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Sio Capital Management, LLC

Institutional InvestorSimilar funds →SEC EDGAR: CIK 1482416
Institutional-grade research for retail investors

Sector Allocation

  • Healthcare77.7%$453.4M
  • Industrials9.1%$53.0M
  • Consumer Staples8.4%$49.1M
  • Technology4.8%$28.1M

AUM History

13fpro.ai/research/fund/sio-capital-management-llc-1482416

Conviction and streaks

Concentrating · top 10 = 50.1%

From the fund's last 12 quarters of 13F filings: positions held longest at size, and names it added to or trimmed several quarters running.

AVR$AVRConviction hold9.4% weight · held 7 quartersMMS$MMSConviction hold6.6% weight · held 8 quartersTYRA$TYRAConviction hold3.8% weight · held 10 quartersSNY$SNYConviction hold2.7% weight · held 5 quartersRAPP$RAPPConviction hold2.2% weight · held 4 quartersAVR$AVRAccumulating+213% shares · 3 quarters runningTYRA$TYRAAccumulating+35% shares · 3 quarters runningCOR$CORAccumulating+992% shares · 2 quarters runningGMED$GMEDAccumulating+46% shares · 2 quarters runningGSK$GSKAccumulating+62% shares · 2 quarters runningCELC$CELCTrimming-86% shares · 3 quarters runningDNTH$DNTHTrimming-90% shares · 3 quarters runningOVID$OVIDTrimming-30% shares · 2 quarters running

Largest positions — Q2 2026

Top 20 stock positions. Options are left out: 13F reports them at the underlying's value.

13fpro.ai/research/fund/sio-capital-management-llc-1482416

Sio Capital Management, LLC 13F holdings — Q2 2026

$604.3M portfolio (-13.3% QoQ) · 59 holdings · Q2 2026 13F · top 10 are 50% of the stock portfolio

Includes $20.8M of put/call options ($18.2M puts, $2.6M calls), which 13F rules report at the value of the underlying shares, not the premium at risk. Stocks alone: $583.5M. Weights use the stock portfolio.

All holdings — Sio Capital Management, LLC (Q2 2026)

59 disclosed positions from the Form 13F-HR on SEC EDGAR, with quarter-over-quarter share changes. Largest by value first; the ten above are not repeated.

Company
SLS$SLSPUTSELLAS Life Sciences Group, Inc.$18.2MNew
CI$CICigna Group$15.9MNew
SNY$SNYSanofiadr$15.5M+52%
ICLR$ICLRICON PLC$15.3M-71%
VTRS$VTRSViatris Inc$15.2MNew
CCRN$CCRNCROSS COUNTRY HEALTHCARE INC$14.5M—
RAPP$RAPPRapport Therapeutics, Inc.$12.8M-16%
ABT$ABTABBOTT LABORATORIES$11.7M-31%
CELC$CELCCelcuity Inc.$11.5M-43%
ZBH$ZBHZIMMER BIOMET HOLDINGS, INC.$11.3M+110%
REGN$REGNREGENERON PHARMACEUTICALS, INC.$11.2MNew
BMY$BMYBRISTOL MYERS SQUIBB CO$11.1MNew
MDT$MDTMedtronic plc$11.1MNew
VIR$VIRVir Biotechnology, Inc.$11.0M-28%
SENS$SENSSenseonics Holdings, Inc.$9.0M+1276%

What changed in Q2 2026

Against the previous quarter's 13F: 16 new, 10 added to, 22 trimmed, 33 sold out. Share-count changes; largest moves by dollar size first.

New positions (16)

  • ALLO$ALLOAllogene Therapeutics, Inc.$27.7M

    first bought this quarter

  • GMED$GMEDGLOBUS MEDICAL INC$23.8M

    first bought this quarter

  • SLS$SLSPUTSELLAS Life Sciences Group, Inc.$18.2M

    first bought this quarter

  • IDYA$IDYAIDEAYA Biosciences, Inc.$17.9M

    first bought this quarter

  • CI$CICigna Group$15.9M

    first bought this quarter

  • VTRS$VTRSViatris Inc$15.2M

    first bought this quarter

+10 more in the Excel export

Added to (10)

  • COR$CORCencora, Inc.+72%

    now $49.1M · held 3 qtrs, 3 adds in a row

  • SENS$SENSSenseonics Holdings, Inc.+1276%

    now $9.0M · held 5 qtrs

  • ZBH$ZBHZIMMER BIOMET HOLDINGS, INC.+110%

    now $11.3M · held 3 qtrs

  • SNY$SNYSanofi+52%

    now $15.5M · held 5 qtrs

  • ORKA$ORKAOruka Therapeutics, Inc.+34%

    now $16.9M · held 3 qtrs, 3 adds in a row

  • TYRA$TYRATyra Biosciences, Inc.+15%

    now $22.2M · held 10+ qtrs, 3 adds in a row

+4 more in the Excel export

Trimmed (22)

  • ICLR$ICLRICON PLC-71%

    now $15.3M · held 3 qtrs

  • DNTH$DNTHDianthus Therapeutics, Inc. /DE/-84%

    now $5.8M · held 6 qtrs, 3 trims in a row

  • WAY$WAYWaystar Holding Corp.-44%

    now $19.0M · held 3 qtrs

  • ANIP$ANIPANI PHARMACEUTICALS INC-63%

    now $8.1M · held 7 qtrs

  • CELC$CELCCelcuity Inc.-43%

    now $11.5M · held 4 qtrs, 3 trims in a row

  • SION$SIONSionna Therapeutics, Inc.-57%

    now $5.6M · held 2 qtrs

+16 more in the Excel export

Sold out (33)

  • CORT$CORTCORCEPT THERAPEUTICS INCwas $27.2M

    held 1 qtr

  • LIVN$LIVNLivaNova PLCwas $26.8M

    held 2 qtrs

  • EMBC$EMBCEmbecta Corp.was $16.3M

    held 1 qtr

  • ABVX$ABVXAbivax S.A.was $15.1M

    held 2 qtrs

  • HAE$HAEHAEMONETICS CORPwas $12.4M

    held 3 qtrs

  • TFX$TFXTELEFLEX INCwas $11.3M

+27 more in the Excel export

Firm AUM (Form ADV): $1.3B as of 2025-12-31 · SEC IAPD

Share

Holdings by quarter

Every 13F Sio Capital Management, LLC has filed, 41 earlier quarters. Pick one to see what it held then.

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Is it too late to follow Sio Capital Management?

Q2 2026 13F filed with the SEC on Aug 14, 2026. Prices are closing prices as of Oct 27, 2026.

Average quality of Sio Capital Management's top 20 holdings: 56/100 (our AI quality score, weighted by position size; 12 of the 20 are scored)

Top 10 since filing

-10.0%

Value-weighted move of the 10 largest stock positions

Turnover

32%

Last quarter; 140% over the last 4

Top 10 weight

50%

Share of the stock portfolio in its 10 largest positions

Held 4+ quarters

37%

Share of portfolio value in positions held a year or more

Highest-quality names it owns(among its 100 largest positions)

The 8 highest-scoring companies in this portfolio are a Pro feature.

How these are measured
  • Moves since the quarter-end and since the filing date use our own daily closing prices, from the close on (or just before) each date to the latest close.
  • Turnover is the lesser of shares bought or sold in a quarter, valued at the quarter-end prices in the 13F, divided by the average of the two quarters' stock portfolio values.
  • Quarters held and add/trim streaks count back only through quarters whose filed holdings add up to the filing's own cover-page total (back to Q1 2024 for this fund). A change counts as an add or a trim when the split-adjusted share count moves by more than 1%.
  • Estimate, not the fund's reported cost. For each quarter in the current holding period in which the fund's share count rose (split-adjusted), we take that quarter's average daily close and weight it by the shares added; sales do not change an average cost. Quarters where the stock's price history and the 13F's own implied price disagree by more than 2x are left out.
  • Put and call option rows report the value of the underlying shares, not a position the fund paid for, so they are left out of all of the above.

Portfolio Overview

Sio Capital Management, LLC disclosed 59 positions worth $604.3M in its Form 13F-HR for Q2 2026 — $583.5M in common stock plus $20.8M of put/call option positions (reported at underlying notional value, not premium at risk), led by $AVR (Anteris Technologies Global Corp.) at 9.4% of the equity portfolio, followed by $COR and $MMS. During the quarter the fund opened 16 new positions and exited 33 — including a new stake in $ALLO and a full exit from $CORT. The portfolio is most concentrated in Healthcare (77.7% of disclosed assets). All figures are sourced directly from Sio Capital Management, LLC’s Form 13F-HR filing with the SEC under CIK 1482416.

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AI-Powered Hedge Fund Analysis: Sio Capital Management, LLC

13F Pro is an AI hedge fund tracker and stock research platform. For Sio Capital Management, LLC (SEC CIK: 1482416), the platform ingests every quarterly Form 13F filing and applies AI-powered analysis on top — 10 specialized AI analysts (value, growth, momentum, macro, activist, and more) debate the fund's top positions and publish AI-generated analysis with cited SEC sources.

Every holding in Sio Capital Management, LLC's portfolio is scored on an AI quality ranking built from its SEC filings (ROIC, FCF margin, revenue growth, institutional flow, earnings quality, shareholder dilution, and more). Track accumulation and distribution quarter over quarter, identify conviction positions, and see AI stock analysis for each position — alongside 8,700+ other institutional filers and 2,800+ AI-ranked companies.