How is hedge fund similarity measured?

Similarity is computed from each fund's top conviction holdings in their latest 13F filing. Funds are scored by the overlap of distinctive shared positions (the mega-caps that nearly every fund owns are excluded), so the ranking reflects genuinely shared strategy rather than common index exposure.

Hedge Funds Similar to Opaleye

13F Portfolio OverlapQ1 2026Opaleye portfolio →

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Most similar hedge funds by 13F overlap

Opaleye Management Inc. is an institutional investor managing $759M across 54 U.S. equity positions as of Q1 2026. Based on the overlap of conviction holdings in their latest 13F filings, the hedge funds with portfolios most similar to Opaleye are GREAT POINT PARTNERS, Caligan Partners, MPM BioImpact, with shared positions in $SLGL, $APGE, $ANNX, $ALMS, $RLMD, $JBIO. The full ranking of 25 similar funds is below.

#1GREAT POINT PARTNERS LLCActive

Notable overlap · 7 shared positions

$SLGL $APGE $ANNX $ALMS $RLMD $JBIO

$435M

42 positions

#2Caligan Partners LPActive

Notable overlap · 3 shared positions

$LQDA $RVMD $MBX

$1.5B

28 positions

#3MPM BioImpact LLCActive

Notable overlap · 7 shared positions

$LQDA $EWTX $STOK $ALMS $URGN $RVMD

$1.3B

41 positions

#4PERCEPTIVE ADVISORS LLCActive

Notable overlap · 5 shared positions

$RYTM $APGE $EWTX $MGTX $PTGX

$5.1B

94 positions

#5BVF INC/ILActive

Notable overlap · 7 shared positions

$STOK $IRON $CBIO $ANNX $RVMD $XOMA

$3.1B

41 positions

#6KVP Capital Advisors, LPActive

Notable overlap · 9 shared positions

$IRON $EWTX $PTGX $RVMD $MBX $OCUL

$134M

32 positions

#7NEXTBio Capital Management LPActive

Notable overlap · 4 shared positions

$RYTM $CBIO $IRON $PTGX

$215M

24 positions

#8Ally Bridge Group (NY) LLCActive

Notable overlap · 5 shared positions

$URGN $CATX $EWTX $ALMS $RLMD

$124M

27 positions

#9Siren, L.L.C.Active

Notable overlap · 7 shared positions

$EWTX $STOK $IRON $RYTM $RVMD $ANNX

$3.6B

100 positions

#10Checkpoint Capital L.P.Active

Notable overlap · 4 shared positions

$RYTM $IRON $RVMD $TRVI

$279M

8 positions

#11SILVERARC CAPITAL MANAGEMENT, LLCActive

Notable overlap · 5 shared positions

$URGN $RYTM $IRON $CGON $TRVI

$980M

73 positions

#12RA CAPITAL MANAGEMENT, L.P.Smart money

Notable overlap · 4 shared positions

$RYTM $EWTX $IRON $JBIO

$9.4B

85 positions

#13StemPoint Capital LPActive

Notable overlap · 7 shared positions

$EWTX $PTGX $RVMD $MBX $ALMS $CGON

$515M

82 positions

#14VR Adviser, LLCSmart money

Notable overlap · 5 shared positions

$APGE $CBIO $RLMD $JBIO $OCUL

$2.7B

33 positions

#15Ikarian Capital, LLCPassive

Notable overlap · 6 shared positions

$HROW $ALMS $RVMD $RLMD $ACOG $JBIO

$1.2B

161 positions

#16RTW INVESTMENTS, LPActive

Some overlap · 6 shared positions

$APGE $STOK $PTGX $CGON $URGN $RCKT

$10.0B

88 positions

#17First Light Asset Management, LLCActive

Some overlap · 4 shared positions

$APGE $EWTX $RYTM $TECX

$1.1B

35 positions

#18TCG Crossover Management, LLCActive

Some overlap · 8 shared positions

$IRON $RVMD $CATX $CGON $MBX $TECX

$3.5B

49 positions

#19Affinity Asset Advisors, LLCActive

Some overlap · 5 shared positions

$APGE $PTGX $CATX $STRO $TRVI

$1.9B

105 positions

#20Logos Global Management LPActive

Some overlap · 6 shared positions

$RYTM $IRON $RVMD $CGON $OCUL $TRVI

$2.0B

66 positions

#21Remedium Capital Partners, LLCActive

Some overlap · 3 shared positions

$APGE $CBIO $JBIO

$320M

6 positions

#22Integral Health Asset Management, LLCActive

Some overlap · 4 shared positions

$RYTM $EWTX $RVMD $ALMS

$2.1B

90 positions

#23Seven Fleet Capital Management LPActive

Some overlap · 4 shared positions

$LQDA $RVMD $CATX $CGON

$315M

114 positions

#24Boxer Capital Management, LLCSmart money

Some overlap · 7 shared positions

$PTGX $RVMD $URGN $CBIO $APGE $RLMD

$762M

54 positions

#25Birchview Capital, LPActive

Some overlap · 5 shared positions

$STOK $PTGX $RLMD $OCUL $BDSX

$176M

73 positions

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Similarity is derived from each fund’s latest 13F-HR filing with the SEC. Funds are ranked by the overlap of distinctive conviction holdings; near-universal mega-cap positions are excluded so the ranking reflects shared strategy, not common index exposure. Data is informational only and not investment advice.