| Sep 15, 2026 | TVTXChief Legal Officer and GC | Open-market saleCode S · direct | 300 | $65.31 | $20K@ $65.31 | 105,389 | Form 4 |
| Sep 15, 2026 | TVTXChief Legal Officer and GC | Open-market saleCode S · direct | 1,400 | $63.69 | $89K@ $63.69 | 105,689 | Form 4 |
| Sep 15, 2026 | TVTXChief Legal Officer and GC | Open-market saleCode S · direct | 13,874 | $62.63 | $869K@ $62.63 | 107,089 | Form 4 |
| Sep 15, 2026 | TVTXChief Legal Officer and GC | Open-market saleCode S · direct | 21,926 | $62.03 | $1.4M@ $62.03 | 120,963 | Form 4 |
| Sep 15, 2026 | TVTXChief Legal Officer and GC | Option exerciseCode M · direct | 37,500 | $15.46 | $580K@ $15.46 | 142,889 | Form 4 |
| May 6, 2026 | TVTXChief Legal Officer and GC | Open-market saleCode S · direct | 2,076 | $43.95 | $91K@ $43.95 | 105,211 | Form 4 |
| May 5, 2026 | TVTXChief Legal Officer and GC | Open-market saleCode S · directAlso reported by Inrig Jula, Heerma Peter | 2,174 | $46.65 | $101K@ $46.65 | 107,287 | Form 4 |
| May 4, 2026 | TVTXChief Legal Officer and GC | Grant or awardCode A · direct | 8,500 | — | — | 8,500 | Form 4 |
| May 4, 2026 | TVTXChief Legal Officer and GC | Option exerciseCode M · direct | 4,250 | — | — | 109,461 | Form 4 |
| May 4, 2026 | TVTXChief Legal Officer and GC | Option exerciseCode M · direct | 20,000 | $17.96 | $359K@ $17.96 | 125,211 | Form 4 |
| Apr 15, 2026 | TVTXChief Legal Officer and GC | Open-market saleCode S · direct | 1,559 | $42.53 | $66K@ $42.53 | 105,211 | Form 4 |
| Apr 15, 2026 | TVTXChief Legal Officer and GC | Open-market saleCode S · direct | 5,226 | $41.62 | $218K@ $41.62 | 106,770 | Form 4 |
| Apr 14, 2026 | TVTXChief Legal Officer and GC | Open-market saleCode S · directAlso reported by Heerma Peter, Inrig Jula | 7,215 | $41.93 | $303K@ $41.93 | 111,996 | Form 4 |
| Apr 14, 2026 | TVTXChief Legal Officer and GC | Open-market saleCode S · direct | 37,500 | $41.07 | $1.5M@ $41.07 | 119,211 | Form 4 |
| Apr 14, 2026 | TVTXChief Legal Officer and GC | Option exerciseCode M · direct | 7,500 | $15.46 | $116K@ $15.46 | 156,711 | Form 4 |
| Apr 14, 2026 | TVTXChief Legal Officer and GC | Option exerciseCode M · direct | 20,000 | $17.96 | $359K@ $17.96 | 149,211 | Form 4 |
| Apr 14, 2026 | TVTXChief Legal Officer and GC | Option exerciseCode M · direct | 10,000 | $19.08 | $191K@ $19.08 | 129,211 | Form 4 |
| Apr 13, 2026 | TVTXChief Legal Officer and GC | Grant or awardCode A · direct | 14,000 | — | — | 119,211 | Form 4 |
| Apr 1, 2026 | TVTXChief Legal Officer and GC | Option exerciseCode M · direct | 10,000 | $15.46 | $155K@ $15.46 | 115,211 | Form 4 |
| Mar 16, 2026 | TVTXChief Legal Officer and GC | Option exerciseCode M · direct | 10,000 | $19.08 | $191K@ $19.08 | 115,211 | Form 4 |
| Feb 17, 2026 | TVTXChief Legal Officer and GC | Open-market saleCode S · direct | 4,321 | $28.26 | $122K@ $28.26 | 105,211 | Form 4 |
| Feb 17, 2026 | TVTXChief Legal Officer and GC | Open-market saleCode S · direct | 5,679 | $27.50 | $156K@ $27.50 | 109,532 | Form 4 |
| Feb 17, 2026 | TVTXChief Legal Officer and GC | Option exerciseCode M · direct | 10,000 | $19.08 | $191K@ $19.08 | 115,211 | Form 4 |
| Feb 4, 2026 | TVTXChief Legal Officer and GC | Open-market saleCode S · direct | 509 | $32.74 | $17K@ $32.74 | 105,211 | Form 4 |
| Feb 4, 2026 | TVTXChief Legal Officer and GC | Open-market saleCode S · direct | 2,485 | $32.07 | $80K@ $32.07 | 105,720 | Form 4 |
| Feb 3, 2026 | TVTXChief Legal Officer and GC | Open-market saleCode S · direct | 7,175 | $32.12 | $230K@ $32.12 | 108,205 | Form 4 |
| Jan 31, 2026 | TVTXChief Legal Officer and GC | Grant or awardCode A · direct | 66,960 | — | — | 66,960 | Form 4 |
| Jan 31, 2026 | TVTXChief Legal Officer and GC | Grant or awardCode A · direct | 25,110 | — | — | 115,380 | Form 4 |
| Jan 20, 2026 | TVTXChief Legal Officer and GC | Option exerciseCode M · direct | 10,000 | $19.08 | $191K@ $19.08 | 100,270 | Form 4 |