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Hedge Funds Similar to Opaleye

13F Portfolio OverlapQ2 2026Opaleye portfolio →
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Most similar hedge funds by 13F overlap

Opaleye Management Inc. is an institutional investor managing $1.1B across 58 U.S. equity positions as of Q2 2026. Based on the overlap of conviction holdings in their latest 13F filings, the hedge funds with portfolios most similar to Opaleye are Caligan Partners, MPM BioImpact, BVF, with shared positions in $LQDA, $RVMD, $MBX, $IRD, $URGN, $EWTX. The full ranking of 25 similar funds is below.

#1Caligan Partners LPSmart money
Substantial overlap · 4 shared positions
$LQDA$RVMD$MBX$IRD
$2.1B
28 positions
#2MPM BioImpact LLCActive
Notable overlap · 9 shared positions
$LQDA$URGN$EWTX$RVMD$GLUE$STOK
$1.6B
37 positions
#3BVF INC/ILActive
Notable overlap · 9 shared positions
$IRON$STOK$RVMD$GLUE$XOMA$CBIO
$3.9B
44 positions
#4Exome Asset Management LLCActive
Notable overlap · 8 shared positions
$TGTX$LQDA$GLUE$CBIO$ALMS$RYTM
$162M
52 positions
#5KVP Capital Advisors, LPActive
Notable overlap · 8 shared positions
$IRON$EWTX$IMMX$MBX$PTGX$CABA
$136M
35 positions
#6PERCEPTIVE ADVISORS LLCActive
Notable overlap · 6 shared positions
$APGE$MGTX$EWTX$RVMD$RYTM$PTGX
$6.7B
109 positions
#7PSP Research LLCActive
Notable overlap · 8 shared positions
$IRON$TGTX$GLUE$LQDA$STOK$PTGX
$188M
75 positions
#8GREAT POINT PARTNERS LLCActive
Notable overlap · 7 shared positions
$SLGL$IMMX$ALMS$RZLT$ANNX$RLMD
$529M
42 positions
#9Saturn V Capital Management LPActive
Notable overlap · 4 shared positions
$IRON$IMMX$ALMS$TRVI
$697M
23 positions
#10Boxer Capital Management, LLCSmart money
Notable overlap · 10 shared positions
$RVMD$URGN$REPL$PTGX$FIXX$APGE
$1.3B
63 positions
#11Paradigm Biocapital Advisors LPActive
Notable overlap · 5 shared positions
$APGE$EWTX$RVMD$MBX$EDIT
$5.3B
28 positions
#12Logos Global Management LPActive
Notable overlap · 6 shared positions
$IRON$RVMD$CBIO$REPL$OCUL$TRVI
$2.3B
68 positions
#13SILVERARC CAPITAL MANAGEMENT, LLCActive
Notable overlap · 4 shared positions
$URGN$GLUE$RYTM$TRVI
$962M
73 positions
#14Affinity Asset Advisors, LLCActive
Some overlap · 4 shared positions
$APGE$RVMD$PTGX$TRVI
$2.2B
113 positions
#15DIADEMA PARTNERS LPActive
Some overlap · 7 shared positions
$EWTX$RVMD$REPL$GLUE$ALMS$TGTX
$791M
149 positions
#16Checkpoint Capital L.P.Active
Some overlap · 4 shared positions
$IRON$RVMD$RYTM$TRVI
$390M
6 positions
#17SUPERSTRING CAPITAL MANAGEMENT LPActive
Some overlap · 4 shared positions
$URGN$RVMD$CABA$TRVI
$158M
32 positions
#18First Light Asset Management, LLCActive
Some overlap · 4 shared positions
$APGE$EWTX$RYTM$TRVI
$1.6B
31 positions
#19Foresite Capital Management V, LLCActive
Some overlap · 3 shared positions
$IRON$ALMS$LYEL
$362M
9 positions
#20Siren, L.L.C.Active
Some overlap · 5 shared positions
$EWTX$RVMD$STOK$IRON$RYTM
$4.9B
117 positions
#21Vestal Point Capital, LPActive
Some overlap · 5 shared positions
$IRON$RVMD$GLUE$CBIO$TRVI
$4.3B
68 positions
#22TCG Crossover Management, LLCActive
Some overlap · 5 shared positions
$IRON$GLUE$RVMD$EDIT$MBX
$4.2B
54 positions
#23Seven Fleet Capital Management LP
Some overlap · 5 shared positions
$LQDA$RVMD$PTGX$EDIT$RLMD
$606M
96 positions
#24Squadron Capital Management LLCActive
Some overlap · 6 shared positions
$RZLT$EWTX$SLGL$IRON$ZNTL$RLMD
$322M
43 positions
#25VR Adviser, LLCSmart money
Some overlap · 4 shared positions
$APGE$CBIO$RLMD$OCUL
$3.3B
33 positions

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Similarity is derived from each fund’s latest 13F-HR filing with the SEC. Funds are ranked by the overlap of distinctive conviction holdings; near-universal mega-cap positions are excluded so the ranking reflects shared strategy, not common index exposure. Data is informational only and not investment advice.