 sh	19	$467.00
Missouri & Investment19 sh	19	$466.00
Signature Equity Partners16 sh	16	$393.00
Wealth Preservation Advisors4 sh	4	$98.00
Larson Financial Group1 sh	1	$25.00
TWIN PEAKS WEALTH ADVISORS1 sh	1	$25.00

Source: Form 13F-HR filings on SEC EDGAR, Q2 2026. Values are as reported by each manager at quarter end. “% of portfolio” is the position’s share of the manager’s total reported 13F value for the same quarter. “New” means the manager filed a 13F for Q1 2026 without this position; a dash means no comparison is available. Where a manager’s own filing is internally inconsistent its value is withheld and it is listed last. 13F data shows reported holdings, not recommendations.