How is hedge fund similarity measured?

Similarity is computed from each fund's top conviction holdings in their latest 13F filing. Funds are scored by the overlap of distinctive shared positions (the mega-caps that nearly every fund owns are excluded), so the ranking reflects genuinely shared strategy rather than common index exposure.

Hedge Funds Similar to RTW INVESTMENTS

13F Portfolio OverlapQ2 2026RTW INVESTMENTS portfolio →

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Most similar hedge funds by 13F overlap

RTW INVESTMENTS, LP is an institutional investor managing $11.7B across 84 U.S. equity positions as of Q2 2026. Based on the overlap of conviction holdings in their latest 13F filings, the hedge funds with portfolios most similar to RTW INVESTMENTS are Avoro Advisors, Eagle Health Investments, Affinity Asset Advisors, with shared positions in $MDGL, $ARGX, $CELC, $CYTK, $QURE, $TSHA. The full ranking of 25 similar funds is below.

#1Avoro Capital Advisors LLCSmart money

Substantial overlap · 8 shared positions

$MDGL $ARGX $CELC $CYTK $QURE $TSHA

$11.1B

26 positions

#2Eagle Health Investments LPActive

Substantial overlap · 9 shared positions

$ARGX $PTGX $INSM $RARE $GH $CMPS

$603M

27 positions

#3Affinity Asset Advisors, LLCActive

Notable overlap · 11 shared positions

$INSM $SYRE $ERAS $ORKA $CYTK $MDGL

$2.2B

113 positions

#4BAKER BROS. ADVISORS LPSmart money

Notable overlap · 10 shared positions

$MDGL $INSM $CELC $ACAD $IMVT $ALKS

$20.0B

84 positions

#5PSP Research LLCActive

Notable overlap · 12 shared positions

$ARGX $RARE $PTCT $NBIX $TARS $ACAD

$188M

75 positions

#6Rock Springs Capital Management LPActive

Notable overlap · 11 shared positions

$MDGL $ARGX $INSM $RARE $IRTC $ERAS

$2.0B

104 positions

#7Paradigm Biocapital Advisors LPActive

Notable overlap · 7 shared positions

$TNGX $SYRE $ERAS $INSM $ORKA $TARS

$5.3B

28 positions

#8Seven Fleet Capital Management LPActive

Notable overlap · 11 shared positions

$CGON $TNGX $CYTK $TARS $ERAS $XNCR

$606M

96 positions

#9TANG CAPITAL MANAGEMENT LLCActive

Notable overlap · 8 shared positions

$PTCT $SYRE $CELC $TARS $IMCR $CMPS

$2.2B

41 positions

#10StemPoint Capital LPPassive

Notable overlap · 9 shared positions

$TNGX $ERAS $CGON $ORKA $CELC $SYRE

$581M

84 positions

#11Logos Global Management LPActive

Notable overlap · 10 shared positions

$TNGX $CGON $ERAS $CMPS $IMVT $BLTE

$2.3B

68 positions

#12TCG Crossover Management, LLCActive

Notable overlap · 7 shared positions

$CGON $TNGX $SYRE $ZLAB $IMVT $XNCR

$4.2B

54 positions

#13Artia Global Partners LPActive

Notable overlap · 9 shared positions

$ARGX $INSM $CELC $CYTK $GH $ALKS

$542M

48 positions

#14Palo Alto Investors LPActive

Notable overlap · 10 shared positions

$PTCT $INSM $RARE $TSHA $ALKS $ORKA

$724M

52 positions

#15Boxer Capital Management, LLCSmart money

Notable overlap · 10 shared positions

$TNGX $CELC $PTGX $QURE $URGN $PTCT

$1.3B

63 positions

#16Deep Track Capital, LPActive

Notable overlap · 11 shared positions

$ORKA $TNGX $GH $TARS $GHRS $CMPS

$6.9B

67 positions

#17Bellevue Group AGActive

Notable overlap · 6 shared positions

$ARGX $INSM $ORKA $RARE $IMCR $CGON

$4.8B

148 positions

#18First Turn Management, LLCActive

Notable overlap · 7 shared positions

$INSM $CELC $ERAS $CYTK $ORKA $QURE

$935M

31 positions

#19PERCEPTIVE ADVISORS LLCActive

Notable overlap · 8 shared positions

$SYRE $CELC $ORKA $PTGX $TNGX $IMTX

$6.7B

109 positions

#20HighVista Strategies LLCPassive

Notable overlap · 13 shared positions

$TNGX $SYRE $CYTK $TARS $CMPS $IMVT

$439M

147 positions

#21Siren, L.L.C.Active

Notable overlap · 9 shared positions

$TNGX $ERAS $SYRE $STOK $CYTK $KLRA

$4.9B

117 positions

#22ADAR1 Capital Management, LLCActive

Notable overlap · 9 shared positions

$PTGX $CYTK $SYRE $INSM $ZLAB $IMVT

$2.2B

277 positions

#23Tri Locum Partners LPActive

Notable overlap · 4 shared positions

$ARGX $MDGL $CYTK $TARS

$813M

19 positions

#24SILVERARC CAPITAL MANAGEMENT, LLCActive

Notable overlap · 8 shared positions

$CELC $ERAS $ORKA $GH $URGN $IMVT

$962M

73 positions

#25KVP Capital Advisors, LPActive

Notable overlap · 5 shared positions

$PTGX $TNGX $ERAS $INSM $CELC

$136M

35 positions

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Similarity is derived from each fund’s latest 13F-HR filing with the SEC. Funds are ranked by the overlap of distinctive conviction holdings; near-universal mega-cap positions are excluded so the ranking reflects shared strategy, not common index exposure. Data is informational only and not investment advice.