How is hedge fund similarity measured?

Similarity is computed from each fund's top conviction holdings in their latest 13F filing. Funds are scored by the overlap of distinctive shared positions (the mega-caps that nearly every fund owns are excluded), so the ranking reflects genuinely shared strategy rather than common index exposure.

Hedge Funds Similar to SR ONE ,

13F Portfolio OverlapQ1 2026SR ONE , portfolio →

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Most similar hedge funds by 13F overlap

SR ONE CAPITAL MANAGEMENT, LP is an institutional investor managing $915M across 14 U.S. equity positions as of Q1 2026. Based on the overlap of conviction holdings in their latest 13F filings, the hedge funds with portfolios most similar to SR ONE , are NEA Company,, Paradigm Biocapital Advisors, Nextech Invest, Ltd., with shared positions in $ACLX, $ZBIO, $ORIC, $CRSP, $NKTX, $ORKA. The full ranking of 25 similar funds is below.

#1NEA Management Company, LLCSmart money

Substantial overlap · 5 shared positions

$ACLX $ZBIO $ORIC $CRSP $NKTX

$1.8B

26 positions

#2Paradigm Biocapital Advisors LPActive

Notable overlap · 4 shared positions

$ACLX $ORKA $MANE $ORIC

$4.9B

35 positions

#3Nextech Invest, Ltd.Smart money

Notable overlap · 4 shared positions

$ORIC $ALMS $ENGN $SPRY

$1.4B

17 positions

#4Samsara BioCapital, LLCSmart money

Notable overlap · 4 shared positions

$ALMS $MLYS $NKTX $ACLX

$1.0B

22 positions

#5GREAT POINT PARTNERS LLCActive

Notable overlap · 3 shared positions

$ALMS $ZBIO $ORKA

$435M

42 positions

#6NEXTBio Capital Management LPActive

Notable overlap · 3 shared positions

$ZBIO $ORIC $OCS

$215M

24 positions

#7EcoR1 Capital, LLCSmart money

Some overlap · 3 shared positions

$ORIC $CRSP $ZBIO

$2.4B

30 positions

#8MPM BioImpact LLCActive

Some overlap · 3 shared positions

$ALMS $ORIC $ENGN

$1.3B

41 positions

#9Monashee Investment Management LLCPassive

Some overlap · 4 shared positions

$MANE $ZBIO $CRSP $ENGN

$184M

45 positions

#10SPHERA FUNDS MANAGEMENT LTD.Passive

Some overlap · 3 shared positions

$MLYS $ORIC $RARE

$630M

96 positions

#11Ikarian Capital, LLCPassive

Some overlap · 3 shared positions

$ALMS $ORKA $RARE

$1.2B

161 positions

#12SILVERARC CAPITAL MANAGEMENT, LLCActive

Some overlap · 3 shared positions

$ZBIO $ORIC $ORKA

$980M

73 positions

#13Affinity Asset Advisors, LLCActive

Some overlap · 3 shared positions

$ACLX $ORKA $MLYS

$1.9B

105 positions

#14Catalio Capital Management, LPActive

Some overlap · 3 shared positions

$MLYS $MANE $RARE

$479M

41 positions

#15Vivo Capital, LLCActive

Some overlap · 3 shared positions

$ORIC $MANE $DSGN

$1.2B

45 positions

#16VR Adviser, LLCSmart money

Some overlap · 3 shared positions

$ORKA $ORIC $ENGN

$2.7B

33 positions

#17Siren, L.L.C.Active

Some overlap · 3 shared positions

$MANE $ORIC $ENGN

$3.6B

100 positions

#18Ishara Investments LPActive

Some overlap · 3 shared positions

$MLYS $ORIC $RARE

$106M

37 positions

#19Jones Hill Capital LPActive

Some overlap · 3 shared positions

$ORKA $MANE $RARE

$466M

26 positions

#20Integral Health Asset Management, LLCActive

Slight overlap · 3 shared positions

$MLYS $ORIC $ALMS

$2.1B

90 positions

#21Elmind Capital, LPActive

Slight overlap · 3 shared positions

$ALMS $DSGN $ENGN

$352M

34 positions

#22Birchview Capital, LPActive

Slight overlap · 3 shared positions

$ZBIO $ENGN $RARE

$176M

73 positions

#23Blue Owl Capital Holdings LPActive

Slight overlap · 4 shared positions

$ENGN $ORIC $RARE $MLYS

$372M

75 positions

#24Privium Fund Management B.V.Active

Slight overlap · 3 shared positions

$ENGN $CRSP $RARE

$480M

60 positions

#25Palo Alto Investors LPActive

Slight overlap · 3 shared positions

$ORKA $RARE $CRSP

$654M

51 positions

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Similarity is derived from each fund’s latest 13F-HR filing with the SEC. Funds are ranked by the overlap of distinctive conviction holdings; near-universal mega-cap positions are excluded so the ranking reflects shared strategy, not common index exposure. Data is informational only and not investment advice.